{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:55:50Z","timestamp":1761155750348},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiat Oncol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Meta-analysis of randomized trials has shown that postoperative radiotherapy (PORT) had a detrimental effect on overall survival (OS) in patients with resected N1 non\u2013small cell lung cancer (NSCLC). Conversely, the locoregional recurrence (LR) rate is reported to be high without adjuvant PORT in these patients. We have evaluated the pattern of failure, actuarial risk and risk factors for LR in order to identify the subset of N1 NSCLC patients with the highest risk of LR. These patients could potentially benefit from PORT.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We conducted a retrospective study on 199 patients with pathologically confirmed T1\u20133N1M0 NSCLC who underwent surgery. None of the patients had positive surgical margins or received preoperative therapy or PORT. The median follow-up was 53.8\u00a0months. Complete mediastinal lymph node (MLN) dissection and examination was defined as \u22653 dissected and examined MLN stations; incomplete MLN dissection or examination (IMD) was defined as &lt;3 dissected or examined MLN stations. The primary end point of this study was freedom from LR (FFLR). Differences between patient groups were compared and risk factors for LR were identified by univariate and multivariate analyses.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>LR was identified in 41 (20.6%) patients, distant metastasis (DM) was identified in 79 (39.7%) patients and concurrent LR and DM was identified in 25 (12.6%) patients. The 3- and 5-year OS rates in patients with resected N1 NSCLC were 78.4% and 65.6%, respectively. The corresponding FFLR rates were 80.8% and 77.3%, respectively. Univariate analyses identified that nonsmokers, \u226423 dissected lymph nodes, visceral pleural invasion and lymph node ratio &gt;10% were significantly associated with lower FFLR rates (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Multivariate analyses further confirmed positive lymph nodes at station 10 and IMD as risk factors for LR (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The 5-year LR rate was highest in patients with both these risk factors (48%).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The incidence of LR in patients with surgically resected T1\u20133N1M0 NSCLC is high. Patients with IMD and positive lymph nodes at station 10 have the highest risk of LR, and may therefore benefit from adjuvant PORT. Further investigations of PORT in this subset of patients are warranted.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1748-717x-8-286","type":"journal-article","created":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T22:01:04Z","timestamp":1386626464000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Risk factors for locoregional recurrence in patients with resected N1 non-small cell lung cancer: a retrospective study to identify patterns of failure and implications for adjuvant radiotherapy"],"prefix":"10.1186","volume":"8","author":[{"given":"Chengcheng","family":"Fan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shugeng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhouguang","family":"Hui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jima","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luhua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,12,9]]},"reference":[{"key":"1246_CR1","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1056\/NEJMoa031644","volume":"350","author":"R Arriagada","year":"2004","unstructured":"Arriagada R, Bergman B, Dunant A, Le Chevalier T, Pignon JP, Vansteenkiste J, International Adjuvant Lung Cancer Trial Collaborative G: Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer. N Engl J Med 2004, 350: 351-360.","journal-title":"N Engl J Med"},{"key":"1246_CR2","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/S1470-2045(06)70804-X","volume":"7","author":"JY Douillard","year":"2006","unstructured":"Douillard JY, Rosell R, De Lena M, Carpagnano F, Ramlau R, Gonzales-Larriba JL, Grodzki T, Pereira JR, Le Groumellec A, Lorusso V, et al.: Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB-IIIA non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]): a randomised controlled trial. Lancet Oncol 2006, 7: 719-727. 