{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:57:08Z","timestamp":1791251828297,"version":"4.1.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neural Dev"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The development of the corticospinal tract (CST) in higher vertebrates relies on a series of axon guidance decisions along its long projection pathway. Several guidance molecules are known to be involved at various decision points to regulate the projection of CST axons. However, previous analyses of the CST guidance defects in mutant mice lacking these molecules have suggested that there are other molecules involved in CST axon guidance that are yet to be identified. In this study, we investigate the role of plexin signaling in the guidance of motor CST axons\n                      <jats:italic>in vivo<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Expression pattern studies show that\n                      <jats:italic>plexin-A3<\/jats:italic>\n                      ,\n                      <jats:italic>plexin-A4<\/jats:italic>\n                      , and\n                      <jats:italic>neuropilin-1<\/jats:italic>\n                      are expressed in the developing cerebral cortex when the motor CST axons originating from layer V cortical neurons are guided down to the spinal cord. By analyzing mutant mice, we show that motor CST axons that turn dorsally to cross the midline at the pyramidal decussation require plexin-A3 and plexin-A4 signaling. Although other CST guidance defects are found in neuropilin-1 mutants, this dorsal turning defect is not observed in either neuropilin-1 or neuropilin-2 mutants, suggesting that the local cues that activate plexin signaling at the dorsal turning point are membrane-bound semaphorins. Further expression pattern study and mutant analysis indicate that Sema6A is one of the local cues for motor CST axon turning at the pyramidal decussation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dorsal turning and midline crossing at the pyramidal decussation is a crucial step to properly direct CST axons into the dorsal spinal cord. We show that the signaling of plexin-A3, plexin-A4, and Sema6A is at least partially required for dorsal turning of the CST axons, while neuropilin-1 is required for proper fasciculation of the tract at midline crossing. Together with previous reports, these results demonstrate that several guidance cues are specifically utilized to regulate the dorsal turning and midline crossing of developing CST axons.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1749-8104-3-21","type":"journal-article","created":{"date-parts":[[2008,8,26]],"date-time":"2008-08-26T14:12:51Z","timestamp":1219759971000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Dorsal turning of motor corticospinal axons at the pyramidal decussation requires plexin signaling"],"prefix":"10.1186","volume":"3","author":[{"given":"Regina L","family":"Faulkner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence K","family":"Low","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Coble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward G","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwai-Jong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,8,26]]},"reference":[{"key":"53_CR1","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1126\/science.1072165","volume":"298","author":"BJ Dickson","year":"2002","unstructured":"Dickson BJ: Molecular mechanisms of axon guidance. Science. 2002, 298: 1959-1964.","journal-title":"Science"},{"key":"53_CR2","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1146\/annurev.neuro.26.010302.081139","volume":"26","author":"AB Huber","year":"2003","unstructured":"Huber AB, Kolodkin AL, Ginty DD, Cloutier JF: Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance. Annu Rev Neurosci. 2003, 26: 509-563.","journal-title":"Annu Rev Neurosci"},{"key":"53_CR3","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1126\/science.274.5290.1123","volume":"274","author":"M Tessier-Lavigne","year":"1996","unstructured":"Tessier-Lavigne M, Goodman CS: The molecular biology of axon guidance. Science. 