{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:11:57Z","timestamp":1773864717198,"version":"3.50.1"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,9,14]],"date-time":"2006-09-14T00:00:00Z","timestamp":1158192000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orphanet J Rare Dis"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1186\/1750-1172-1-35","type":"journal-article","created":{"date-parts":[[2006,9,14]],"date-time":"2006-09-14T14:22:21Z","timestamp":1158243741000},"source":"Crossref","is-referenced-by-count":32,"title":["Brugada syndrome"],"prefix":"10.1186","volume":"1","author":[{"given":"Carlo","family":"Napolitano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia G","family":"Priori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,9,14]]},"reference":[{"key":"35_CR1","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1046\/j.1540-8167.2001.01008.x","volume":"12","author":"SG Priori","year":"2001","unstructured":"Priori SG: Foretelling the future in Brugada syndrome: do we have the crystal ball?. J Cardiovasc Electrophysiol. 2001, 12: 1008-1009. 10.1046\/j.1540-8167.2001.01008.x.","journal-title":"J Cardiovasc Electrophysiol"},{"key":"35_CR2","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1016\/0735-1097(92)90253-J","volume":"20","author":"P Brugada","year":"1992","unstructured":"Brugada P, Brugada J: Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. J Am Coll Cardiol. 1992, 20: 1391-1396.","journal-title":"J Am Coll Cardiol"},{"key":"35_CR3","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1053\/euhj.2000.2231","volume":"21","author":"AA Wilde","year":"2000","unstructured":"Wilde AA, Priori SG: Brugada syndrome and sudden death. Eur Heart J. 2000, 21: 1483-10.1053\/euhj.2000.2231.","journal-title":"Eur Heart J"},{"key":"35_CR4","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0002-9149(00)00835-3","volume":"86","author":"JS Hermida","year":"2000","unstructured":"Hermida JS, Lemoine JL, Aoun FB, Jarry G, Rey JL, Quiret JC: Prevalence of the brugada syndrome in an apparently healthy population. Am J Cardiol. 2000, 86: 91-94. 10.1016\/S0002-9149(00)00835-3.","journal-title":"Am J Cardiol"},{"key":"35_CR5","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1136\/heart.86.2.161","volume":"86","author":"M Furuhashi","year":"2001","unstructured":"Furuhashi M, Uno K, Tsuchihashi K, Nagahara D, Hyakukoku M, Ohtomo T, Satoh S, Nishimiya T, Shimamoto K: Prevalence of asymptomatic ST segment elevation in right precordial leads with right bundle branch block (Brugada-type ST shift) among the general Japanese population. Heart. 2001, 86: 161-166. 10.1136\/heart.86.2.161.","journal-title":"Heart"},{"key":"35_CR6","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/S0735-1097(01)01419-X","volume":"38","author":"Y Miyasaka","year":"2001","unstructured":"Miyasaka Y, Tsuji H, Yamada K, Tokunaga S, Saito D, Imuro Y, Matsumoto N, Iwasaka T: Prevalence and mortality of the Brugada-type electrocardiogram in one city in Japan. J Am Coll Cardiol. 2001, 38: 771-774. 10.1016\/S0735-1097(01)01419-X.","journal-title":"J Am Coll Cardiol"},{"key":"35_CR7","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1097\/00000441-200601000-00008","volume":"331","author":"H Ito","year":"2006","unstructured":"Ito H, Yano K, Chen R, He Q, Curb JD: The prevalence and prognosis of a Brugada-type electrocardiogram in a population of middle-aged Japanese-American men with follow-up of three decades. Am J Med Sci. 2006, 331: 25-29. 