10.1016\/S1470-2045(06)70804-X","journal-title":"Lancet Oncol"},{"key":"1246_CR3","doi-asserted-by":"publisher","first-page":"3552","DOI":"10.1200\/JCO.2007.13.9030","volume":"26","author":"JP Pignon","year":"2008","unstructured":"Pignon JP, Tribodet H, Scagliotti GV, Douillard JY, Shepherd FA, Stephens RJ, Dunant A, Torri V, Rosell R, Seymour L, et al.: Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE collaborative group. J Clin Oncol 2008, 26: 3552-3559. 10.1200\/JCO.2007.13.9030","journal-title":"J Clin Oncol"},{"key":"1246_CR4","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1016\/S0140-6736(10)60059-1","volume":"375","author":"R Arriagada","year":"2010","unstructured":"Arriagada R, Auperin A, Burdett S, Higgins JP, Johnson DH, Le Chevalier T, Le Pechoux C, Parmar MK, Pignon JP, Group NM-aC, et al.: Adjuvant chemotherapy, with or without postoperative radiotherapy, in operable non-small-cell lung cancer: two meta-analyses of individual patient data. Lancet 2010, 375: 1267-1277.","journal-title":"Lancet"},{"key":"1246_CR5","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/0360-3016(80)90105-4","volume":"6","author":"P Van Houtte","year":"1980","unstructured":"Van Houtte P, Rocmans P, Smets P, Goffin JC, Lustman-Marechal J, Vanderhoeft P, Henry J: Postoperative radiation therapy in lung caner: a controlled trial after resection of curative design. Int J Radiat Oncol Biol Phys 1980, 6: 983-986. 10.1016\/0360-3016(80)90105-4","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1246_CR6","doi-asserted-by":"publisher","first-page":"2998","DOI":"10.1200\/JCO.2005.04.6110","volume":"24","author":"BE Lally","year":"2006","unstructured":"Lally BE, Zelterman D, Colasanto JM, Haffty BG, Detterbeck FC, Wilson LD: Postoperative radiotherapy for stage II or III non-small-cell lung cancer using the surveillance, epidemiology, and end results database. J Clin Oncol 2006, 24: 2998-3006. 10.1200\/JCO.2005.04.6110","journal-title":"J Clin Oncol"},{"key":"1246_CR7","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.ijrobp.2008.01.044","volume":"72","author":"JY Douillard","year":"2008","unstructured":"Douillard JY, Rosell R, De Lena M, Riggi M, Hurteloup P, Mahe MA, Adjuvant Navelbine International Trialist A: Impact of postoperative radiation therapy on survival in patients with complete resection and stage I, II, or IIIA non-small-cell lung cancer treated with adjuvant chemotherapy: the adjuvant Navelbine International Trialist Association (ANITA) Randomized Trial. Int J Radiat Oncol Biol Phys 2008, 72: 695-701. 10.1016\/j.ijrobp.2008.01.044","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1246_CR8","doi-asserted-by":"crossref","unstructured":"Postoperative radiotherapy in non-small-cell lung cancer: systematic review and meta-analysis of individual patient data from nine randomised controlled trials. PORT meta-analysis trialists group Lancet 1998, 352: 257-263.","DOI":"10.1016\/S0140-6736(98)06341-7"},{"key":"1246_CR9","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/S0360-3016(00)00509-5","volume":"47","author":"QF Feng","year":"2000","unstructured":"Feng QF, Wang M, Wang LJ, Yang ZY, Zhang YG, Zhang DW, Yin WB: A study of postoperative radiotherapy in patients with non-small-cell lung cancer: a randomized trial. Int J Radiat Oncol Biol Phys 2000, 47: 925-929. 10.1016\/S0360-3016(00)00509-5","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1246_CR10","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1097\/JTO.0b013e31815ba227","volume":"2","author":"K Matsuoka","year":"2007","unstructured":"Matsuoka K, Sumitomo S, Misaki N: Prognostic factors in patients with pathologic T1-2N1M0 disease in non-small cell carcinoma of the lung. J Thorac Oncol 2007, 2: 1098-1102. 10.1097\/JTO.0b013e31815ba227","journal-title":"J Thorac Oncol"},{"key":"1246_CR11","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.semradonc.2010.01.008","volume":"20","author":"M Saynak","year":"2010","unstructured":"Saynak M, Higginson DS, Morris DE, Marks LB: Current status of postoperative radiation for non-small-cell lung cancer. Semin Radiat Oncol 2010, 20: 192-200. 