1996, 274: 1123-1133.","journal-title":"Science"},{"key":"53_CR4","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/S0079-6123(08)64137-0","volume":"57","author":"EG Jones","year":"1982","unstructured":"Jones EG, Schreyer DJ, Wise SP: Growth and maturation of the rat corticospinal tract. Prog Brain Res. 1982, 57: 361-379.","journal-title":"Prog Brain Res"},{"key":"53_CR5","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1177\/1073858404270843","volume":"11","author":"JH Martin","year":"2005","unstructured":"Martin JH: The corticospinal system: from development to motor control. Neuroscientist. 2005, 11: 161-173.","journal-title":"Neuroscientist"},{"key":"53_CR6","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/0896-6273(93)90049-W","volume":"10","author":"DD O'Leary","year":"1993","unstructured":"O'Leary DD, Koester SE: Development of projection neuron types, axon pathways, and patterned connections of the mammalian cortex. Neuron. 1993, 10: 991-1006.","journal-title":"Neuron"},{"key":"53_CR7","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0301-0082(92)90039-H","volume":"38","author":"BB Stanfield","year":"1992","unstructured":"Stanfield BB: The development of the corticospinal projection. Prog Neurobiol. 1992, 38: 169-202.","journal-title":"Prog Neurobiol"},{"key":"53_CR8","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/0168-0102(95)00895-9","volume":"22","author":"T Terashima","year":"1995","unstructured":"Terashima T: Anatomy, development and lesion-induced plasticity of rodent corticospinal tract. Neurosci Res. 1995, 22: 139-161.","journal-title":"Neurosci Res"},{"key":"53_CR9","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1146\/annurev.neuro.28.061604.135632","volume":"28","author":"L Luo","year":"2005","unstructured":"Luo L, O'Leary DD: Axon retraction and degeneration in development and disease. Annu Rev Neurosci. 2005, 28: 127-156.","journal-title":"Annu Rev Neurosci"},{"key":"53_CR10","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.pneurobio.2008.02.001","volume":"85","author":"AJ Canty","year":"2008","unstructured":"Canty AJ, Murphy M: Molecular mechanisms of axon guidance in the developing corticospinal tract. Prog Neurobiol. 2008, 85: 214-235.","journal-title":"Prog Neurobiol"},{"key":"53_CR11","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S0896-6273(02)00561-5","volume":"33","author":"A Bagri","year":"2002","unstructured":"Bagri A, Marin O, Plump AS, Mak J, Pleasure SJ, Rubenstein JL, Tessier-Lavigne M: Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain. Neuron. 2002, 33: 233-248.","journal-title":"Neuron"},{"key":"53_CR12","doi-asserted-by":"crossref","first-page":"10346","DOI":"10.1523\/JNEUROSCI.22-23-10346.2002","volume":"22","author":"JH Finger","year":"2002","unstructured":"Finger JH, Bronson RT, Harris B, Johnson K, Przyborski SA, Ackerman SL: The netrin 1 receptors Unc5h3 and Dcc are necessary at multiple choice points for the guidance of corticospinal tract axons. J Neurosci. 2002, 22: 10346-10356.","journal-title":"J Neurosci"},{"key":"53_CR13","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/S0960-9822(98)70017-X","volume":"8","author":"NR Cohen","year":"1998","unstructured":"Cohen NR, Taylor JS, Scott LB, Guillery RW, Soriano P, Furley AJ: Errors in corticospinal axon guidance in mice lacking the neural cell adhesion molecule L1. Curr Biol. 1998, 8: 26-33.","journal-title":"Curr Biol"},{"key":"53_CR14","doi-asserted-by":"crossref","first-page":"8357","DOI":"10.1523\/JNEUROSCI.22-19-08357.2002","volume":"22","author":"B Rolf","year":"2002","unstructured":"Rolf B, Bastmeyer M, Schachner M, Bartsch U: Pathfinding errors of corticospinal axons in neural cell adhesion molecule-deficient mice. J Neurosci. 2002, 22: 8357-8362.","journal-title":"J Neurosci"},{"key":"53_CR15","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1038\/nn1520","volume":"8","author":"Y Liu","year":"2005","unstructured":"Liu Y, Shi J, Lu CC, Wang ZB, Lyuksyutova AI, Song XJ, Zou Y: Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract. Nat Neurosci. 