{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T09:24:56Z","timestamp":1697448296214},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Syst Biol"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The completion of several genome projects showed that most genes have not yet been characterized, especially in multicellular organisms. Although most genes have unknown functions, a large collection of data is available describing their transcriptional activities under many different experimental conditions. In many cases, the coregulatation of a set of genes across a set of conditions can be used to infer roles for genes of unknown function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We developed a search engine, the Multiple-Species Gene Recommender (MSGR), which scans gene expression datasets from multiple organisms to identify genes that participate in a genetic pathway. The MSGR takes a query consisting of a list of genes that function together in a genetic pathway from one of six organisms:<jats:italic>Homo sapiens<\/jats:italic>,<jats:italic>Drosophila melanogaster<\/jats:italic>,<jats:italic>Caenorhabditis elegans<\/jats:italic>,<jats:italic>Saccharomyces cerevisiae<\/jats:italic>,<jats:italic>Arabidopsis thaliana<\/jats:italic>, and<jats:italic>Helicobacter pylori<\/jats:italic>. Using a probabilistic method to merge searches, the MSGR identifies genes that are significantly coregulated with the query genes in one or more of those organisms. The MSGR achieves its highest accuracy for many human pathways when searches are combined across species. We describe specific examples in which new genes were identified to be involved in a neuromuscular signaling pathway and a cell-adhesion pathway.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The search engine can scan large collections of gene expression data for new genes that are significantly coregulated with a pathway of interest. By integrating searches across organisms, the MSGR can identify pathway members whose coregulation is either ancient or newly evolved.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1752-0509-1-20","type":"journal-article","created":{"date-parts":[[2007,5,4]],"date-time":"2007-05-04T18:59:11Z","timestamp":1178305151000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A search engine to identify pathway genes from expression data on multiple organisms"],"prefix":"10.1186","volume":"1","author":[{"given":"Chunnuan","family":"Chen","sequence":"first","affiliation":[]},{"given":"Matthew T","family":"Weirauch","sequence":"additional","affiliation":[]},{"given":"Corey C","family":"Powell","sequence":"additional","affiliation":[]},{"given":"Alexander C","family":"Zambon","sequence":"additional","affiliation":[]},{"given":"Joshua M","family":"Stuart","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2007,5,4]]},"reference":[{"issue":"5235","key":"20_CR1","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1126\/science.270.5235.467","volume":"270","author":"M Schena","year":"1995","unstructured":"Schena M, Shalon D, Davis RW, Brown PO: Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science. 1995, 270 (5235): 467-470. 10.1126\/science.270.5235.467","journal-title":"Science"},{"issue":"25","key":"20_CR2","doi-asserted-by":"publisher","first-page":"14863","DOI":"10.1073\/pnas.95.25.14863","volume":"95","author":"MB Eisen","year":"1998","unstructured":"Eisen MB, Spellman PT, Brown PO, Botstein D: Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA. 1998, 95 (25): 14863-14868. 10.1073\/pnas.95.25.14863","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5537","key":"20_CR3","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1126\/science.1061603","volume":"293","author":"SK Kim","year":"2001","unstructured":"Kim SK, Lund J, Kiraly M, Duke K, Jiang M, Stuart JM, Eizinger A, Wylie BN, Davidson GS: A gene expression map for Caenorhabditis elegans. Science. 2001, 293 (5537): 2087-2092. 