{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:53:12Z","timestamp":1793173992594,"version":"4.5.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,11,4]],"date-time":"2010-11-04T00:00:00Z","timestamp":1288828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orphanet J Rare Dis"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1186\/1750-1172-5-29","type":"journal-article","created":{"date-parts":[[2010,11,5]],"date-time":"2010-11-05T03:37:00Z","timestamp":1288928220000},"source":"Crossref","is-referenced-by-count":190,"title":["Wolcott-Rallison syndrome"],"prefix":"10.1186","volume":"5","author":[{"given":"C\u00e9cile","family":"Julier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Nicolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,11,4]]},"reference":[{"key":"192_CR1","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/S0022-3476(72)80596-1","volume":"80","author":"CD Wolcott","year":"1972","unstructured":"Wolcott CD, Rallison MV: Infancy-onset diabetes mellitus and multiple epiphyseal dysplasia. J Pediatr. 1972, 80: 292-297. 10.1016\/S0022-3476(72)80596-1.","journal-title":"J Pediatr"},{"key":"192_CR2","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.2337\/diabetes.53.7.1876","volume":"53","author":"V Senee","year":"2004","unstructured":"Senee V, Vattem KM, Delepine M, Rainbow LA, Haton C, Lecoq A, Shaw NJ, Robert JJ, Rooman R, Diatloff-Zito C: Wolcott-Rallison Syndrome: Clinical, Genetic, and Functional Study of EIF2AK3 Mutations and Suggestion of Genetic Heterogeneity. Diabetes. 2004, 53: 1876-1883. 10.2337\/diabetes.53.7.1876.","journal-title":"Diabetes"},{"key":"192_CR3","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1111\/j.1399-5448.2009.00591.x","volume":"11","author":"MN Ozbek","year":"2010","unstructured":"Ozbek MN, Sen\u00e9e V, Aydemir S, Kotan LD, Mungan NO, Yuksel B, Julier C, Topaloglu AK: Wolcott-Rallison syndrome due to the same mutation (W522X) in EIF2AK3 in two unrelated families and review of the literature. Pediatric Diabetes. 2010, 11: 279-285. 10.1111\/j.1399-5448.2009.00591.x.","journal-title":"Pediatric Diabetes"},{"key":"192_CR4","doi-asserted-by":"publisher","first-page":"4162","DOI":"10.1210\/jc.2009-1137","volume":"94","author":"O Rubio-Cabezas","year":"2009","unstructured":"Rubio-Cabezas O, Patch AM, Minton JA, Flanagan SE, Edghill EL, Hussain K, Balafrej A, Deeb A, Buchanan CR, Jefferson IG: Wolcott-Rallison syndrome is the most common genetic cause of permanent neonatal diabetes in consanguineous families. J Clin Endocrinol Metab. 2009, 94: 4162-4170. 10.1210\/jc.2009-1137.","journal-title":"J Clin Endocrinol Metab"},{"key":"192_CR5","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1097\/00019605-199507000-00006","volume":"4","author":"LI Al-Gazali","year":"1995","unstructured":"Al-Gazali LI, Makia S, Hall CM: Wolcott-Rallison syndrome. Clinical Dysmorphology. 1995, 4: 227-233. 10.1097\/00019605-199507000-00006.","journal-title":"Clinical Dysmorphology"},{"key":"192_CR6","first-page":"323","volume":"37","author":"P Goumy","year":"1980","unstructured":"Goumy P, Maroteaux P, Stanescu V, Stanescu R, Labbe A, Menut G: Syndrome de transmission recessive autosomique, associant un diabete congenital et des desoirdres de la croissances des epiphyses. Arch Fr Pediatr. 1980, 37: 323-328.","journal-title":"Arch Fr Pediatr"},{"key":"192_CR7","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1111\/j.1651-2227.2004.tb02748.x","volume":"93","author":"S Iyer","year":"2004","unstructured":"Iyer S, Korada M, Rainbow L, Kirk J, Brown RM, Shaw N, Barrett TG: Wolcott-Rallison syndrome: a clinical and genetic study of three children, novel mutation in EIF2AK3 and a review of the literature. Acta Paediatr. 2004, 93: 1195-1201. 