{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:18:58Z","timestamp":1791019138707,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiat Oncol"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1186\/1748-717x-7-217","type":"journal-article","created":{"date-parts":[[2012,12,18]],"date-time":"2012-12-18T06:14:39Z","timestamp":1355811279000},"source":"Crossref","is-referenced-by-count":63,"title":["Factors of influence on acute skin toxicity of breast cancer patients treated with standard three-dimensional conformal radiotherapy (3D-CRT) after breast conserving surgery (BCS)"],"prefix":"10.1186","volume":"7","author":[{"given":"Uta","family":"Kraus-Tiefenbacher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Sfintizky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grit","family":"Welzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Simeonova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Sperk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Siebenlist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Wenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,12,18]]},"reference":[{"key":"761_CR1","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1056\/NEJMoa022152","volume":"347","author":"B Fisher","year":"2002","unstructured":"Fisher B, Anderson S, Bryant J, et al.: Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 2002, 347: 1233-1241. 10.1056\/NEJMoa022152","journal-title":"N Engl J Med"},{"key":"761_CR2","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1023\/A:1015296607061","volume":"73","author":"E Lopez","year":"2002","unstructured":"Lopez E, Nunez MI, Guerrero MR, et al.: Breast cancer acute radiotherapy morbidity evaluated by different scoring systems. Breast Canc Res Treat 2002, 73: 127-134. 10.1023\/A:1015296607061","journal-title":"Breast Canc Res Treat"},{"key":"761_CR3","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1046\/j.1365-2354.1999.00153.x","volume":"8","author":"D Porock","year":"1998","unstructured":"Porock D, Kristjanson L: Skin reactions during chemotherapy for breast cancer: the use and impact of topical agents and dressings. Eur J Cancer Care 1998, 8: 143-153.","journal-title":"Eur J Cancer Care"},{"key":"761_CR4","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1016\/S0360-3016(00)00782-3","volume":"48","author":"J Fisher","year":"2000","unstructured":"Fisher J, Scott C, Stevens R, et al.: Randomized phase III study comparing Best Supportive Care to Biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: Radiation Therapy Oncology Group (RTOG) 97\u201313. Int J Radiat Oncol Biol Phys 2000, 48: 1307-1310. 10.1016\/S0360-3016(00)00782-3","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"761_CR5","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1016\/j.ijrobp.2007.02.044","volume":"68","author":"A Harsolia","year":"2007","unstructured":"Harsolia A, Kestin L, Grills I, et al.: Intensity-modulated radiotherapy results in significant decrease in clinical toxicities compared with conventional wedge-based breast radiotherapy. Int J Radiat Oncol Bio lPhys 2007, 68: 1375-1380. 10.1016\/j.ijrobp.2007.02.044","journal-title":"Int J Radiat Oncol Bio lPhys"},{"key":"761_CR6","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1200\/JCO.2007.15.2488","volume":"26","author":"J Pignol","year":"2008","unstructured":"Pignol J, Olivotto I, Rakovitch E, et al.: A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis. J Clin Oncol 2008, 26: 2085-2092. 10.1200\/JCO.2007.15.2488","journal-title":"J Clin Oncol"},{"key":"761_CR7","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.clon.2003.08.005","volume":"16","author":"M Back","year":"2004","unstructured":"Back M, Guerrieri M, Wratten C, et al.: Impact of radiation therapy on acute toxicity in breast conservation therapy for early breast cancer. Clin Oncol 2004, 16: 12-16. 10.1016\/j.clon.2003.08.005","journal-title":"Clin Oncol"},{"key":"761_CR8","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1200\/JCO.2006.09.1041","volume":"25","author":"SC Formenti","year":"2007","unstructured":"Formenti SC, Gidea-Addeo D, Goldberg JD, et al.: Phase I-II trial of prone accelerated intensity modulated radiation therapy to the breast to optimally spare normal tissue. J Clin Oncol 2007, 25: 2236-2242. 10.1200\/JCO.2006.09.1041","journal-title":"J Clin Oncol"},{"key":"761_CR9","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.breast.2007.07.033","volume":"17","author":"R Jalali","year":"2008","unstructured":"Jalali R, Malde R, Bhutani R, et al.: Prospective evaluation of concomitant tumour bed boost with whole breast irradiation in patients with locally advanced breast cancer undergoing breast-conserving therapy. Breast 2008, 17: 64-70. 