10.1126\/science.1061603","journal-title":"Science"},{"key":"20_CR4","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1093\/bioinformatics\/btg1078","volume":"19","author":"Q Sheng","year":"2003","unstructured":"Sheng Q, Moreau Y, De Moor B: Biclustering microarray data by Gibbs sampling. Bioinformatics. 2003, 19: 196-205. 10.1093\/bioinformatics\/btg1078.","journal-title":"Bioinformatics"},{"issue":"6","key":"20_CR5","doi-asserted-by":"publisher","first-page":"2907","DOI":"10.1073\/pnas.96.6.2907","volume":"96","author":"P Tamayo","year":"1999","unstructured":"Tamayo P, Slonim D, Mesirov J, Zhu Q, Kitareewan S, Dmitrovsky E, Lander ES, Golub TR: Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation. Proc Natl Acad Sci USA. 1999, 96 (6): 2907-2912. 10.1073\/pnas.96.6.2907","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"20_CR6","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/ng941","volume":"31","author":"J Ihmels","year":"2002","unstructured":"Ihmels J, Friedlander G, Bergmann S, Sarig O, Ziv Y, Barkai N: Revealing modular organization in the yeast transcriptional network. Nat Genet. 2002, 31 (4): 370-377.","journal-title":"Nat Genet"},{"issue":"8","key":"20_CR7","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1101\/gr.1125403","volume":"13","author":"AB Owen","year":"2003","unstructured":"Owen AB, Stuart J, Mach K, Villeneuve AM, Kim S: A gene recommender algorithm to identify coexpressed genes in C. elegans. Genome Res. 2003, 13 (8): 1828-1837.","journal-title":"Genome Res"},{"key":"20_CR8","first-page":"61","volume":"12","author":"LC Lazzeroni","year":"2002","unstructured":"Lazzeroni LC, Owen AB: Plaid models for gene expression data. Statistica Sinica. 2002, 12: 61-86.","journal-title":"Statistica Sinica"},{"key":"20_CR9","first-page":"93","volume":"8","author":"Y Cheng","year":"2000","unstructured":"Cheng Y, Church GM: Biclustering of expression data. Proc Int Conf Intell Syst Mol Biol. 2000, 8: 93-103.","journal-title":"Proc Int Conf Intell Syst Mol Biol"},{"issue":"4","key":"20_CR10","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1101\/gr.648603","volume":"13","author":"Y Kluger","year":"2003","unstructured":"Kluger Y, Basri R, Chang JT, Gerstein M: Spectral biclustering of microarray data: coclustering genes and conditions. Genome Res. 2003, 13 (4): 703-716. 10.1101\/gr.648603","journal-title":"Genome Res"},{"issue":"Suppl 1","key":"20_CR11","doi-asserted-by":"publisher","first-page":"S136","DOI":"10.1093\/bioinformatics\/18.suppl_1.S136","volume":"18","author":"A Tanay","year":"2002","unstructured":"Tanay A, Sharan R, Shamir R: Discovering statistically significant biclusters in gene expression data. Bioinformatics. 2002, 18 (Suppl 1): S136-144.","journal-title":"Bioinformatics"},{"issue":"1","key":"20_CR12","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/ng0502-19","volume":"31","author":"KD Dahlquist","year":"2002","unstructured":"Dahlquist KD, Salomonis N, Vranizan K, Lawlor SC, Conklin BR: GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways. Nat Genet. 2002, 31 (1): 19-20. 10.1038\/ng0502-19","journal-title":"Nat Genet"},{"issue":"1","key":"20_CR13","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT: Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 2000, 25 (1): 25-29. 10.1038\/75556","journal-title":"Nat Genet"},{"issue":"1","key":"20_CR14","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/nar\/27.1.29","volume":"27","author":"H Ogata","year":"1999","unstructured":"Ogata H, Goto S, Sato K, Fujibuchi W, Bono H, Kanehisa M: KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res. 1999, 27 (1): 29-34. 10.1093\/nar\/27.1.29","journal-title":"Nucleic Acids Res"},{"issue":"13","key":"20_CR15","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1096\/fasebj.5.13.1916105","volume":"5","author":"M van der Rest","year":"1991","unstructured":"van der Rest M, Garrone R: Collagen family of proteins. Faseb J. 1991, 5 (13): 2814-2823.","journal-title":"Faseb J"},{"issue":"3","key":"20_CR16","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.conb.2005.05.003","volume":"15","author":"T Collin","year":"2005","unstructured":"Collin T, Marty A, Llano I: Presynaptic calcium stores and synaptic transmission. Curr Opin Neurobiol. 