{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:25:55Z","timestamp":1759206355489},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Source Code Biol Med"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Randomized, prospective trials involving multi-institutional collaboration have become a central part of clinical and translational research. However, data management and coordination of multi-center studies is a complex process that involves developing systems for data collection and quality control, tracking data queries and resolutions, as well as developing communication procedures. We describe DADOS-Prospective, an open-source Web-based application for collecting and managing prospective data on human subjects for clinical and translational trials. DADOS-Prospective not only permits users to create new clinical research forms (CRF) and supports electronic signatures, but also offers the advantage of containing, in a single environment, raw research data in downloadable spreadsheet format, source documentation and regulatory files stored in PDF format, and audit trails.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Feedback from formal and field usability tests was used to guide the design and development of DADOS-Prospective. To date, DADOS-Prospective has been implemented in five prospective clinical studies at our institution. Four of these studies are still in the CRF creation phase and one study has been entirely launched.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>DADOS-Prospective has significant advantages over existing Web-based data collecting programs. At our institution, it has been demonstrated to be an efficient tool for prospective clinical studies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1751-0473-1-7","type":"journal-article","created":{"date-parts":[[2006,11,14]],"date-time":"2006-11-14T07:18:21Z","timestamp":1163488701000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["DADOS-Prospective: an open source application for Web-based prospective data collection"],"prefix":"10.1186","volume":"1","author":[{"given":"Lam","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Harker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrique","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"McCready","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreia","family":"Menezes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danny O","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Pietrobon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,11,13]]},"reference":[{"issue":"5","key":"7_CR1","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1097\/01.ju.0000120221.39184.3c","volume":"171","author":"CD Lallas","year":"2004","unstructured":"Lallas CD, Preminger GM, Pearle MS, Leveillee RJ, Lingeman JE, Schwope JP, Pietrow PK, Auge BK: Internet based multi-institutional clinical research: a convenient and secure option. J Urol. 2004, 171 (5): 1880-1885. 10.1097\/01.ju.0000120221.39184.3c.","journal-title":"J Urol"},{"issue":"2","key":"7_CR2","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.cct.2004.11.017","volume":"26","author":"C Lopez-Carrero","year":"2005","unstructured":"Lopez-Carrero C, Arriaza E, Bolanos E, Ciudad A, Municio M, Ramos J, Hesen W: Internet in clinical research based on a pilot experience. Contemp Clin Trials. 2005, 26 (2): 234-243. 10.1016\/j.cct.2004.11.017.","journal-title":"Contemp Clin Trials"},{"key":"7_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1742-5573-3-1","volume":"3","author":"CJ Cooper","year":"2006","unstructured":"Cooper CJ, Cooper SP, Del Junco DJ, Shipp EM, Whitworth R, Cooper SR: Web-based data collection: detailed methods of a questionnaire and data gathering tool. 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