10.1016\/j.breast.2007.07.033","journal-title":"Breast"},{"key":"761_CR10","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/S0936-6555(05)80657-0","volume":"8","author":"IN Fernando","year":"1996","unstructured":"Fernando IN, Ford HT, Powles TJ, et al.: Factors affecting acute skin toxicity in patients having breast irradiation after conservative surgery: a prospective study of treatment practice at the Royal Marsden Hospital. J Clin Oncol (R Coll Radiol) 1996, 8: 226-233. 10.1016\/S0936-6555(05)80657-0","journal-title":"J Clin Oncol (R Coll Radiol)"},{"key":"761_CR11","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1007\/s00066-011-2204-z","volume":"187","author":"M Becker-Schiebe","year":"2011","unstructured":"Becker-Schiebe M, Mengs U, Schaefer M, et al.: Topical use of a silymarin-based preparation to prevent radiodermatitis: results of a prospective study in breast cancer patients. Strahlenther Onkol 2011, 187: 485-491. 10.1007\/s00066-011-2204-z","journal-title":"Strahlenther Onkol"},{"key":"761_CR12","volume-title":"Int J Radiat Oncol Biol Phys","author":"C Pinnix","year":"2011","unstructured":"Pinnix C, Perkins GH, Strom EA, et al.: Topical Hyaluronic Acid vs. Standard of Care for the Prevention of Radiation Dermatitis After Adjuvant Radiotherapy for Breast Cancer: Single-Blind Randomized Phase III Clinical Trial. Int J Radiat Oncol Biol Phys 2011. Epub ahead of print"},{"key":"761_CR13","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1016\/S0360-3016(02)03746-X","volume":"54","author":"FA Vicini","year":"2002","unstructured":"Vicini FA, Sharpe M, Kestin L, et al.: Optimizing breast cancer treatment efficacy with intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys 2002, 54: 1336-1344. 10.1016\/S0360-3016(02)03746-X","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"761_CR14","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1097\/01.coc.0000197661.09628.03","volume":"29","author":"GM Freedman","year":"2006","unstructured":"Freedman GM, Anderson PR, Li J, et al.: Intensity modulated radiation therapy (IMR) decreases acute skin toxicity for women receiving radiation for breast cancer. Am J Clin Oncol 2006, 29: 66-70. 10.1097\/01.coc.0000197661.09628.03","journal-title":"Am J Clin Oncol"},{"key":"761_CR15","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1016\/S0360-3016(99)00388-0","volume":"46","author":"EM Donovan","year":"2000","unstructured":"Donovan EM, Johnson U, Shentall G, et al.: Evaluation of compensation in breast radiotherapy: A planning study using multiple static fields. Int J Radiat Oncol Biol Phys 2000, 46: 1307-1310.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"761_CR16","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.radonc.2004.07.032","volume":"73","author":"M Wells","year":"2004","unstructured":"Wells M, Macmillan M, Raab G, et al.: Doesaquaeous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomized controlled trial. Radiother Oncol 2004, 73: 153-162. 10.1016\/j.radonc.2004.07.032","journal-title":"Radiother Oncol"},{"key":"761_CR17","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0167-8140(01)00327-9","volume":"59","author":"A Bostrom","year":"2001","unstructured":"Bostrom A, Lindman H, Swarting C, et al.: Potent corticosteroid cream (mometasonefuroate) significantly reduces acute radiation dermatitis: results from a double-blind, randomized study. Radiother Oncol 2001, 59: 257-265. 10.1016\/S0167-8140(01)00327-9","journal-title":"Radiother Oncol"},{"key":"761_CR18","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/1748-717X-2-30","volume":"21","author":"SK Mai","year":"2007","unstructured":"Mai SK, Welzel G, Haegele V, et al.: The influence of smoking and other risk factors on the outcome after radiochemotherapy for anal cancer. Radiat Oncol 2007, 21: 30-3.","journal-title":"Radiat Oncol"},{"key":"761_CR19","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1046\/j.1365-2133.2002.04751.x","volume":"146","author":"W Schmuth","year":"2002","unstructured":"Schmuth W, Wimmer MA, Hofer S, et al.: Topical corticosteroid therapy for acute radiation dermatitis: A prospective, randomized, double-blind study. Br J Dermatology 2002, 146: 983-991. 10.1046\/j.1365-2133.2002.04751.x","journal-title":"Br J Dermatology"},{"key":"761_CR20","doi-asserted-by":"publisher","first-page":"180","DOI":"10.4103\/0019-509X.29424","volume":"4","author":"PN Shukla","year":"2006","unstructured":"Shukla PN, Gairola M, Mohanti BK, et al.: Prophylactic beclomethason spray to the skin during postoperative radiotherapy of carcinoma breast: A prospective randomized study. Indian Journal of Cancer 2006, 4: 180-184.","journal-title":"Indian Journal of Cancer"},{"key":"761_CR21","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1046\/j.1365-2354.1999.00153.x","volume":"8","author":"D Porock","year":"1999","unstructured":"Porock D, Kristjanson L: Skin reactions during radiotherapy for breast cancer: the use and impact of topical agents and dressings. Eur J Cancer Care 1999, 8: 142-153.","journal-title":"Eur J Cancer Care"},{"key":"761_CR22","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/0360-3016(94)00480-3","volume":"31","author":"ME Taylor","year":"1995","unstructured":"Taylor ME, Perez CA, Halverson KJ, et al.: Factors influencing cosmetic results after conservation therapy for breast cancer. Int J Radiat Oncol Biol Phys 1995, 31: 753-764. 