{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:40:02Z","timestamp":1788878402154,"version":"build-2803163510"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,11,8]],"date-time":"2011-11-08T00:00:00Z","timestamp":1320710400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiat Oncol"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1186\/1748-717x-6-151","type":"journal-article","created":{"date-parts":[[2011,11,8]],"date-time":"2011-11-08T19:19:21Z","timestamp":1320779961000},"source":"Crossref","is-referenced-by-count":38,"title":["Myocardial perfusion imaging with 99 mTc - tetrofosmin SPECT in breast cancer patients that received postoperative radiotherapy: a case-control study"],"prefix":"10.1186","volume":"6","author":[{"given":"Chrissa","family":"Sioka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Exarchopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifigenia","family":"Tasiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eftychia","family":"Tzima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Fotou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Capizzello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasilios","family":"Ragos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Periklis","family":"Tsekeris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Fotopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,11,8]]},"reference":[{"key":"474_CR1","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1002\/ijc.25516","volume":"127","author":"J Ferlay","year":"2010","unstructured":"Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010, 127: 2893-2917. 10.1002\/ijc.25516","journal-title":"Int J Cancer"},{"key":"474_CR2","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.semradonc.2009.05.009","volume":"19","author":"R Jagsi","year":"2009","unstructured":"Jagsi R, Pierce L: Postmastectomy radiation therapy for patients with locally advanced breast cancer. Semin Radiat Oncol 2009, 19: 236-243. 10.1016\/j.semradonc.2009.05.009","journal-title":"Semin Radiat Oncol"},{"key":"474_CR3","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1002\/cncr.25623","volume":"117","author":"SB Motwani","year":"2011","unstructured":"Motwani SB, Goyal S, Moran MS, Chhabra A, Haffty BG: Ductal carcinoma in situ treated with breast-conserving surgery and radiotherapy: A comparison with ECOG study 5194. Cancer 2011, 117: 1156-1162. 10.1002\/cncr.25623","journal-title":"Cancer"},{"key":"474_CR4","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1016\/S0140-6736(05)67887-7","volume":"366","author":"M Clarke","year":"2005","unstructured":"Clarke M, Collins R, Darby S, Davies C, Elphinstone P, Evans E, Godwin J, Gray R, Hicks C, James S, et al.: Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005, 366: 2087-2106.","journal-title":"Lancet"},{"key":"474_CR5","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1093\/jnci\/dji067","volume":"97","author":"SH Giordano","year":"2005","unstructured":"Giordano SH, Kuo YF, Freeman JL, Buchholz TA, Hortobagyi GN, Goodwin JS: Risk of cardiac death after adjuvant radiotherapy for breast cancer. J Natl Cancer Inst 2005, 97: 419-424. 10.1093\/jnci\/dji067","journal-title":"J Natl Cancer Inst"},{"key":"474_CR6","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0167-8140(00)00152-3","volume":"55","author":"CW Hurkmans","year":"2000","unstructured":"Hurkmans CW, Borger JH, Bos LJ, van der Horst A, Pieters BR, Lebesque JV, Mijnheer BJ: Cardiac and lung complication probabilities after breast cancer irradiation. Radiother Oncol 2000, 55: 145-151. 10.1016\/S0167-8140(00)00152-3","journal-title":"Radiother Oncol"},{"key":"474_CR7","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1016\/0360-3016(94)90500-2","volume":"28","author":"G Gyenes","year":"1994","unstructured":"Gyenes G, Fornander T, Carlens P, Rutqvist LE: Morbidity of ischemic heart disease in early breast cancer 15-20 years after adjuvant radiotherapy. Int J Radiat Oncol Biol Phys 1994, 28: 1235-1241. 10.1016\/0360-3016(94)90500-2","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"474_CR8","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S0167-8140(98)00062-0","volume":"48","author":"G Gyenes","year":"1998","unstructured":"Gyenes G, Rutqvist LE, Liedberg A, Fornander T: Long-term cardiac morbidity and mortality in a randomized trial of pre- and postoperative radiation therapy versus surgery alone in primary breast cancer. Radiother Oncol 1998, 48: 185-190. 