2005, 8: 1151-1159.","journal-title":"Nat Neurosci"},{"key":"53_CR16","doi-asserted-by":"publisher","first-page":"13248","DOI":"10.1073\/pnas.95.22.13248","volume":"95","author":"M Dottori","year":"1998","unstructured":"Dottori M, Hartley L, Galea M, Paxinos G, Polizzotto M, Kilpatrick T, Bartlett PF, Murphy M, Kontgen F, Boyd AW: EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract. Proc Natl Acad Sci USA. 1998, 95: 13248-13253.","journal-title":"Proc Natl Acad Sci USA"},{"key":"53_CR17","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1101\/gad.868901","volume":"15","author":"K Kullander","year":"2001","unstructured":"Kullander K, Croll SD, Zimmer M, Pan L, McClain J, Hughes V, Zabski S, DeChiara TM, Klein R, Yancopoulos GD, Gale NW: Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control. Genes Dev. 2001, 15: 877-888.","journal-title":"Genes Dev"},{"key":"53_CR18","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0959-4388(03)00003-5","volume":"13","author":"RJ Pasterkamp","year":"2003","unstructured":"Pasterkamp RJ, Kolodkin AL: Semaphorin junction: making tracks toward neural connectivity. Curr Opin Neurobiol. 2003, 13: 79-89.","journal-title":"Curr Opin Neurobiol"},{"key":"53_CR19","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1146\/annurev.cellbio.22.010605.093554","volume":"23","author":"TS Tran","year":"2007","unstructured":"Tran TS, Kolodkin AL, Bharadwaj R: Semaphorin regulation of cellular morphology. Annu Rev Cell Dev Biol. 2007, 23: 263-292.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"53_CR20","first-page":"RE1","volume-title":"Sci STKE","author":"Z He","year":"2002","unstructured":"He Z, Wang KC, Koprivica V, Ming G, Song HJ: Knowing how to navigate: mechanisms of semaphorin signaling in the nervous system. Sci STKE. 2002, RE1-"},{"key":"53_CR21","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1098\/rstb.2006.1892","volume":"361","author":"RJ Pasterkamp","year":"2006","unstructured":"Pasterkamp RJ, Verhaagen J: Semaphorins in axon regeneration: developmental guidance molecules gone wrong?. Philos Trans R Soc Lond B Biol Sci. 2006, 361: 1499-1511.","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"53_CR22","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1177\/1073858406292631","volume":"12","author":"KE Waimey","year":"2006","unstructured":"Waimey KE, Cheng HJ: Axon pruning and synaptic development: how are they per-plexin?. Neuroscientist. 2006, 12: 398-409.","journal-title":"Neuroscientist"},{"key":"53_CR23","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1002\/neu.10337","volume":"59","author":"H Fujisawa","year":"2004","unstructured":"Fujisawa H: Discovery of semaphorin receptors, neuropilin and plexin, and their functions in neural development. J Neurobiol. 2004, 59: 24-33.","journal-title":"J Neurobiol"},{"key":"53_CR24","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.1242\/dev.125.24.5043","volume":"125","author":"D Bagnard","year":"1998","unstructured":"Bagnard D, Lohrum M, Uziel D, Puschel AW, Bolz J: Semaphorins act as attractive and repulsive guidance signals during the development of cortical projections. Development. 1998, 125: 5043-5053.","journal-title":"Development"},{"key":"53_CR25","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0896-6273(00)00033-7","volume":"27","author":"V Castellani","year":"2000","unstructured":"Castellani V, Chedotal A, Schachner M, Faivre-Sarrailh C, Rougon G: Analysis of the L1-deficient mouse phenotype reveals cross-talk between Sema3A and L1 signaling pathways in axonal guidance. Neuron. 2000, 27: 237-249.","journal-title":"Neuron"},{"key":"53_CR26","doi-asserted-by":"publisher","first-page":"6348","DOI":"10.1093\/emboj\/cdf645","volume":"21","author":"V Castellani","year":"2002","unstructured":"Castellani V, De Angelis E, Kenwrick S, Rougon G: Cis and trans interactions of L1 with neuropilin-1 control axonal responses to semaphorin 3A. EMBO J. 2002, 21: 6348-6357.","journal-title":"EMBO J"},{"key":"53_CR27","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.neuron.2007.10.019","volume":"56","author":"S Chauvet","year":"2007","unstructured":"Chauvet S, Cohen S, Yoshida Y, Fekrane L, Livet J, Gayet O, Segu L, Buhot MC, Jessell TM, Henderson CE, Mann F: Gating of Sema3E\/PlexinD1 signaling by neuropilin-1 switches axonal repulsion to attraction during brain development. Neuron. 