{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:02:03Z","timestamp":1789153323996,"version":"build-2803163510"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiat Oncol"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1748-717x-9-104","type":"journal-article","created":{"date-parts":[[2014,5,2]],"date-time":"2014-05-02T01:03:47Z","timestamp":1398992627000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["V30 as a predictor for radiation-induced hypothyroidism: a dosimetric analysis in patients who received radiotherapy to the neck"],"prefix":"10.1186","volume":"9","author":[{"given":"Zuleyha","family":"Akgun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beste M","family":"Atasoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Ozen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Yavuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahadir","family":"Gulluoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meric","family":"Sengoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ufuk","family":"Abacioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,5,2]]},"reference":[{"key":"1078_CR1","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1016\/0360-3016(95)00019-U","volume":"30","author":"SL Hancock","year":"1995","unstructured":"Hancock SL, McDougall IR, Constine LS: Thyroid abnormalities after therapeutic external radiation. Int J Radiat Oncol Biol Phys 1995, 30: 1165-1170.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1078_CR2","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1001\/archotol.126.5.652","volume":"126","author":"RJ Sinard","year":"2000","unstructured":"Sinard RJ, Tobin EJ, Mazzaferri EL, Hodgson SE, Young DC, Kunz AL, Malhotra PS, Fritz MA, Schuller DE: Hypothyroidism after treatment for nonthyroid head and neck cancer. Arch Otolaryngol Head Neck Surg 2000, 126: 652-657. 10.1001\/archotol.126.5.652","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"1078_CR3","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.radonc.2013.06.029","volume":"109","author":"MF1 R\u00f8njom","year":"2013","unstructured":"R\u00f8njom MF1, Brink C, Bentzen SM, Heged\u00fcs L, Overgaard J, Johansen J: Hypothyroidism after primary radiotherapy for head and neck squamous cell carcinoma: normal tissue complication probability modeling with latent time correction. Radiother Oncol 2013, 109: 317-322. 10.1016\/j.radonc.2013.06.029","journal-title":"Radiother Oncol"},{"key":"1078_CR4","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.ctrv.2003.12.003","volume":"30","author":"BA Jereczek-Fossa","year":"2004","unstructured":"Jereczek-Fossa BA, Alterio D, Jassem J, Gibelli B, Tradati N, Orecchia R: Radiotherapy induced thyroid disorders. Cancer Tr Rew 2004, 30: 369-384. 10.1016\/j.ctrv.2003.12.003","journal-title":"Cancer Tr Rew"},{"key":"1078_CR5","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/j.ijrobp.2007.01.029","volume":"68","author":"N Bhandare","year":"2007","unstructured":"Bhandare N, Kennedy L, Malpaya RS, Morris CG, Mendelhall WM: Primary and central hypothyroidism after radiotherapy for head and neck tumors. Int J Radiat Oncol Biol Phys 2007, 68: 1131-1139. 10.1016\/j.ijrobp.2007.01.029","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1078_CR6","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1002\/hed.2880130508","volume":"13","author":"MC Weissler","year":"1991","unstructured":"Weissler MC, Berry BW: Thyroid-stimulating hormone levels after radiotherapy and combined therapy for head and neck cancer. Head Neck 1991, 13: 420-423. 10.1002\/hed.2880130508","journal-title":"Head Neck"},{"key":"1078_CR7","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0167-8140(00)00276-0","volume":"57","author":"EJ Kumpulainen","year":"2000","unstructured":"Kumpulainen EJ, Hirvikoski PP, Viraniemi JA, Johansson RT, Simonen PM, Ter\u00e4v\u00e4 MT, Asikainen RJ, Nyk\u00e4nen KJ, Kosma V: Hypothyroidism after radiotherapy for laryngeal cancer. Radiother Oncol 2000, 57: 97-101. 