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In this paper, we explore the importance of <jats:italic>Nav2<\/jats:italic> in nervous system development and function <jats:italic>in vivo<\/jats:italic>.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p><jats:italic>Nav2<\/jats:italic> hypomorphic homozygous mutants show decreased survival starting at birth. <jats:italic>Nav2<\/jats:italic> mutant embryos show an overall reduction in nerve fiber density, as well as specific defects in cranial nerves IX (glossopharyngeal) and X (vagus). <jats:italic>Nav2<\/jats:italic> hypomorphic mutant adult mice also display a blunted baroreceptor response compared to wild-type controls.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p><jats:italic>Nav2<\/jats:italic> functions in mammalian nervous system development, and is required for normal cranial nerve development and blood pressure regulation in the adult.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/1749-8104-5-6","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T19:14:59Z","timestamp":1267125299000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Nav2 is necessary for cranial nerve development and blood pressure regulation"],"prefix":"10.1186","volume":"5","author":[{"given":"Elizabeth M","family":"McNeill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth P","family":"Roos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieder","family":"Moechars","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Clagett-Dame","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,2,25]]},"reference":[{"key":"118_CR1","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/S0959-437X(00)00100-3","volume":"10","author":"A Gavalas","year":"2000","unstructured":"Gavalas A, Krumlauf R: Retinoid signalling and hindbrain patterning. 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