10.1111\/j.1651-2227.2004.tb02748.x.","journal-title":"Acta Paediatr"},{"key":"192_CR8","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1136\/jmg.40.9.685","volume":"40","author":"S Brickwood","year":"2003","unstructured":"Brickwood S, Bonthron DT, Al-Gazali LI, Piper K, Hearn T, Wilson DI, Hanley NA: Wolcott-Rallison syndrome: pathogenic insights into neonatal diabetes from new mutation and expression studies of EIF2AK3. J Med Genet. 2003, 40: 685-689. 10.1136\/jmg.40.9.685.","journal-title":"J Med Genet"},{"key":"192_CR9","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/PL00008394","volume":"159","author":"P Castelnau","year":"2000","unstructured":"Castelnau P, Le Merrer M, Diatloff-Zito C, Marquis E, Tete MJ, Robert JJ: Wolcott-Rallison syndrome: a case with endocrine and exocrine pancreatic deficiency and pancreatic hypotrophy. Eur J Pediatr. 2000, 159: 631-613. 10.1007\/PL00008394.","journal-title":"Eur J Pediatr"},{"key":"192_CR10","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/ajmg.10495","volume":"111","author":"B Bin-Abbas","year":"2002","unstructured":"Bin-Abbas B, Al-Mulhim A, Al-Ashwal A: Wolcott-Rallison syndrome in two siblings with isolated central hypothyroidism. Am J Med Genet. 2002, 111: 187-190. 10.1002\/ajmg.10495.","journal-title":"Am J Med Genet"},{"key":"192_CR11","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s10048-006-0061-1","volume":"7","author":"MC de Wit","year":"2006","unstructured":"de Wit MC, de Coo IF, Julier C, Delepine M, Lequin MH, van de Laar I, Sibbles BJ, Bruining GJ, Mancini GM: Microcephaly and simplified gyral pattern of the brain associated with early onset insulin-dependent diabetes mellitus. Neurogenetics. 2006, 7: 259-263. 10.1007\/s10048-006-0061-1.","journal-title":"Neurogenetics"},{"key":"192_CR12","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1002\/(SICI)1096-9136(199712)14:5+<S7::AID-DIA522>3.3.CO;2-I","volume":"14","author":"AF Amos","year":"1997","unstructured":"Amos AF, McCarty DJ, Zimmet P: The rising global burden of diabetes and its complications: estimates and projections to the year 2010. Diabet Med. 1997, 14: S1-85. 10.1002\/(SICI)1096-9136(199712)14:5+<S7::AID-DIA522>3.3.CO;2-I.","journal-title":"Diabet Med"},{"key":"192_CR13","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.ecl.2007.04.007","volume":"36","author":"SM Adler","year":"2007","unstructured":"Adler SM, Wartofsky L: The nonthyroidal illness syndrome. Endocrinol Metab Clin North Am. 2007, 36: 657-672. 10.1016\/j.ecl.2007.04.007.","journal-title":"Endocrinol Metab Clin North Am"},{"key":"192_CR14","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1080\/15513819709168589","volume":"17","author":"CM Thornton","year":"1997","unstructured":"Thornton CM, Carson DJ, Stewart FJ: Autopsy findings in the Wolcott-Rallison syndrome. Pediatr Pathol Lab Med. 1997, 17: 487-496. 10.1080\/107710497174778.","journal-title":"Pediatr Pathol Lab Med"},{"key":"192_CR15","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/78085","volume":"25","author":"M Delepine","year":"2000","unstructured":"Delepine M, Nicolino M, Barrett T, Golamaully M, Lathrop GM, Julier C: EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome. Nat Genet. 2000, 25: 406-409. 10.1038\/78085.","journal-title":"Nat Genet"},{"key":"192_CR16","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.1089\/ars.2007.1764","volume":"9","author":"RC Wek","year":"2007","unstructured":"Wek RC, Cavener DR: Translational control and the unfolded protein response. Antioxid Redox Signal. 2007, 9: 2357-2371. 10.1089\/ars.2007.1764.","journal-title":"Antioxid Redox Signal"},{"key":"192_CR17","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1210\/er.2007-0015","volume":"29","author":"DL Eizirik","year":"2008","unstructured":"Eizirik DL, Cardozo AK, Cnop M: The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev. 2008, 29: 42-61. 