{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:52:42Z","timestamp":1794019962586,"version":"4.8.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orphanet J Rare Dis","Orphanet Journal of Rare Diseases"],"published-print":{"date-parts":[[2013]]},"DOI":"10.1186\/1750-1172-8-198","type":"journal-article","created":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T03:58:32Z","timestamp":1387857512000},"page":"198","source":"Crossref","is-referenced-by-count":113,"title":["Reconciling uncertainty of costs and outcomes with the need for access to orphan medicinal products: a comparative study of managed entry agreements across seven European countries"],"prefix":"10.1186","volume":"8","author":[{"given":"Thomas","family":"Morel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Arickx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustaf","family":"Befrits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Siviero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"van der Meijden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Entela","family":"Xoxi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Simoens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"10.1186\/1750-1172-8-198-B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2010.03877.x"},{"key":"10.1186\/1750-1172-8-198-B3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2009.03369.x"},{"key":"10.1186\/1750-1172-8-198-B4","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-012-1423-2"},{"key":"10.1186\/1750-1172-8-198-B5","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-124"},{"key":"10.1186\/1750-1172-8-198-B6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.769"},{"key":"10.1186\/1750-1172-8-198-B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2013.06.012"},{"key":"-","doi-asserted-by":"publisher","DOI":"10.1007\/s10551-009-0259-x"},{"key":"10.1186\/1750-1172-8-198-B9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031894"},{"key":"10.1186\/1750-1172-8-198-B10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.278129"},{"key":"10.1186\/1750-1172-8-198-B11","doi-asserted-by":"publisher","DOI":"10.2165\/11531880-000000000-00000"},{"key":"10.1186\/1750-1172-8-198-B12","doi-asserted-by":"publisher","DOI":"10.2165\/11590170-000000000-00000"},{"key":"10.1186\/1750-1172-8-198-B13","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c6471"},{"key":"10.1186\/1750-1172-8-198-B14","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-6-42"},{"key":"10.1186\/1750-1172-8-198-B15","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-6-62"},{"key":"10.1186\/1750-1172-8-198-B18","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-10-153"},{"key":"10.1186\/1750-1172-8-198-B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.healthpol.2010.02.005"},{"key":"10.1186\/1750-1172-8-198-B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2013.04.011"},{"key":"10.1186\/1750-1172-8-198-B21","doi-asserted-by":"publisher","DOI":"10.1017\/S0266462310001297"},{"key":"10.1186\/1750-1172-8-198-B22","doi-asserted-by":"publisher","DOI":"10.2165\/11530850-000000000-00000"},{"key":"10.1186\/1750-1172-8-198-B23","doi-asserted-by":"publisher","DOI":"10.2165\/11530820-000000000-00000"},{"key":"10.1186\/1750-1172-8-198-B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2011.12.013"},{"key":"-","doi-asserted-by":"publisher","DOI":"10.1179\/1757092112Z.0000000009"},{"key":"10.1186\/1750-1172-8-198-B41","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909859"},{"key":"10.1186\/1750-1172-8-198-B42","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-29"},{"key":"10.1186\/1750-1172-8-198-B43","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e5461"},{"key":"10.1186\/1750-1172-8-198-B44","doi-asserted-by":"publisher","DOI":"10.1007\/s40258-012-0004-y"},{"key":"10.1186\/1750-1172-8-198-B48","doi-asserted-by":"publisher","DOI":"10.1007\/s40258-012-0008-7"}],"container-title":["Orphanet Journal of Rare Diseases"],"original-title":[],"language":"en","deposited":{"date-parts":[[2016,5,16]],"date-time":"2016-05-16T17:13:52Z","timestamp":1463418832000},"score":1,"resource":{"primary":{"URL":"http:\/\/ojrd.biomedcentral.com\/articles\/10.1186\/1750-1172-8-198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013]]}},"alternative-id":["1750-1172-8-198"],"URL":"https:\/\/doi.org\/10.1186\/1750-1172-8-198","relation":{},"ISSN":["1750-1172"],"issn-type":[{"value":"1750-1172","type":"print"}],"subject":[],"published":{"date-parts":[[2013]]}}}