10.1097\/00000441-200601000-00008.","journal-title":"Am J Med Sci"},{"key":"35_CR8","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1161\/01.CIR.102.20.2509","volume":"102","author":"SG Priori","year":"2000","unstructured":"Priori SG, Napolitano C, Gasparini M, Pappone C, Della BP, Brignole M, Giordano U, Giovannini T, Menozzi C, Bloise R, Crotti L, Terreni L, Schwartz PJ: Clinical and genetic heterogeneity of right bundle branch block and ST-segment elevation syndrome: A prospective evaluation of 52 families. Circulation. 2000, 102: 2509-2515.","journal-title":"Circulation"},{"key":"35_CR9","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.1016\/S0735-1097(01)01239-6","volume":"37","author":"H Atarashi","year":"2001","unstructured":"Atarashi H, Ogawa S, Harumi K, Sugimoto T, Inoue H, Murayama M, Toyama J, Hayakawa H: Three-year follow-up of patients with right bundle branch block and ST segment elevation in the right precordial leads: Japanese Registry of Brugada Syndrome. Idiopathic Ventricular Fibrillation Investigators. J Am Coll Cardiol. 2001, 37: 1916-1920. 10.1016\/S0735-1097(01)01239-6.","journal-title":"J Am Coll Cardiol"},{"key":"35_CR10","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1046\/j.1540-8167.2001.00002.x","volume":"12","author":"S Takenaka","year":"2001","unstructured":"Takenaka S, Kusano KF, Hisamatsu K, Nagase S, Nakamura K, Morita H, Matsubara H, Emori T, Ohe T: Relatively benign clinical course in asymptomatic patients with brugada-type electrocardiogram without family history of sudden death. J Cardiovasc Electrophysiol. 2001, 12: 2-6. 10.1046\/j.1540-8167.2001.00002.x.","journal-title":"J Cardiovasc Electrophysiol"},{"key":"35_CR11","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1161\/01.CIR.97.5.457","volume":"97","author":"J Brugada","year":"1998","unstructured":"Brugada J, Brugada R, Brugada P: Right bundle-branch block and ST-segment elevation in leads V1 through V3: a marker for sudden death in patients without demonstrable structural heart disease. Circulation. 1998, 97: 457-460.","journal-title":"Circulation"},{"key":"35_CR12","doi-asserted-by":"publisher","first-page":"3092","DOI":"10.1161\/01.CIR.0000104568.13957.4F","volume":"108","author":"J Brugada","year":"2003","unstructured":"Brugada J, Brugada R, Brugada P: Determinants of sudden cardiac death in individuals with the electrocardiographic pattern of Brugada syndrome and no previous cardiac arrest. Circulation. 2003, 108: 3092-3096. 10.1161\/01.CIR.0000104568.13957.4F.","journal-title":"Circulation"},{"key":"35_CR13","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1161\/01.CIR.0000152479.54298.51","volume":"111","author":"C Antzelevitch","year":"2005","unstructured":"Antzelevitch C, Brugada P, Borggrefe M, Brugada J, Brugada R, Corrado D, Gussak I, LeMarec H, Nademanee K, Perez Riera AR, Shimizu W, Schulze-Bahr E, Tan H, Wilde A: Brugada syndrome: report of the second consensus conference. Circulation. 2005, 111: 659-670. 10.1161\/01.CIR.0000152479.54298.51.","journal-title":"Circulation"},{"key":"35_CR14","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/32675","volume":"392","author":"Q Chen","year":"1998","unstructured":"Chen Q, Kirsch GE, Zhang D, Brugada R, Brugada J, Brugada P, Potenza D, Moya A, Borggrefe M, Breithardt G, Ortiz-Lopez R, Wang Z, Antzelevitch C, O'Brien RE, Schulze-Bahr E, Keating MT, Towbin JA, Wang Q: Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature. 1998, 392: 293-296. 10.1038\/32675.","journal-title":"Nature"},{"key":"35_CR15","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/0092-8674(95)90359-3","volume":"80","author":"Q Wang","year":"1995","unstructured":"Wang Q, Shen J, Splawski I, Atkinson D, Li Z, Robinson JL, Moss AJ, Towbin JA, Keating MT: SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell. 1995, 80: 805-811. 