10.1210\/er.2007-0015.","journal-title":"Endocr Rev"},{"key":"192_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/hmg\/ddi001","volume":"14","author":"S Duchatelet","year":"2005","unstructured":"Duchatelet S, Ostergaard E, Cortes D, Lemainque A, Julier C: Recessive mutations in PTHR1 cause contrasting skeletal dysplasias in Eiken and Blomstrand syndromes. Hum Mol Genet. 2005, 14: 1-5. 10.1093\/hmg\/ddi001.","journal-title":"Hum Mol Genet"},{"key":"192_CR19","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/BF00572767","volume":"141","author":"M Eiken","year":"1984","unstructured":"Eiken M, Prag J, Petersen K, Kaufmann H: - A new familial skeletal dysplasia with severely retarded ossification and abnormal modeling of bones especially of the epiphyses, the hands, and feet. Eur J Pediatr. 1984, 141: 231-235. 10.1007\/BF00572767.","journal-title":"Eur J Pediatr"},{"key":"192_CR20","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/S1097-2765(01)00264-7","volume":"7","author":"HP Harding","year":"2001","unstructured":"Harding HP, Zeng H, Zhang Y, Jungries R, Chung P, Plesken H, Sabatini DD, Ron D: Diabetes mellitus and exocrine pancreatic dysfunction in perk-\/- mice reveals a role for translational control in secretory cell survival. Mol Cell. 2001, 7: 1153-1163. 10.1016\/S1097-2765(01)00264-7.","journal-title":"Mol Cell"},{"key":"192_CR21","doi-asserted-by":"publisher","first-page":"3864","DOI":"10.1128\/MCB.22.11.3864-3874.2002","volume":"22","author":"P Zhang","year":"2002","unstructured":"Zhang P, McGrath B, Li S, Frank A, Zambito F, Reinert J, Gannon M, Ma K, McNaughton K, Cavener DR: The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol. 2002, 22: 3864-3874. 10.1128\/MCB.22.11.3864-3874.2002.","journal-title":"Mol Cell Biol"},{"key":"192_CR22","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.cmet.2006.11.002","volume":"4","author":"W Zhang","year":"2006","unstructured":"Zhang W, Feng D, Li Y, Iida K, McGrath B, Cavener DR: PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis. Cell Metab. 2006, 4: 491-497. 10.1016\/j.cmet.2006.11.002.","journal-title":"Cell Metab"},{"key":"192_CR23","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/1471-2121-8-38","volume":"8","author":"K Iida","year":"2007","unstructured":"Iida K, Li Y, McGrath BC, Frank A, Cavener DR: PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice. BMC Cell Biol. 2007, 8: 38-10.1186\/1471-2121-8-38.","journal-title":"BMC Cell Biol"},{"key":"192_CR24","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1002\/jcp.21543","volume":"217","author":"J Wei","year":"2008","unstructured":"Wei J, Sheng X, Feng D, McGrath B, Cavener DR: PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation. J Cell Physiol. 2008, 217: 693-707. 10.1002\/jcp.21543.","journal-title":"J Cell Physiol"},{"key":"192_CR25","doi-asserted-by":"publisher","first-page":"3505","DOI":"10.1210\/en.2003-0236","volume":"144","author":"Y Li","year":"2003","unstructured":"Li Y, Iida K, O'Neil J, Zhang P, Li S, Frank A, Gabai A, Zambito F, Liang SH, Rosen CJ, Cavener DR: PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver. Endocrinology. 2003, 144: 3505-3513. 10.1210\/en.2003-0236.","journal-title":"Endocrinology"},{"key":"192_CR26","doi-asserted-by":"publisher","first-page":"S455","DOI":"10.2337\/diabetes.51.2007.S455","volume":"51","author":"HP Harding","year":"2002","unstructured":"Harding HP, Ron D: Endoplasmic reticulum stress and the development of diabetes: a review. Diabetes. 2002, 51: S455-461. 10.2337\/diabetes.51.2007.S455.","journal-title":"Diabetes"},{"key":"192_CR27","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/2441","volume":"20","author":"H Inoue","year":"1998","unstructured":"Inoue H, Tanizawa Y, Wasson J, Behn P, Kalidas K, Bernal-Mizrachi E, Mueckler M, Marshall H, Donis-Keller H, Crock P: A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome). Nat Genet. 1998, 20: 143-148. 