{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T11:10:58Z","timestamp":1777115458512,"version":"3.51.4"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T00:00:00Z","timestamp":1384992000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>The aim of this study was to analyze the profile of tumor recurrence for patients operated on for cancer of oesophagogastric junction or oesophagus by Ivor-Lewis oesophagectomy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Patients undergoing potentially curative Ivor-Lewis oesophageal resection between January 1999 to December 2008 at a single center institution were retrospectively analyzed. Their clinical records, details of surgical procedure, postoperative course, pathological findings, recurrence and long term survival were reviewed retrospectively. Univariate and multivariate survival analyses were performed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>One hundred and twenty patients were analyzed. Fifty three patients (44%) presented recurrence during median follow-up of 58\u00a0months. Five-year relapse free survival (RFS) rate was 51% (95%CI = [46; 65%]). On multivariate analysis, pT stage\u2009&gt;\u20092 (HR = 2.42, 95%CI = [1.22; 4.79] p = 0.011), positive lymph node status (HR = 3.69; 95% CI = [1.53; 8.96] p = 0.004) and lymph node ratio\u2009&gt;\u20090.2 (HR = 2.57; 95%CI = [1.38; 4.76] p = 0.003) were associated with a poorer RFS and their combination was correlated to relapse risk. Moreover, preoperative tumor stenosis was associated with an increased risk of local recurrence (HR = 3.46; 95% CI = [1.38; 8.70] p = 0.008) whereas poor or undifferentiated tumor was associated with an increased risk of distant recurrence (HR = 3.32; 95% CI = [1.03; 10.04] p = 0.044).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>pT stage\u2009&gt;\u20092, positive lymph node status and lymph node ratio\u2009&gt;\u20090.2 are independent prognostic factors of recurrence after Ivor-Lewis surgery for cancer. Their combination is correlated with an increasing risk of recurrence that may argue favorably, in addition with preoperative tumor stenosis assessment, for adjuvant treatment or reinforced follow-up.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1749-8090-8-215","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T18:01:37Z","timestamp":1385056897000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Recurrence risk after Ivor Lewis oesophagectomy for cancer"],"prefix":"10.1186","volume":"8","author":[{"given":"Mael Chalret","family":"du Rieu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Filleron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benoit","family":"Beluchon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marine","family":"Humeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles-Henri","family":"Julio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Bloom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Ghouti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Kirzin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Portier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Prad\u00e8re","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Carr\u00e8re","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,11,21]]},"reference":[{"key":"1588_CR1","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/S1470-2045(05)70288-6","volume":"6","author":"BH Burmeister","year":"2005","unstructured":"Burmeister BH, Smithers BM, Gebski V, Fitzgerald L, Simes RJ, Devitt P, Ackland S, Gotley DC, Joseph D, Millar J, North J, Walpole ET, Denham JW: Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trial. Lancet Oncol. 2005, 6: 659-668. 10.1016\/S1470-2045(05)70288-6.","journal-title":"Lancet Oncol"},{"key":"1588_CR2","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1200\/JCO.2005.04.7118","volume":"25","author":"L Bedenne","year":"2007","unstructured":"Bedenne L, Michel P, Bouche O, Milan C, Mariette C, Conroy T, Pezet D, Roullet B, Seitz JF, Herr JP, Paillot B, Arveux P, Bonnetain F, Binquet C: Chemoradiation followed by surgery compared with chemoradiation alone in squamous cancer of the esophagus: FFCD 9102. J Clin Oncol. 