{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:29:27Z","timestamp":1760707767555},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2007,1,9]],"date-time":"2007-01-09T00:00:00Z","timestamp":1168300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Syst Biol"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1186\/1752-0509-1-7","type":"journal-article","created":{"date-parts":[[2007,1,26]],"date-time":"2007-01-26T20:35:19Z","timestamp":1169843719000},"source":"Crossref","is-referenced-by-count":32,"title":["Synthetic tetracycline-inducible regulatory networks: computer-aided design of dynamic phenotypes"],"prefix":"10.1186","volume":"1","author":[{"given":"Vassilios","family":"Sotiropoulos","sequence":"first","affiliation":[]},{"given":"Yiannis N","family":"Kaznessis","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2007,1,9]]},"reference":[{"issue":"8","key":"7_CR1","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/sj.gt.3302251","volume":"11","author":"C Toniatti","year":"2004","unstructured":"Toniatti C, Bujard H, Cortese R, Ciliberto G: Gene therapy progress and prospects: transcription regulatory systems. Gene Ther. 2004, 11 (8): 649-657. 10.1038\/sj.gt.3302251","journal-title":"Gene Ther"},{"issue":"9","key":"7_CR2","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1172\/JCI10027","volume":"105","author":"S Agha-Mohammadi","year":"2000","unstructured":"Agha-Mohammadi S, Lotze MT: Regulatable systems: applications in gene therapy and replicating viruses. J Clin Invest. 2000, 105 (9): 1177-1183.","journal-title":"J Clin Invest"},{"issue":"2","key":"7_CR3","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.ymthe.2005.03.022","volume":"12","author":"S Goverdhana","year":"2005","unstructured":"Goverdhana S, Puntel M, Xiong W, Zirger JM, Barcia C, Curtin JF, Soffer EB, Mondkar S, King GD, Hu J, Sciascia SA, Candolfi M, Greengold DS, Lowenstein PR, Castro MG: Regulatable gene expression systems for gene therapy applications: progress and future challenges. Mol Ther. 2005, 12 (2): 189-211. 10.1016\/j.ymthe.2005.03.022","journal-title":"Mol Ther"},{"issue":"15","key":"7_CR4","doi-asserted-by":"publisher","first-page":"3109","DOI":"10.1046\/j.1432-1033.2003.03694.x","volume":"270","author":"C Berens","year":"2003","unstructured":"Berens C, Hillen W: Gene regulation by tetracyclines. Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes. Eur J Biochem. 2003, 270 (15): 3109-3121. 10.1046\/j.1432-1033.2003.03694.x","journal-title":"Eur J Biochem"},{"key":"7_CR5","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/S0076-6879(00)27292-3","volume":"327","author":"U Baron","year":"2000","unstructured":"Baron U, Bujard H: Tet repressor-based system for regulated gene expression in eukaryotic cells: principles and advances. Methods Enzymol. 2000, 327: 401-421.","journal-title":"Methods Enzymol"},{"issue":"14","key":"7_CR6","doi-asserted-by":"publisher","first-page":"2723","DOI":"10.1093\/nar\/25.14.2723","volume":"25","author":"U Baron","year":"1997","unstructured":"Baron U, Gossen M, Bujard H: Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential. Nucleic Acids Res. 1997, 25 (14): 2723-2729. 10.1093\/nar\/25.14.2723","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"7_CR7","doi-asserted-by":"publisher","first-page":"5547","DOI":"10.1073\/pnas.89.12.5547","volume":"89","author":"M Gossen","year":"1992","unstructured":"Gossen M, Bujard H: Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci U S A. 1992, 89 (12): 5547-5551. 10.1073\/pnas.89.12.5547","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5218","key":"7_CR8","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1126\/science.7792603","volume":"268","author":"M Gossen","year":"1995","unstructured":"Gossen M, Freundlieb S, Bender G, Muller G, Hillen W, Bujard H: Transcriptional activation by tetracyclines in mammalian cells. Science. 1995, 268 (5218): 1766-1769. 10.1126\/science.7792603","journal-title":"Science"},{"issue":"14","key":"7_CR9","doi-asserted-by":"publisher","first-page":"7963","DOI":"10.1073\/pnas.130192197","volume":"97","author":"S Urlinger","year":"2000","unstructured":"Urlinger S, Baron U, Thellmann M, Hasan MT, Bujard H, Hillen W: Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity. Proc Natl Acad Sci U S A. 2000, 97 (14): 7963-7968. 10.1073\/pnas.130192197","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"7_CR10","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/sj.gt.3301889","volume":"10","author":"JK Koponen","year":"2003","unstructured":"Koponen JK, Kankkonen H, Kannasto J, Wirth T, Hillen W, Bujard H, Yla-Herttuala S: Doxycycline-regulated lentiviral vector system with a novel reverse transactivator rtTA2S-M2 shows a tight control of gene expression in vitro and in vivo. Gene Ther. 2003, 10 (6): 459-466. 