{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T21:14:18Z","timestamp":1777065258153,"version":"3.51.4"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiat Oncol"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1748-717x-9-118","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T07:07:14Z","timestamp":1400656034000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Early results of urethral dose reduction and small safety margin in intensity-modulated radiation therapy (IMRT) for localized prostate cancer using a real-time tumor-tracking radiotherapy (RTRT) system"],"prefix":"10.1186","volume":"9","author":[{"given":"Shinichi","family":"Shimizu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Nishioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryusuke","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Shinohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashige","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumiko","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Katoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikiya","family":"Onimaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Shirato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,5,21]]},"reference":[{"key":"1088_CR1","doi-asserted-by":"publisher","first-page":"e325","DOI":"10.1016\/j.ijrobp.2011.02.006","volume":"81","author":"JE Bekelman","year":"2011","unstructured":"Bekelman JE, Mitra N, Efstathiou J, Liao K, Sunderland R, Yeboa DN, Armstrong K: Outcomes after intensity-modulated versus conformal radiotherapy in older men with nonmetastatic prostate cancer. Int J Radiat Oncol Biol Phys 2011, 81: e325-34. 10.1016\/j.ijrobp.2011.02.006","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"1088_CR2","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.ijrobp.2011.11.047","volume":"84","author":"MJ Zelefsky","year":"2012","unstructured":"Zelefsky MJ, Kollmeier M, Cox B, Fidaleo A, Sperling D, Pei X, Carver B, Coleman J, Lovelock M, Hunt M: Improved clinical outcomes with high-dose image guided radiotherapy compared with non-IGRT for the treatment of clinically localized prostate cancer. Int J Radiat Oncol Biol Phys 2012,84(1):125-9. 10.1016\/j.ijrobp.2011.11.047","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1088_CR3","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.radonc.2011.10.025","volume":"103","author":"G Crehange","year":"2012","unstructured":"Crehange G, Mirjolet C, Gauthier M, Martin E, Truc G, Peignaux-Casasnovas K, Azelie C, Bonnetain F, Naudy S, Maingon P: Clinical impact of margin reduction on late toxicity and short-term biochemical control for patients treated with daily on-line image guided IMRT for prostate cancer. Radiother Oncol 2012, 103: 244-246. 10.1016\/j.radonc.2011.10.025","journal-title":"Radiother Oncol"},{"key":"1088_CR4","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.eururo.2011.09.027","volume":"61","author":"L Bud\u00e4us","year":"2012","unstructured":"Bud\u00e4us L, Bolla M, Bossi A, Cozzarini C, Crook J, Widmark A, Wiegel T: Functional outcomes and complications following radiation therapy for prostate cancer: a critical analysis of the literature. Eur Urol 2012, 61: 112-127. 10.1016\/j.eururo.2011.09.027","journal-title":"Eur Urol"},{"key":"1088_CR5","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1016\/S0140-6736(99)00700-X","volume":"353","author":"H Shirato","year":"1999","unstructured":"Shirato H, Shimizu S, Shimizu T, Nishioka T, Miyasaka K: Real-time tumor-tracking radiotherapy. Lancet 1999, 353: 1331-1332.","journal-title":"Lancet"},{"key":"1088_CR6","doi-asserted-by":"publisher","first-page":"e393","DOI":"10.1016\/j.ijrobp.2011.04.043","volume":"81","author":"S Shimizu","year":"2011","unstructured":"Shimizu S, Osaka Y, Shinohara N, Sazawa A, Nishioka K, Suzuki R, Onimaru R, Shirato H: Use of implanted markers and interportal adjustment with real-time tracking radiotherapy system to reduce intrafraction prostate motion. Int J Radiat Oncol Biol Phys 2011, 81: e393-9. 10.1016\/j.ijrobp.2011.04.043","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1088_CR7","doi-asserted-by":"crossref","first-page":"162","DOI":"10.6004\/jnccn.2010.0012","volume":"8","author":"J Mohler","year":"2010","unstructured":"Mohler J, Bahnson RR, Boston B, Busby JE, D'Amico A, Eastham JA, Enke CA, George D, Horwitz EM, Huben RP, Kantoff P, Kawachi M, Kuettel M, Lange PH, Macvicar G, Plimack ER, Pow-Sang JM, Roach M 3rd, Rohren E, Roth BJ, Shrieve DC, Smith MR, Srinivas S, Twardowski P, Walsh PC: NCCN clinical practice guidelines in oncology: prostate cancer. J Natl Compr Canc Netw 2010, 8: 162-200.","journal-title":"J Natl Compr Canc Netw"},{"key":"1088_CR8","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1016\/S0360-3016(00)00809-9","volume":"48","author":"S Shimizu","year":"2000","unstructured":"Shimizu S, Shirato H, Kitamura K, Shinohara N, Harabayashi T, Tsukamoto T, Koyanagi T, Miyasaka K: Use of an implanted marker and real-time tracking of the marker for the positioning of prostate and bladder cancers. Int J Radiat Oncol Biol Phys 2000, 48: 1591-1597. 10.1016\/S0360-3016(00)00809-9","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1088_CR9","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1016\/j.ijrobp.2007.01.067","volume":"68","author":"PA Kupelian","year":"2007","unstructured":"Kupelian PA, Willoughby TR, Reddy CA, Klein EA, Mahadevan A: Hypofractionated intensity-modulated radiotherapy (70\u00a0Gy at 2.5\u00a0Gy per fraction) for localized prostate cancer: Cleveland Clinic experience. Int J Radiat Oncol Biol Phys 2007, 68: 1424-1430. 