{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:43:45Z","timestamp":1773078225684,"version":"3.50.1"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,4,29]],"date-time":"2008-04-29T00:00:00Z","timestamp":1209427200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Atrial myxomas are the most common primary cardiac tumors. They are usually small or moderate in size by the time of the diagnosis, exhibiting non specific cardiac or systemic symptoms, and are most frequently soft and friable without microscopic signs of ossification. We describe herein an extremely rare case of an asymptomatic giant left atrial myxoma with angiographic neovascularization and ossification.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>An asymptomatic 58-year-old male with a giant left atrial tumor, was transferred to our Unit for surgical treatment. The tumor was an incidental finding during a work-up for hemoptysis due to bronchectasis. The coronary angiogram showed tumor vessels originating from the RCA. The tumor macroscopically did not resemble a myxoma, considering its dimensions (12 \u00d7 10 cm) and its solid substance. The mass was excised together with the interatrial septum and the right lateral LA wall close to the right pulmonary veins orifices. The defect was closed with Dacron patches in order to prevent malformation of both atria. The pathology study revealed a benign myxoma with excessive osteoid (mature bone) content.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>We consider our case as extremely rare because of the asymptomatic course despite the large size of the tumor, the blood supply from the right coronary artery and the bone formation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1749-8090-3-19","type":"journal-article","created":{"date-parts":[[2008,4,29]],"date-time":"2008-04-29T18:13:34Z","timestamp":1209492814000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Large asymptomatic Left Atrial Myxoma with ossification: case report"],"prefix":"10.1186","volume":"3","author":[{"given":"Mattheos","family":"Panagiotou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos D","family":"Panagopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiota","family":"Ravazoula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loukas","family":"Kaklamanis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efstratios N","family":"Koletsis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,4,29]]},"reference":[{"key":"119_CR1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0167-5273(02)00136-5","volume":"84","author":"Q Meng","year":"2002","unstructured":"Meng Q, Lai H, Lima J, Tong W, Qian Y, Lai S: Echocardiographic and pathologic characteristics of primary cardiac tumors: a study of 149 cases. Int J Cardiol. 2002, 84: 69-75. 10.1016\/S0167-5273(02)00136-5.","journal-title":"Int J Cardiol"},{"key":"119_CR2","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1056\/NEJM199512143332407","volume":"333","author":"K Reynen","year":"1995","unstructured":"Reynen K: Cardiac myxomas. New Engl J Med. 1995, 333: 1610-1617. 10.1056\/NEJM199512143332407.","journal-title":"New Engl J Med"},{"key":"119_CR3","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1016\/S0002-9149(99)00156-3","volume":"83","author":"JW Ha","year":"1999","unstructured":"Ha JW, Kang WC, Chung N, Chang BC, Rim SJ, Kwon JW, Jang Y, Shim WH, Cho SY, Kim SS, Cho SH: Echocardiographic and morphologic characteristics of left atrial myxoma and their relation to systemic embolism. Am J Cardiol. 1999, 83: 1579-82. 10.1016\/S0002-9149(99)00156-3.","journal-title":"Am J Cardiol"},{"key":"119_CR4","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/j.1540-8183.1993.tb00844.x","volume":"6","author":"S Sharma","year":"1993","unstructured":"Sharma S, Sundaram U, Loya Y: Selective coronary angiography in intracardiac tumors. J Interv Cardiol. 1993, 6: 125-9. 10.1111\/j.1540-8183.1993.tb00844.x.","journal-title":"J Interv Cardiol"},{"key":"119_CR5","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s00392-004-1010-3","volume":"93","author":"K Reynen","year":"2004","unstructured":"Reynen K, Kockeritz U, Taha M, Strasser R: Neovascularization in left atrial myxomas. Z Kardiol. 2004, 93: 69-71. 10.1007\/s00392-004-1010-3.","journal-title":"Z Kardiol"},{"key":"119_CR6","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1177\/153857449302700609","volume":"27","author":"K Aytemir","year":"1993","unstructured":"Aytemir K, Nazli N, Tokgozoglu SL, Demircin M, Ozin B: Tumor vascularity in left atrial myxoma supplied by left circumflex artery-a case report. Vasc Surg. 1993, 27: 475-","journal-title":"Vasc Surg"},{"key":"119_CR7","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1136\/heart.86.2.206","volume":"86","author":"F Burzotta","year":"2001","unstructured":"Burzotta F, Pieroni M, Rossi E: Left atrial myxoma supplied from the right coronary arteries. Heart. 2001, 86: 206-10.1136\/heart.86.2.206.","journal-title":"Heart"},{"key":"119_CR8","first-page":"1796","volume":"44","author":"T Ishikawa","year":"1996","unstructured":"Ishikawa T, Shimizu Y, Kimura E, Nishizawa K, Takanashi S, Kaneko K: A surgical case report of ossified left atrial myxomas. Nippon Kyobu Geka Gakkai Zasshi. 1996, 44: 1796-9.","journal-title":"Nippon Kyobu Geka Gakkai Zasshi"},{"key":"119_CR9","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1354\/vp.37-5-460","volume":"37","author":"MD Campbell","year":"2000","unstructured":"Campbell MD, Gelberg H: Endocardial Ossifying Myxoma of the Right Atrium in a Cat. Vet Pathol. 2000, 37: 460-462. 10.1354\/vp.37-5-460.","journal-title":"Vet Pathol"},{"key":"119_CR10","first-page":"376","volume":"55","author":"T Kugai","year":"2002","unstructured":"Kugai T, Chibana M: Left atrial myxoma with extramedullary hematopoiesis and ossification. Kyobu Geka. 2002, 55: 376-8.","journal-title":"Kyobu Geka"}],"container-title":["Journal of Cardiothoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1749-8090-3-19.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1749-8090-3-19\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1749-8090-3-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1749-8090-3-19.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:47:19Z","timestamp":1630457239000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiothoracicsurgery.biomedcentral.com\/articles\/10.1186\/1749-8090-3-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,29]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["119"],"URL":"https:\/\/doi.org\/10.1186\/1749-8090-3-19","relation":{},"ISSN":["1749-8090"],"issn-type":[{"value":"1749-8090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,29]]},"assertion":[{"value":"19 July 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2008","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2008","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"19"}}