2005, 15 (3): 275-281. 10.1016\/j.conb.2005.05.003","journal-title":"Curr Opin Neurobiol"},{"issue":"5","key":"20_CR17","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1080\/10409239891204251","volume":"33","author":"A D'Andrea","year":"1998","unstructured":"D'Andrea A, Pellman D: Deubiquitinating enzymes: a new class of biological regulators. Crit Rev Biochem Mol Biol. 1998, 33 (5): 337-352. 10.1080\/10409239891204251","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"20_CR18","volume-title":"J Biol Chem","author":"R Zhou","year":"2005","unstructured":"Zhou R, Silverman N, Hong M, Liao DS, Chung Y, Chen ZJ, Maniatis T: The role of ubiquitnation in Drosophila innate immunity. J Biol Chem. 2005"},{"issue":"2","key":"20_CR19","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.mcn.2004.01.004","volume":"26","author":"J Aruga","year":"2004","unstructured":"Aruga J: The role of Zic genes in neural development. Mol Cell Neurosci. 2004, 26 (2): 205-221. 10.1016\/j.mcn.2004.01.004","journal-title":"Mol Cell Neurosci"},{"issue":"1","key":"20_CR20","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/ana.10434","volume":"53","author":"L Bataller","year":"2003","unstructured":"Bataller L, Wade DF, Graus F, Rosenfeld MR, Dalmau J: The MAZ protein is an autoantigen of Hodgkin's disease and paraneoplastic cerebellar dysfunction. Ann Neurol. 2003, 53 (1): 123-127. 10.1002\/ana.10434","journal-title":"Ann Neurol"},{"issue":"6","key":"20_CR21","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/0896-6273(93)90231-F","volume":"11","author":"H Fujii","year":"1993","unstructured":"Fujii H, Hamada H: A CNS-specific POU transcription factor, Brn-2, is required for establishing mammalian neural cell lineages. Neuron. 1993, 11 (6): 1197-1206. 10.1016\/0896-6273(93)90231-F","journal-title":"Neuron"},{"issue":"1\u20132","key":"20_CR22","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0165-3806(98)00192-8","volume":"113","author":"K Hagino-Yamagishi","year":"1999","unstructured":"Hagino-Yamagishi K, Minamikawa-Tachino R, Ichikawa M, Yazaki K: Expression of brain-2 in the developing olfactory bulb. Brain Res Dev Brain Res. 1999, 113 (1\u20132): 133-137. 10.1016\/S0165-3806(98)00192-8","journal-title":"Brain Res Dev Brain Res"},{"issue":"1\u20132","key":"20_CR23","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/S0006-8993(96)01472-2","volume":"752","author":"K Hagino-Yamagishi","year":"1997","unstructured":"Hagino-Yamagishi K, Saijoh Y, Ikeda M, Ichikawa M, Minamikawa-Tachino R, Hamada H: Predominant expression of Brn-2 in the postmitotic neurons of the developing mouse neocortex. Brain Res. 1997, 752 (1\u20132): 261-268. 10.1016\/S0006-8993(96)01472-2","journal-title":"Brain Res"},{"issue":"6","key":"20_CR24","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/jlb.57.6.837","volume":"57","author":"GM Roberts","year":"1995","unstructured":"Roberts GM, Davies EV, Hallett MB: Slow Ca2+ waves in large myeloid cells as a result of a diffusible cytosolic factor. J Leukoc Biol. 1995, 57 (6): 837-841.","journal-title":"J Leukoc Biol"},{"issue":"6","key":"20_CR25","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1083\/jcb.150.6.1435","volume":"150","author":"AF Fomina","year":"2000","unstructured":"Fomina AF, Fanger CM, Kozak JA, Cahalan MD: Single channel properties and regulated expression of Ca(2+) release-activated Ca(2+) (CRAC) channels in human T cells. J Cell Biol. 2000, 150 (6): 1435-1444. 10.1083\/jcb.150.6.1435","journal-title":"J Cell Biol"},{"issue":"Pt 3","key":"20_CR26","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1042\/bj20030507","volume":"374","author":"PA Bignone","year":"2003","unstructured":"Bignone PA, Baines AJ: Spectrin alpha II and beta II isoforms interact with high affinity at the tetramerization site. Biochem J. 2003, 374 (Pt 3): 613-624. 