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This study aims to investigate the effects of QJF treatment of MG patients on the protein, peptide and metabolite levels in serum.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>High-throughput proteomic, peptidomic and metabolomic techniques were applied to investigate serum samples from 21 healthy individuals and 47 MG patients before and after QJF treatment via two-dimensional gel electrophoresis, matrix-assisted laser desorption\/ionization time of flight mass spectrometry and liquid chromatography Fourier transform mass spectrometry, respectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>After QJF treatment, the expression levels of peptides <jats:italic>m\/z<\/jats:italic> 1865.019, 2021.128 and 1211.668 of complement C3f increased (<jats:italic>P<\/jats:italic>\u2009=\u20090.004, <jats:italic>P<\/jats:italic>\u2009=\u20090.001 and <jats:italic>P<\/jats:italic>\u2009=\u20090.043, respectively), while that of peptide <jats:italic>m\/z<\/jats:italic> 1739.931 of component C4b decreased (<jats:italic>P<\/jats:italic>\u2009=\u20090.043), in the serum of MG patients. The levels of \u03b3-aminobutyric acid (<jats:italic>P<\/jats:italic>\u2009=\u20090.000) and coenzyme Q4 (<jats:italic>P<\/jats:italic>\u2009=\u20090.000) resumed their normal states.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>QJF could inhibit the activity of the complement system and restore the normal levels of metabolites.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1749-8546-7-16","type":"journal-article","created":{"date-parts":[[2012,7,28]],"date-time":"2012-07-28T14:14:18Z","timestamp":1343484858000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Serum proteomic, peptidomic and metabolomic profiles in myasthenia gravis patients during treatment with Qiangji Jianli Fang"],"prefix":"10.1186","volume":"7","author":[{"given":"Chunmei","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonghai","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhixi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huangquan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiuwa","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saiming","family":"Ngai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,7,28]]},"reference":[{"key":"157_CR1","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1159\/000279334","volume":"34","author":"A McGrogan","year":"2010","unstructured":"McGrogan A, Sneddon S, de Vries CS: The incidence of myasthenia gravis: a systematic literature review. 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