10.1016\/0092-8674(95)90359-3.","journal-title":"Cell"},{"key":"35_CR16","doi-asserted-by":"publisher","first-page":"3081","DOI":"10.1161\/hc5001.100834","volume":"104","author":"F Kyndt","year":"2001","unstructured":"Kyndt F, Probst V, Potet F, Demolombe S, Chevallier JC, Baro I, Moisan JP, Boisseau P, Schott JJ, Escande D, Le Marec H: Novel SCN5A mutation leading either to isolated cardiac conduction defect or Brugada syndrome in a large French family. Circulation. 2001, 104: 3081-3086.","journal-title":"Circulation"},{"key":"35_CR17","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/12618","volume":"23","author":"JJ Schott","year":"1999","unstructured":"Schott JJ, Alshinawi C, Kyndt F, Probst V, Hoorntje TM, Hulsbeek M, Wilde AA, Escande D, Mannens MM, Le Marec H: Cardiac conduction defects associate with mutations in SCN5A. Nat Genet. 1999, 23: 20-21. 10.1038\/12618.","journal-title":"Nat Genet"},{"key":"35_CR18","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1172\/JCI200318062","volume":"112","author":"DW Benson","year":"2003","unstructured":"Benson DW, Wang DW, Dyment M, Knilans TK, Fish FA, Strieper MJ, Rhodes TH, George AL Jr: Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A). J Clin Invest. 2003, 112: 1019-1028. 10.1172\/JCI200318062.","journal-title":"J Clin Invest"},{"key":"35_CR19","doi-asserted-by":"publisher","first-page":"30623","DOI":"10.1074\/jbc.M104471200","volume":"276","author":"I Rivolta","year":"2001","unstructured":"Rivolta I, Abriel H, Tateyama M, Liu H, Memmi M, Vardas P, Napolitano C, Priori SG, Kass RS: Inherited brugada and LQT-3 syndrome mutations of a single residue of the cardiac sodium channel confer distinct channel and clinical phenotypes. J Biol Chem. 2001, 276: 30623-30630. 10.1074\/jbc.M104471200.","journal-title":"J Biol Chem"},{"key":"35_CR20","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1161\/01.CIR.102.9.945","volume":"102","author":"SG Priori","year":"2000","unstructured":"Priori SG, Napolitano C, Schwartz PJ, Bloise R, Crotti L, Ronchetti E: The elusive link between LQT3 and brugada syndrome: the role of flecainide challenge. Circulation. 2000, 102: 945-947.","journal-title":"Circulation"},{"key":"35_CR21","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1161\/01.RES.85.12.1206","volume":"85","author":"C Bezzina","year":"1999","unstructured":"Bezzina C, Veldkamp MW, van Den Berg MP, Postma AV, Rook MB, Viersma JW, van Langen IM, Tan-Sindhunata G, Bink-Boelkens MT, Der Hout AH, Mannens MM, Wilde AA: A single Na(+) channel mutation causing both long-QT and Brugada syndromes. Circ Res. 1999, 85: 1206-1213.","journal-title":"Circ Res"},{"issue":"suppl II","key":"35_CR22","first-page":"310","volume":"104","author":"AO Grant","year":"2001","unstructured":"Grant AO, Carboni MP, Neplioueva V, Starmer F, Memmi M, Napolitano C, Priori SG: A spontaneous mutation identifies a residue critical for closed-state inactivation of cardiac sodium channels [abstract]. Circulation. 2001, 104 (suppl II): 310.","journal-title":"Circulation"},{"key":"35_CR23","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1161\/hc1102.105288","volume":"105","author":"SG Priori","year":"2002","unstructured":"Priori SG, Napolitano C, Gasparini M, Pappone C, Bella PD, Giordano U, Bloise R, Giustetto C, De Nardis R, Grillo M, Ronchetti E, Faggiano G, Nastoli J: Natural history of Brugada syndrome: insights for risk stratification and management. Circulation. 2002, 105: 1342-1347. 10.1161\/hc1102.105288.","journal-title":"Circulation"},{"key":"35_CR24","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1053\/euhj.1999.1751","volume":"21","author":"P Brugada","year":"2000","unstructured":"Brugada P, Brugada R, Brugada J: Sudden death in patients and relatives with the syndrome of right bundle branch block, ST segment elevation in the precordial leads V(1)to V(3)and sudden death. Eur Heart J. 2000, 21: 321-326. 