{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:09:27Z","timestamp":1790932167072,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T00:00:00Z","timestamp":1211328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiat Oncol"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1186\/1748-717x-3-15","type":"journal-article","created":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T19:50:25Z","timestamp":1211399425000},"source":"Crossref","is-referenced-by-count":79,"title":["High-dose intensity-modulated radiotherapy for prostate cancer using daily fiducial marker-based position verification: acute and late toxicity in 331 patients"],"prefix":"10.1186","volume":"3","author":[{"given":"Irene M","family":"Lips","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homan","family":"Dehnad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla H","family":"van Gils","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arto E","family":"Boeken Kruger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uulke A","family":"van der Heide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"van Vulpen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,5,21]]},"reference":[{"key":"108_CR1","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1200\/JCO.2005.05.2530","volume":"24","author":"ST Peeters","year":"2006","unstructured":"Peeters ST, Heemsbergen WD, Koper PC, van Putten WL, Slot A, Dielwart MF, Bonfrer JM, Incrocci L, Lebesque JV: Dose-response in radiotherapy for localized prostate cancer: results of the Dutch multicenter randomized phase III trial comparing 68 Gy of radiotherapy with 78 Gy. J Clin Oncol 2006, 24: 1990-1996. 10.1200\/JCO.2005.05.2530","journal-title":"J Clin Oncol"},{"key":"108_CR2","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/S0360-3016(02)02829-8","volume":"53","author":"A Pollack","year":"2002","unstructured":"Pollack A, Zagars GK, Starkschall G, Antolak JA, Lee JJ, Huang E, von Eschenbach AC, Kuban DA, Rosen I: Prostate cancer radiation dose response: results of the M. D. Anderson phase III randomized trial. Int J Radiat Oncol Biol Phys 2002, 53: 1097-1105. 10.1016\/S0360-3016(02)02829-8","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"108_CR3","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1001\/jama.294.10.1233","volume":"294","author":"AL Zietman","year":"2005","unstructured":"Zietman AL, DeSilvio ML, Slater JD, Rossi CJ Jr., Miller DW, Adams JA, Shipley WU: Comparison of conventional-dose vs high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: a randomized controlled trial. JAMA 2005, 294: 1233-1239. 10.1001\/jama.294.10.1233","journal-title":"JAMA"},{"key":"108_CR4","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.ijrobp.2007.01.008","volume":"68","author":"TN Eade","year":"2007","unstructured":"Eade TN, Hanlon AL, Horwitz EM, Buyyounouski MK, Hanks GE, Pollack A: What dose of external-beam radiation is high enough for prostate cancer? Int J Radiat Oncol Biol Phys 2007, 68: 682-689.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"108_CR5","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1002\/1097-0142(20001015)89:8<1800::AID-CNCR21>3.0.CO;2-D","volume":"89","author":"ME Chen","year":"2000","unstructured":"Chen ME, Johnston DA, Tang K, Babaian RJ, Troncoso P: Detailed mapping of prostate carcinoma foci: biopsy strategy implications. Cancer 2000, 89: 1800-1809. 10.1002\/1097-0142(20001015)89:8<1800::AID-CNCR21>3.0.CO;2-D","journal-title":"Cancer"},{"key":"108_CR6","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.semradonc.2007.09.007","volume":"18","author":"O Cahlon","year":"2008","unstructured":"Cahlon O, Hunt M, Zelefsky MJ: Intensity-modulated radiation therapy: supportive data for prostate cancer. Semin Radiat Oncol 2008, 18: 48-57. 10.1016\/j.semradonc.2007.09.007","journal-title":"Semin Radiat Oncol"},{"key":"108_CR7","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.ijrobp.2004.04.017","volume":"60","author":"G De Meerleer","year":"2004","unstructured":"De Meerleer G, Vakaet L, Meersschout S, Villeirs G, Verbaeys A, Oosterlinck W, De Neve W: Intensity-modulated radiotherapy as primary treatment for prostate cancer: acute toxicity in 114 patients. Int J Radiat Oncol Biol Phys 2004, 60: 777-787.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"108_CR8","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/S0360-3016(02)02857-2","volume":"53","author":"MJ Zelefsky","year":"2002","unstructured":"Zelefsky MJ, Fuks Z, Hunt M, Yamada Y, Marion C, Ling CC, Amols H, Venkatraman ES, Leibel SA: High-dose intensity modulated radiation therapy for prostate cancer: early toxicity and biochemical outcome in 772 patients. Int J Radiat Oncol Biol Phys 2002, 53: 1111-1116. 