{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:18:59Z","timestamp":1791058739982,"version":"4.1.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiat Oncol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The purpose of this study was to determine the \u03b1\/\u03b2 ratio for normal liver with hepatitis by analyzing the toxicity data from patients with unresectable hepatocellular carcinoma treated with helical tomotherapy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Between March 2006 and February 2012, 98 patients were eligible for this study. 66 patients received 45\u201350\u2009Gy in 4.5-5\u2009Gy fractions (Group A) and 32 patients received 36\u201360\u2009Gy in 2.5-3\u2009Gy fractions (Group B). Radiation-induced hepatic toxicity was defined as an increase of at least 2 points in the Child-Pugh score within 4\u2009months of completing helical tomotherapy. We attempted to find the statistically significant parameters in the 2 groups using \u03b1\/\u03b2 ratios of 2, 4, 6, 8, or 10, and compared the estimated probability curves of each significant parameter. We hypothesized that the \u03b1\/\u03b2 ratio associated with the best matches for the curves between the 2 groups would be equivalent to the \u03b1\/\u03b2 ratio for the normal liver.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>When using an \u03b1\/\u03b2 ratio of 2 or 4, different parameters were found to be statistically significant in a multivariate analysis (Group A: V<jats:sub>BED30<\/jats:sub> for \u03b1\/\u03b2 ratio\u2009=\u20092 and V<jats:sub>BED25<\/jats:sub> for \u03b1\/\u03b2 ratio\u2009=\u20094, Group B: V<jats:sub>BED25<\/jats:sub> for \u03b1\/\u03b2 ratio\u2009=\u20092 and V<jats:sub>BED20<\/jats:sub> for \u03b1\/\u03b2 ratio\u2009=\u20094). When using an \u03b1\/\u03b2 ratio of 6, 8, or 10, V<jats:sub>BED20<\/jats:sub> was found to be a statistically significant parameter in both groups. Comparison of the estimated probability curve of each significant parameter between the groups revealed that an \u03b1\/\u03b2 ratio of 8 resulted in the best matches.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>We suggest that the \u03b1\/\u03b2 ratio of the normal liver with hepatitis is 8. We hope that previously reported parameters and their values can be effectively used in different fractionation schemes by calculating the biologically effective dose using an \u03b1\/\u03b2 ratio of 8.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1748-717x-8-61","type":"journal-article","created":{"date-parts":[[2013,3,16]],"date-time":"2013-03-16T05:12:19Z","timestamp":1363410739000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Determination of the \u03b1\/\u03b2 ratio for the normal liver on the basis of radiation-induced hepatic toxicities in patients with hepatocellular carcinoma"],"prefix":"10.1186","volume":"8","author":[{"given":"Seok Hyun","family":"Son","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Seok","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyochun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Ock","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Nam","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Won","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Kew","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul Seung","family":"Kay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,3,15]]},"reference":[{"issue":"4","key":"808_CR1","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1002\/1097-0142(19850815)56:4<918::AID-CNCR2820560437>3.0.CO;2-E","volume":"56","author":"K Okuda","year":"1985","unstructured":"Okuda K, Ohtsuki T, Obata H, Tomimatsu M, Okazaki N, Hasegawa H, Nakajima Y, Ohnishi K: Natural history of hepatocellular carcinoma and prognosis in relation to treatment. 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