10.1016\/S0167-8140(00)00276-0","journal-title":"Radiother Oncol"},{"key":"1078_CR8","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1093\/jjco\/hyt235","volume":"44","author":"MY Kim","year":"2014","unstructured":"Kim MY, Yu T, Wu HG: Dose-volumetric Parameters for Predicting Hypothyroidism after Radiotherapy for Head and Neck Cancer. Jpn J Clin Oncol 2014, 44: 331-337. 10.1093\/jjco\/hyt235","journal-title":"Jpn J Clin Oncol"},{"issue":"7","key":"1078_CR9","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1373\/clinchem.2007.101428","volume":"54","author":"G van der Watt","year":"2008","unstructured":"van der Watt G, Haarburger D, Berman P: Euthyroid patient with elevated serum free thyroxine. Clin Chem 2008,54(7):1239-1241. 10.1373\/clinchem.2007.101428","journal-title":"Clin Chem"},{"key":"1078_CR10","volume-title":"Radiat Oncol","author":"CC Bonato","year":"2014","unstructured":"Bonato CC, Dias HB, Alves Mda S, Duarte LO, Dias TM, Dalenogare MO, Viegas CC, Elnecave RH: In vivo dosimetry of thyroid doses from different irradiated sites in children and adolescents: a cross-sectional study. Radiat Oncol 2014. doi:10.1186\/1748-717X-9-40"},{"issue":"5","key":"1078_CR11","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1016\/j.ijrobp.2010.09.054","volume":"82","author":"L Cella","year":"2012","unstructured":"Cella L, Conson M, Caterino M, De Rosa N, Liuzzi R, Picardi M, Grimaldi F, Solla R, Farella A, Salvatore M, Pacelli R: Thyroid V30 predicts radiation-induced hypothyroidism in patients treated with sequential chemo-radiotherapy for Hodgkin\u2019s lymphoma. Int J Radiat Oncol Biol Phys 2012,82(5):1802-1808. 10.1016\/j.ijrobp.2010.09.054","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"1078_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.radonc.2011.03.002","volume":"99","author":"MJ Boomsa","year":"2011","unstructured":"Boomsa MJ, Bijl HP, Langendijk JA: Radiation-induced hypothyroidism in head and neck cancer patients: a systematic review. Radiat Oncol 2011,99(1):1-5. 10.1016\/j.radonc.2011.03.002","journal-title":"Radiat Oncol"},{"key":"1078_CR13","first-page":"878","volume-title":"Williams Textbook of Endocrinology (12th ed.)","author":"S Melmed","year":"1984","unstructured":"Melmed S: Williams Textbook of Endocrinology (12th ed.). Volume 53. 12th edition. Philadelphia: Elsevier\/Saunders.p.355 Children with Hodgkin\u2019s disease. Cancer; 1984:878-83.","edition":"12"},{"issue":"3","key":"1078_CR14","first-page":"146","volume":"64","author":"E Yoden","year":"2004","unstructured":"Yoden E, Soejima T, Maruta T, Demizu Y, Nishimura H, Ejima Y, Sasaki R, Yamada K, Sugimura K: Hypothyroidism after radiotherapy to the neck. Nihon Igaku Hoshasen Gakkai Zasshi 2004,64(3):146-150.","journal-title":"Nihon Igaku Hoshasen Gakkai Zasshi"},{"key":"1078_CR15","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/S0950-351X(88)80065-X","volume":"2","author":"LJ DeGroot","year":"1988","unstructured":"DeGroot LJ: Radiation and thyroid disease. Bailliere Clin Endocrinol Metabol 1988, 2: 777-791. 10.1016\/S0950-351X(88)80065-X","journal-title":"Bailliere Clin Endocrinol Metabol"},{"key":"1078_CR16","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1148\/radiology.134.1.7350607","volume":"134","author":"YH Kim","year":"1980","unstructured":"Kim YH, Fayos JV, Sisson JC: Thyroid function following neck irradiation for malignant lymphoma. Radiology 1980, 134: 205-208.","journal-title":"Radiology"},{"key":"1078_CR17","first-page":"51","volume":"9","author":"JH Dobbs","year":"1983","unstructured":"Dobbs JH: Thyroid damage after treatment of Hodgkin\u2019s disease. Clin Oncol 1983, 9: 51-56.","journal-title":"Clin Oncol"},{"issue":"23","key":"1078_CR18","doi-asserted-by":"publisher","first-page":"5250","DOI":"10.1002\/cncr.26186","volume":"117","author":"IR1 Vogelius","year":"2011","unstructured":"Vogelius IR1, Bentzen SM, Maraldo MV, Petersen PM, Specht L: Risk factors for radiation induced hypothyroidism:a literature-based meta-analysis. Cancer 2011,117(23):5250-5260. 