{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T06:25:29Z","timestamp":1768803929012,"version":"3.49.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,8,21]],"date-time":"2013-08-21T00:00:00Z","timestamp":1377043200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiat Oncol"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1186\/1748-717x-8-204","type":"journal-article","created":{"date-parts":[[2013,8,21]],"date-time":"2013-08-21T12:27:37Z","timestamp":1377088057000},"source":"Crossref","is-referenced-by-count":16,"title":["Concurrent whole brain radiotherapy and bortezomib for brain metastasis"],"prefix":"10.1186","volume":"8","author":[{"given":"Christopher D","family":"Lao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judah","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina I","family":"Tsien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel P","family":"Normolle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt","family":"Schipper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Van Poznak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Hamstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Hayman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce G","family":"Redman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,8,21]]},"reference":[{"key":"928_CR1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3171\/jns.1998.88.1.0011","volume":"88","author":"JH Sampson","year":"1998","unstructured":"Sampson JH, Carter JH Jr, Friedman AH, Seigler HF: Demographics, prognosis, and therapy in 702 patients with brain metastases from malignant melanoma. J Neurosurg 1998, 88: 11-20. 10.3171\/jns.1998.88.1.0011","journal-title":"J Neurosurg"},{"key":"928_CR2","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1056\/NEJMoa1003466","volume":"363","author":"FS Hodi","year":"2010","unstructured":"Hodi FS, O\u2019Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, Gonzalez R, Robert C, Schadendorf D, Hassel JC, et al.: Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010, 363: 711-723. 10.1056\/NEJMoa1003466","journal-title":"N Engl J Med"},{"key":"928_CR3","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1056\/NEJMoa1103782","volume":"364","author":"PB Chapman","year":"2011","unstructured":"Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J, Dummer R, Garbe C, Testori A, Maio M, et al.: Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011, 364: 2507-2516. 10.1056\/NEJMoa1103782","journal-title":"N Engl J Med"},{"key":"928_CR4","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S1470-2045(12)70090-6","volume":"13","author":"K Margolin","year":"2012","unstructured":"Margolin K, Ernstoff MS, Hamid O, Lawrence D, McDermott D, Puzanov I, Wolchok JD, Clark JI, Sznol M, Logan TF, et al.: Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial. Lancet Oncol 2012, 13: 459-465. 10.1016\/S1470-2045(12)70090-6","journal-title":"Lancet Oncol"},{"key":"928_CR5","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1200\/JCO.2010.30.1655","volume":"29","author":"M Kocher","year":"2011","unstructured":"Kocher M, Soffietti R, Abacioglu U, Villa S, Fauchon F, Baumert BG, Fariselli L, Tzuk-Shina T, Kortmann RD, Carrie C, et al.: Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952\u201326001 study. J Clin Oncol 2011, 29: 134-141. 10.1200\/JCO.2010.30.1655","journal-title":"J Clin Oncol"},{"key":"928_CR6","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1007\/s00432-002-0323-8","volume":"128","author":"K Margolin","year":"2002","unstructured":"Margolin K, Atkins B, Thompson A, Ernstoff S, Weber J, Flaherty L, Clark I, Weiss G, Sosman J, W IIS, et al.: Temozolomide and whole brain irradiation in melanoma metastatic to the brain: a phase II trial of the Cytokine Working Group. J Cancer Res Clin Oncol 2002, 128: 214-218. 10.1007\/s00432-002-0323-8","journal-title":"J Cancer Res Clin Oncol"},{"key":"928_CR7","doi-asserted-by":"publisher","first-page":"2584","DOI":"10.1002\/cncr.21108","volume":"103","author":"SN Markovic","year":"2005","unstructured":"Markovic SN, Geyer SM, Dawkins F, Sharfman W, Albertini M, Maples W, Fracasso PM, Fitch T, Lorusso P, Adjei AA, Erlichman C: A phase II study of bortezomib in the treatment of metastatic malignant melanoma. Cancer 2005, 103: 2584-2589. 