2007, 25: 1160-1168. 10.1200\/JCO.2005.04.7118.","journal-title":"J Clin Oncol"},{"key":"1588_CR3","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1200\/JCO.2005.00.034","volume":"23","author":"M Stahl","year":"2005","unstructured":"Stahl M, Stuschke M, Lehmann N, Meyer HJ, Walz MK, Seeber S, Klump B, Budach W, Teichmann R, Schmitt M, Schmitt G, Franke C, Wilke H: Chemoradiation with and without surgery in patients with locally advanced squamous cell carcinoma of the esophagus. J Clin Oncol. 2005, 23: 2310-2317. 10.1200\/JCO.2005.00.034.","journal-title":"J Clin Oncol"},{"key":"1588_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-642-59600-1_1","volume":"155","author":"M Pera","year":"2000","unstructured":"Pera M: Epidemiology of esophageal cancer, especially adenocarcinoma of the esophagus and esophagogastric junction. Recent Results Cancer Res. 2000, 155: 1-14. 10.1007\/978-3-642-59600-1_1.","journal-title":"Recent Results Cancer Res"},{"key":"1588_CR5","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/S1470-2045(11)70142-5","volume":"12","author":"KM Sjoquist","year":"2011","unstructured":"Sjoquist KM, Burmeister BH, Smithers BM, Zalcberg JR, Simes RJ, Barbour A, Gebski V: Survival after neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal carcinoma: an updated meta-analysis. Lancet Oncol. 2011, 12: 681-692. 10.1016\/S1470-2045(11)70142-5.","journal-title":"Lancet Oncol"},{"key":"1588_CR6","volume-title":"Th\u00e9saurus National de Canc\u00e9rologie digestive - Soci\u00e9t\u00e9 Nationale Fran\u00e7aise de Gastro-Ent\u00e9rologie","author":"G Lledo","year":"2013","unstructured":"Lledo G, Barrioz T, Landi B, Mariette C, Maingon P, Raoul JL, Rougier P, Seitz JF, Triboulet JP: Th\u00e9saurus National de Canc\u00e9rologie digestive - Soci\u00e9t\u00e9 Nationale Fran\u00e7aise de Gastro-Ent\u00e9rologie. 2013, http:\/\/www.snfge.asso.fr\/data\/ModuleDocument\/publication\/5\/pdf\/TNCD-chapitre-1.pdf]"},{"key":"1588_CR7","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1007\/s00595-011-4542-y","volume":"41","author":"Y Akutsu","year":"2011","unstructured":"Akutsu Y, Matsubara H: The significance of lymph node status as a prognostic factor for esophageal cancer. Surg Today. 2011, 41: 1190-1195. 10.1007\/s00595-011-4542-y.","journal-title":"Surg Today"},{"key":"1588_CR8","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.ejso.2009.09.005","volume":"36","author":"YP Liu","year":"2010","unstructured":"Liu YP, Ma L, Wang SJ, Chen YN, Wu GX, Han M, Wang XL: Prognostic value of lymph node metastases and lymph node ratio in esophageal squamous cell carcinoma. Eur J Surg Oncol. 2010, 36: 155-159. 10.1016\/j.ejso.2009.09.005.","journal-title":"Eur J Surg Oncol"},{"key":"1588_CR9","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1097\/SLA.0b013e31815aaadf","volume":"247","author":"C Mariette","year":"2008","unstructured":"Mariette C, Piessen G, Briez N, Triboulet JP: The number of metastatic lymph nodes and the ratio between metastatic and examined lymph nodes are independent prognostic factors in esophageal cancer regardless of neoadjuvant chemoradiation or lymphadenectomy extent. Ann Surg. 2008, 247: 365-371. 10.1097\/SLA.0b013e31815aaadf.","journal-title":"Ann Surg"},{"key":"1588_CR10","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1097\/00004836-200012000-00010","volume":"31","author":"M Tachibana","year":"2000","unstructured":"Tachibana M, Dhar DK, Kinugasa S, Kotoh T, Shibakita M, Ohno S, Masunaga R, Kubota H, Nagasue N: Esophageal cancer with distant lymph node metastasis: prognostic significance of metastatic lymph node ratio. J Clin Gastroenterol. 2000, 31: 318-322. 10.1097\/00004836-200012000-00010.","journal-title":"J Clin Gastroenterol"},{"key":"1588_CR11","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1245\/s10434-009-0818-5","volume":"17","author":"Y Hu","year":"2010","unstructured":"Hu Y, Hu C, Zhang H, Ping Y, Chen LQ: How does the number of resected lymph nodes influence TNM staging and prognosis for esophageal carcinoma?. Ann Surg Oncol. 