{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:37:52Z","timestamp":1790473072134,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,10,21]],"date-time":"2011-10-21T00:00:00Z","timestamp":1319155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiat Oncol"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1186\/1748-717x-6-141","type":"journal-article","created":{"date-parts":[[2011,11,9]],"date-time":"2011-11-09T20:30:40Z","timestamp":1320870640000},"source":"Crossref","is-referenced-by-count":46,"title":["Toxicity after radiochemotherapy for glioblastoma using temozolomide - a retrospective evaluation"],"prefix":"10.1186","volume":"6","author":[{"given":"Marcus","family":"Niewald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Berdel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Fleckenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Licht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Ketter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"R\u00fcbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,10,21]]},"reference":[{"key":"460_CR1","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1056\/NEJMoa043330","volume":"352","author":"R Stupp","year":"2005","unstructured":"Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, et al.: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. The New England journal of medicine 2005, 352: 987-996. 10.1056\/NEJMoa043330","journal-title":"The New England journal of medicine"},{"key":"460_CR2","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s11060-007-9398-z","volume":"85","author":"R Jalali","year":"2007","unstructured":"Jalali R, Singh P, Menon H, Gujral S: Unexpected case of aplastic anemia in a patient with glioblastoma multiforme treated with Temozolomide. J Neurooncol 2007, 85: 105-107. 10.1007\/s11060-007-9398-z","journal-title":"J Neurooncol"},{"key":"460_CR3","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s11060-008-9754-7","volume":"92","author":"M Nagane","year":"2009","unstructured":"Nagane M, Nozue K, Shimizu S, Waha A, Miyazaki H, Kurita H, Homori M, Fujioka Y, Shiokawa Y: Prolonged and severe thrombocytopenia with pancytopenia induced by radiation-combined temozolomide therapy in a patient with newly diagnosed glioblastoma--analysis of O6-methylguanine-DNA methyltransferase status. J Neurooncol 2009, 92: 227-232. 10.1007\/s11060-008-9754-7","journal-title":"J Neurooncol"},{"key":"460_CR4","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s11060-007-9403-6","volume":"85","author":"N Singhal","year":"2007","unstructured":"Singhal N, Selva-Nayagam S, Brown MP: Prolonged and severe myelosuppression in two patients after low-dose temozolomide treatment-case study and review of literature. J Neurooncol 2007, 85: 229-230. 10.1007\/s11060-007-9403-6","journal-title":"J Neurooncol"},{"key":"460_CR5","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1212\/01.wnl.0000259430.48835.b5","volume":"68","author":"MG Chheda","year":"2007","unstructured":"Chheda MG, Drappatz J, Greenberger NJ, Kesari S, Weiss SE, Gigas DC, Doherty LM, Wen PY: Hepatitis B reactivation during glioblastoma treatment with temozolomide: a cautionary note. Neurology 2007, 68: 955-956. 10.1212\/01.wnl.0000259430.48835.b5","journal-title":"Neurology"},{"key":"460_CR6","unstructured":"Common Toxicity Criteria2006. [\n                    http:\/\/www.eortc.be\/services\/doc\/ctc\/ctcaev3.pdf\n                    \n                  ]"},{"key":"460_CR7","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1016\/S0959-8049(96)00258-4","volume":"32A","author":"ES Newlands","year":"1996","unstructured":"Newlands ES, O'Reilly SM, Glaser MG, Bower M, Evans H, Brock C, Brampton MH, Colquhoun I, Lewis P, Rice-Edwards JM, et al.: The Charing Cross Hospital experience with temozolomide in patients with gliomas. Eur J Cancer 1996, 32A: 2236-2241.","journal-title":"Eur J Cancer"},{"key":"460_CR8","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/S0959-8049(05)80198-4","volume":"29A","author":"SM O'Reilly","year":"1993","unstructured":"O'Reilly SM, Newlands ES, Glaser MG, Brampton M, Rice-Edwards JM, Illingworth RD, Richards PG, Kennard C, Colquhoun IR, Lewis P, et al.: Temozolomide: a new oral cytotoxic chemotherapeutic agent with promising activity against primary brain tumours. Eur J Cancer 1993, 29A: 940-942.","journal-title":"Eur J Cancer"},{"key":"460_CR9","first-page":"4363","volume":"58","author":"CS