10.1002\/cncr.21108","journal-title":"Cancer"},{"key":"928_CR8","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1097\/00000421-200110000-00013","volume":"24","author":"M Pervan","year":"2001","unstructured":"Pervan M, Pajonk F, Sun JR, Withers HR, McBride WH: Molecular pathways that modify tumor radiation response. Am J Clin Oncol 2001, 24: 481-485. 10.1097\/00000421-200110000-00013","journal-title":"Am J Clin Oncol"},{"key":"928_CR9","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0360-3016(01)01446-8","volume":"50","author":"SM Russo","year":"2001","unstructured":"Russo SM, Tepper JE, Baldwin AS Jr, Liu R, Adams J, Elliott P, Cusack JC Jr: Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappaB. Int J Radiat Oncol Biol Phys 2001, 50: 183-193. 10.1016\/S0360-3016(01)01446-8","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"928_CR10","doi-asserted-by":"publisher","first-page":"4426","DOI":"10.1200\/JCO.2005.04.3844","volume":"24","author":"D Normolle","year":"2006","unstructured":"Normolle D, Lawrence T: Designing dose-escalation trials with late-onset toxicities using the time-to-event continual reassessment method. J Clin Oncol 2006, 24: 4426-4433. 10.1200\/JCO.2005.04.3844","journal-title":"J Clin Oncol"},{"key":"928_CR11","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1200\/JCO.1990.8.7.1277","volume":"8","author":"DR Macdonald","year":"1990","unstructured":"Macdonald DR, Cascino TL, Schold SC Jr, Cairncross JG: Response criteria for phase II studies of supratentorial malignant glioma. J Clin Oncol 1990, 8: 1277-1280.","journal-title":"J Clin Oncol"},{"key":"928_CR12","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1118\/1.1999737","volume":"32","author":"Y Cao","year":"2005","unstructured":"Cao Y: Development of image software tools for radiation therapy assessment. Med Phys 2005, 32: 2136.","journal-title":"Med Phys"},{"key":"928_CR13","doi-asserted-by":"publisher","first-page":"e57768","DOI":"10.1371\/journal.pone.0057768","volume":"8","author":"CH Chapman","year":"2013","unstructured":"Chapman CH, Nazem-Zadeh M, Lee OE, Schipper MJ, Tsien CI, Lawrence TS, Cao Y: Regional variation in brain white matter diffusion index changes following chemoradiotherapy: a prospective study using tract-based spatial statistics. PLoS One 2013, 8: e57768. 10.1371\/journal.pone.0057768","journal-title":"PLoS One"},{"key":"928_CR14","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.neuroimage.2007.12.035","volume":"40","author":"S Mori","year":"2008","unstructured":"Mori S, Oishi K, Jiang H, Jiang L, Li X, Akhter K, Hua K, Faria AV, Mahmood A, Woods R, et al.: Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template. Neuroimage 2008, 40: 570-582. 10.1016\/j.neuroimage.2007.12.035","journal-title":"Neuroimage"},{"key":"928_CR15","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1098\/rstb.2001.0915","volume":"356","author":"J Mazziotta","year":"2001","unstructured":"Mazziotta J, Toga A, Evans A, Fox P, Lancaster J, Zilles K, Woods R, Paus T, Simpson G, Pike B, et al.: A probabilistic atlas and reference system for the human brain: International Consortium for Brain Mapping (ICBM). Philos Trans R Soc Lond B Biol Sci 2001, 356: 1293-1322. 10.1098\/rstb.2001.0915","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"928_CR16","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.ijrobp.2011.05.044","volume":"83","author":"EA Wiegner","year":"2012","unstructured":"Wiegner EA, Daly ME, Murphy JD, Abelson J, Chapman CH, Chung M, Yu Y, Colevas AD, Kaplan MJ, Fischbein N, et al.: Intensity-modulated radiotherapy for tumors of the nasal cavity and paranasal sinuses: clinical outcomes and patterns of failure. Int J Radiat Oncol Biol Phys 2012, 83: 243-251. 10.1016\/j.ijrobp.2011.05.044","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"928_CR17","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.exphem.2005.04.005","volume":"33","author":"A Goel","year":"2005","unstructured":"Goel A, Dispenzieri A, Greipp PR, Witzig TE, Mesa RA, Russell SJ: PS-341-mediated selective targeting of multiple myeloma cells by synergistic increase in ionizing radiation-induced apoptosis. Exp Hematol 2005, 33: 784-795. 