{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:12:18Z","timestamp":1791058338026,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neural Dev"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The WAVE\/SCAR complex, consisting of CYFIP (PIR121 or Sra1), Kette (Nap1), Abi, SCAR (WAVE) and HSPC300, is known to regulate the actin nucleating Arp2\/3 complex in a Rac1-dependent manner. While <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> studies have demonstrated that CYFIP, Kette, Abi and SCAR work as subunits of the complex, the role of the small protein HSPC300 remains unclear.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In the present study, we identify the <jats:italic>HSPC300<\/jats:italic> gene and characterize its interaction with the WAVE\/SCAR complex in the <jats:italic>Drosophila<\/jats:italic> animal model. On the basis of several lines of evidence, we demonstrate that HSPC300 is an indispensable component of the complex controlling axonal and neuromuscular junction (NMJ) growth. First, the <jats:italic>Drosophila HSPC300<\/jats:italic> expression profile resembles that of other members of the WAVE\/SCAR complex. Second, <jats:italic>HSPC300<\/jats:italic> mutation, as well as mutations in the other complex subunits, results in identical axonal and NMJ growth defects. Third, like with other complex subunits, defects in NMJ architecture are rescued by presynaptic expression of the respective wild-type gene. Fourth, HSPC300 genetically interacts with another subunit of the WAVE\/SCAR complex. Fifth, HSPC300 physically associates with CYFIP and SCAR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Present data provide the first evidence for HSPC300 playing a role in nervous system development and demonstrate <jats:italic>in vivo<\/jats:italic> that this small protein works in the context of the WAVE\/SCAR complex.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/1749-8104-2-18","type":"journal-article","created":{"date-parts":[[2007,9,25]],"date-time":"2007-09-25T19:41:53Z","timestamp":1190749313000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["HSPC300 and its role in neuronal connectivity"],"prefix":"10.1186","volume":"2","author":[{"given":"Abrar","family":"Qurashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H Bahar","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Carrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Gautreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Schenck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Giangrande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,9,25]]},"reference":[{"issue":"6899","key":"22_CR1","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/nature00859","volume":"418","author":"S Eden","year":"2002","unstructured":"Eden S, Rohatgi R, Podtelejnikov AV, Mann M, Kirschner MW: Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. 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