10.1016\/j.semradonc.2010.01.008","journal-title":"Semin Radiat Oncol"},{"key":"1246_CR12","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1245\/s10434-010-0985-4","volume":"17","author":"SB Edge","year":"2010","unstructured":"Edge SB, Compton CC: The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 2010, 17: 1471-1474. 10.1245\/s10434-010-0985-4","journal-title":"Ann Surg Oncol"},{"key":"1246_CR13","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1097\/JTO.0b013e3181a0d82e","volume":"4","author":"VW Rusch","year":"2009","unstructured":"Rusch VW, Asamura H, Watanabe H, Giroux DJ, Rami-Porta R, Goldstraw P: Members of ISC: The IASLC lung cancer staging project: a proposal for a new international lymph node map in the forthcoming seventh edition of the TNM classification for lung cancer. J Thorac Oncol 2009, 4: 568-577. 10.1097\/JTO.0b013e3181a0d82e","journal-title":"J Thorac Oncol"},{"key":"1246_CR14","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.ijrobp.2010.09.004","volume":"82","author":"M Machtay","year":"2012","unstructured":"Machtay M, Bae K, Movsas B, Paulus R, Gore EM, Komaki R, Albain K, Sause WT, Curran WJ: Higher biologically effective dose of radiotherapy is associated with improved outcomes for locally advanced non-small cell lung carcinoma treated with chemoradiation: an analysis of the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 2012, 82: 425-434. 10.1016\/j.ijrobp.2010.09.004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1246_CR15","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1097\/JTO.0b013e3182429682","volume":"7","author":"M Machtay","year":"2012","unstructured":"Machtay M, Paulus R, Moughan J, Komaki R, Bradley J, Choy H, Albain K, Movsas B, Sause WT, Curran WJ: Defining local-regional control and its importance in locally advanced non-small cell lung carcinoma: a radiation therapy oncology group analysis. J Thorac Oncol 2012, 7: 716-722. 10.1097\/JTO.0b013e3182429682","journal-title":"J Thorac Oncol"},{"key":"1246_CR16","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1016\/0360-3016(80)90007-3","volume":"6","author":"G Kopelson","year":"1980","unstructured":"Kopelson G, Choi NC: Radiation therapy for postoperative local-regionally recurrent lung cancer. Int J Radiat Oncol Biol Phys 1980, 6: 1503-1506. 10.1016\/0360-3016(80)90007-3","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1246_CR17","doi-asserted-by":"crossref","unstructured":"Effects of postoperative mediastinal radiation on completely resected stage II and stage III epidermoid cancer of the lung. The lung cancer study group N Engl J Med 1986, 315: 1377-1381.","DOI":"10.1056\/NEJM198611273152202"},{"key":"1246_CR18","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1038\/bjc.1996.413","volume":"74","author":"RJ Stephens","year":"1996","unstructured":"Stephens RJ, Girling DJ, Bleehen NM, Moghissi K, Yosef HM, Machin D: The role of post-operative radiotherapy in non-small-cell lung cancer: a multicentre randomised trial in patients with pathologically staged T1-2, N1-2, M0 disease. Medical research council lung cancer working party. Br J Cancer 1996, 74: 632-639. 10.1038\/bjc.1996.413","journal-title":"Br J Cancer"},{"key":"1246_CR19","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/S0003-4975(96)00507-3","volume":"62","author":"JJ Lafitte","year":"1996","unstructured":"Lafitte JJ, Ribet ME, Prevost BM, Gosselin BH, Copin MC, Brichet AH: Postresection irradiation for T2 N0 M0 non-small cell carcinoma: a prospective, randomized study. Ann Thorac Surg 1996, 62: 830-834. 10.1016\/S0003-4975(96)00507-3","journal-title":"Ann Thorac Surg"},{"key":"1246_CR20","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S0167-8140(01)00478-9","volume":"62","author":"L Trodella","year":"2002","unstructured":"Trodella L, Granone P, Valente S, Valentini V, Balducci M, Mantini G, Turriziani A, Margaritora S, Cesario A, Ramella S, et al.: Adjuvant radiotherapy in non-small cell lung cancer with pathological stage I: definitive results of a phase III randomized trial. Radiother Oncol 2002, 62: 11-19. 10.1016\/S0167-8140(01)00478-9","journal-title":"Radiother Oncol"},{"key":"1246_CR21","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1378\/chest.112.4.954","volume":"112","author":"R Mayer","year":"1997","unstructured":"Mayer R, Smolle-Juettner FM, Szolar D, Stuecklschweiger GF, Quehenberger F, Friehs G, Hackl A: Postoperative radiotherapy in radically resected non-small cell lung cancer. Chest 1997, 112: 954-959. 