10.1038\/2441.","journal-title":"Nat Genet"},{"key":"192_CR28","doi-asserted-by":"publisher","first-page":"15040","DOI":"10.1073\/pnas.0707291104","volume":"104","author":"J Stoy","year":"2007","unstructured":"Stoy J, Edghill EL, Flanagan SE, Ye H, Paz VP, Pluzhnikov A, Below JE, Hayes MG, Cox NJ, Lipkind GM: Insulin gene mutations as a cause of permanent neonatal diabetes. Proc Natl Acad Sci USA. 2007, 104: 15040-15044. 10.1073\/pnas.0707291104.","journal-title":"Proc Natl Acad Sci USA"},{"key":"192_CR29","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.coph.2009.07.003","volume":"9","author":"SG Fonseca","year":"2009","unstructured":"Fonseca SG, Burcin M, Gromada J, Urano F: Endoplasmic reticulum stress in beta-cells and development of diabetes. Curr Opin Pharmacol. 2009, 9: 763-770. 10.1016\/j.coph.2009.07.003.","journal-title":"Curr Opin Pharmacol"},{"key":"192_CR30","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/nrd2755","volume":"7","author":"I Kim","year":"2008","unstructured":"Kim I, Xu W, Reed JC: Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat Rev Drug Discov. 2008, 7: 1013-1030. 10.1038\/nrd2755.","journal-title":"Nat Rev Drug Discov"},{"key":"192_CR31","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","volume":"140","author":"GS Hotamisligil","year":"2010","unstructured":"Hotamisligil GS: Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease. Cell. 2010, 140: 900-917. 10.1016\/j.cell.2010.02.034.","journal-title":"Cell"},{"key":"192_CR32","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/1471-2121-10-61","volume":"10","author":"D Feng","year":"2009","unstructured":"Feng D, Wei J, Gupta S, McGrath BC, Cavener DR: Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation. BMC Cell Biol. 2009, 10: 61-10.1186\/1471-2121-10-61.","journal-title":"BMC Cell Biol"},{"key":"192_CR33","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.2337\/db09-1064","volume":"59","author":"S Gupta","year":"2010","unstructured":"Gupta S, McGrath B, Cavener DR: PERK (EIF2AK3) Regulates Proinsulin Trafficking and Quality Control in the Secretory Pathway. Diabetes. 2010, 59: 1937-1947. 10.2337\/db09-1064.","journal-title":"Diabetes"},{"key":"192_CR34","first-page":"323","volume":"37","author":"P Goumy","year":"1980","unstructured":"Goumy P, Maroteaux P, Stanescu V, Stanescu R, Labbe A, Menut G: [A syndrome of congenital diabetes with disordered epiphyseal growth with autosomal recessive inheritance (author's transl)]. Arch Fr Pediatr. 1980, 37: 323-328.","journal-title":"Arch Fr Pediatr"},{"key":"192_CR35","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1007\/BF00441137","volume":"138","author":"H Stoss","year":"1982","unstructured":"Stoss H, Pesch H-J, Pontz B, Otten A, Spranger J: Wolcott-Rallison syndrome: diabetes mellitus and spondylo-epiphyseal dysplasia. Eur J Pediatr. 1982, 138: 120-129. 10.1007\/BF00441137.","journal-title":"Eur J Pediatr"},{"key":"192_CR36","first-page":"A215","volume":"50","author":"PM Nicolino","year":"1998","unstructured":"Nicolino PM, Dupin H, Macabeo V, Treppoz S, Chatelain PG: Wolcott-Rallison syndrome (diabetes mellitus and spondyloepiphyseal dysplasia): a plausible existence of a gene(s) important for the maturation of neonatal pancreatic beta cell function. Hormone Research. 1998, 50: A215-","journal-title":"Hormone Research"},{"key":"192_CR37","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1007\/s00125-002-0837-2","volume":"45","author":"D Iafusco","year":"2002","unstructured":"Iafusco D, Stazi MA, Cotichini R, Cotellessa M, Martinucci ME, Mazzella M, Cherubini V, Barbetti F, Martinetti M, Cerutti F, Prisco F: Permanent diabetes mellitus in the first year of life. Diabetologia. 2002, 45: 798-804. 10.1007\/s00125-002-0837-2.","journal-title":"Diabetologia"},{"key":"192_CR38","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.2337\/db06-0094","volume":"55","author":"EL Edghill","year":"2006","unstructured":"Edghill EL, Dix RJ, Flanagan SE, Bingley PJ, Hattersley AT, Ellard S, Gillespie KM: HLA genotyping supports a nonautoimmune etiology in patients diagnosed with diabetes under the age of 6 months. Diabetes. 