10.1053\/euhj.1999.1751.","journal-title":"Eur Heart J"},{"key":"35_CR25","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1161\/CIRCULATIONAHA.105.580811","volume":"113","author":"CR Bezzina","year":"2006","unstructured":"Bezzina CR, Shimizu W, Yang P, Koopmann TT, Tanck MW, Miyamoto Y, Kamakura S, Roden DM, Wilde AA: Common sodium channel promoter haplotype in asian subjects underlies variability in cardiac conduction. Circulation. 2006, 113: 338-344. 10.1161\/CIRCULATIONAHA.105.580811.","journal-title":"Circulation"},{"key":"35_CR26","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1016\/0002-8703(89)90011-2","volume":"118","author":"B Martini","year":"1989","unstructured":"Martini B, Nava A, Thiene G, Buja GF, Canciani B, Scognamiglio R, Daliento L, Dalla VS: Ventricular fibrillation without apparent heart disease: description of six cases. Am Heart J. 1989, 118: 1203-1209. 10.1016\/0002-8703(89)90011-2.","journal-title":"Am Heart J"},{"key":"35_CR27","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/0735-1097(93)90082-C","volume":"22","author":"B Martini","year":"1993","unstructured":"Martini B, Nava A, Canciani B, Thiene G: Right bundle branch block, persistent ST segment elevation and sudden cardiac death. J Am Coll Cardiol. 1993, 22: 633.","journal-title":"J Am Coll Cardiol"},{"key":"35_CR28","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1161\/01.CIR.0000144458.58660.BB","volume":"110","author":"WP McNair","year":"2004","unstructured":"McNair WP, Ku L, Taylor MR, Fain PR, Dao D, Wolfel E, Mestroni L: SCN5A mutation associated with dilated cardiomyopathy, conduction disorder, and arrhythmia. Circulation. 2004, 110: 2163-2167. 10.1161\/01.CIR.0000144458.58660.BB.","journal-title":"Circulation"},{"key":"35_CR29","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1161\/01.RES.0000052672.97759.36","volume":"92","author":"CR Bezzina","year":"2003","unstructured":"Bezzina CR, Rook MB, Groenewegen WA, Herfst LJ, van der Wal AC, Lam J, Jongsma HJ, Wilde AA, Mannens MM: Compound heterozygosity for mutations (W156X and R225W) in SCN5A associated with severe cardiac conduction disturbances and degenerative changes in the conduction system. Circ Res. 2003, 92: 159-168. 10.1161\/01.RES.0000052672.97759.36.","journal-title":"Circ Res"},{"key":"35_CR30","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1001\/archsurg.1974.01350280130021","volume":"108","author":"SW Carveth","year":"1974","unstructured":"Carveth SW, Olson D, Bechtel J: Proceedings: Emergency medical care system. Lincoln (Beb) mobile heart team. Arch Surg. 1974, 108: 528-530.","journal-title":"Arch Surg"},{"key":"35_CR31","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1001\/jama.293.4.447","volume":"293","author":"TM Olson","year":"2005","unstructured":"Olson TM, Michels VV, Ballew JD, Reyna SP, Karst ML, Herron KJ, Horton SC, Rodeheffer RJ, Anderson JL: Sodium channel mutations and susceptibility to heart failure and atrial fibrillation. JAMA. 2005, 293: 447-454. 10.1001\/jama.293.4.447.","journal-title":"JAMA"},{"key":"35_CR32","doi-asserted-by":"publisher","first-page":"3680","DOI":"10.1161\/CIRCULATIONAHA.105.520999","volume":"112","author":"A Frustaci","year":"2005","unstructured":"Frustaci A, Priori SG, Pieroni M, Chimenti C, Napolitano C, Rivolta I, Sanna T, Bellocci F, Russo MA: Cardiac histological substrate in patients with clinical phenotype of Brugada syndrome. Circulation. 2005, 112: 3680-3687. 