{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:56:05Z","timestamp":1756385765713},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,8,21]],"date-time":"2010-08-21T00:00:00Z","timestamp":1282348800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Cogan's syndrome is a rare disorder of unknown origin characterized by inflammatory ocular disease and vestibuloauditory symptoms. Systemic vasculitis is found in about 10% of cases.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>A 46-year-old female with Cogans's syndrome and a history of arterial hypertension presented with severe chest pain caused by an aneurysm of the ascending aorta with a dissection membrane located a few centimeters distal from the aortic root. After surgery, histopathological analysis revealed that vascular matrix integrity and expression of the major matrix molecules was characterized by elastolysis and collagenolysis and thus a dramatic loss of structural integrity. Remarkably, exceeding matrix deterioration was associated with massively increased levels of granulocyte macrophage colony stimulating factor (GM-CSF).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Our data suggest that the persistently increased secretion of the inflammatory mediator GM-CSF by resident inflammatory cells but also by SMC may be the trigger of aortic wall structural deterioration.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1749-8090-5-66","type":"journal-article","created":{"date-parts":[[2010,8,21]],"date-time":"2010-08-21T18:13:44Z","timestamp":1282414424000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Aortic dissection associated with cogans's syndrome: deleterious loss of vascular structural integrity is associated with GM-CSF overstimulation in macrophages and smooth muscle cells"],"prefix":"10.1186","volume":"5","author":[{"given":"Gabriele","family":"Weissen-Plenz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6mer","family":"Sezer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Vahlhaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horst","family":"Robenek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Hoffmeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonny DT","family":"Tjan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans H","family":"Scheld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen R","family":"Sindermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,8,21]]},"reference":[{"key":"299_CR1","doi-asserted-by":"publisher","first-page":"483","DOI":"10.4065\/81.4.483","volume":"81","author":"MB Gluth","year":"2006","unstructured":"Gluth MB, Baratz KH, Matteson EL, Driscoll CL: Cogan syndrome: a retrospective review of 60 patients throughout a half century. Mayo Clin Proc. 2006, 81: 483-488. 10.4065\/81.4.483.","journal-title":"Mayo Clin Proc"},{"issue":"4","key":"299_CR2","first-page":"463","volume":"19","author":"M Gaubitz","year":"2001","unstructured":"Gaubitz M, L\u00fcbben B, Seidel M, Schotte H, Gramley F, Domschke W: Cogan's syndrome: organ-specific autoimmune disease or systemic vasculitis? A report of two cases and review of the literature. Clin Exp Rheumatol. 2001, 19 (4): 463-469.","journal-title":"Clin Exp Rheumatol"},{"key":"299_CR3","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1016\/j.athoracsur.2009.04.081","volume":"88","author":"TE Bisdas","year":"2009","unstructured":"Bisdas TE, Teebken OE, Wilhelmi M, Lotz J, Bredt M, Haverich A, Pichlmaier MA: Surgical treatment of a thoracoabdominal aneurysm in Cogan's syndrome. Ann Thorac Surg. 2009, 88: 1668-1670. 10.1016\/j.athoracsur.2009.04.081.","journal-title":"Ann Thorac Surg"},{"key":"299_CR4","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1080\/03009740600907923","volume":"36","author":"AH Low","year":"2007","unstructured":"Low AH, Su JW, Sin KY, Fong KY, Thumboo J: Cogan's syndrome with recurrent carotid and aortic aneurysms: a potentially fatal disorder mimicking Marfan syndrome. Scand J Rheumatol. 2007, 36: 71-73. 10.1080\/03009740600907923.","journal-title":"Scand J Rheumatol"},{"key":"299_CR5","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1096\/fj.02-1035com","volume":"17","author":"G Plenz","year":"2003","unstructured":"Plenz G, Eschert H, Beissert S, Arps V, Sindermann JR, Robenek H, V\u00f6lker W: Alterations in the vascular extracellular matrix of granulocyte macrophage colony-stimulating factor (GM-CSF) -deficient mice. FASEB J. 2003, 17: 1451-1457. 10.1096\/fj.02-1035com.","journal-title":"FASEB J"},{"key":"299_CR6","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1159\/000109819","volume":"45","author":"G Weissen-Plenz","year":"2008","unstructured":"Weissen-Plenz G, Eschert H, Volker W, Sindermann JR, Beissert S, Robenek H, Scheld HH, Breithardt G: Granulocyte macrophage colony-stimulating factor deficiency affects vascular elastin production and integrity of elastic lamellae. J Vasc Res. 2008, 45: 103-110. 10.1159\/000109819.","journal-title":"J Vasc Res"}],"container-title":["Journal of Cardiothoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1749-8090-5-66.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1749-8090-5-66\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1749-8090-5-66","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1749-8090-5-66.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T05:43:35Z","timestamp":1630475015000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiothoracicsurgery.biomedcentral.com\/articles\/10.1186\/1749-8090-5-66"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,21]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["299"],"URL":"https:\/\/doi.org\/10.1186\/1749-8090-5-66","relation":{},"ISSN":["1749-8090"],"issn-type":[{"value":"1749-8090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,21]]},"assertion":[{"value":"10 February 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"66"}}