{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T10:16:04Z","timestamp":1763201764340},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T00:00:00Z","timestamp":1365379200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Since the advent of cardiopulmonary bypass, many efforts have been made to avoid the complications related with it. Any component of the pump participates in occurrence of these adverse events, one of which is the type of prime solution. In this study, we aimed to compare the effects of 6% hydroxyethyl starch 130\/0.4 with a commonly used balanced electrolyte solution on postoperative outcomes following coronary bypass surgery.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Two hundred patients undergoing elective coronary bypass surgery were prospectively studied. The patients were randomized in to two groups. First group received a balanced electrolyte solution and the second group received 6% hydoxyethyl starch 130\/0.4 as prime solution. The postoperative outcomes of the patients were studied.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The mean age of the patients was 61.81\u2009\u00b1\u200910.12 in the crystalloid group whereas 61.52\u2009\u00b1\u20099.29 in the HES group. There were 77 male patients in crystalloid group and 74 in HES group. 6% hydroxyethyl starch 130\/0.4 did not have any detrimental effects on renal and pulmonary functions. The intensive care unit stay and postoperative hospital length of stay were shorter in hydroxyethyl starch group (p\u2009&lt;\u20090.05 for each). Hydroxyethyl starch did not increase postoperative blood loss, amount of blood and fresh frozen plasma used, but it decreased platelet concentrate requirement. It did not have any effect on occurrence of post-coronary bypass atrial fibrillation (p\u2009&gt;\u20090.05).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>6% hydroxyethyl starch 130\/0.4 when used as a prime solution did not adversely affect postoperative outcomes including renal functions and postoperative blood transfusion following coronary bypass surgery.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1749-8090-8-71","type":"journal-article","created":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T12:14:30Z","timestamp":1365423270000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Hydroxyethyl starch 6%, 130\/0.4 vs. a balanced crystalloid solution in cardiopulmonary bypass priming: a randomized, prospective study"],"prefix":"10.1186","volume":"8","author":[{"given":"Hasan Alper","family":"Gurbuz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet Baris","family":"Durukan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nevriye","family":"Salman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Tavlasoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Durukan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halil \u0130brahim","family":"Ucar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cem","family":"Yorgancioglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,4,8]]},"reference":[{"key":"714_CR1","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1191\/0267659105pf829oa","volume":"20","author":"I Bahar","year":"2005","unstructured":"Bahar I, Akgul A, Ozatik MA, Vural KM, Demirbag AE, Boran M, Tasdemir O: Acute renal failure following open heart surgery: risk factors and prognosis. Perfusion. 2005, 20: 317-322. 10.1191\/0267659105pf829oa.","journal-title":"Perfusion"},{"key":"714_CR2","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1177\/0267659109105398","volume":"23","author":"H Vermeer","year":"2008","unstructured":"Vermeer H, Teerenstra S, de Sevaux RG, van Swieten HA, Weerwind PW: The effect of hemodilution during normothermic cardiac surgery on renal physiology and function: a review. Perfusion. 2008, 23: 329-338. 10.1177\/0267659109105398.","journal-title":"Perfusion"},{"key":"714_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/rcs.230","volume":"5","author":"P Atluri","year":"2009","unstructured":"Atluri P, Kozin ED, Hiesinger W, Woo YJ: Off-pump, minimally invasive and robotic coronary revascularization yield improved outcomes over traditional on-pump CABG. Int J Med Robot. 2009, 5: 1-12. 10.1002\/rcs.230.","journal-title":"Int J Med Robot"},{"key":"714_CR4","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1053\/j.jvca.2008.08.007","volume":"23","author":"OJ Warren","year":"2009","unstructured":"Warren OJ, Smith AJ, Alexiou C, Rogers PL, Jawad N, Vincent C, Darzi AW, Athanasiou T: The inflammatory response to cardiopulmonary bypass: part 1-mechanisms of pathogenesis. J Cardiothorac Vasc Anesth. 2009, 23: 223-231. 10.1053\/j.jvca.2008.08.007.","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"714_CR5","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1053\/j.jvca.2008.09.007","volume":"23","author":"OJ Warren","year":"2009","unstructured":"Warren OJ, Watret AL, de Wit KL, Alexiou C, Vincent C, Darzi AW, Athanasiou T: The inflammatory response to cardiopulmonary bypass: part 2-anti-inflammatory therapeutic strategies. J Cardiothorac Vasc Anesth. 2009, 23: 384-393. 10.1053\/j.jvca.2008.09.007.","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"714_CR6","first-page":"584","volume":"76","author":"YS Choi","year":"2010","unstructured":"Choi YS, Shim JK, Hong SW, Kim JC, Kwak YL: Comparing the effects of 5% albumin and 6% hydroxyethyl starch 130\/0.4 on coagulation and inflammatory response when used as priming solutions for cardiopulmonary bypass. Minerva Anestesiol. 2010, 76: 584-591.","journal-title":"Minerva Anestesiol"},{"key":"714_CR7","doi-asserted-by":"publisher","first-page":"210","DOI":"10.4077\/CJP.2012.BAA028","volume":"55","author":"HL Liou","year":"2012","unstructured":"Liou HL, Shih CC, Chao YF, Lin NT, Lai ST, Wang SH, Chen HI: Inflammatory response to colloids compared to crystalloid priming in cardiac surgery patients with cardiopulmonary bypass. Chin J Physiol. 