{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T23:35:59Z","timestamp":1717544159009},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiat Oncol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Tissue expanders are used in breast reconstruction after mastectomy to stretch the remaining tissue to create space for placement of permanent breast implants. The AeroForm\u2122 Tissue Expander, developed by AirXpanders\u2122 Inc., contains electronic components designed to activate the release of carbon dioxide from an internal reservoir to inflate the expander. Breast cancer patients who undergo mastectomy and tissue expander\/implant-based breast reconstruction may require radiation therapy at doses up to 50\u201360\u00a0Gy while the expander is in place. The ionizing radiation used in postmastectomy radiation therapy interacts with electronic components in medical implants, which may cause degradation in performance above certain levels. Most commercial electronic components used in medical devices, such as complementary metal-oxide semiconductor or bipolar integrated circuits can withstand radiation levels in the 50\u00a0Gy range without any performance degradation. Beyond this level, the performance may still be sufficient to guarantee functionality, but this needs to be confirmed at the system and electronic circuit level. We assessed the impact of radiation levels up to 75\u00a0Gy on 32 AeroForm\u2122 Tissue Expanders (AirXpanders, Inc., Palo Alto, CA USA) and on the associated internal printed circuit assemblies.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Findings<\/jats:title>\n            <jats:p>The electronics inside the AeroForm\u2122 Tissue Expander implant continued to function properly after exposure to radiation levels up to 75\u00a0Gy, which is well above the maximum total dose level typically used in postmastectomy radiation therapy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Standard postmastectomy radiation therapy doses do not damage or affect the functionality of the AeroForm\u2122 Tissue Expander.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1748-717x-8-235","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T16:03:45Z","timestamp":1381507425000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Radiation testing of the AeroForm co2-based breast tissue expander implant"],"prefix":"10.1186","volume":"8","author":[{"given":"James L","family":"Rembert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Heitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,10,11]]},"reference":[{"key":"954_CR1","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.surg.2007.10.006","volume":"143","author":"S Ueda","year":"2008","unstructured":"Ueda S, Tamaki Y, Yano K, Okishiro N, Yanagisawa T, Imasato M, Shimazu K, Kim SJ, Miyoshi Y, Tanji Y, Taguchi T, Noguchi S: Cosmetic outcome and patient satisfaction after skin-sparing mastectomy for breast cancer with immediate reconstruction of the breast. 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