10.1016\/0360-3016(94)00480-3","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"761_CR23","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1002\/(SICI)1097-0142(19970815)80:4<732::AID-CNCR12>3.0.CO;2-U","volume":"80","author":"DE Wazer","year":"1997","unstructured":"Wazer DE, Morr J, Erban JK, et al.: The effects of postradiation treatment with tamoxifen on local control and cosmetic outcome in the conservatively treated breast. Cancer 1997, 80: 732-740. 10.1002\/(SICI)1097-0142(19970815)80:4<732::AID-CNCR12>3.0.CO;2-U","journal-title":"Cancer"},{"key":"761_CR24","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/0360-3016(96)00185-X","volume":"35","author":"B Fowble","year":"1996","unstructured":"Fowble B, Fein DA, Hanlon AL, et al.: The impact of tamoxifen on breast recurrence, cosmesis, comlications and survival in estrogen receptor-positivealry-stage breast cancer. Int J Radiat Oncol Biol Phys 1996, 35: 669-677. 10.1016\/0360-3016(96)00185-X","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"761_CR25","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/S0360-3016(02)03826-9","volume":"55","author":"G Rayan","year":"2003","unstructured":"Rayan G, Dawson LA, Bezjak A, et al.: Prospective comparison of breast pain in patients participating in a randomized trial of breast-conserving surgery and tamoxifen with or without radiotherapy. Int J Radiat Oncol Biol Phys 2003, 55: 154-161. 10.1016\/S0360-3016(02)03826-9","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"761_CR26","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1093\/annonc\/mdn029","volume":"19","author":"Y Belkac\u00e9mi","year":"2008","unstructured":"Belkac\u00e9mi Y, Gligorov J, Ozsahin M, et al.: Concurrent trastuzumab with adjuvant radiotherapy in HER2-positive breast cancer patients: acute toxicity analyses from the French multicentric study. Ann Oncol 2008, 19: 1110-1116. 10.1093\/annonc\/mdn029","journal-title":"Ann Oncol"},{"key":"761_CR27","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/S1470-2045(10)70013-9","volume":"11","author":"D Azria","year":"2010","unstructured":"Azria D, Belkac\u00e9mi Y, Romieu G, et al.: Concurrent or sequential adjuvant letrozole and radiotherapy after conservative surgery for early-stage breast cancer (CO-HO-RT): a phase 2 randomized trial. Lancet Oncol 2010, 11: 258-265. 10.1016\/S1470-2045(10)70013-9","journal-title":"Lancet Oncol"},{"key":"761_CR28","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1200\/JCO.2004.07.063","volume":"22","author":"P Pommier","year":"2004","unstructured":"Pommier P, Gomez F, Sunyach MP, et al.: Phase 3 randomized trial of Calendula officinalis compared to trolamine for prevention of acute dermatitis during irradiation for breast cancer. J Clin Oncol 2004, 22: 1447-1453. 10.1200\/JCO.2004.07.063","journal-title":"J Clin Oncol"},{"key":"761_CR29","doi-asserted-by":"publisher","first-page":"145.153","DOI":"10.1016\/S0167-8140(03)00166-X","volume":"69","author":"D Twardella","year":"2003","unstructured":"Twardella D, Popanda O, Helmbold I, et al.: Personal characteristics, therapy modalities and individual DNA repair capacity as prede factors of acute skin toxicity in an unselected cohort of breast cancer patients receiving radiotherapy. Radiother Oncol 2003, 69: 145.153.","journal-title":"Radiother Oncol"},{"key":"761_CR30","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/S0959-8049(03)00178-3","volume":"39","author":"WE Fiets","year":"2003","unstructured":"Fiets WE, Van Helvoit RP, Nortier JWR, et al.: Acute toxicity of concurrent adjvant radiotherapy and chemotherapy (CMF or AC) in breast cancer patients: a prospective, comparative, non-randomized study. Eur J Cancer 2003, 39: 1081-1088. 10.1016\/S0959-8049(03)00178-3","journal-title":"Eur J Cancer"}],"container-title":["Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1748-717X-7-217.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1748-717X-7-217\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1748-717X-7-217.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T00:17:02Z","timestamp":1548202622000},"score":1,"resource":{"primary":{"URL":"https:\/\/ro-journal.biomedcentral.com\/articles\/10.1186\/1748-717X-7-217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["761"],"URL":"https:\/\/doi.org\/10.1186\/1748-717x-7-217","relation":{},"ISSN":["1748-717X"],"issn-type":[{"value":"1748-717X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12]]},"article-number":"217"}}