10.1161\/CIRCULATIONAHA.105.520999.","journal-title":"Circulation"},{"key":"35_CR33","unstructured":"[\n                    http:\/\/www.fsm.it\/cardmoc\/\n                    \n                  ]"},{"key":"35_CR34","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/S0008-6363(01)00224-3","volume":"50","author":"SG Priori","year":"2001","unstructured":"Priori SG, Napolitano C, Grillo M: Concealed arrhythmogenic syndromes: the hidden substrate of idiopathic ventricular fibrillation?. Cardiovasc Res. 2001, 50: 218-223. 10.1016\/S0008-6363(01)00224-3.","journal-title":"Cardiovasc Res"},{"issue":"suppl II","key":"35_CR35","first-page":"461","volume":"104","author":"SG Priori","year":"2001","unstructured":"Priori SG, Bloise R, Napolitano C, Nastoli J, Giordano U, Folli R, Vicentini A, Faggiano G: Clinical characterization of the genetic variant of Brugada syndrome associated with SCN5A mutations [abstract]. Circulation. 2001, 104 (suppl II): 461.","journal-title":"Circulation"},{"key":"35_CR36","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/S0735-1097(02)01962-9","volume":"40","author":"JP Smits","year":"2002","unstructured":"Smits JP, Eckardt L, Probst V, Bezzina CR, Schott JJ, Remme CA, Haverkamp W, Breithardt G, Escande D, Schulze-Bahr E, LeMarec H, Wilde AA: Genotype-phenotype relationship in Brugada syndrome: electrocardiographic features differentiate SCN5A-related patients from non-SCN5A-related patients. J Am Coll Cardiol. 2002, 40: 350-356. 10.1016\/S0735-1097(02)01962-9.","journal-title":"J Am Coll Cardiol"},{"key":"35_CR37","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1213\/01.ANE.0000067410.32384.3A","volume":"97","author":"N Phillips","year":"2003","unstructured":"Phillips N, Priestley M, Denniss AR, Uther JB: Brugada-type electrocardiographic pattern induced by epidural bupivacaine. Anesth Analg. 2003, 97: 264-267. 10.1213\/01.ANE.0000067410.32384.3A.","journal-title":"Anesth Analg"},{"key":"35_CR38","doi-asserted-by":"publisher","first-page":"845","DOI":"10.4065\/75.8.845","volume":"75","author":"L Littmann","year":"2000","unstructured":"Littmann L, Monroe MH, Svenson RH: Brugada-type electrocardiographic pattern induced by cocaine. Mayo Clin Proc. 2000, 75: 845-849.","journal-title":"Mayo Clin Proc"},{"key":"35_CR39","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/0735-1097(95)00613-3","volume":"27","author":"T Miyazaki","year":"1996","unstructured":"Miyazaki T, Mitamura H, Miyoshi S, Soejima K, Aizawa Y, Ogawa S: Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome. J Am Coll Cardiol. 1996, 27: 1061-1070. 10.1016\/0735-1097(95)00613-3.","journal-title":"J Am Coll Cardiol"},{"key":"35_CR40","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1161\/01.CIR.0000105762.94855.46","volume":"109","author":"M Kimura","year":"2004","unstructured":"Kimura M, Kobayashi T, Owada S, Ashikaga K, Higuma T, Sasaki S, Iwasa A, Motomura S, Okumura K: Mechanism of ST elevation and ventricular arrhythmias in an experimental Brugada syndrome model. Circulation. 2004, 109: 125-131. 10.1161\/01.CIR.0000105762.94855.46.","journal-title":"Circulation"},{"key":"35_CR41","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1016\/S0735-1097(02)02494-4","volume":"40","author":"T Noda","year":"2002","unstructured":"Noda T, Shimizu W, Taguchi A, Satomi K, Suyama K, Kurita T, Aihara N, Kamakura S: ST-segment elevation and ventricular fibrillation without coronary spasm by intracoronary injection of acetylcholine and\/or ergonovine maleate in patients with Brugada syndrome. J Am Coll Cardiol. 2002, 40: 1841-1847. 