2012, 55: 210-218.","journal-title":"Chin J Physiol"},{"key":"714_CR8","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1213\/01.ANE.0000096006.60716.F6","volume":"98","author":"AH Kuitunen","year":"2004","unstructured":"Kuitunen AH, Hynynen MJ, Vahtera E, Salmenpera MT: Hydroxyethyl starch as a priming solution for cardiopulmonary bypass impairs hemostasis after cardiac surgery. Anesth Analg. 2004, 98: 291-297.","journal-title":"Anesth Analg"},{"key":"714_CR9","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/1749-8090-3-45","volume":"3","author":"O Tiryakioglu","year":"2008","unstructured":"Tiryakioglu O, Yildiz G, Vural H, Goncu T, Ozyazicioglu A, Yavuz S: Hydroxyethyl starch versus Ringer solution in vardiopulmonary bypass prime solutions (a randomized controlled trial). J Cardiothorac Surg. 2008, 3: 45-10.1186\/1749-8090-3-45.","journal-title":"J Cardiothorac Surg"},{"key":"714_CR10","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1177\/0267659107077903","volume":"22","author":"WW Yap","year":"2007","unstructured":"Yap WW, Young D, Pathi V: Effects of gelatine and medium molecular weight starch as priming fluid in cardiopulmonary bypass- a randomized controlled trial. Perfusion. 2007, 22: 57-61. 10.1177\/0267659107077903.","journal-title":"Perfusion"},{"key":"714_CR11","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1007\/s00228-011-1008-5","volume":"67","author":"XY Shi","year":"2011","unstructured":"Shi XY, Zou Z, He XY, Xu HT, Yuan HB, Liu H: Hydroxyethyl starch for cardiovascular surgery: a systematic review of randomized controlled trials. Eur J Clin Pharmacol. 2011, 67: 767-782. 10.1007\/s00228-011-1008-5.","journal-title":"Eur J Clin Pharmacol"},{"key":"714_CR12","doi-asserted-by":"publisher","first-page":"210","DOI":"10.3109\/0886022X.2012.747139","volume":"35","author":"FG Akkucuk","year":"2013","unstructured":"Akkucuk FG, Kanbak M, Ayhan B, Celebioglu B, Aypar U: The effect of HES (130\/0.4) usage as the priming solution on renal function in children undergoing cardiac surgery. Ren Fail. 2013, 35: 210-215. 10.3109\/0886022X.2012.747139.","journal-title":"Ren Fail"},{"key":"714_CR13","first-page":"111","volume":"103","author":"C Ertmer","year":"2012","unstructured":"Ertmer C, Wulf H, Van Aken H, Friederich P, Mahl C, Bepperling F, Westphal M, Gogarten W: Efficacy and safety of 10% HES 130\/0.4 versus 10% HES 200\/0.5 for plasma volume expansion in cardiac surgery patients. Minerva Med. 2012, 103: 111-122.","journal-title":"Minerva Med"},{"key":"714_CR14","doi-asserted-by":"publisher","first-page":"428","DOI":"10.5830\/CVJA-2012-026","volume":"23","author":"SM Alavi","year":"2012","unstructured":"Alavi SM, Ahmadi BB, Baharestani B, Babaei T: Comparison of the effects of gelatin, Ringer\u2019s solution and a modern hydroxyl ethyl starch solution after coronary artery bypass graft surgery. Cardiovasc J Afr. 2012, 23: 428-431. 10.5830\/CVJA-2012-026.","journal-title":"Cardiovasc J Afr"},{"key":"714_CR15","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1093\/europace\/eur208","volume":"14","author":"B Maesen","year":"2012","unstructured":"Maesen B, Nijs J, Maesen J, Allessie M, Schotten U: Post-Operative Atrial Fibrillation: A Maze of Mechanisms. Europace. 2012, 14: 159-174. 10.1093\/europace\/eur208.","journal-title":"Europace"},{"key":"714_CR16","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.1016\/j.jacc.2012.04.063","volume":"60","author":"Y Guo","year":"2012","unstructured":"Guo Y, Lip GY, Apostolakis S: Inflammation in Atrial Fibrillation. J Am Coll Cardiol. 2012, 60: 2263-2270. 10.1016\/j.jacc.2012.04.063.","journal-title":"J Am Coll Cardiol"},{"key":"714_CR17","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.molmed.2011.05.007","volume":"17","author":"K Friedrichs","year":"2011","unstructured":"Friedrichs K, Klinke A, Baldus S: Inflammatory pathways underlying Atrial Fibrillation. Trends Mol Med. 2011, 17: 556-563. 10.1016\/j.molmed.2011.05.007.","journal-title":"Trends Mol Med"},{"key":"714_CR18","first-page":"451","volume":"33","author":"J Tian","year":"2003","unstructured":"Tian J, Lin X, Zhou W, Xu J: Hydroxyethyl starch inhibits NF-KappaB activation and prevents the expression of inflammatory mediators in Endotoxic Rats. Ann Clin Lab Sci. 2003, 33: 451-458.","journal-title":"Ann Clin Lab Sci"},{"key":"714_CR19","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.jss.2009.05.050","volume":"160","author":"J Xie","year":"2010","unstructured":"Xie J, Lv R, Yu L, Huang W: Hydroxyethyl Starch 130\/0.4 inhibits production of plasma Proinflammatory cytokines and attenuates nuclear factor-KappaB activation and Toll-Like receptors expression in Monocytes during Sepsis. J Surg Res. 2010, 160: 133-138. 10.1016\/j.jss.2009.05.050.","journal-title":"J Surg Res"}],"container-title":["Journal of Cardiothoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1749-8090-8-71.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1749-8090-8-71\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1749-8090-8-71","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1749-8090-8-71.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T22:56:49Z","timestamp":1630537009000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiothoracicsurgery.biomedcentral.com\/articles\/10.1186\/1749-8090-8-71"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,8]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["714"],"URL":"https:\/\/doi.org\/10.1186\/1749-8090-8-71","relation":{},"ISSN":["1749-8090"],"issn-type":[{"value":"1749-8090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,8]]},"assertion":[{"value":"16 February 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"71"}}