{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:10:10Z","timestamp":1783941010395,"version":"3.55.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chin Med"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Peanut allergy is characterized by increased levels of peanut-specific IgE in the serum of most patients. Thus, the most logical therapy would be to inhibit the IgE production by committed B-cells. This study aims to investigate the unreported anti-IgE effects of Chinese herbal extracts of <jats:italic>Rubia cordifolia<\/jats:italic> (<jats:italic>Qiancao<\/jats:italic>) and <jats:italic>Dianthus superbus<\/jats:italic> (<jats:italic>Qumai<\/jats:italic>).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Seventy herbal extracts were tested for their ability to reduce IgE secretion by a human B-cell line. Those with the lowest inhibitory concentration 50 (IC<jats:sub>50<\/jats:sub>) values were tested in a mouse model of peanut-anaphylaxis. Anaphylactic scores, body temperature, plasma histamine and peanut-specific-immunoglobulins were determined.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>\n              <jats:italic>Rubia cordifolia<\/jats:italic> and <jats:italic>Dianthus superbus<\/jats:italic> inhibited the <jats:italic>in vitro<\/jats:italic> IgE production by a human B-cell line in a dose-dependent manner and the <jats:italic>in vivo IgE<\/jats:italic> production in a murine model of peanut allergy without affecting peanut-specific-IgG1 levels. After challenge, all mice in the sham groups developed anaphylactic reactions and increased plasma histamine levels. The extract-treated mice demonstrated significantly reduced peanut-triggered anaphylactic reactions and plasma histamine levels.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The extracts of <jats:italic>Rubia cordifolia<\/jats:italic> and <jats:italic>Dianthus superbus<\/jats:italic> inhibited the IgE production <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> as well as reduced anaphylactic reactions in peanut-allergic mice, suggesting potentials for allergy treatments.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1749-8546-6-35","type":"journal-article","created":{"date-parts":[[2011,9,30]],"date-time":"2011-09-30T18:30:59Z","timestamp":1317407459000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Chinese herbal extracts of Rubia cordifolia and Dianthus superbus suppress IgE production and prevent peanut-induced anaphylaxis"],"prefix":"10.1186","volume":"6","author":[{"given":"Iv\u00e1n","family":"L\u00f3pez-Exp\u00f3sito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banghao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,9,30]]},"reference":[{"key":"138_CR1","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1016\/j.jaci.2010.03.029","volume":"125","author":"SH Sicherer","year":"2010","unstructured":"Sicherer SH, Munoz-Furlong A, Godbold JH, Sampson HA: US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up. 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