2007, 56: 807-822.","journal-title":"Neuron"},{"key":"53_CR28","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/35007001","volume":"404","author":"F Polleux","year":"2000","unstructured":"Polleux F, Morrow T, Ghosh A: Semaphorin 3A is a chemoattractant for cortical apical dendrites. Nature. 2000, 404: 567-573.","journal-title":"Nature"},{"key":"53_CR29","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.neures.2006.02.008","volume":"55","author":"Z Molnar","year":"2006","unstructured":"Molnar Z, Cheung AF: Towards the classification of subpopulations of layer V pyramidal projection neurons. Neurosci Res. 2006, 55: 105-115.","journal-title":"Neurosci Res"},{"key":"53_CR30","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.neuron.2004.12.036","volume":"45","author":"P Arlotta","year":"2005","unstructured":"Arlotta P, Molyneaux BJ, Chen J, Inoue J, Kominami R, Macklis JD: Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo. Neuron. 2005, 45: 207-221.","journal-title":"Neuron"},{"key":"53_CR31","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1038\/emboj.2008.86","volume":"27","author":"A Bechara","year":"2008","unstructured":"Bechara A, Nawabi H, Moret F, Yaron A, Weaver E, Bozon M, Abouzid K, Guan J-L, Tessier-Lavigne M, Lemmon V, Castellani V: FAK-MAPK-dependent adhesion disassembly downstream of L1 contributes to semaphorin3A-induced collapse. EMBO J. 2008, 27: 1549-1562.","journal-title":"EMBO J"},{"key":"53_CR32","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1002\/(SICI)1096-9861(20000214)417:3<275::AID-CNE2>3.0.CO;2-7","volume":"417","author":"KE Fujimori","year":"2000","unstructured":"Fujimori KE, Takeuchi K, Yazaki T, Uyemura K, Nojyo Y, Tamamki N: Expression of L1 and TAG-1 in the corticospinal, callosal, and hippocampal commissural neurons in the developing rat telencephalon as revealed by retrograde and in situ hybridization double labeling. J Comp Neurol. 2000, 417: 275-288.","journal-title":"J Comp Neurol"},{"key":"53_CR33","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/BF00186001","volume":"192","author":"T Terashima","year":"1995","unstructured":"Terashima T, Ochiishi T, Yamauchi T: Alpha calcium\/calmodulin-dependent protein kinase II immunoreactivity in corticospinal neurons: combination of axonal transport method and immunofluorescence. Anat Embryol. 1995, 192: 123-136.","journal-title":"Anat Embryol"},{"key":"53_CR34","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0896-6273(00)80870-3","volume":"25","author":"H Chen","year":"2000","unstructured":"Chen H, Bagri A, Zupicich JA, Zou Y, Stoeckli E, Pleasure SJ, Lowenstein DH, Skarnes WC, Chedotal A, Tessier-Lavigne M: Neuropilin-2 regulates the development of selective cranial and sensory nerves and hippocampal mossy fiber projections. Neuron. 2000, 25: 43-56.","journal-title":"Neuron"},{"key":"53_CR35","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S1534-5807(03)00169-2","volume":"5","author":"C Gu","year":"2003","unstructured":"Gu C, Rodriguez ER, Reimert DV, Shu T, Fritzsch B, Richards LJ, Kolodkin AL, Ginty DD: Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Dev Cell. 2003, 5: 45-57.","journal-title":"Dev Cell"},{"key":"53_CR36","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.neuroscience.2007.10.007","volume":"150","author":"M Sibbe","year":"2007","unstructured":"Sibbe M, Taniguchi M, Schachner M, Bartsch U: Development of the corticospinal tract in Semaphorin3A- and CD24-deficient mice. Neuroscience. 2007, 150: 898-904.","journal-title":"Neuroscience"},{"key":"53_CR37","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1126\/science.1105416","volume":"307","author":"C Gu","year":"2005","unstructured":"Gu C, Yoshida Y, Livet J, Reimert DV, Mann F, Merte J, Henderson CE, Jessell TM, Kolodkin AL, Ginty DD: Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Science. 