10.1378\/chest.112.4.954","journal-title":"Chest"},{"key":"1246_CR22","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.cllc.2012.09.002","volume":"14","author":"F Xu","year":"2013","unstructured":"Xu F, Qi L, Yue D, Wang C: The effect of the extent of lymph node dissection for stage IA non-small-cell lung cancer on patient disease-free survival. Clin Lung Cancer 2013, 14: 181-187. 10.1016\/j.cllc.2012.09.002","journal-title":"Clin Lung Cancer"},{"key":"1246_CR23","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1097\/JTO.0b013e31822a35c3","volume":"6","author":"H Saji","year":"2011","unstructured":"Saji H, Tsuboi M, Yoshida K, Kato Y, Nomura M, Matsubayashi J, Nagao T, Kakihana M, Usuda J, Kajiwara N, et al.: Prognostic impact of number of resected and involved lymph nodes at complete resection on survival in non-small cell lung cancer. J Thorac Oncol 2011, 6: 1865-1871. 10.1097\/JTO.0b013e31822a35c3","journal-title":"J Thorac Oncol"},{"key":"1246_CR24","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1016\/j.athoracsur.2012.01.065","volume":"93","author":"CE Nwogu","year":"2012","unstructured":"Nwogu CE, Groman A, Fahey D, Yendamuri S, Dexter E, Demmy TL, Miller A, Reid M: Number of lymph nodes and metastatic lymph node ratio are associated with survival in lung cancer. Ann Thorac Surg 2012, 93: 1614-1619. discussion 1619\u20131620 10.1016\/j.athoracsur.2012.01.065","journal-title":"Ann Thorac Surg"},{"key":"1246_CR25","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1016\/j.athoracsur.2005.06.071","volume":"80","author":"AG Little","year":"2005","unstructured":"Little AG, Rusch VW, Bonner JA, Gaspar LE, Green MR, Webb WR, Stewart AK: Patterns of surgical care of lung cancer patients. Ann Thorac Surg 2005, 80: 2051-2056. discussion 2056 10.1016\/j.athoracsur.2005.06.071","journal-title":"Ann Thorac Surg"},{"key":"1246_CR26","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1378\/chest.128.3.1545","volume":"128","author":"MS Ludwig","year":"2005","unstructured":"Ludwig MS, Goodman M, Miller DL, Johnstone PA: Postoperative survival and the number of lymph nodes sampled during resection of node-negative non-small cell lung cancer. Chest 2005, 128: 1545-1550. 10.1378\/chest.128.3.1545","journal-title":"Chest"},{"key":"1246_CR27","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1097\/01.JTO.0000263722.22686.1c","volume":"2","author":"P De Leyn","year":"2007","unstructured":"De Leyn P, Lardinois D, Van Schil P, Rami-Porta R, Passlick B, Zielinski M, Waller D, Lerut T, Weder W: Ests: European trends in preoperative and intraoperative nodal staging: ESTS guidelines. J Thorac Oncol 2007, 2: 357-361. 10.1097\/01.JTO.0000263722.22686.1c","journal-title":"J Thorac Oncol"},{"key":"1246_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejcts.2007.01.075","volume":"32","author":"P De Leyn","year":"2007","unstructured":"De Leyn P, Lardinois D, Van Schil PE, Rami-Porta R, Passlick B, Zielinski M, Waller DA, Lerut T, Weder W: ESTS guidelines for preoperative lymph node staging for non-small cell lung cancer. Eur J Cardiothorac Surg 2007, 32: 1-8. 10.1016\/j.ejcts.2007.01.075","journal-title":"Eur J Cardiothorac Surg"},{"key":"1246_CR29","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1634\/theoncologist.2010-0343","volume":"16","author":"H Dai","year":"2011","unstructured":"Dai H, Hui Z, Ji W, Liang J, Lu J, Ou G, Zhou Z, Feng Q, Xiao Z, Chen D, et al.: Postoperative radiotherapy for resected pathological stage IIIA-N2 non-small cell lung cancer: a retrospective study of 221 cases from a single institution. Oncologist 2011, 16: 641-650. 10.1634\/theoncologist.2010-0343","journal-title":"Oncologist"},{"key":"1246_CR30","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/S0003-4975(99)00678-5","volume":"68","author":"TE Sawyer","year":"1999","unstructured":"Sawyer TE, Bonner JA, Gould PM, Foote RL, Deschamps C, Lange CM, Li H: Factors predicting patterns of recurrence after resection of N1 non-small cell lung carcinoma. Ann Thorac Surg 1999, 68: 1171-1176. 10.1016\/S0003-4975(99)00678-5","journal-title":"Ann Thorac Surg"},{"key":"1246_CR31","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.lungcan.2003.08.020","volume":"43","author":"T Osaki","year":"2004","unstructured":"Osaki T, Nagashima A, Yoshimatsu T, Tashima Y, Yasumoto K: Survival and characteristics of lymph node involvement in patients with N1 non-small cell lung cancer. Lung Cancer 2004, 43: 151-157. 