{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T22:25:07Z","timestamp":1781475907733,"version":"3.54.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiat Oncol"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1186\/1748-717x-8-267","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T04:02:09Z","timestamp":1384401729000},"source":"Crossref","is-referenced-by-count":102,"title":["Adjuvant radiotherapy of regional lymph nodes in breast cancer - a meta-analysis of randomized trials"],"prefix":"10.1186","volume":"8","author":[{"given":"Wilfried","family":"Budach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Kammers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Boelke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Matuschek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,11,14]]},"reference":[{"key":"985_CR1","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1016\/S0140-6736(11)61629-2","volume":"378","author":"S Darby","year":"2011","unstructured":"Darby S, McGale P, Correa C, et al.: Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet 2011, 378: 1707-1716.","journal-title":"Lancet"},{"key":"985_CR2","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1007\/s00066-013-0437-8","volume":"189","author":"F Sedlmayer","year":"2013","unstructured":"Sedlmayer F, Sautter-Bihl ML, Budach W, et al.: DEGRO practical guidelines:radiotherapy of breast cancer I: radiotherapy following breast conserving therapy for invasive breast cancer. Strahlenther Onkol 2013, 189: 825-833. 10.1007\/s00066-013-0437-8","journal-title":"Strahlenther Onkol"},{"key":"985_CR3","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1016\/S0140-6736(05)67887-7","volume":"366","author":"M Clarke","year":"2005","unstructured":"Clarke M, Collins R, Darby S, et al.: Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005, 366: 2087-2106.","journal-title":"Lancet"},{"key":"985_CR4","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1016\/j.ejca.2012.09.010","volume":"49","author":"A Glechner","year":"2013","unstructured":"Glechner A, Wockel A, Gartlehner G, et al.: Sentinel lymph node dissection only versus complete axillary lymph node dissection in early invasive breast cancer: a systematic review and meta-analysis. Eur J Cancer 2013, 49: 812-825. 10.1016\/j.ejca.2012.09.010","journal-title":"Eur J Cancer"},{"key":"985_CR5","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s10555-011-9343-7","volume":"31","author":"J Engel","year":"2012","unstructured":"Engel J, Emeny RT, Holzel D: Positive lymph nodes do not metastasize. Cancer Metastasis Rev 2012, 31: 235-246. 10.1007\/s10555-011-9343-7","journal-title":"Cancer Metastasis Rev"},{"key":"985_CR6","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1016\/S0959-8049(99)00133-1","volume":"35","author":"U Veronesi","year":"1999","unstructured":"Veronesi U, Marubini E, Mariani L, et al.: The dissection of internal mammary nodes does not improve the survival of breast cancer patients. 30-year results of a randomised trial. Eur J Cancer 1999, 35: 1320-1325. 10.1016\/S0959-8049(99)00133-1","journal-title":"Eur J Cancer"},{"key":"985_CR7","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/0167-8140(88)90003-5","volume":"11","author":"R Arriagada","year":"1988","unstructured":"Arriagada R, Le MG, Mouriesse H, et al.: Long-term effect of internal mammary chain treatment. Results of a multivariate analysis of 1195 patients with operable breast cancer and positive axillary nodes. Radiother Oncol 1988, 11: 213-222. 10.1016\/0167-8140(88)90003-5","journal-title":"Radiother Oncol"},{"key":"985_CR8","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1007\/s00066-004-9193-0","volume":"180","author":"GG Grabenbauer","year":"2004","unstructured":"Grabenbauer GG: Internal mammary nodes in invasive breast carcinoma. To treat or not to treat? Strahlenther Onkol 2004, 180: 690-694. 10.1007\/s00066-004-9193-0","journal-title":"Strahlenther Onkol"},{"key":"985_CR9","volume-title":"Radiother Oncol","author":"A Courdi","year":"2013","unstructured":"Courdi A, Chamorey E, Ferrero JM, Hannoun-Levi JM: Influence of internal mammary node irradiation on long-term outcome and contralateral breast cancer incidence in node-negative breast cancer patients. Radiother Oncol 2013."