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We investigated the metabolic network between wild-type and 2 mutant (<jats:italic>methionine-over accumulation 1<\/jats:italic> [<jats:italic>mto1<\/jats:italic>] and <jats:italic>transparent testa4<\/jats:italic> [<jats:italic>tt4<\/jats:italic>]) plants regarding the alteration of metabolite accumulation in <jats:italic>Arabidopsis thaliana<\/jats:italic>.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>In the GC-TOF\/MS analysis, we acquired quantitative information regarding over 170 metabolites, which has been analyzed by a novel score (ZMC, z-score of metabolite correlation) describing a characteristic metabolite in terms of correlation. Although the 2 mutants revealed no apparent morphological abnormalities, the overall correlation values in <jats:italic>mto1<\/jats:italic> were much lower than those of the wild-type and <jats:italic>tt4<\/jats:italic> plants, indicating the loss of overall network stability due to the uncontrolled accumulation of methionine. In the <jats:italic>tt4<\/jats:italic> mutant, a new correlation between malate and sinapate was observed although the levels of malate, sinapate, and sinapoylmalate remain unchanged, suggesting an adaptive reconfiguration of the network. Gene-expression correlations presumably responsible for these metabolic networks were determined using the metabolite correlations as clues.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Two Arabidopsis mutants, <jats:italic>mto1<\/jats:italic> and <jats:italic>tt4<\/jats:italic>, exhibited the following changes in entire metabolome networks: the overall loss of metabolic stability (<jats:italic>mto1<\/jats:italic>) or the generation of a metabolic network of a backup pathway for the lost physiological functions (<jats:italic>tt4<\/jats:italic>). The expansion of metabolite correlation to gene-expression correlation provides detailed insights into the systemic understanding of the plant cellular process regarding metabolome and transcriptome.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-0509-1-53","type":"journal-article","created":{"date-parts":[[2007,11,21]],"date-time":"2007-11-21T07:13:15Z","timestamp":1195629195000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Unbiased characterization of genotype-dependent metabolic regulations by metabolomic approach in Arabidopsis thaliana"],"prefix":"10.1186","volume":"1","author":[{"given":"Miyako","family":"Kusano","sequence":"first","affiliation":[]},{"given":"Atsushi","family":"Fukushima","sequence":"additional","affiliation":[]},{"given":"Masanori","family":"Arita","sequence":"additional","affiliation":[]},{"given":"P\u00e4r","family":"Jonsson","sequence":"additional","affiliation":[]},{"given":"Thomas","family":"Moritz","sequence":"additional","affiliation":[]},{"given":"Makoto","family":"Kobayashi","sequence":"additional","affiliation":[]},{"given":"Naomi","family":"Hayashi","sequence":"additional","affiliation":[]},{"given":"Takayuki","family":"Tohge","sequence":"additional","affiliation":[]},{"given":"Kazuki","family":"Saito","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2007,11,21]]},"reference":[{"key":"53_CR1","volume-title":"Springer Verlag, Heidelberg.","author":"K Saito","year":"2006","unstructured":"Saito K, Dixon R, Willmitzer , : Biotechnology in Agriculture and Forestry 57 Plant Metabolomics. 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