10.1016\/S0167-8140(98)00062-0","journal-title":"Radiother Oncol"},{"key":"474_CR9","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.clon.2005.11.003","volume":"18","author":"CW Taylor","year":"2006","unstructured":"Taylor CW, McGale P, Darby SC: Cardiac risks of breast-cancer radiotherapy: a contemporary view. Clin Oncol (R Coll Radiol) 2006, 18: 236-246. 10.1016\/j.clon.2005.11.003","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"474_CR10","doi-asserted-by":"publisher","first-page":"546","DOI":"10.2967\/jnumed.108.055954","volume":"50","author":"A Gimelli","year":"2009","unstructured":"Gimelli A, Rossi G, Landi P, Marzullo P, Iervasi G, L'Abbate A, Rovai D: Stress\/Rest Myocardial Perfusion Abnormalities by Gated SPECT: Still the Best Predictor of Cardiac Events in Stable Ischemic Heart Disease. J Nucl Med 2009, 50: 546-553. 10.2967\/jnumed.108.055954","journal-title":"J Nucl Med"},{"issue":"Suppl 1","key":"474_CR11","doi-asserted-by":"publisher","first-page":"i1","DOI":"10.1136\/heart.90.suppl_1.i1","volume":"90","author":"C Anagnostopoulos","year":"2004","unstructured":"Anagnostopoulos C, Harbinson M, Kelion A, Kundley K, Loong CY, Notghi A, Reyes E, Tindale W, Underwood SR: Procedure guidelines for radionuclide myocardial perfusion imaging. Heart 2004,90(Suppl 1):i1-10.","journal-title":"Heart"},{"key":"474_CR12","doi-asserted-by":"publisher","first-page":"e39","DOI":"10.1016\/j.nuclcard.2007.09.023","volume":"14","author":"CL Hansen","year":"2007","unstructured":"Hansen CL, Goldstein RA, Akinboboye OO, Berman DS, Botvinick EH, Churchwell KB, Cooke CD, Corbett JR, Cullom SJ, Dahlberg ST, et al.: Myocardial perfusion and function: single photon emission computed tomography. J Nucl Cardiol 2007, 14: e39-60. 10.1016\/j.nuclcard.2007.09.023","journal-title":"J Nucl Cardiol"},{"key":"474_CR13","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1067\/mnc.2002.123122","volume":"9","author":"MD Cerqueira","year":"2002","unstructured":"Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, Pennell DJ, Rumberger JA, Ryan T, Verani MS: Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. J Nucl Cardiol 2002, 9: 240-245. 10.1067\/mnc.2002.123122","journal-title":"J Nucl Cardiol"},{"key":"474_CR14","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1097\/FJC.0b013e31817bdd66","volume":"51","author":"R Belardinelli","year":"2008","unstructured":"Belardinelli R, Cianci G, Gigli M, Mazzanti M, Lacalaprice F: Effects of trimetazidine on myocardial perfusion and left ventricular systolic function in type 2 diabetic patients with ischemic cardiomyopathy. J Cardiovasc Pharmacol 2008, 51: 611-615. 10.1097\/FJC.0b013e31817bdd66","journal-title":"J Cardiovasc Pharmacol"},{"key":"474_CR15","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1080\/028418698429522","volume":"37","author":"G Gyenes","year":"1998","unstructured":"Gyenes G: Radiation-induced ischemic heart disease in breast cancer--a review. Acta Oncol 1998, 37: 241-246. 10.1080\/028418698429522","journal-title":"Acta Oncol"},{"key":"474_CR16","doi-asserted-by":"crossref","unstructured":"Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group Lancet 2000, 355: 1757-1770.","DOI":"10.1016\/S0140-6736(00)02263-7"},{"key":"474_CR17","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.ijrobp.2007.06.060","volume":"69","author":"WA Beckham","year":"2007","unstructured":"Beckham WA, Popescu CC, Patenaude VV, Wai ES, Olivotto IA: Is multibeam IMRT better than standard treatment for patients with left-sided breast cancer? Int J Radiat Oncol Biol Phys 2007, 69: 918-924. 10.1016\/j.ijrobp.2007.06.060","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"474_CR18","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.radonc.2006.12.008","volume":"82","author":"E Donovan","year":"2007","unstructured":"Donovan E, Bleakley N, Denholm E, Evans P, Gothard L, Hanson J, Peckitt C, Reise S, Ross G, Sharp G, et al.: Randomised trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapy. Radiother Oncol 2007, 82: 254-264. 