2005, 307: 265-268.","journal-title":"Science"},{"key":"53_CR38","doi-asserted-by":"publisher","first-page":"3628","DOI":"10.1523\/JNEUROSCI.4480-04.2005","volume":"25","author":"F Suto","year":"2005","unstructured":"Suto F, Ito K, Uemura M, Shimizu M, Shinkawa Y, Sanbo M, Shinoda T, Tsuboi M, Takashima S, Yagi T, Fujisawa H: Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance. J Neurosci. 2005, 25: 3628-3637.","journal-title":"J Neurosci"},{"key":"53_CR39","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.neuron.2007.01.028","volume":"53","author":"F Suto","year":"2007","unstructured":"Suto F, Tsuboi M, Kamiya H, Mizuno H, Kiyama Y, Komai S, Shimizu M, Sanbo M, Yagi T, Hiromi Y, Chedotal A, Mitchell KJ, Manabe T, Fujisawa H: Interactions between Plexin-A2, Plexin-A4, and Semaphorin 6A control lamina-restricted projection of hippocampal mossy fibers. Neuron. 2007, 53: 535-547.","journal-title":"Neuron"},{"key":"53_CR40","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1146\/annurev.ne.18.030195.002433","volume":"18","author":"SA Colamarino","year":"1995","unstructured":"Colamarino SA, Tessier-Lavigne M: The role of the floor plate in axon guidance. Annu Rev Neurosci. 1995, 18: 497-529.","journal-title":"Annu Rev Neurosci"},{"key":"53_CR41","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1002\/dvdy.1143","volume":"221","author":"Z Kaprielian","year":"2001","unstructured":"Kaprielian Z, Runko E, Imondi R: Axon guidance at the midline choice point. Dev Dyn. 2001, 221: 154-181.","journal-title":"Dev Dyn"},{"key":"53_CR42","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/nn1827","volume":"10","author":"PF Maness","year":"2007","unstructured":"Maness PF, Schachner M: Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and neuronal migration. Nat Neurosci. 2007, 10: 19-26.","journal-title":"Nat Neurosci"},{"key":"53_CR43","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.neuron.2005.10.024","volume":"48","author":"J Falk","year":"2005","unstructured":"Falk J, Bechara A, Fiore R, Nawabi H, Zhou H, Hoyo-Becerra C, Bozon M, Rougon G, Grumet M, Puschel AW, Sanes JR, Castellani V: Dual functional activity of semaphorin 3B is required for positioning the anterior commissure. Neuron. 2005, 48: 63-75.","journal-title":"Neuron"},{"key":"53_CR44","doi-asserted-by":"publisher","first-page":"13667","DOI":"10.1523\/JNEUROSCI.2888-07.2007","volume":"27","author":"AG Wright","year":"2007","unstructured":"Wright AG, Demyanenko GP, Powell A, Schachner M, Enriquez-Barrerto L, Tran TS, Polleux F, Maness PF: Close homolog of L1 and Neuropilin 1 mediate guidance of thalamocortical axons at the ventral telencephalon. J Neurosci. 2007, 27: 13667-13679.","journal-title":"J Neurosci"},{"key":"53_CR45","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/nn2064","volume":"11","author":"J Renaud","year":"2008","unstructured":"Renaud J, Kerjan G, Sumita I, Zagar Y, Georget V, Kim D, Fouquet C, Suda K, Sanbo M, Suto F, Ackerman SL, Mitchell KJ, Fujisawa H, Chedotal A: Plexin-A2 and its ligand, Sema6A, control nucleus-centrosome coupling in migrating granule cells. Nat Neurosci. 2008, 11: 440-449.","journal-title":"Nat Neurosci"},{"key":"53_CR46","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/S0092-8674(03)00267-8","volume":"113","author":"A Bagri","year":"2003","unstructured":"Bagri A, Cheng HJ, Yaron A, Pleasure SJ, Tessier-Lavigne M: Stereotyped pruning of long hippocampal axon branches triggered by retraction inducers of the semaphorin family. Cell. 2003, 113: 285-299.","journal-title":"Cell"},{"key":"53_CR47","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1159\/000096207","volume":"29","author":"RL Faulkner","year":"2007","unstructured":"Faulkner RL, Low LK, Cheng HJ: Axon pruning in the developing vertebrate hippocampus. Dev Neurosci. 2007, 29: 6-13.","journal-title":"Dev Neurosci"},{"key":"53_CR48","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.ydbio.2008.01.002","volume":"315","author":"KE Waimey","year":"2008","unstructured":"Waimey KE, Huang PH, Chen M, Cheng HJ: Plexin-A3 and Plexin-A4 restrict the migration of sympathetic neurons but not their neural crest precursors. Dev Biol. 2008, 315: 448-458.","journal-title":"Dev Biol"},{"key":"53_CR49","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.neuron.2005.01.013","volume":"45","author":"A Yaron","year":"2005","unstructured":"Yaron A, Huang PH, Cheng HJ, Tessier-Lavigne M: Differential requirement for Plexin-A3 and -A4 in mediating responses of sensory and sympathetic neurons to distinct class 3 Semaphorins. Neuron. 