{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:17:13Z","timestamp":1761862633276},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Surg Innov Res"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Inflammation is a recognized risk factor for the vulnerable atherosclerotic plaque.<\/jats:p>\n          <jats:p>USPIO-enhanced MRI imaging is a promising non-invasive method to identify high-risk atheromatous plaque inflammation in vivo in humans, in which areas of focal signal loss on MR images have been shown to correspond to the location of activated macrophages, typically at the shoulder regions of the plaque. This is the first report in humans describing simultaneous USPIO uptake within atheroma in two different arterial territories and again emphasises that atherosclerosis is a truly systemic disease. With further work, USPIO-enhanced MR imaging may be useful in identifying inflamed vulnerable atheromatous plaques in vivo, so refining patient selection for intervention and allowing appropriate early aggressive pharmacotherapy to prevent plaque rupture.<\/jats:p>","DOI":"10.1186\/1750-1164-1-4","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T19:06:49Z","timestamp":1172084809000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Non-invasive MR imaging of inflammation in a patient with both asymptomatic carotid atheroma and an abdominal aortic aneurysm: a case report"],"prefix":"10.1186","volume":"1","author":[{"given":"Simon PS","family":"Howarth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tjun Y","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin J","family":"Graves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Marie","family":"U-King-Im","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stewart R","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E","family":"Gaunt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan H","family":"Gillard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,2,21]]},"reference":[{"issue":"5","key":"4_CR1","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1161\/01.CIR.92.5.1355","volume":"92","author":"HC Stary Chandler,","year":"1995","unstructured":"Stary HC Chandler, A. B., Dinsmore, R. E. Fuster, V., Glagov, S., Insull, W., Jr., Rosenfeld, M. E., Schwartz, C. J., Wagner, W. D., Wissler, R. W.: A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 1995,92(5):1355\u20131374.","journal-title":"Circulation"},{"issue":"7","key":"4_CR2","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1161\/01.ATV.0000222920.59760.df","volume":"26","author":"RA Trivedi Mallawarac","year":"2006","unstructured":"Trivedi RA Mallawarachi, C., U. King-Im JM, Graves, M. J., Horsley, J., Goddard, M. J., Brown, A., Wang, L., Kirkpatrick, P. J., Brown, J., and Gillard, J. H.: Identifying Inflamed Carotid Plaques Using In Vivo USPIO-Enhanced MR Imaging to Label Plaque Macrophages. Arterioscler Thromb Vasc Biol 2006,26(7):1601\u20131606. 10.1161\/01.ATV.0000222920.59760.df","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"9170","key":"4_CR3","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1016\/S0140-6736(98)11415-0","volume":"353","author":"PM Rothwell Warlow, C.","year":"1999","unstructured":"Rothwell PM Warlow, C. P.: Prediction of benefit from carotid endarterectomy in individual patients: a risk-modelling study. European Carotid Surgery Trialists' Collaborative Group. Lancet 1999,353(9170):2105\u20132110. 10.1016\/S0140-6736(98)11415-0","journal-title":"Lancet"},{"issue":"12","key":"4_CR4","doi-asserted-by":"publisher","first-page":"2764","DOI":"10.1161\/01.STR.0000190895.51934.43","volume":"36","author":"N Nighoghossian Derex, L.,","year":"2005","unstructured":"Nighoghossian N Derex, L., Douek, P.: The vulnerable carotid artery plaque: current imaging methods and new perspectives. Stroke 2005,36(12):2764\u20132772. 10.1161\/01.STR.0000190895.51934.43","journal-title":"Stroke"},{"issue":"22","key":"4_CR5","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1056\/NEJM198705283162204","volume":"316","author":"S Glagov Weisenberg","year":"1987","unstructured":"Glagov S Weisenberg, E., Zarins, C. K., Stankunavicius, R., Kolettis, G. J.: Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med 1987,316(22):1371\u20131375.","journal-title":"N Engl J Med"},{"issue":"7","key":"4_CR6","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1161\/01.STR.0000131268.50418.b7","volume":"35","author":"RA Trivedi U -King-Im","year":"2004","unstructured":"Trivedi RA U -King-Im J. M., Graves, M. J., Cross, J. J., Horsley, J., Goddard, M. J., Skepper, J. N., Quartey, G., Warburton, E., Joubert, I., Wang, L., Kirkpatrick, P. J., Brown, J., Gillard, J. H.: In vivo detection of macrophages in human carotid atheroma: temporal dependence of ultrasmall superparamagnetic particles of iron oxide-enhanced MRI. Stroke 2004,35(7):1631\u20131635. 10.1161\/01.STR.0000131268.50418.b7","journal-title":"Stroke"},{"issue":"2","key":"4_CR7","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1056\/NEJM199901143400207","volume":"340","author":"R Ross","year":"1999","unstructured":"Ross R: Atherosclerosis--an inflammatory disease. N Engl J Med 1999,340(2):115\u2013126. 10.1056\/NEJM199901143400207","journal-title":"N Engl J Med"},{"key":"4_CR8","volume-title":"Stroke","author":"T Tang Howarth, S","year":"2006","unstructured":"Tang T Howarth, S. P. S., Miller, S. R., Trivedi, R. A., Graves, M. J., U- King-Im, J. M., Li, Z. Y., Brown, A. P., Kirkpatrick, P. J., Gaunt, M. E., Gillard, J. H.: Assessment of Inflammatory Burden Contralateral to the Symptomatic Carotid Stenosis Using High-Resolution Ultrasmall, Superparamagnetic Iron Oxide-Enhanced MRI. Stroke 2006."},{"key":"4_CR9","first-page":"2608","volume":"13","author":"M Stuber","year":"2005","unstructured":"Stuber M: Shedding Light on the Dark Spot with IRON - A Method that Generates Positive Contrast in the Presence of Superparamagnetic Nanoparticles . Proc Intl Soc Mag Reson Med 2005, 13: 2608.","journal-title":"Proc Intl Soc Mag Reson Med"}],"container-title":["Annals of Surgical Innovation and Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1750-1164-1-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T21:16:34Z","timestamp":1630444594000},"score":1,"resource":{"primary":{"URL":"https:\/\/asir-journal.biomedcentral.com\/articles\/10.1186\/1750-1164-1-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2,21]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["4"],"URL":"https:\/\/doi.org\/10.1186\/1750-1164-1-4","relation":{},"ISSN":["1750-1164"],"issn-type":[{"value":"1750-1164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2,21]]},"assertion":[{"value":"3 October 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2007","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2007","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"4"}}