2006, 55: 1895-1898. 10.2337\/db06-0094.","journal-title":"Diabetes"},{"key":"192_CR39","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/ng1097-138","volume":"17","author":"DA Stoffers","year":"1997","unstructured":"Stoffers DA, Ferrer J, Clarke WL, Habener JF: Early-onset type-II diabetes mellitus (MODY4) linked to IPF1. Nat Genet. 1997, 17: 138-139. 10.1038\/ng1097-138.","journal-title":"Nat Genet"},{"key":"192_CR40","doi-asserted-by":"publisher","first-page":"733","DOI":"10.2337\/db09-1284","volume":"59","author":"M Nicolino","year":"2009","unstructured":"Nicolino M, Clairborn K, Sen\u00e9e V, Boland A, Stoffers D, Julier C: A novel hypomorphic PDX1 mutation responsible for Permanent Neonatal Diabetes with subclinical exocrine deficiency. Diabetes. 2009, 59: 733-740. 10.2337\/db09-1284.","journal-title":"Diabetes"},{"key":"192_CR41","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1038\/ng1475","volume":"36","author":"GS Sellick","year":"2004","unstructured":"Sellick GS, Barker KT, Stolte-Dijkstra I, Fleischmann C, Coleman RJ, Garrett C, Gloyn AL, Edghill EL, Hattersley AT, Wellauer PK: Mutations in PTF1A cause pancreatic and cerebellar agenesis. Nat Genet. 2004, 36: 1301-1305. 10.1038\/ng1475.","journal-title":"Nat Genet"},{"key":"192_CR42","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/ng1802","volume":"38","author":"V Senee","year":"2006","unstructured":"Senee V, Chelala C, Duchatelet S, Feng D, Blanc H, Cossec JC, Charon C, Nicolino M, Boileau P, Cavener DR: Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism. Nat Genet. 2006, 38: 682-687. 10.1038\/ng1802.","journal-title":"Nat Genet"},{"key":"192_CR43","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/83707","volume":"27","author":"RS Wildin","year":"2001","unstructured":"Wildin RS, Ramsdell F, Peake J, Faravelli F, Casanova JL, Buist N, Levy-Lahad E, Mazzella M, Goulet O, Perroni L: X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet. 2001, 27: 18-20. 10.1038\/83707.","journal-title":"Nat Genet"},{"key":"192_CR44","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.2337\/db09-0685","volume":"58","author":"DA Cunha","year":"2009","unstructured":"Cunha DA, Ladriere L, Ortis F, Igoillo-Esteve M, Gurzov EN, Lupi R, Marchetti P, Eizirik DL, Cnop M: Glucagon-Like Peptide-1 Agonists Protect Pancreatic -Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB. Diabetes. 2009, 58: 2851-2862. 10.2337\/db09-0685.","journal-title":"Diabetes"},{"key":"192_CR45","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1007\/s00125-009-1270-6","volume":"52","author":"M Akiyama","year":"2009","unstructured":"Akiyama M, Hatanaka M, Ohta Y, Ueda K, Yanai A, Uehara Y, Tanabe K, Tsuru M, Miyazaki M, Saeki S: Increased insulin demand promotes while pioglitazone prevents pancreatic beta cell apoptosis in Wfs1 knockout mice. Diabetologia. 2009, 52: 653-663. 10.1007\/s00125-009-1270-6.","journal-title":"Diabetologia"}],"container-title":["Orphanet Journal of Rare Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1750-1172-5-29.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1750-1172-5-29\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1750-1172-5-29.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T21:47:27Z","timestamp":1548193647000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojrd.biomedcentral.com\/articles\/10.1186\/1750-1172-5-29"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,4]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["192"],"URL":"https:\/\/doi.org\/10.1186\/1750-1172-5-29","relation":{},"ISSN":["1750-1172"],"issn-type":[{"value":"1750-1172","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,4]]},"article-number":"29"}}