},{"key":"985_CR10","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.1200\/JCO.2003.09.096","volume":"21","author":"SM Stemmer","year":"2003","unstructured":"Stemmer SM, Rizel S, Hardan I, et al.: The role of irradiation of the internal mammary lymph nodes in high-risk stage II to IIIA breast cancer patients after high-dose chemotherapy: a prospective sequential nonrandomized study. J Clin Oncol 2003, 21: 2713-2718. 10.1200\/JCO.2003.09.096","journal-title":"J Clin Oncol"},{"key":"985_CR11","doi-asserted-by":"publisher","first-page":"e35","DOI":"10.1016\/j.ijrobp.2011.11.066","volume":"83","author":"RA Olson","year":"2012","unstructured":"Olson RA, Woods R, Speers C, et al.: Does the intent to irradiate the internal mammary nodes impact survival in women with breast cancer? a population-based analysis in British Columbia. Int J Radiat Oncol Biol Phys 2012, 83: e35-e41. 10.1016\/j.ijrobp.2011.11.066","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"985_CR12","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/S0360-3016(00)00526-5","volume":"47","author":"B Fowble","year":"2000","unstructured":"Fowble B, Hanlon A, Freedman G, et al.: Internal mammary node irradiation neither decreases distant metastases nor improves survival in stage I and II breast cancer. Int J Radiat Oncol Biol Phys 2000, 47: 883-894. 10.1016\/S0360-3016(00)00526-5","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"985_CR13","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1016\/S0140-6736(98)09201-0","volume":"353","author":"M Overgaard","year":"1999","unstructured":"Overgaard M, Jensen MB, Overgaard J, et al.: Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial. Lancet 1999, 353: 1641-1648. 10.1016\/S0140-6736(98)09201-0","journal-title":"Lancet"},{"key":"985_CR14","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1016\/j.ijrobp.2011.01.066","volume":"82","author":"L Yates","year":"2012","unstructured":"Yates L, Kirby A, Crichton S, et al.: Risk factors for regional nodal relapse in breast cancer patients with one to three positive axillary nodes. Int J Radiat Oncol Biol Phys 2012, 82: 2093-2103. 10.1016\/j.ijrobp.2011.01.066","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"985_CR15","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/j.ijrobp.2013.03.021","volume":"86","author":"C Hennequin","year":"2013","unstructured":"Hennequin C, Bossard N, Servagi-Vernat S, et al.: Ten-year survival results of a randomized trial of irradiation of internal mammary nodes after mastectomy. Int J Radiat Oncol Biol Phys 2013, 86: 860-866. 10.1016\/j.ijrobp.2013.03.021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"985_CR16","first-page":"29","volume-title":"J Clin Oncol ASCO Annual Meeting Proceed (Post-Meeting Edition)","author":"TJOI Whelan","year":"2011","unstructured":"Whelan TJOI, Ackerman I, Chapman JW, Chua B, Nabid A, Vallis KA, White JR, Rousseau P, Fortin A, Pierce LJ, Manchul L, Craighead P, Nolan MC, Bowen J, McCready DR, Pritchard KI, Leine MN, Parulekar W, Parulekar W: NCIC-CTG MA.20: An intergroup trial of regional nodal irradiation in early breast cancer. J Clin Oncol ASCO Annual Meeting Proceed (Post-Meeting Edition) 2011, 29."},{"key":"985_CR17","doi-asserted-by":"crossref","unstructured":"Poortmans PSH, Kirkove C, Budach V, Maingon P, Valli MC, Collette S, Fourquet A, Bartelink H, Van den Bogaert W: Irradiation of the internal mammary and medial supraclavicular lymph nodes in stage I to III breast cancer: 10 years results of the EORTC radiation oncology and breast cancer groups phase III trial 22922\/10925. EJC 2013.,47(Suppl 2):","DOI":"10.1016\/S0167-8140(15)30629-0"},{"key":"985_CR18","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.ejca.2006.11.015","volume":"43","author":"E Musat","year":"2007","unstructured":"Musat E, Poortmans P, Van den Bogaert W, et al.: Quality assurance in breast cancer: EORTC experiences in the phase III trial on irradiation of the internal mammary nodes. Eur J Cancer 2007, 43: 718-724. 10.1016\/j.ejca.2006.11.015","journal-title":"Eur J Cancer"},{"key":"985_CR19","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1002\/(SICI)1097-0258(19981230)17:24<2815::AID-SIM110>3.0.CO;2-8","volume":"17","author":"MK Parmar","year":"1998","unstructured":"Parmar MK, Torri V, Stewart L: Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med 1998, 17: 2815-2834. 