10.1042\/BJ20030507","journal-title":"Biochem J"},{"issue":"3","key":"20_CR27","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0197-4580(02)00224-5","volume":"24","author":"CD Link","year":"2003","unstructured":"Link CD, Taft A, Kapulkin V, Duke K, Kim S, Fei Q, Wood DE, Sahagan BG: Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model. Neurobiol Aging. 2003, 24 (3): 397-413. 10.1016\/S0197-4580(02)00224-5","journal-title":"Neurobiol Aging"},{"issue":"6","key":"20_CR28","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1002\/ana.10767","volume":"54","author":"D Selcen","year":"2003","unstructured":"Selcen D, Engel AG: Myofibrillar myopathy caused by novel dominant negative alpha B-crystallin mutations. Ann Neurol. 2003, 54 (6): 804-810. 10.1002\/ana.10767","journal-title":"Ann Neurol"},{"issue":"3","key":"20_CR29","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1530\/eje.1.01872","volume":"152","author":"C Punyadeera","year":"2005","unstructured":"Punyadeera C, Zorenc AH, Koopman R, McAinch AJ, Smit E, Manders R, Keizer HA, Cameron-Smith D, van Loon LJ: The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle. Eur J Endocrinol. 2005, 152 (3): 427-436. 10.1530\/eje.1.01872","journal-title":"Eur J Endocrinol"},{"issue":"19","key":"20_CR30","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1093\/hmg\/ddi321","volume":"14","author":"M Ralser","year":"2005","unstructured":"Ralser M, Nonhoff U, Albrecht M, Lengauer T, Wanker EE, Lehrach H, Krobitsch S: Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways. Hum Mol Genet. 2005, 14 (19): 2893-2909. 10.1093\/hmg\/ddi321","journal-title":"Hum Mol Genet"},{"issue":"3","key":"20_CR31","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.orthres.2003.10.007","volume":"22","author":"T Nakazawa","year":"2004","unstructured":"Nakazawa T, Nakajima A, Seki N, Okawa A, Kato M, Moriya H, Amizuka N, Einhorn TA, Yamazaki M: Gene expression of periostin in the early stage of fracture healing detected by cDNA microarray analysis. J Orthop Res. 2004, 22 (3): 520-525. 10.1016\/j.orthres.2003.10.007","journal-title":"J Orthop Res"},{"issue":"12","key":"20_CR32","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1515\/BC.2002.208","volume":"383","author":"D Alexander","year":"2002","unstructured":"Alexander D, Judex M, Meyringer R, Weis-Klemm M, Gay S, Muller-Ladner U, Aicher WK: Transcription factor Egr-1 activates collagen expression in immortalized fibroblasts or fibrosarcoma cells. Biol Chem. 2002, 383 (12): 1845-1853. 10.1515\/BC.2002.208","journal-title":"Biol Chem"},{"issue":"8","key":"20_CR33","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1101\/gr.3715005","volume":"15","author":"A Siepel","year":"2005","unstructured":"Siepel A, Bejerano G, Pedersen JS, Hinrichs AS, Hou M, Rosenbloom K, Clawson H, Spieth J, Hillier LW, Richards S: Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. Genome Res. 2005, 15 (8): 1034-1050. 10.1101\/gr.3715005","journal-title":"Genome Res"},{"key":"20_CR34","unstructured":"http:\/\/www.biocarta.com\/"},{"issue":"1","key":"20_CR35","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/35048107","volume":"2","author":"AJ Walhout","year":"2001","unstructured":"Walhout AJ, Vidal M: Protein interaction maps for model organisms. Nat Rev Mol Cell Biol. 2001, 2 (1): 55-62. 10.1038\/35048107","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"20_CR36","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/S1046-2023(03)00050-1","volume":"30","author":"RS Kamath","year":"2003","unstructured":"Kamath RS, Ahringer J: Genome-wide RNAi screening in Caenorhabditis elegans. Methods. 2003, 30 (4): 313-321. 10.1016\/S1046-2023(03)00050-1","journal-title":"Methods"},{"issue":"5","key":"20_CR37","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1006\/jmbi.2000.5197","volume":"314","author":"M Remm","year":"2001","unstructured":"Remm M, Storm CE, Sonnhammer EL: Automatic clustering of orthologs and in-paralogs from pairwise species comparisons. J Mol Biol. 2001, 314 (5): 1041-1052. 10.1006\/jmbi.2000.5197","journal-title":"J Mol Biol"},{"issue":"9","key":"20_CR38","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.1101\/gr.1224503","volume":"13","author":"L Li","year":"2003","unstructured":"Li L, Stoeckert CJ, Roos DS: OrthoMCL: identification of ortholog groups for eukaryotic genomes. Genome Res. 2003, 13 (9): 2178-2189. 