10.1016\/j.lungcan.2003.08.020","journal-title":"Lung Cancer"},{"key":"1246_CR32","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/0003-4975(92)90435-7","volume":"54","author":"N Martini","year":"1992","unstructured":"Martini N, Burt ME, Bains MS, McCormack PM, Rusch VW, Ginsberg RJ: Survival after resection of stage II non-small cell lung cancer. Ann Thorac Surg 1992, 54: 460-465. discussion 466 10.1016\/0003-4975(92)90435-7","journal-title":"Ann Thorac Surg"},{"key":"1246_CR33","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1093\/annonc\/mds274","volume":"24","author":"JL Lopez Guerra","year":"2013","unstructured":"Lopez Guerra JL, Gomez DR, Lin SH, Levy LB, Zhuang Y, Komaki R, Jaen J, Vaporciyan AA, Swisher SG, Cox JD, et al.: Risk factors for local and regional recurrence in patients with resected N0-N1 non-small-cell lung cancer, with implications for patient selection for adjuvant radiation therapy. Ann Oncol 2013, 24: 67-74. 10.1093\/annonc\/mds274","journal-title":"Ann Oncol"},{"key":"1246_CR34","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.lungcan.2010.06.001","volume":"71","author":"M Saynak","year":"2011","unstructured":"Saynak M, Veeramachaneni NK, Hubbs JL, Nam J, Qaqish BF, Bailey JE, Chung W, Marks LB: Local failure after complete resection of N0-1 non-small cell lung cancer. Lung Cancer 2011, 71: 156-165. 10.1016\/j.lungcan.2010.06.001","journal-title":"Lung Cancer"},{"key":"1246_CR35","doi-asserted-by":"publisher","first-page":"5218","DOI":"10.1002\/cncr.24625","volume":"115","author":"CR Kelsey","year":"2009","unstructured":"Kelsey CR, Marks LB, Hollis D, Hubbs JL, Ready NE, D'Amico TA, Boyd JA: Local recurrence after surgery for early stage lung cancer: an 11-year experience with 975 patients. Cancer 2009, 115: 5218-5227. 10.1002\/cncr.24625","journal-title":"Cancer"},{"key":"1246_CR36","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.ijrobp.2011.07.018","volume":"83","author":"KA Higgins","year":"2012","unstructured":"Higgins KA, Chino JP, Berry M, Ready N, Boyd J, Yoo DS, Kelsey CR: Local failure in resected N1 lung cancer: implications for adjuvant therapy. Int J Radiat Oncol Biol Phys 2012, 83: 727-733.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1246_CR37","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.jtcvs.2006.04.019","volume":"132","author":"T Fujimoto","year":"2006","unstructured":"Fujimoto T, Cassivi SD, Yang P, Barnes SA, Nichols FC, Deschamps C, Allen MS, Pairolero PC: Completely resected N1 non-small cell lung cancer: factors affecting recurrence and long-term survival. J Thorac Cardiovasc Surg 2006, 132: 499-506. 10.1016\/j.jtcvs.2006.04.019","journal-title":"J Thorac Cardiovasc Surg"},{"key":"1246_CR38","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.ijrobp.2010.05.022","volume":"81","author":"JM Varlotto","year":"2011","unstructured":"Varlotto JM, Medford-Davis LN, Recht A, Flickinger JC, Schaefer E, DeCamp MM: Failure rates and patterns of recurrence in patients with resected N1 non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 2011, 81: 353-359. 10.1016\/j.ijrobp.2010.05.022","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1246_CR39","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/0003-4975(95)00537-U","volume":"60","author":"RJ Ginsberg","year":"1995","unstructured":"Ginsberg RJ, Rubinstein LV: Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung cancer study group. Ann Thorac Surg 1995, 60: 615-622. discussion 622\u2013613 10.1016\/0003-4975(95)00537-U","journal-title":"Ann Thorac Surg"}],"container-title":["Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1748-717X-8-286.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T19:12:17Z","timestamp":1630609937000},"score":1,"resource":{"primary":{"URL":"https:\/\/ro-journal.biomedcentral.com\/articles\/10.1186\/1748-717X-8-286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["1246"],"URL":"https:\/\/doi.org\/10.1186\/1748-717x-8-286","relation":{},"ISSN":["1748-717X"],"issn-type":[{"value":"1748-717X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"26 August 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"286"}}