10.1016\/S0360-3016(02)02857-2","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"108_CR9","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.ijrobp.2006.12.064","volume":"68","author":"M Skala","year":"2007","unstructured":"Skala M, Rosewall T, Dawson L, Divanbeigi L, Lockwood G, Thomas C, Crook J, Chung P, Warde P, Catton C: Patient-assessed late toxicity rates and principal component analysis after image-guided radiation therapy for prostate cancer. Int J Radiat Oncol Biol Phys 2007, 68: 690-698.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"108_CR10","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.radonc.2006.12.007","volume":"82","author":"GO De Meerleer","year":"2007","unstructured":"De Meerleer GO, Fonteyne VH, Vakaet L, Villeirs GM, Denoyette L, Verbaeys A, Lummen N, De Neve WJ: Intensity-modulated radiation therapy for prostate cancer: late morbidity and results on biochemical control. Radiother Oncol 2007, 82: 160-166. 10.1016\/j.radonc.2006.12.007","journal-title":"Radiother Oncol"},{"key":"108_CR11","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/j.juro.2006.06.002","volume":"176","author":"MJ Zelefsky","year":"2006","unstructured":"Zelefsky MJ, Chan H, Hunt M, Yamada Y, Shippy AM, Amols H: Long-term outcome of high dose intensity modulated radiation therapy for patients with clinically localized prostate cancer. J Urol 2006, 176: 1415-1419. 10.1016\/j.juro.2006.06.002","journal-title":"J Urol"},{"key":"108_CR12","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/j.ijrobp.2004.11.032","volume":"62","author":"R de Crevoisier","year":"2005","unstructured":"de Crevoisier R, Tucker SL, Dong L, Mohan R, Cheung R, Cox JD, Kuban DA: Increased risk of biochemical and local failure in patients with distended rectum on the planning CT for prostate cancer radiotherapy. Int J Radiat Oncol Biol Phys 2005, 62: 965-973.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"108_CR13","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/S0167-8140(03)00078-1","volume":"67","author":"H Dehnad","year":"2003","unstructured":"Dehnad H, Nederveen AJ, van der Heide UA, van Moorselaar RJ, Hofman P, Lagendijk JJ: Clinical feasibility study for the use of implanted gold seeds in the prostate as reliable positioning markers during megavoltage irradiation. Radiother Oncol 2003, 67: 295-302. 10.1016\/S0167-8140(03)00078-1","journal-title":"Radiother Oncol"},{"key":"108_CR14","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.radonc.2006.11.002","volume":"82","author":"UA van der Heide","year":"2007","unstructured":"van der Heide UA, Kotte AN, Dehnad H, Hofman P, Lagenijk JJ, van Vulpen M: Analysis of fiducial marker-based position verification in the external beam radiotherapy of patients with prostate cancer. Radiother Oncol 2007, 82: 38-45. 10.1016\/j.radonc.2006.11.002","journal-title":"Radiother Oncol"},{"key":"108_CR15","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/j.ijrobp.2004.05.033","volume":"60","author":"V Beckendorf","year":"2004","unstructured":"Beckendorf V, Guerif S, Le Prise E, Cosset JM, Lefloch O, Chauvet B, Salem N, Chapet O, Bourdin S, Bachaud JM, Maingon P, Lagrange JL, Malissard L, Simon JM, Pommier P, Hay MH, Dubray B, Luporsi E, Bey P: The GETUG 70 Gy vs. 80 Gy randomized trial for localized prostate cancer: feasibility and acute toxicity. Int J Radiat Oncol Biol Phys 2004, 60: 1056-1065.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"108_CR16","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.ijrobp.2004.11.028","volume":"62","author":"JM Michalski","year":"2005","unstructured":"Michalski JM, Winter K, Purdy JA, Parliament M, Wong H, Perez CA, Roach M, Bosch W, Cox JD: Toxicity after three-dimensional radiotherapy for prostate cancer on RTOG 9406 dose Level V. Int J Radiat Oncol Biol Phys 2005, 62: 706-713.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"108_CR17","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/j.ijrobp.2004.07.715","volume":"61","author":"ST Peeters","year":"2005","unstructured":"Peeters ST, Heemsbergen WD, van Putten WL, Slot A, Tabak H, Mens JW, Lebesque JV, Koper PC: Acute and late complications after radiotherapy for prostate cancer: results of a multicenter randomized trial comparing 68 Gy to 78 Gy. Int J Radiat Oncol Biol Phys 2005, 61: 1019-1034.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"108_CR18","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/S0360-3016(00)00700-8","volume":"48","author":"MR Storey","year":"2000","unstructured":"Storey MR, Pollack A, Zagars G, Smith L, Antolak J, Rosen I: Complications from radiotherapy dose escalation in prostate cancer: preliminary results of a randomized trial. Int J Radiat Oncol Biol Phys 2000, 48: 635-642.