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We examined the safety and efficacy of thoracic re-irradiation using high-precision image-guided stereotactic body radiation therapy (SBRT).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Records of 39 patients with prior intra-thoracic conventionally fractionated radiation therapy (RT) who underwent SBRT for a subsequent primary, recurrent or metastatic lung tumor from 11\/2004 to 7\/2011 were retrospectively reviewed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Median dose of prior RT was 61 Gy (range 30\u201380 Gy). Median biologically effective prescription dose (\u03b1\/\u03b2\u2009=\u200910) (BED<jats:sub>10<\/jats:sub>) of SBRT was 70.4 Gy (range 42.6-180 Gy). With a median followup of 12.6 months among survivors, 1- and 2-year actuarial local progression-free survival (LPFS) were 77% and 64%, respectively. Median recurrence-free (RFS) and overall survival (OS) were 13.8 and 22.0 months, respectively. Patients without overlap of high-dose regions of the primary and re-irradiation plans were more likely to receive a BED<jats:sub>10<\/jats:sub> \u2265100 Gy, which was associated with higher LPFS (hazard ratio, [HR]\u2009=\u20090.18, p\u2009=\u20090.04), RFS ([HR]\u2009=\u20090.31, p\u2009=\u20090.038) and OS ([HR]\u2009=\u20090.25, p\u2009=\u20090.014). Grade 2 and 3 pulmonary toxicity was observed in 18% and 5% of patients, respectively. Other grade 2\u20134 toxicities included chest wall pain in 18%, fatigue in 15% and skin toxicity in 5%. No grade 5 events occurred.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>SBRT can be safely and successfully administered to patients with prior thoracic RT. Dose reduction for cases with direct overlap of successive radiation fields results in acceptable re-treatment toxicity profile.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1748-717x-8-99","type":"journal-article","created":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:14:51Z","timestamp":1366848891000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Toxicity and outcomes of thoracic re-irradiation using stereotactic body radiation therapy (SBRT)"],"prefix":"10.1186","volume":"8","author":[{"given":"Marsha","family":"Reyngold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham J","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"McLane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meier","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas F","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice Y","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth E","family":"Rosenzweig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen D","family":"Yorke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Rimner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,4,25]]},"reference":[{"key":"824_CR1","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/S0360-3016(00)01401-2","volume":"49","author":"S Tyldesley","year":"2001","unstructured":"Tyldesley S, Boyd C, Schulze K, Walker H, Mackillop WJ: Estimating the need for radiotherapy for lung cancer: an evidence-based, epidemiologic approach. 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