2010, 17: 784-790. 10.1245\/s10434-009-0818-5.","journal-title":"Ann Surg Oncol"},{"key":"1588_CR12","volume-title":"TNM classification of malignant tumours","author":"L Sobin","year":"2009","unstructured":"Sobin L, Gospodarowicz M, Wittekind C: TNM classification of malignant tumours. 2009, New York: Wiley-Blackwell, 7","edition":"7"},{"key":"1588_CR13","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1016\/S0003-4975(99)01171-6","volume":"68","author":"T Nishimaki","year":"1999","unstructured":"Nishimaki T, Tanaka O, Ando N, Ide H, Watanabe H, Shinoda M, Takiyama W, Yamana H, Ishida K, Isono K, Endo M, Ikeuchi T, Mitomi T, Koizumi H, Imamura M, Iizuka T: Evaluation of the accuracy of preoperative staging in thoracic esophageal cancer. Ann Thorac Surg. 1999, 68: 2059-2064. 10.1016\/S0003-4975(99)01171-6.","journal-title":"Ann Thorac Surg"},{"key":"1588_CR14","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/sj.bjc.6604200","volume":"98","author":"EP van Vliet","year":"2008","unstructured":"van Vliet EP, Heijenbrok-Kal MH, Hunink MG, Kuipers EJ, Siersema PD: Staging investigations for oesophageal cancer: a meta-analysis. Br J Cancer. 2008, 98: 547-557. 10.1038\/sj.bjc.6604200.","journal-title":"Br J Cancer"},{"key":"1588_CR15","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1097\/00000658-200110000-00011","volume":"234","author":"JA Hagen","year":"2001","unstructured":"Hagen JA, DeMeester SR, Peters JH, Chandrasoma P, DeMeester TR: Curative resection for esophageal adenocarcinoma: analysis of 100 en bloc esophagectomies. Ann Surg. 2001, 234: 520-530. 10.1097\/00000658-200110000-00011. discussion 530-521","journal-title":"Ann Surg"},{"key":"1588_CR16","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1038\/sj.bjc.6600931","volume":"88","author":"OA Khan","year":"2003","unstructured":"Khan OA, Fitzgerald JJ, Soomro I, Beggs FD, Morgan WE, Duffy JP: Prognostic significance of circumferential resection margin involvement following oesophagectomy for cancer. Br J Cancer. 2003, 88: 1549-1552. 10.1038\/sj.bjc.6600931.","journal-title":"Br J Cancer"},{"key":"1588_CR17","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1097\/01.sla.0000251703.35919.02","volume":"245","author":"BP Wijnhoven","year":"2007","unstructured":"Wijnhoven BP, Tran KT, Esterman A, Watson DI, Tilanus HW: An evaluation of prognostic factors and tumor staging of resected carcinoma of the esophagus. Ann Surg. 2007, 245: 717-725. 10.1097\/01.sla.0000251703.35919.02.","journal-title":"Ann Surg"},{"key":"1588_CR18","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1245\/s10434-011-1983-x","volume":"19","author":"Y Hosokawa","year":"2012","unstructured":"Hosokawa Y, Kinoshita T, Konishi M, Takahashi S, Gotohda N, Kato Y, Daiko H, Nishimura M, Katsumata K, Sugiyama Y, Kinoshita T: Clinicopathological features and prognostic factors of Adenocarcinoma of the Esophagogastric junction according to Siewert classification: experiences at a single institution in Japan. Ann Surg Oncol. 2012, 19: 677-683. 10.1245\/s10434-011-1983-x.","journal-title":"Ann Surg Oncol"},{"key":"1588_CR19","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.ejca.2010.09.009","volume":"47","author":"BH Burmeister","year":"2011","unstructured":"Burmeister BH, Thomas JM, Burmeister EA, Walpole ET, Harvey JA, Thomson DB, Barbour AP, Gotley DC, Smithers BM: Is concurrent radiation therapy required in patients receiving preoperative chemotherapy for adenocarcinoma of the oesophagus? A randomised phase II trial. Eur J Cancer. 2011, 47: 354-360. 10.1016\/j.ejca.2010.09.009.","journal-title":"Eur J Cancer"},{"key":"1588_CR20","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1002\/bjs.7175","volume":"97","author":"EF Courrech Staal","year":"2010","unstructured":"Courrech Staal EF, Aleman BM, Boot H, van Velthuysen ML, van Tinteren H, van Sandick JW: Systematic review of the benefits and risks of neoadjuvant chemoradiation for oesophageal cancer. Br J Surg. 2010, 97: 1482-1496. 