{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:26:44Z","timestamp":1777354004653,"version":"3.51.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infect Agents Cancer"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>An increasing incidence of malignant mesothelioma (MM) cases in patients with low levels of asbestos exposure suggests the interference of alternative cofactors. SV40 infection was detected, as co-morbidity factor, only in 22% of asbestos-MM patients from a North-Eastern Italy area. An additional mechanism of injury related to asbestos exposure in MM development has been recently associated to inflammatory responses, principally driven by interleukin (IL)-1 beta (\u00df) activated within the inflammasome complex.<\/jats:p>\n            <jats:p>\n              <jats:italic>NLRP3<\/jats:italic> inflammosome has been described as the intracellular sensor for asbestos able to induce inflammasome activation and IL-1\u00df secretion while <jats:italic>NLRP1<\/jats:italic> is expressed in lung epithelial cells and alveolar macrophages and contributes to the immune response and to survival\/apoptosis balance. This study proposes to evaluate the impact of known <jats:italic>NLRP3<\/jats:italic> and <jats:italic>NLRP1<\/jats:italic> polymorphisms in the individual susceptibility to asbestos-induced mesothelioma in subjects from a hyperendemic area for MM.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>134 Italian patients with diagnosis of mesothelioma due (MMAE, n=69) or not (MMAF, n=65) to asbestos, 256 healthy Italian blood donors and 101 Italian healthy subjects exposed to asbestos (HCAE) were genotyped for <jats:italic>NLRP1<\/jats:italic> (rs2670660 and rs12150220) and <jats:italic>NLRP3<\/jats:italic> (rs35829419 and rs10754558) polymorphisms.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>While NLRP3 SNPs were not associated to mesothelioma, the NLRP1 rs12150220 allele T was significantly more frequent in MMAE (0.55) than in HCAE (0.41) (p=0.011; OR=1.79) suggesting a predisponent effect of this allele on the development of mesothelioma. This effect was amplified when the <jats:italic>NLRP1<\/jats:italic> rs2670660 allele was combined with the <jats:italic>NLRP1<\/jats:italic> rs12150220 allele (p=0.004; OR=0.52).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Although <jats:italic>NLRP3<\/jats:italic> SNPs was not involved in mesothelioma predisposition, these data proposed <jats:italic>NLRP1<\/jats:italic> as a novel factor possibly involved in the development of mesothelioma.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1750-9378-7-25","type":"journal-article","created":{"date-parts":[[2012,10,3]],"date-time":"2012-10-03T01:28:20Z","timestamp":1349227700000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["NLRP1 polymorphisms in patients with asbestos-associated mesothelioma"],"prefix":"10.1186","volume":"7","author":[{"given":"Martina","family":"Girardelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iva","family":"Maestri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa R","family":"Rinaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Tognon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renzo","family":"Boldorini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Bovenzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Crovella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manola","family":"Comar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,10,2]]},"reference":[{"issue":"2-3","key":"404_CR1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s11864-008-0067-z","volume":"9","author":"H Yang","year":"2008","unstructured":"Yang H, Testa JR, Carbone M: Mesothelioma epidemiology, carcinogenesis, and pathogenesis. 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