10.1101\/gr.1224503","journal-title":"Genome Res"},{"key":"20_CR39","unstructured":"http:\/\/sysbio.cse.ucsc.edu\/msgr"},{"issue":"5643","key":"20_CR40","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1126\/science.1087447","volume":"302","author":"JM Stuart","year":"2003","unstructured":"Stuart JM, Segal E, Koller D, Kim SK: A gene-coexpression network for global discovery of conserved genetic modules. Science. 2003, 302 (5643): 249-255. 10.1126\/science.1087447","journal-title":"Science"},{"issue":"Database","key":"20_CR41","doi-asserted-by":"publisher","first-page":"D54","DOI":"10.1093\/nar\/gki031","volume":"33","author":"D Maglott","year":"2005","unstructured":"Maglott D, Ostell J, Pruitt KD, Tatusova T: Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005, 33 (Database): D54-58. 10.1093\/nar\/gki031","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"20_CR42","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","volume":"215","author":"SF Altschul","year":"1990","unstructured":"Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ: Basic local alignment search tool. J Mol Biol. 1990, 215 (3): 403-410.","journal-title":"J Mol Biol"},{"issue":"1","key":"20_CR43","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1093\/nar\/24.1.238","volume":"24","author":"E Wingender","year":"1996","unstructured":"Wingender E, Dietze P, Karas H, Knuppel R: TRANSFAC: a database on transcription factors and their DNA binding sites. Nucleic Acids Res. 1996, 24 (1): 238-241. 10.1093\/nar\/24.1.238","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"20_CR44","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1093\/nar\/gkg129","volume":"31","author":"D Karolchik","year":"2003","unstructured":"Karolchik D, Baertsch R, Diekhans M, Furey TS, Hinrichs A, Lu YT, Roskin KM, Schwartz M, Sugnet CW, Thomas DJ: The UCSC Genome Browser Database. Nucleic Acids Res. 2003, 31 (1): 51-54. 10.1093\/nar\/gkg129","journal-title":"Nucleic Acids Res"},{"issue":"6822","key":"20_CR45","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/35057062","volume":"409","author":"ES Lander","year":"2001","unstructured":"Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W: Initial sequencing and analysis of the human genome. Nature. 2001, 409 (6822): 860-921. 10.1038\/35057062","journal-title":"Nature"},{"issue":"13","key":"20_CR46","doi-asserted-by":"publisher","first-page":"3518","DOI":"10.1093\/nar\/gkg579","volume":"31","author":"S Schwartz","year":"2003","unstructured":"Schwartz S, Elnitski L, Li M, Weirauch M, Riemer C, Smit A, Green ED, Hardison RC, Miller W: MultiPipMaker and supporting tools: Alignments and analysis of multiple genomic DNA sequences. Nucleic Acids Res. 2003, 31 (13): 3518-3524. 10.1093\/nar\/gkg579","journal-title":"Nucleic Acids Res"},{"issue":"5696","key":"20_CR47","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1126\/science.1105136","volume":"306","author":"TE Consortium","year":"2004","unstructured":"Consortium TE: The ENCODE (ENCyclopedia Of DNA Elements) Project. Science. 2004, 306 (5696): 636-640. 10.1126\/science.1105136","journal-title":"Science"}],"container-title":["BMC Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-0509-1-20.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T18:34:17Z","timestamp":1683830057000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsystbiol.biomedcentral.com\/articles\/10.1186\/1752-0509-1-20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,4]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["20"],"URL":"https:\/\/doi.org\/10.1186\/1752-0509-1-20","relation":{},"ISSN":["1752-0509"],"issn-type":[{"value":"1752-0509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,4]]},"assertion":[{"value":"18 January 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2007","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2007","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"20"}}