10.1016\/j.exphem.2005.04.005","journal-title":"Exp Hematol"},{"key":"928_CR18","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.ijrobp.2009.07.1715","volume":"78","author":"TJ Pugh","year":"2010","unstructured":"Pugh TJ, Chen C, Rabinovitch R, Eckhardt SG, Rusthoven KE, Swing R, Raben D: Phase I trial of bortezomib and concurrent external beam radiation in patients with advanced solid malignancies. Int J Radiat Oncol Biol Phys 2010, 78: 521-526. 10.1016\/j.ijrobp.2009.07.1715","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"928_CR19","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3816\/CCC.2010.n.017","volume":"9","author":"BH O\u2019Neil","year":"2010","unstructured":"O\u2019Neil BH, Raftery L, Calvo BF, Chakravarthy AB, Ivanova A, Myers MO, Kim HJ, Chan E, Wise PE, Caskey LS, et al.: A phase I study of bortezomib in combination with standard 5-fluorouracil and external-beam radiation therapy for the treatment of locally advanced or metastatic rectal cancer. Clin Colorectal Cancer 2010, 9: 119-125. 10.3816\/CCC.2010.n.017","journal-title":"Clin Colorectal Cancer"},{"key":"928_CR20","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.ijrobp.2008.08.050","volume":"74","author":"GJ Kubicek","year":"2009","unstructured":"Kubicek GJ, Werner-Wasik M, Machtay M, Mallon G, Myers T, Ramirez M, Andrews D, Curran WJ Jr, Dicker AP: Phase I trial using proteasome inhibitor bortezomib and concurrent temozolomide and radiotherapy for central nervous system malignancies. Int J Radiat Oncol Biol Phys 2009, 74: 433-439. 10.1016\/j.ijrobp.2008.08.050","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"928_CR21","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1158\/1078-0432.CCR-08-1420","volume":"15","author":"Y Cao","year":"2009","unstructured":"Cao Y, Tsien CI, Sundgren PC, Nagesh V, Normolle D, Buchtel H, Junck L, Lawrence TS: Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for prediction of radiation-induced neurocognitive dysfunction. Clin Cancer Res 2009, 15: 1747-1754. 10.1158\/1078-0432.CCR-08-1420","journal-title":"Clin Cancer Res"},{"key":"928_CR22","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/S1470-2045(09)70263-3","volume":"10","author":"EL Chang","year":"2009","unstructured":"Chang EL, Wefel JS, Hess KR, Allen PK, Lang FF, Kornguth DG, Arbuckle RB, Swint JM, Shiu AS, Maor MH, Meyers CA: Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol 2009, 10: 1037-1044. 10.1016\/S1470-2045(09)70263-3","journal-title":"Lancet Oncol"},{"key":"928_CR23","doi-asserted-by":"publisher","first-page":"S140","DOI":"10.1016\/j.ijrobp.2009.08.077","volume":"76","author":"R Jeraj","year":"2010","unstructured":"Jeraj R, Cao Y, Ten Haken RK, Hahn C, Marks L: Imaging for assessment of radiation-induced normal tissue effects. Int J Radiat Oncol Biol Phys 2010, 76: S140-S144. 10.1016\/j.ijrobp.2009.08.077","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"928_CR24","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1016\/j.ijrobp.2011.01.068","volume":"82","author":"CH Chapman","year":"2012","unstructured":"Chapman CH, Nagesh V, Sundgren PC, Buchtel H, Chenevert TL, Junck L, Lawrence TS, Tsien CI, Cao Y: Diffusion tensor imaging of normal-appearing white matter as biomarker for radiation-induced late delayed cognitive decline. Int J Radiat Oncol Biol Phys 2012, 82: 2033-2040. 10.1016\/j.ijrobp.2011.01.068","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1748-717X-8-204.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1748-717X-8-204\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1748-717X-8-204.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T06:53:18Z","timestamp":1548226398000},"score":1,"resource":{"primary":{"URL":"https:\/\/ro-journal.biomedcentral.com\/articles\/10.1186\/1748-717X-8-204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,21]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["928"],"URL":"https:\/\/doi.org\/10.1186\/1748-717x-8-204","relation":{},"ISSN":["1748-717X"],"issn-type":[{"value":"1748-717X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,21]]},"article-number":"204"}}