10.1016\/S0735-1097(02)02494-4.","journal-title":"J Am Coll Cardiol"},{"key":"35_CR42","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1056\/NEJM200205163462020","volume":"346","author":"D Goldgran-Toledano","year":"2002","unstructured":"Goldgran-Toledano D, Sideris G, Kevorkian JP: Overdose of cyclic antidepressants and the Brugada syndrome. N Engl J Med. 2002, 346: 1591-1592. 10.1056\/NEJM200205163462020.","journal-title":"N Engl J Med"},{"key":"35_CR43","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1172\/JCI114340","volume":"84","author":"DC Whitcomb","year":"1989","unstructured":"Whitcomb DC, Gilliam FR, Starmer CF, Grant AO: Marked QRS complex abnormalities and sodium channel blockade by propoxyphene reversed with lidocaine. J Clin Invest. 1989, 84: 1629-1636.","journal-title":"J Clin Invest"},{"key":"35_CR44","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1161\/CIRCULATIONAHA.105.548487","volume":"112","author":"D Darbar","year":"2005","unstructured":"Darbar D, Yang T, Churchwell K, Wilde AA, Roden DM: Unmasking of brugada syndrome by lithium. Circulation. 2005, 112: 1527-1531. 10.1161\/CIRCULATIONAHA.105.548487.","journal-title":"Circulation"},{"key":"35_CR45","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1046\/j.1540-8167.2001.01192.x","volume":"12","author":"A Pastor","year":"2001","unstructured":"Pastor A, Nunez A, Cantale C, Cosio FG: Asymptomatic brugada syndrome case unmasked during dimenhydrinate infusion. J Cardiovasc Electrophysiol. 2001, 12: 1192-1194. 10.1046\/j.1540-8167.2001.01192.x.","journal-title":"J Cardiovasc Electrophysiol"},{"key":"35_CR46","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.hrthm.2005.11.005","volume":"3","author":"K Vernooy","year":"2006","unstructured":"Vernooy K, Delhaas T, Cremer OL, Di Diego JM, Oliva A, Timmermans C, Volders PG, Prinzen FW, Crijns HJ, Antzelevitch C, Kalkman CJ, Rodriguez LM, Brugada R: Electrocardiographic changes predicting sudden death in propofol-related infusion syndrome. Heart Rhythm. 2006, 3: 131-137. 10.1016\/j.hrthm.2005.11.005.","journal-title":"Heart Rhythm"},{"key":"35_CR47","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0195-0668X(02)00809-6","volume":"24","author":"SG Priori","year":"2003","unstructured":"Priori SG, Aliot E, Blomstrom-Lundqvist C, Bossaert L, Breithardt G, Brugada P, Camm JA, Cappato R, Cobbe SM, Di Mario C, Maron BJ, McKenna WJ, Pedersen AK, Ravens U, Schwartz PJ, Trusz-Gluza M, Vardas P, Wellens HJ, Zipes DP: Update of the guidelines on sudden cardiac death of the European Society of Cardiology. Eur Heart J. 2003, 24: 13-15. 10.1016\/S0195-0668X(02)00809-6.","journal-title":"Eur Heart J"},{"key":"35_CR48","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1046\/j.1540-8167.2003.02517.x","volume":"14","author":"P Brugada","year":"2003","unstructured":"Brugada P, Brugada R, Mont L, Rivero M, Geelen P, Brugada J: Natural history of Brugada syndrome: the prognostic value of programmed electrical stimulation of the heart. J Cardiovasc Electrophysiol. 2003, 14: 455-457. 10.1046\/j.1540-8167.2003.02517.x.","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"suppl II","key":"35_CR49","first-page":"540","volume":"104","author":"SG Priori","year":"2001","unstructured":"Priori SG, Grillo M, Napolitano C, Faggiano G, Barbaro C, Gasparini M, Manozzi C: Epidemiology of Brugada Syndrome: A prospective Evaluation of 192 Individuals [abstract]. Circulation. 2001, 104 (suppl II): 540.","journal-title":"Circulation"},{"key":"35_CR50","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1046\/j.1540-8167.2001.01004.x","volume":"12","author":"P Brugada","year":"2001","unstructured":"Brugada P, Geelen P, Brugada R, Mont L, Brugada J: Prognostic value of electrophysiologic investigations in Brugada syndrome. J Cardiovasc Electrophysiol. 