10.1002\/bjs.7175.","journal-title":"Br J Surg"},{"key":"1588_CR21","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1097\/SLA.0b013e3182263781","volume":"254","author":"PR Boshier","year":"2011","unstructured":"Boshier PR, Anderson O, Hanna GB: Transthoracic versus transhiatal esophagectomy for the treatment of esophagogastric cancer: a meta-analysis. Ann Surg. 2011, 254: 894-906. 10.1097\/SLA.0b013e3182263781.","journal-title":"Ann Surg"},{"key":"1588_CR22","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1097\/SLA.0b013e31815c4037","volume":"246","author":"JM Omloo","year":"2007","unstructured":"Omloo JM, Lagarde SM, Hulscher JB, Reitsma JB, Fockens P, van Dekken H, Ten Kate FJ, Obertop H, Tilanus HW, van Lanschot JJ: Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the mid\/distal esophagus: five-year survival of a randomized clinical trial. Ann Surg. 2007, 246: 992-1000. 10.1097\/SLA.0b013e31815c4037. discussion 1000-1001","journal-title":"Ann Surg"},{"key":"1588_CR23","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.ejso.2003.11.009","volume":"30","author":"ED Mulligan","year":"2004","unstructured":"Mulligan ED, Dunne B, Griffin M, Keeling N, Reynolds JV: Margin involvement and outcome in oesophageal carcinoma: a 10-year experience in a specialist unit. Eur J Surg Oncol. 2004, 30: 313-317. 10.1016\/j.ejso.2003.11.009.","journal-title":"Eur J Surg Oncol"},{"key":"1588_CR24","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1245\/s10434-009-0396-6","volume":"16","author":"AK Saha","year":"2009","unstructured":"Saha AK, Sutton C, Rotimi O, Dexter S, Sue-Ling H, Sarela AI: Neoadjuvant chemotherapy and surgery for esophageal adenocarcinoma: prognostic value of circumferential resection margin and stratification of N1 category. Ann Surg Oncol. 2009, 16: 1364-1370. 10.1245\/s10434-009-0396-6.","journal-title":"Ann Surg Oncol"},{"key":"1588_CR25","first-page":"3421","volume":"32","author":"H Tanaka","year":"2012","unstructured":"Tanaka H, Ohira M, Kubo N, Muguruma K, Yamashita Y, Sawada T, Hirakawa K: Association of location of lymph node metastases with postoperative recurrence of esophageal squamous cell carcinoma. Anticancer Res. 2012, 32: 3421-3426.","journal-title":"Anticancer Res"},{"key":"1588_CR26","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1097\/JTO.0b013e318260dfe8","volume":"7","author":"K Wang","year":"2012","unstructured":"Wang K, Ma W, Wang J, Yu L, Zhang X, Wang Z, Tan B, Wang N, Bai B, Yang S, Liu H, Zhu S, Cheng Y: Tumor-stroma ratio is an independent predictor for survival in esophageal squamous cell carcinoma. J Thorac Oncol. 2012, 7: 1457-1461. 10.1097\/JTO.0b013e318260dfe8.","journal-title":"J Thorac Oncol"},{"key":"1588_CR27","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1245\/s10434-012-2273-y","volume":"19","author":"BY Wang","year":"2012","unstructured":"Wang BY, Liu CY, Lin CH, Hsu PK, Hsu WH, Wu YC, Cheng CY: Endoscopic tumor length is an independent prognostic factor in esophageal squamous cell carcinoma. Ann Surg Oncol. 2012, 19: 2149-2158. 10.1245\/s10434-012-2273-y.","journal-title":"Ann Surg Oncol"},{"key":"1588_CR28","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1016\/j.jtcvs.2011.01.053","volume":"141","author":"PC Lee","year":"2011","unstructured":"Lee PC, Mirza FM, Port JL, Stiles BM, Paul S, Christos P, Altorki NK: Predictors of recurrence and disease-free survival in patients with completely resected esophageal carcinoma. J Thorac Cardiovasc Surg. 2011, 141: 1196-1206. 10.1016\/j.jtcvs.2011.01.053.