Brock","year":"1998","unstructured":"Brock CS, Newlands ES, Wedge SR, Bower M, Evans H, Colquhoun I, Roddie M, Glaser M, Brampton MH, Rustin GJ: Phase I trial of temozolomide using an extended continuous oral schedule. Cancer Res 1998, 58: 4363-4367.","journal-title":"Cancer Res"},{"key":"460_CR10","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1200\/JCO.20.5.1375","volume":"20","author":"R Stupp","year":"2002","unstructured":"Stupp R, Dietrich PY, Ostermann Kraljevic S, Pica A, Maillard I, Maeder P, Meuli R, Janzer R, Pizzolato G, Miralbell R, et al.: Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide. Journal of clinical oncology: official journal of the American Society of Clinical Oncology 2002, 20: 1375-1382. 10.1200\/JCO.20.5.1375","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"key":"460_CR11","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1200\/JCO.2005.00.331","volume":"23","author":"H Athanassiou","year":"2005","unstructured":"Athanassiou H, Synodinou M, Maragoudakis E, Paraskevaidis M, Verigos C, Misailidou D, Antonadou D, Saris G, Beroukas K, Karageorgis P: Randomized phase II study of temozolomide and radiotherapy compared with radiotherapy alone in newly diagnosed glioblastoma multiforme. Journal of clinical oncology: official journal of the American Society of Clinical Oncology 2005, 23: 2372-2377. 10.1200\/JCO.2005.00.331","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"issue":"15S","key":"460_CR12","first-page":"S513","volume":"26","author":"TS Armstrong","year":"2008","unstructured":"Armstrong TS, Cao Y, Vera E, et al.: Pharmacoepidemiology of myelotoxicity (TOX) with temozolomide 8TEM) in malignant glioma patients. Journal of clinical oncology: official journal of the American Society of Clinical Oncology 2008,26(15S):S513.","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"key":"460_CR13","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1007\/s00066-005-1359-x","volume":"181","author":"SE Combs","year":"2005","unstructured":"Combs SE, Gutwein S, Schulz-Ertner D, van Kampen M, Thilmann C, Edler L, Wannenmacher MM, Debus Jr: Temozolomide combined with irradiation as postoperative treatment of primary glioblastoma multiforme. Phase I\/II study. Strahlentherapie Und Onkologie: Organ Der Deutschen R\u00f6ntgengesellschaft [Et Al] 2005, 181: 372-377.","journal-title":"Strahlentherapie Und Onkologie: Organ Der Deutschen R\u00f6ntgengesellschaft [Et Al]"},{"key":"460_CR14","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.ijrobp.2007.11.064","volume":"71","author":"SE Combs","year":"2008","unstructured":"Combs SE, Wagner J, Bischof M, Welzel T, Edler L, Rausch R, Wagner F, Zabel-du Bois A, Debus J, Schulz-Ertner D: Radiochemotherapy in patients with primary glioblastoma comparing two temozolomide dose regimens. Int J Radiat Oncol Biol Phys 2008, 71: 999-1005. 10.1016\/j.ijrobp.2007.11.064","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"460_CR15","doi-asserted-by":"crossref","unstructured":"Fiorica F, Berretta M, Colosimo C, Stefanelli A, Ursino S, Zanet E, Palmucci T, Maugeri D, Malaguarnera M, Palmucci S, et al.: Glioblastoma in elderly patients: safety and efficacy of adjuvant radiotherapy with concomitant temozolomide. Arch Gerontol Geriatr 51: 31-35.","DOI":"10.1016\/j.archger.2009.06.011"},{"key":"460_CR16","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1215\/15228517-2006-024","volume":"9","author":"DE Gerber","year":"2007","unstructured":"Gerber DE, Grossman SA, Zeltzman M, Parisi MA, Kleinberg L: The impact of thrombocytopenia from temozolomide and radiation in newly diagnosed adults with high-grade gliomas. Neuro Oncol 2007, 9: 47-52.","journal-title":"Neuro Oncol"},{"key":"460_CR17","doi-asserted-by":"crossref","unstructured":"Gerstein J, Franz K, Steinbach JP, Seifert V, Fraunholz I, Weiss C, R\u00f6del C: Postoperative radiotherapy and concomitant temozolomide for elderly patients with glioblastoma. Radiotherapy And Oncology: Journal Of The European Society For Therapeutic Radiology And Oncology 97: 382-386.","DOI":"10.1016\/j.radonc.2010.06.014"},{"key":"460_CR18","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.clineuro.2009.06.013","volume":"111","author":"HJ Jeon","year":"2009","unstructured":"Jeon HJ, Kong DS, Park KB, Lee JI, Park K, Kim JH, Kim ST, Lim do H, Kim WS, Nam DH: Clinical outcome of concomitant chemoradiotherapy followed by adjuvant temozolomide therapy for glioblastaomas: single-center experience. Clin Neurol Neurosurg 2009, 111: 679-682. 