2001, 12: 1004-1007. 10.1046\/j.1540-8167.2001.01004.x.","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"suppl2","key":"35_CR51","first-page":"677","volume":"102","author":"M Gasparini","year":"2000","unstructured":"Gasparini M, Priori SG, Mantica M, Coltorti F, Galimberti P, Ceriotti C, Napolitano C, Bloise R: Provocative tests in the Brugada syndrome: do we have the right tools? [abstract]. Circulation. 2000, 102 (suppl2): 677.","journal-title":"Circulation"},{"key":"35_CR52","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1161\/CIRCULATIONAHA.104.485326","volume":"112","author":"SG Priori","year":"2005","unstructured":"Priori SG, Napolitano C: Should patients with an asymptomatic Brugada electrocardiogram undergo pharmacological and electrophysiological testing?. Circulation. 2005, 112: 279-292. 10.1161\/CIRCULATIONAHA.104.485326.","journal-title":"Circulation"},{"key":"35_CR53","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1046\/j.1540-8167.2001.00268.x","volume":"12","author":"C Antzelevitch","year":"2001","unstructured":"Antzelevitch C: The Brugada syndrome: ionic basis and arrhythmia mechanisms. J Cardiovasc Electrophysiol. 2001, 12: 268-272. 10.1046\/j.1540-8167.2001.00268.x.","journal-title":"J Cardiovasc Electrophysiol"},{"key":"35_CR54","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1161\/01.CIR.100.15.1660","volume":"100","author":"GX Yan","year":"1999","unstructured":"Yan GX, Antzelevitch C: Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation. Circulation. 1999, 100: 1660-1666.","journal-title":"Circulation"},{"key":"35_CR55","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1111\/j.1540-8167.1999.tb00183.x","volume":"10","author":"B Belhassen","year":"1999","unstructured":"Belhassen B, Viskin S, Fish R, Glick A, Setbon I, Eldar M: Effects of electrophysiologic-guided therapy with Class IA antiarrhythmic drugs on the long-term outcome of patients with idiopathic ventricular fibrillation with or without the Brugada syndrome. J Cardiovasc Electrophysiol. 1999, 10: 1301-1312.","journal-title":"J Cardiovasc Electrophysiol"},{"key":"35_CR56","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1016\/j.jacc.2003.12.046","volume":"43","author":"JS Hermida","year":"2004","unstructured":"Hermida JS, Denjoy I, Clerc J, Extramiana F, Jarry G, Milliez P, Guicheney P, Di Fusco S, Rey JL, Cauchemez B, Leenhardt A: Hydroquinidine therapy in Brugada syndrome. J Am Coll Cardiol. 2004, 43: 1853-1860. 10.1016\/j.jacc.2003.12.046.","journal-title":"J Am Coll Cardiol"},{"key":"35_CR57","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1161\/01.CIR.0000143159.30585.90","volume":"110","author":"B Belhassen","year":"2004","unstructured":"Belhassen B, Glick A, Viskin S: Efficacy of quinidine in high-risk patients with Br ugada syndrome. Circulation. 2004, 110: 1731-1737. 10.1161\/01.CIR.0000143159.30585.90.","journal-title":"Circulation"}],"container-title":["Orphanet Journal of Rare Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1750-1172-1-35.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1750-1172-1-35\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1750-1172-1-35.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T21:17:49Z","timestamp":1548191869000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojrd.biomedcentral.com\/articles\/10.1186\/1750-1172-1-35"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,14]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["35"],"URL":"https:\/\/doi.org\/10.1186\/1750-1172-1-35","relation":{},"ISSN":["1750-1172"],"issn-type":[{"value":"1750-1172","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,14]]},"article-number":"35"}}