10.1016\/j.ijrobp.2007.01.067","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1088_CR10","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/S0360-3016(98)00438-6","volume":"43","author":"DJ Brenner","year":"1999","unstructured":"Brenner DJ, Hall EJ: Fractionation and protraction for radiotherapy of prostate carcinoma. Int J Radiat Oncol Biol Phys 1999, 43: 1095-1101. 10.1016\/S0360-3016(98)00438-6","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"1088_CR11","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.ijrobp.2009.12.045","volume":"79","author":"GI Arcangeli","year":"2011","unstructured":"Arcangeli GI, Fowler J, Gomellini S, Arcangeli S, Saracino B, Petrongari MG, Benassi M, Strigari L: Acute and late toxicity in a randomized trial of conventional versus hypofractionated three-dimensional conformal radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys 2011,79(4):1013-1021. doi:10.1016\/j.ijrobp.2009.12.045 10.1016\/j.ijrobp.2009.12.045","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"1088_CR12","doi-asserted-by":"publisher","first-page":"e483","DOI":"10.1016\/j.ijrobp.2012.04.012","volume":"84","author":"V Fonteyne","year":"2012","unstructured":"Fonteyne V, Soete G, Arcangeli S, De Neve W, Rappe B, Storme G, Strigari L, Arcangeli G, De Meerleer G: Hypofractionated high-dose radiation therapy for prostate cancer: long-term results of a multi-institutional phase II trial. Radiation Oncology Biology 2012,84(4):e483-e490. doi:10.1016\/j.ijrobp.2012.04.012 10.1016\/j.ijrobp.2012.04.012","journal-title":"Radiation Oncology Biology"},{"issue":"1","key":"1088_CR13","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S1470-2045(11)70293-5","volume":"13","author":"D Dearnaley","year":"2011","unstructured":"Dearnaley D, Syndikus I, Sumo G, Bidmead M, Bloomfield D, Clark C, Gao A, Hassan S, Horwich A, Huddart R, Khoo V, Kirkbride P, Mayles H, Mayles P, Naismith O, Parker C, Patterson H, Russell M, Scrase C, South C, Staffurth J, Hall E: Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: preliminary safety results from the CHHiP randomised controlled trial. Lancet Oncology 2011,13(1):43-54. doi:10.1016\/S1470-2045(11)70293-5","journal-title":"Lancet Oncology"},{"issue":"1","key":"1088_CR14","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.radonc.2009.03.013","volume":"92","author":"V Fonteyne","year":"2009","unstructured":"Fonteyne V, Villeirs G, Lumen N, De Meerleer G: Urinary toxicity after high dose intensity modulated radiotherapy as primary therapy for prostate cancer. Radiother Oncol 2009,92(1):42-47. 10.1016\/j.radonc.2009.03.013","journal-title":"Radiother Oncol"},{"key":"1088_CR15","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3322\/CA.2008.0002","volume":"58","author":"MD Michaelson","year":"2008","unstructured":"Michaelson MD, Cotter SE, Gargollo PC, Zietman AL, Dahl DM, Smith MR: Management of complications of prostate cancer treatment. CA Cancer J Clin 2008, 58: 196-213. 10.3322\/CA.2008.0002","journal-title":"CA Cancer J Clin"},{"key":"1088_CR16","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1016\/j.ijrobp.2007.11.044","volume":"70","author":"MJI Zelefsky","year":"2008","unstructured":"Zelefsky MJI, Levin EJ, Hunt M, Yamada Y, Shippy AM, Jackson A, Amols HI: Incidence of late rectal and urinary toxicities after three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys 2008, 70: 1124-1129. 10.1016\/j.ijrobp.2007.11.044","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"6","key":"1088_CR17","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/nrurol.2009.83","volume":"6","author":"JJ Coen","year":"2009","unstructured":"Coen JJ, Zietman AL: Proton radiation for localized prostate cancer. Nat Rev Urol 2009,6(6):324-30. 10.1038\/nrurol.2009.83","journal-title":"Nat Rev Urol"},{"key":"1088_CR18","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/1748-717X-7-82","volume":"7","author":"J Vainshtein","year":"2012","unstructured":"Vainshtein J, Abu-Isa E, Olson KB, Ray ME, Sandler HM, Normolle D, Litzenberg DW, Masi K, Pan C, Hamstra DA: Randomized phase II trial of urethral sparing intensity modulated radiation therapy in low-risk prostate cancer: implications for focal therapy. Radiat Oncol 2012, 7: 82. 10.1186\/1748-717X-7-82","journal-title":"Radiat Oncol"},{"issue":"2","key":"1088_CR19","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.radonc.2013.08.006","volume":"109","author":"V Fonteyne","year":"2013","unstructured":"Fonteyne V, Lumen N, Ost P, Van Praet C, Vandecasteele K, De Gersem Ir W, Villeirs G, De Neve W, Decaestecker K, De Meerleer G: Hypofractionated intensity-modulated arc therapy for lymph node metastasized prostate cancer: Early late toxicity and 3-year clinical outcome. Radiother Oncol 2013,109(2):229-234. 10.1016\/j.radonc.2013.08.006","journal-title":"Radiother Oncol"}],"container-title":["Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1748-717X-9-118.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T07:03:15Z","timestamp":1548226995000},"score":1,"resource":{"primary":{"URL":"https:\/\/ro-journal.biomedcentral.com\/articles\/10.1186\/1748-717X-9-118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,21]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["1088"],"URL":"https:\/\/doi.org\/10.1186\/1748-717x-9-118","relation":{},"ISSN":["1748-717X"],"issn-type":[{"value":"1748-717X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,21]]},"assertion":[{"value":"10 January 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"118"}}