10.1016\/j.clineuro.2009.06.013","journal-title":"Clin Neurol Neurosurg"},{"key":"460_CR19","doi-asserted-by":"crossref","unstructured":"Kimple RJ, Grabowski S, Papez M, Collichio F, Ewend MG, Morris DE: Concurrent temozolomide and radiation, a reasonable option for elderly patients with glioblastoma multiforme? Am J Clin Oncol 33: 265-270.","DOI":"10.1097\/COC.0b013e3181a76a24"},{"key":"460_CR20","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s11060-008-9538-0","volume":"88","author":"G Minniti","year":"2008","unstructured":"Minniti G, De Sanctis V, Muni R, Filippone F, Bozzao A, Valeriani M, Osti MF, De Paula U, Lanzetta G, Tombolini V, Maurizi Enrici R: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma in elderly patients. J Neurooncol 2008, 88: 97-103. 10.1007\/s11060-008-9538-0","journal-title":"J Neurooncol"},{"key":"460_CR21","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0305-7372(97)90019-0","volume":"23","author":"ES Newlands","year":"1997","unstructured":"Newlands ES, Stevens MF, Wedge SR, Wheelhouse RT, Brock C: Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials. Cancer Treat Rev 1997, 23: 35-61. 10.1016\/S0305-7372(97)90019-0","journal-title":"Cancer Treat Rev"},{"key":"460_CR22","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1056\/NEJMc063696","volume":"356","author":"J Grewal","year":"2007","unstructured":"Grewal J, Dellinger CA, Yung WK: Fatal reactivation of hepatitis B with temozolomide. N Engl J Med 2007, 356: 1591-1592. 10.1056\/NEJMc063696","journal-title":"N Engl J Med"},{"key":"460_CR23","first-page":"131","volume":"108","author":"B Neyns","year":"2008","unstructured":"Neyns B, Hoorens A, Stupp R: Valproic acid related idiosyncratic drug induced hepatotoxicity in a glioblastoma patient treated with temozolomide. Acta Neurol Belg 2008, 108: 131-134.","journal-title":"Acta Neurol Belg"},{"key":"460_CR24","doi-asserted-by":"crossref","unstructured":"Chamberlain MC: Temozolomide: therapeutic limitations in the treatment of adult high-grade gliomas. Expert Rev Neurother 10: 1537-1544.","DOI":"10.1586\/ern.10.32"},{"key":"460_CR25","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1215\/15228517-2008-120","volume":"11","author":"TS Armstrong","year":"2009","unstructured":"Armstrong TS, Cao Y, Scheurer ME, Vera-Bolanos E, Manning R, Okcu MF, Bondy M, Zhou R, Gilbert MR: Risk analysis of severe myelotoxicity with temozolomide: the effects of clinical and genetic factors. Neuro Oncol 2009, 11: 825-832. 10.1215\/15228517-2008-120","journal-title":"Neuro Oncol"},{"key":"460_CR26","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1007\/s00066-005-1359-x","volume":"181","author":"SE Combs","year":"2005","unstructured":"Combs SE, Gutwein S, Schulz-Ertner D, van Kampen M, Thilmann C, Edler L, Wannenmacher MM, Debus J: Temozolomide combined with irradiation as postoperative treatment of primary glioblastoma multiforme. Phase I\/II study. Strahlentherapie und Onkologie 2005, 181: 372-377. 10.1007\/s00066-005-1359-x","journal-title":"Strahlentherapie und Onkologie"},{"key":"460_CR27","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.clineuro.2009.06.013","volume":"111","author":"HJ Jeon","year":"2009","unstructured":"Jeon HJ, Kong DS, Park KB, Lee JI, Park K, Kim JH, Kim ST, Lim DH, Kim WS, Nam D-H: Clinical outcome of concomitant chemoradiotherapy followed by adjuvant temozolomide therapy for glioblastaomas: single-center experience. Clinical Neurology And Neurosurgery 2009, 111: 679-682. 10.1016\/j.clineuro.2009.06.013","journal-title":"Clinical Neurology And Neurosurgery"}],"container-title":["Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1748-717X-6-141.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1748-717X-6-141\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1748-717X-6-141.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T04:58:12Z","timestamp":1548219492000},"score":1,"resource":{"primary":{"URL":"https:\/\/ro-journal.biomedcentral.com\/articles\/10.1186\/1748-717X-6-141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,21]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["460"],"URL":"https:\/\/doi.org\/10.1186\/1748-717x-6-141","relation":{},"ISSN":["1748-717X"],"issn-type":[{"value":"1748-717X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,21]]},"article-number":"141"}}