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Elucidation of this dimerisation network is vital in order to understand the complex dynamics and potential cross-talk involved.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Phylogeny, protein-protein interactions, protein-DNA interactions and gene expression data have been integrated to provide a comprehensive and up-to-date description of the topology and properties of the nuclear receptor interaction network in humans. We discriminate between DNA-binding and non-DNA-binding dimers, and provide a comprehensive interaction map, that identifies potential cross-talk between the various pathways of nuclear receptors.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>We infer that the topology of this network is hub-based, and much more connected than previously thought. The hub-based topology of the network and the wide tissue expression pattern of NRs create a highly competitive environment for the common heterodimerising partners. Furthermore, a significant number of negative feedback loops is present, with the hub protein SHP [NR0B2] playing a major role. We also compare the evolution, topology and properties of the nuclear receptor network with the hub-based dimerisation network of the bHLH transcription factors in order to identify both unique themes and ubiquitous properties in gene regulation. In terms of methodology, we conclude that such a comprehensive picture can only be assembled by semi-automated text-mining, manual curation and integration of data from various sources.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-0509-1-34","type":"journal-article","created":{"date-parts":[[2007,8,2]],"date-time":"2007-08-02T18:16:58Z","timestamp":1186078618000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["A protein interaction atlas for the nuclear receptors: properties and quality of a hub-based dimerisation network"],"prefix":"10.1186","volume":"1","author":[{"given":"Gregory D","family":"Amoutzias","sequence":"first","affiliation":[]},{"given":"Elgar E","family":"Pichler","sequence":"additional","affiliation":[]},{"given":"Nina","family":"Mian","sequence":"additional","affiliation":[]},{"given":"David","family":"De Graaf","sequence":"additional","affiliation":[]},{"given":"Anastasia","family":"Imsiridou","sequence":"additional","affiliation":[]},{"given":"Marc","family":"Robinson-Rechavi","sequence":"additional","affiliation":[]},{"given":"Erich","family":"Bornberg-Bauer","sequence":"additional","affiliation":[]},{"given":"David L","family":"Robertson","sequence":"additional","affiliation":[]},{"given":"Stephen G","family":"Oliver","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2007,7,31]]},"reference":[{"issue":"Pt 4","key":"34_CR1","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1242\/jcs.00247","volume":"116","author":"M Robinson-Rechavi","year":"2003","unstructured":"Robinson-Rechavi M, Escriva Garcia H, Laudet V: The nuclear receptor superfamily. 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