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"108_CR19","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.ijrobp.2007.03.029","volume":"69","author":"AN Kotte","year":"2007","unstructured":"Kotte AN, Hofman P, Lagendijk JJ, van Vulpen M, van der Heide UA: Intrafraction motion of the prostate during external-beam radiation therapy: analysis of 427 patients with implanted fiducial markers. Int J Radiat Oncol Biol Phys 2007, 69: 419-425.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"108_CR20","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0167-8140(01)00405-4","volume":"61","author":"AJ Nederveen","year":"2001","unstructured":"Nederveen AJ, van der Heide UA, Hofman P, Welleweerd H, Lagendijk JJ: Partial boosting of prostate tumours. Radiother Oncol 2001, 61: 117-126. 10.1016\/S0167-8140(01)00405-4","journal-title":"Radiother Oncol"},{"key":"108_CR21","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0360-3016(99)00559-3","volume":"47","author":"A Trotti","year":"2000","unstructured":"Trotti A, Byhardt R, Stetz J, Gwede C, Corn B, Fu K, Gunderson L, McCormick B, Morrisintegral M, Rich T, Shipley W, Curran W: Common toxicity criteria: version 2.0. an improved reference for grading the acute effects of cancer treatment: impact on radiotherapy. Int J Radiat Oncol Biol Phys 2000, 47: 13-47.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"108_CR22","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1016\/0360-3016(95)00060-C","volume":"31","author":"JD Cox","year":"1995","unstructured":"Cox JD, Stetz J, Pajak TF: Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 1995, 31: 1341-1346.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"108_CR23","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.meddos.2004.10.005","volume":"30","author":"BS Teh","year":"2005","unstructured":"Teh BS, Dong L, McGary JE, Mai WY, Grant W III, Butler EB: Rectal wall sparing by dosimetric effect of rectal balloon used during intensity-modulated radiation therapy (IMRT) for prostate cancer. Med Dosim 2005, 30: 25-30.","journal-title":"Med Dosim"},{"key":"108_CR24","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ijrobp.2006.03.055","volume":"66","author":"WD Heemsbergen","year":"2006","unstructured":"Heemsbergen WD, Peeters ST, Koper PC, Hoogeman MS, Lebesque JV: Acute and late gastrointestinal toxicity after radiotherapy in prostate cancer patients: consequential late damage. Int J Radiat Oncol Biol Phys 2006, 66: 3-10.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"108_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.radonc.2004.07.020","volume":"73","author":"PC Koper","year":"2004","unstructured":"Koper PC, Jansen P, van Putten W, van Os M, Wijnmaalen AJ, Lebesque JV, Levendag PC: Gastro-intestinal and genito-urinary morbidity after 3D conformal radiotherapy of prostate cancer: observations of a randomized trial. Radiother Oncol 2004, 73: 1-9. 10.1016\/j.radonc.2004.07.020","journal-title":"Radiother Oncol"},{"key":"108_CR26","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/j.ijrobp.2005.03.060","volume":"63","author":"ST Peeters","year":"2005","unstructured":"Peeters ST, Hoogeman MS, Heemsbergen WD, Slot A, Tabak H, Koper PC, Lebesque JV: Volume and hormonal effects for acute side effects of rectum and bladder during conformal radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys 2005, 63: 1142-1152.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"108_CR27","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0360-3016(96)00468-3","volume":"37","author":"TE Schultheiss","year":"1997","unstructured":"Schultheiss TE, Lee WR, Hunt MA, Hanlon AL, Peter RS, Hanks GE: Late GI and GU complications in the treatment of prostate cancer. Int J Radiat Oncol Biol Phys 1997, 37: 3-11.","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1748-717X-3-15.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1748-717X-3-15\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1748-717X-3-15.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T04:37:01Z","timestamp":1548218221000},"score":1,"resource":{"primary":{"URL":"https:\/\/ro-journal.biomedcentral.com\/articles\/10.1186\/1748-717X-3-15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,21]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["108"],"URL":"https:\/\/doi.org\/10.1186\/1748-717x-3-15","relation":{},"ISSN":["1748-717X"],"issn-type":[{"value":"1748-717X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,21]]},"article-number":"15"}}