2005, 45: 513-523.","journal-title":"Neuron"},{"key":"53_CR50","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/383525a0","volume":"383","author":"O Behar","year":"1996","unstructured":"Behar O, Golden JA, Mashimo H, Schoen FJ, Fishman MC: Semaphorin III is needed for normal patterning and growth of nerves, bones and heart. Nature. 1996, 383: 525-528.","journal-title":"Nature"},{"key":"53_CR51","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0896-6273(01)00478-0","volume":"32","author":"HJ Cheng","year":"2001","unstructured":"Cheng HJ, Bagri A, Yaron A, Stein E, Pleasure SJ, Tessier-Lavigne M: Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections. Neuron. 2001, 32: 249-263.","journal-title":"Neuron"},{"key":"53_CR52","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/35065539","volume":"410","author":"PA Leighton","year":"2001","unstructured":"Leighton PA, Mitchell KJ, Goodrich LV, Lu X, Pinson K, Scherz P, Skarnes WC, Tessier-Lavigne M: Defining brain wiring patterns and mechanisms through gene trapping in mice. Nature. 2001, 410: 174-179.","journal-title":"Nature"},{"key":"53_CR53","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1002\/(SICI)1096-9861(19970922)386:2<293::AID-CNE9>3.0.CO;2-X","volume":"386","author":"C Brosamle","year":"1997","unstructured":"Brosamle C, Schwab ME: Cells of origin, course, and termination patterns of the ventral, uncrossed component of the mature rat corticospinal tract. J Comp Neurol. 1997, 386: 293-303.","journal-title":"J Comp Neurol"},{"key":"53_CR54","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/0896-6273(88)90147-X","volume":"1","author":"DD O'Leary","year":"1988","unstructured":"O'Leary DD, Terashima T: Cortical axons branch to multiple subcortical targets by interstitial axon budding: implications for target recognition and \"waiting periods\". Neuron. 1988, 1: 901-910.","journal-title":"Neuron"},{"key":"53_CR55","doi-asserted-by":"publisher","first-page":"9124","DOI":"10.1523\/JNEUROSCI.2648-05.2005","volume":"25","author":"XB Liu","year":"2005","unstructured":"Liu XB, Low LK, Jones EG, Cheng HJ: Stereotyped axon pruning via plexin signaling is associated with synaptic complex elimination in the hippocampus. J Neurosci. 2005, 25: 9124-9134.","journal-title":"J Neurosci"},{"key":"53_CR56","doi-asserted-by":"publisher","first-page":"8885","DOI":"10.1523\/JNEUROSCI.2476-04.2004","volume":"24","author":"XB Liu","year":"2004","unstructured":"Liu XB, Murray KD, Jones EG: Switching of NMDA receptor 2A and 2B subunits at thalamic and cortical synapses during early postnatal development. J Neurosci. 2004, 24: 8885-8895.","journal-title":"J Neurosci"},{"key":"53_CR57","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/S0896-6273(02)00577-9","volume":"33","author":"D Stellwagen","year":"2002","unstructured":"Stellwagen D, Shatz CJ: An instructive role for retinal waves in the development of retinogeniculate connectivity. Neuron. 2002, 33: 357-367.","journal-title":"Neuron"}],"container-title":["Neural Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1749-8104-3-21.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T09:39:21Z","timestamp":1736415561000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/1749-8104-3-21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,26]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2008,12]]}},"alternative-id":["53"],"URL":"https:\/\/doi.org\/10.1186\/1749-8104-3-21","relation":{},"ISSN":["1749-8104"],"issn-type":[{"value":"1749-8104","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,26]]},"assertion":[{"value":"7 March 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2008","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2008","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"21"}}