10.1016\/j.radonc.2006.12.008","journal-title":"Radiother Oncol"},{"key":"474_CR19","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1016\/S0140-6736(99)02245-X","volume":"354","author":"I Hojris","year":"1999","unstructured":"Hojris I, Overgaard M, Christensen JJ, Overgaard J: Morbidity and mortality of ischaemic heart disease in high-risk breast-cancer patients after adjuvant postmastectomy systemic treatment with or without radiotherapy: analysis of DBCG 82b and 82 c randomised trials. Radiotherapy Committee of the Danish Breast Cancer Cooperative Group. Lancet 1999, 354: 1425-1430. 10.1016\/S0140-6736(99)02245-X","journal-title":"Lancet"},{"key":"474_CR20","doi-asserted-by":"publisher","first-page":"S77","DOI":"10.1016\/j.ijrobp.2009.04.093","volume":"76","author":"G Gagliardi","year":"2010","unstructured":"Gagliardi G, Constine LS, Moiseenko V, Correa C, Pierce LJ, Allen AM, Marks LB: Radiation dose-volume effects in the heart. Int J Radiat Oncol Biol Phys 2010, 76: S77-85. 10.1016\/j.ijrobp.2009.04.093","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"474_CR21","doi-asserted-by":"crossref","first-page":"5098","DOI":"10.1016\/j.ijrobp.2007.12.037","volume":"72","author":"CR Correa","year":"2008","unstructured":"Correa CR, Das IJ, Litt HI, Ferrari V, Hwang WT, Solin LJ, Harris EE: Association between tangential beam treatment parameters and cardiac abnormalities after definitive radiation treatment for left sited breast cancer. Int J Radiat Oncol Biol Phys 2008, 72: 5098-516.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"474_CR22","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1667\/RR1862.1","volume":"174","author":"FA Stewart","year":"2010","unstructured":"Stewart FA, Hoving S, Russell NS: Vascular Damage as an Underlying Mechanism of Cardiac and Cerebral Toxicity in Irradiated Cancer Patients. Radiat Res 2010, 174: 865-869. 10.1667\/RR1862.1","journal-title":"Radiat Res"},{"key":"474_CR23","first-page":"286","volume":"24","author":"G Gyenes","year":"1997","unstructured":"Gyenes G, Fornander T, Carlens P, Glas U, Rutqvist LE: Detection of radiation-induced myocardial damage by technetium-99m sestamibi scintigraphy. Eur J Nucl Med 1997, 24: 286-292.","journal-title":"Eur J Nucl Med"},{"key":"474_CR24","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/S0360-3016(00)01531-5","volume":"49","author":"PH Hardenbergh","year":"2001","unstructured":"Hardenbergh PH, Munley MT, Bentel GC, Kedem R, Borges-Neto S, Hollis D, Prosnitz LR, Marks LB: Cardiac perfusion changes in patients treated for breast cancer with radiation therapy and doxorubicin: preliminary results. Int J Radiat Oncol Biol Phys 2001, 49: 1023-1028. 10.1016\/S0360-3016(00)01531-5","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"474_CR25","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/S0360-3016(02)04156-1","volume":"55","author":"PA Lind","year":"2003","unstructured":"Lind PA, Pagnanelli R, Marks LB, Borges-Neto S, Hu C, Zhou SM, Light K, Hardenbergh PH: Myocardial perfusion changes in patients irradiated for left-sided breast cancer and correlation with coronary artery distribution. Int J Radiat Oncol Biol Phys 2003, 55: 914-920. 10.1016\/S0360-3016(02)04156-1","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"474_CR26","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.ijrobp.2005.01.029","volume":"63","author":"LB Marks","year":"2005","unstructured":"Marks LB, Yu X, Prosnitz RG, Zhou SM, Hardenbergh PH, Blazing M, Hollis D, Lind P, Tisch A, Wong TZ, Borges-Neto S: The incidence and functional consequences of RT-associated cardiac perfusion defects. Int J Radiat Oncol Biol Phys 2005, 63: 214-223. 10.1016\/j.ijrobp.2005.01.029","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"474_CR27","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1002\/cncr.22965","volume":"110","author":"RG Prosnitz","year":"2007","unstructured":"Prosnitz RG, Hubbs JL, Evans ES, Zhou SM, Yu X, Blazing MA, Hollis DR, Tisch A, Wong TZ, Borges-Neto S, et al.: Prospective assessment of radiotherapy-associated cardiac toxicity in breast cancer patients: analysis of data 3 to 6 years after treatment. Cancer 2007, 110: 1840-1850. 10.1002\/cncr.22965","journal-title":"Cancer"},{"key":"474_CR28","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0167-8140(02)00133-0","volume":"64","author":"B Seddon","year":"2002","unstructured":"Seddon B, Cook A, Gothard L, Salmon E, Latus K, Underwood SR, Yarnold J: Detection of defects in myocardial perfusion imaging in patients with early breast cancer treated with radiotherapy. Radiother Oncol 2002, 64: 53-63. 