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"1588_CR29","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1046\/j.1365-2168.2000.01383-5.x","volume":"87","author":"SM Dresner","year":"2000","unstructured":"Dresner SM, Wayman J, Shenfine J, Harris A, Hayes N, Griffin SM: Pattern of recurrence following subtotal oesophagectomy with two field lymphadenectomy. Br J Surg. 2000, 87: 362-373.","journal-title":"Br J Surg"},{"key":"1588_CR30","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1002\/cncr.11228","volume":"97","author":"C Mariette","year":"2003","unstructured":"Mariette C, Balon JM, Piessen G, Fabre S, Van Seuningen I, Triboulet JP: Pattern of recurrence following complete resection of esophageal carcinoma and factors predictive of recurrent disease. Cancer. 2003, 97: 1616-1623. 10.1002\/cncr.11228.","journal-title":"Cancer"},{"key":"1588_CR31","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s002689900228","volume":"21","author":"MS Bhansali","year":"1997","unstructured":"Bhansali MS, Fujita H, Kakegawa T, Yamana H, Ono T, Hikita S, Toh Y, Fujii T, Tou U, Shirouzu K: Pattern of recurrence after extended radical esophagectomy with three-field lymph node dissection for squamous cell carcinoma in the thoracic esophagus. World J Surg. 1997, 21: 275-281. 10.1007\/s002689900228.","journal-title":"World J Surg"},{"key":"1588_CR32","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.semradonc.2006.09.007","volume":"17","author":"JR Siewert","year":"2007","unstructured":"Siewert JR, Ott K: Are squamous and adenocarcinomas of the esophagus the same disease?. Semin Radiat Oncol. 2007, 17: 38-44. 10.1016\/j.semradonc.2006.09.007.","journal-title":"Semin Radiat Oncol"},{"key":"1588_CR33","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/S0022-5223(95)70428-0","volume":"109","author":"MD Lieberman","year":"1995","unstructured":"Lieberman MD, Shriver CD, Bleckner S, Burt M: Carcinoma of the esophagus. Prognostic significance of histologic type. J Thorac Cardiovasc Surg. 1995, 109: 130-138. 10.1016\/S0022-5223(95)70428-0. discussion 139","journal-title":"J Thorac Cardiovasc Surg"},{"key":"1588_CR34","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1002\/bjs.1800761227","volume":"76","author":"O Lund","year":"1989","unstructured":"Lund O, Hasenkam JM, Aagaard MT, Kimose HH: Time-related changes in characteristics of prognostic significance in carcinomas of the oesophagus and cardia. Br J Surg. 1989, 76: 1301-1307. 10.1002\/bjs.1800761227.","journal-title":"Br J Surg"},{"key":"1588_CR35","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1097\/00000658-200109000-00010","volume":"234","author":"JR Siewert","year":"2001","unstructured":"Siewert JR, Stein HJ, Feith M, Bruecher BL, Bartels H, Fink U: Histologic tumor type is an independent prognostic parameter in esophageal cancer: lessons from more than 1,000 consecutive resections at a single center in the Western world. Ann Surg. 2001, 234: 360-367. 10.1097\/00000658-200109000-00010. discussion 368-369","journal-title":"Ann Surg"},{"key":"1588_CR36","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1097\/SLA.0b013e3181b21c7b","volume":"250","author":"G Piessen","year":"2009","unstructured":"Piessen G, Messager M, Leteurtre E, Jean-Pierre T, Mariette C: Signet ring cell histology is an independent predictor of poor prognosis in gastric adenocarcinoma regardless of tumoral clinical presentation. Ann Surg. 2009, 250: 878-887. 10.1097\/SLA.0b013e3181b21c7b.","journal-title":"Ann Surg"}],"container-title":["Journal of Cardiothoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1749-8090-8-215.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1749-8090-8-215\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1749-8090-8-215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1749-8090-8-215.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T18:47:02Z","timestamp":1630608422000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiothoracicsurgery.biomedcentral.com\/articles\/10.1186\/1749-8090-8-215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,21]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["1588"],"URL":"https:\/\/doi.org\/10.1186\/1749-8090-8-215","relation":{},"ISSN":["1749-8090"],"issn-type":[{"value":"1749-8090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,21]]},"assertion":[{"value":"10 March 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"215"}}