10.1002\/cncr.26186","journal-title":"Cancer"},{"issue":"2","key":"1078_CR19","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.ijrobp.2009.05.018","volume":"77","author":"R Diaz","year":"2010","unstructured":"Diaz R, Jaboin JJ, Morales-Paliza M, Koehler E, Phillips JG, Stinson S, Gilbert J, Chung CH, Murphy BA, Yarbrough WG, Murphy PB, Shyr Y, Cmelak AJ: Hypothyroidism as a consequence of intensity modulated radiotherapy with concurrent taxane- based chemotherapy for locally advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys 2010,77(2):468-476. 10.1016\/j.ijrobp.2009.05.018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1078_CR20","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1186\/1748-717X-7-224","volume":"7","author":"L Cella","year":"2012","unstructured":"Cella L, Liuzzi R, Conson M, D'Avino V, Salvatore M, Pacelli R: Development of multivariate NTCP models for radiation-induced hypothyroidism: a comparative analysis. Radiat Oncol 2012, 7: 224. 10.1186\/1748-717X-7-224","journal-title":"Radiat Oncol"},{"key":"1078_CR21","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1288\/00005537-198404000-00002","volume":"94","author":"MR Posner","year":"1984","unstructured":"Posner MR, Ervin TJ, Miller D, Fabian RL, Norris CM Jr, Weichselbaum RR, Rose C: Incidence of hypothyroidism following multimodality treatment for advanced squamous call cancer of the head and neck. Laryngoscope 1984, 94: 451-454. 10.1288\/00005537-198404000-00002","journal-title":"Laryngoscope"},{"key":"1078_CR22","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1177\/000348948109000506","volume":"90","author":"DP Vrabec","year":"1981","unstructured":"Vrabec DP, Heffron TJ: Hypothyroidism following treatment for head and neck cancer. Ann Otol Rhinol Laryngol 1981, 90: 449-453.","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"1078_CR23","first-page":"435","volume":"150","author":"MA Biel","year":"1985","unstructured":"Biel MA, Maisel RH: Indications for performing hemithyroidectomy for tumours requiring total laryngectomy. Arch Otolaryngol Head Neck Surg 1985, 150: 435-439.","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"1078_CR24","volume-title":"Head Neck","author":"V Murthy","year":"2013","unstructured":"Murthy V, Narang K, Ghosh-Laskar S, Gupta T, Budrukkar A, Agrawal JP: Hypothyroidism after 3-dimensional conformal radiotherapy and intensity modulated radiotherapy for head and neck cancers: Prospective data from two randomized controlled trials. Head Neck 2013. doi:10.1002\/hed.23482"},{"key":"1078_CR25","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1046\/j.1365-2273.1999.00214.x","volume":"24","author":"MA Thorp","year":"1999","unstructured":"Thorp MA, Levitt NS, Mortimore S, Isaacs S: Parathyroid and thyroid function five years after treatment of laryngeal and hypopharyngeal carcinoma. Clin Otolaryngol 1999, 24: 104-108. 10.1046\/j.1365-2273.1999.00214.x","journal-title":"Clin Otolaryngol"}],"container-title":["Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1748-717X-9-104.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T12:03:32Z","timestamp":1548245012000},"score":1,"resource":{"primary":{"URL":"https:\/\/ro-journal.biomedcentral.com\/articles\/10.1186\/1748-717X-9-104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,2]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["1078"],"URL":"https:\/\/doi.org\/10.1186\/1748-717x-9-104","relation":{},"ISSN":["1748-717X"],"issn-type":[{"value":"1748-717X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,2]]},"assertion":[{"value":"7 January 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"104"}}