10.1016\/S0167-8140(02)00133-0","journal-title":"Radiother Oncol"},{"key":"474_CR29","first-page":"505","volume":"11","author":"A Tzonevska","year":"2006","unstructured":"Tzonevska A, Tzvetkov K, Parvanova V, Dimitrova M: 99mTc-MIBI myocardial perfusion scintigraphy for assessment of myocardial damage after radiotherapy in patients with breast cancer. J BUON 2006, 11: 505-509.","journal-title":"J BUON"},{"key":"474_CR30","first-page":"193","volume":"4","author":"X Yu","year":"2003","unstructured":"Yu X, Prosnitz RR, Zhou S, Hardenberg PH, Tisch A, Blazing MA, Borges-Neto S, Hollis D, Wong T, Marks LB: Symptomatic cardiac events following radiation therapy for left-sided breast cancer: possible association with radiation therapy-induced changes in regional perfusion. Clin Breast Cancer 2003, 4: 193-197.","journal-title":"Clin Breast Cancer"},{"key":"474_CR31","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.radonc.2011.01.020","volume":"100","author":"CW Taylor","year":"2011","unstructured":"Taylor CW, Bronnum D, Darby SC, Gagliardi G, Hall P, Jensen MB, McGale P, Nisbet A, Ewertz M: Cardiac dose estimates from Danish and Swedish breast cancer radiotherapy during 1977-2001. Radiother Oncol 2011, 100: 176-183. 10.1016\/j.radonc.2011.01.020","journal-title":"Radiother Oncol"},{"key":"474_CR32","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.ijrobp.2006.12.019","volume":"68","author":"JJ Doyle","year":"2007","unstructured":"Doyle JJ, Neugut AI, Jacobson JS, Wang J, McBride R, Grann A, Grann VR, Hershman D: Radiation therapy, cardiac risk factors, and cardiac toxicity in early-stage breast cancer patients. Int J Radiat Oncol Biol Phys 2007, 68: 82-93. 10.1016\/j.ijrobp.2006.12.019","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"474_CR33","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0167-8140(00)00170-5","volume":"55","author":"HL I","year":"2000","unstructured":"I HL, Sand NP, Andersen J, Rehling M, Overgaard M: Myocardial perfusion imaging in breast cancer patients treated with or without post-mastectomy radiotherapy. Radiother Oncol 2000, 55: 163-172. 10.1016\/S0167-8140(00)00170-5","journal-title":"Radiother Oncol"},{"key":"474_CR34","doi-asserted-by":"publisher","first-page":"4100","DOI":"10.1200\/JCO.2005.05.1037","volume":"24","author":"EE Harris","year":"2006","unstructured":"Harris EE, Correa C, Hwang WT, Liao J, Litt HI, Ferrari VA, Solin LJ: Late cardiac mortality and morbidity in early-stage breast cancer patients after breast-conservation treatment. J Clin Oncol 2006, 24: 4100-4106. 10.1200\/JCO.2005.05.1037","journal-title":"J Clin Oncol"},{"key":"474_CR35","first-page":"1531","volume":"44","author":"I Goethals","year":"2003","unstructured":"Goethals I, Dierckx R, De Meerleer G, De Sutter J, De Winter O, De Neve W, Van de Wiele C: The role of nuclear medicine in the prediction and detection of radiation-associated normal pulmonary and cardiac damage. J Nucl Med 2003, 44: 1531-1539.","journal-title":"J Nucl Med"},{"key":"474_CR36","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1093\/annonc\/mdf318","volume":"13","author":"I Goethals","year":"2002","unstructured":"Goethals I, De Winter O, De Bondt P, De Sutter J, Dierckx R, Van De Wiele C: The clinical value of nuclear medicine in the assessment of irradiation-induced and anthracycline-associated cardiac damage. Ann Oncol 2002, 13: 1331-1339. 10.1093\/annonc\/mdf318","journal-title":"Ann Oncol"}],"container-title":["Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1748-717X-6-151.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1748-717X-6-151\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1748-717X-6-151.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T07:29:32Z","timestamp":1560929372000},"score":1,"resource":{"primary":{"URL":"https:\/\/ro-journal.biomedcentral.com\/articles\/10.1186\/1748-717X-6-151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,8]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["474"],"URL":"https:\/\/doi.org\/10.1186\/1748-717x-6-151","relation":{},"ISSN":["1748-717X"],"issn-type":[{"value":"1748-717X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,8]]},"article-number":"151"}}