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While MPS II heterozygotes are asymptomatic in most instances, in Fabry disease most of female carriers show some disease manifestation, which is sometimes severe. It is known that there is a major difference among X-linked diseases depending on the cell autonomy of the gene product involved and, therefore, on the occurrence of cross-correction. Since lysosomal enzymes are usually secreted and uptaken by neighbor cells, the different findings between MPS II and Fabry disease heterozygotes can also be due to different efficiency of cross-correction (higher in MPS II and lower in Fabry disease). In this paper, we review these two X-linked LD in order to discuss the mechanisms that could explain the different rates of penetrance and expressivity observed in the heterozygotes; this could be helpful to better understand the expression of X-linked traits.<\/jats:p>","DOI":"10.1186\/1750-1172-5-14","type":"journal-article","created":{"date-parts":[[2010,5,28]],"date-time":"2010-05-28T18:16:28Z","timestamp":1275070588000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Expression of the disease on female carriers of X-linked lysosomal disorders: a brief review"],"prefix":"10.1186","volume":"5","author":[{"given":"Louise LC","family":"Pinto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiane A","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Giugliani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida VD","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,5,28]]},"reference":[{"key":"177_CR1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1053\/siny.2001.0088","volume":"7","author":"JE Wraith","year":"2002","unstructured":"Wraith JE: Lysosomal disorders. 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