10.1002\/(SICI)1097-0258(19981230)17:24<2815::AID-SIM110>3.0.CO;2-8","journal-title":"Stat Med"},{"key":"985_CR20","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1200\/JCO.2001.19.15.3516","volume":"19","author":"WB Eubank","year":"2001","unstructured":"Eubank WB, Mankoff DA, Takasugi J, et al.: 18fluorodeoxyglucose positron emission tomography to detect mediastinal or internal mammary metastases in breast cancer. J Clin Oncol 2001, 19: 3516-3523.","journal-title":"J Clin Oncol"},{"key":"985_CR21","doi-asserted-by":"publisher","first-page":"116","DOI":"10.3389\/fonc.2012.00116","volume":"2","author":"K Lauber","year":"2012","unstructured":"Lauber K, Ernst A, Orth M, et al.: Dying cell clearance and its impact on the outcome of tumor radiotherapy. Front Oncol 2012, 2: 116.","journal-title":"Front Oncol"},{"key":"985_CR22","volume-title":"Cancer Immunol Immunother","author":"B Frey","year":"2013","unstructured":"Frey B, Rubner Y, Kulzer L, et al.: Antitumor immune responses induced by ionizing irradiation and further immune stimulation. Cancer Immunol Immunother 2013."},{"key":"985_CR23","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/1471-2407-7-153","volume":"7","author":"GA Viani","year":"2007","unstructured":"Viani GA, Afonso SL, Stefano EJ, et al.: Adjuvant trastuzumab in the treatment of her-2-positive early breast cancer: a meta-analysis of published randomized trials. BMC Cancer 2007, 7: 153. 10.1186\/1471-2407-7-153","journal-title":"BMC Cancer"},{"key":"985_CR24","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/S0140-6736(11)61625-5","volume":"379","author":"R Peto","year":"2012","unstructured":"Peto R, Davies C, Godwin J, et al.: Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trials. Lancet 2012, 379: 432-444.","journal-title":"Lancet"},{"key":"985_CR25","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/1748-717X-8-71","volume":"8","author":"SM MacDonald","year":"2013","unstructured":"MacDonald SM, Jimenez R, Paetzold P, et al.: Proton radiotherapy for chest wall and regional lymphatic radiation; dose comparisons and treatment delivery. Radiat Oncol 2013, 8: 71. 10.1186\/1748-717X-8-71","journal-title":"Radiat Oncol"},{"key":"985_CR26","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1748-717X-6-26","volume":"6","author":"V Rudat","year":"2011","unstructured":"Rudat V, Alaradi AA, Mohamed A, et al.: Tangential beam IMRT versus tangential beam 3D-CRT of the chest wall in postmastectomy breast cancer patients: a dosimetric comparison. Radiat Oncol 2011, 6: 26. 10.1186\/1748-717X-6-26","journal-title":"Radiat Oncol"},{"key":"985_CR27","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/S1470-2045(05)70251-5","volume":"6","author":"SC Darby","year":"2005","unstructured":"Darby SC, McGale P, Taylor CW, Peto R: Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about 300,000 women in US SEER cancer registries. Lancet Oncol 2005, 6: 557-565. 10.1016\/S1470-2045(05)70251-5","journal-title":"Lancet Oncol"},{"issue":"2","key":"985_CR28","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.radonc.2013.07.017","volume":"108","author":"ME Mast","year":"2013","unstructured":"Mast ME, van Kempen-Harteveld L, Heijenbrok MW, et al.: Left-sided breast cancer radiotherapy with and without breath-hold: does IMRT reduce the cardiac dose even further? Radiother Oncol 2013,108(2):248-53. 10.1016\/j.radonc.2013.07.017","journal-title":"Radiother Oncol"},{"key":"985_CR29","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3109\/02841860903352959","volume":"49","author":"O Matzinger","year":"2010","unstructured":"Matzinger O, Heimsoth I, Poortmans P, et al.: Toxicity at three years with and without irradiation of the internal mammary and medial supraclavicular lymph node chain in stage I to III breast cancer (EORTC trial 22922\/10925). Acta Oncol 2010, 49: 24-34. 10.3109\/02841860903352959","journal-title":"Acta Oncol"}],"container-title":["Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1748-717X-8-267.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T19:57:05Z","timestamp":1564689425000},"score":1,"resource":{"primary":{"URL":"https:\/\/ro-journal.biomedcentral.com\/articles\/10.1186\/1748-717X-8-267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,14]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["985"],"URL":"https:\/\/doi.org\/10.1186\/1748-717x-8-267","relation":{},"ISSN":["1748-717X"],"issn-type":[{"value":"1748-717X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,14]]},"article-number":"267"}}