10.1038\/sj.gt.3301889","journal-title":"Gene Ther"},{"issue":"4","key":"7_CR11","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1128\/MCB.15.4.1907","volume":"15","author":"U Deuschle","year":"1995","unstructured":"Deuschle U, Meyer WK, Thiesen HJ: Tetracycline-reversible silencing of eukaryotic promoters. Mol Cell Biol. 1995, 15 (4): 1907-1914.","journal-title":"Mol Cell Biol"},{"issue":"1","key":"7_CR12","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/(SICI)1521-2254(199901\/02)1:1<4::AID-JGM4>3.0.CO;2-Y","volume":"1","author":"S Freundlieb","year":"1999","unstructured":"Freundlieb S, Schirra-Muller C, Bujard H: A tetracycline controlled activation\/repression system with increased potential for gene transfer into mammalian cells. J Gene Med. 1999, 1 (1): 4-12. 10.1002\/(SICI)1521-2254(199901\/02)1:1<4::AID-JGM4>3.0.CO;2-Y","journal-title":"J Gene Med"},{"issue":"1-2","key":"7_CR13","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0378-1119(99)00045-1","volume":"229","author":"CA Strathdee","year":"1999","unstructured":"Strathdee CA, McLeod MR, Hall JR: Efficient control of tetracycline-responsive gene expression from an autoregulated bi-directional expression vector. Gene. 1999, 229 (1-2): 21-29. 10.1016\/S0378-1119(99)00045-1","journal-title":"Gene"},{"issue":"10","key":"7_CR14","doi-asserted-by":"crossref","first-page":"8358","DOI":"10.1128\/JVI.72.10.8358-8361.1998","volume":"72","author":"M Molin","year":"1998","unstructured":"Molin M, Shoshan MC, Ohman-Forslund K, Linder S, Akusjarvi G: Two novel adenovirus vector systems permitting regulated protein expression in gene transfer experiments. J Virol. 1998, 72 (10): 8358-8361.","journal-title":"J Virol"},{"issue":"48","key":"7_CR15","doi-asserted-by":"publisher","first-page":"45168","DOI":"10.1074\/jbc.M106924200","volume":"276","author":"W Jiang","year":"2001","unstructured":"Jiang W, Zhou L, Breyer B, Feng T, Cheng H, Haydon R, Ishikawa A, He TC: Tetracycline-regulated gene expression mediated by a novel chimeric repressor that recruits histone deacetylases in mammalian cells. J Biol Chem. 2001, 276 (48): 45168-45174. 10.1074\/jbc.M106924200","journal-title":"J Biol Chem"},{"issue":"5584","key":"7_CR16","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1126\/science.1070919","volume":"297","author":"MB Elowitz","year":"2002","unstructured":"Elowitz MB, Levine AJ, Siggia ED, Swain PS: Stochastic gene expression in a single cell. Science. 2002, 297 (5584): 1183-1186. 10.1126\/science.1070919","journal-title":"Science"},{"issue":"3","key":"7_CR17","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.ces.2005.06.033","volume":"61","author":"YN Kaznessis","year":"2006","unstructured":"Kaznessis YN: Multi-scale models for gene network engineering. Chemical Engineering Science. 2006, 61 (3): 940-10.1016\/j.ces.2005.06.033.","journal-title":"Chemical Engineering Science"},{"issue":"3","key":"7_CR18","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.compchemeng.2004.08.017","volume":"29","author":"H Salis","year":"2005","unstructured":"Salis H, Kaznessis Y: Computers & Chemical Engineering. 2005, 29 (3): 577-10.1016\/j.compchemeng.2004.08.017.Numerical simulation of stochastic gene circuits,Comput. Chem. Eng. (UK) 10.1016\/j.compchemeng.2004.08.017","journal-title":"Computers & Chemical Engineering"},{"issue":"1","key":"7_CR19","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1089\/15362310252780852","volume":"6","author":"DM Wolf","year":"2002","unstructured":"Wolf DM, Arkin AP: Fifteen minutes of fim: control of type 1 pili expression in E. coli. Omics. 2002, 6 (1): 91-114. 10.1089\/15362310252780852","journal-title":"Omics"},{"key":"7_CR20","volume-title":"Biophys J","author":"L Tuttle","year":"2005","unstructured":"Tuttle L, Salis H, Tomshine J, Kaznessis YN: Model-Driven Designs of an Oscillating Gene Network. Biophys J. 2005"},{"issue":"3","key":"7_CR21","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1083\/jcb.200301125","volume":"161","author":"JM Vilar","year":"2003","unstructured":"Vilar JM, Guet CC, Leibler S: Modeling network dynamics: the lac operon, a case study. J Cell Biol. 2003, 161 (3): 471-476. 10.1083\/jcb.200301125","journal-title":"J Cell Biol"},{"issue":"3","key":"7_CR22","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/S0021-9258(18)46038-3","volume":"267","author":"C Berens","year":"1992","unstructured":"Berens C, Altschmied L, Hillen W: The role of the N terminus in Tet repressor for tet operator binding determined by a mutational analysis. J Biol Chem. 1992, 267 (3): 1945-1952.","journal-title":"J Biol Chem"},{"issue":"13","key":"7_CR23","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1002\/j.1460-2075.1991.tb04992.x","volume":"10","author":"A Wissmann","year":"1991","unstructured":"Wissmann A, Baumeister R, Muller G, Hecht B, Helbl V, Pfleiderer K, Hillen W: Amino acids determining operator binding specificity in the helix-turn-helix motif of Tn10 Tet repressor. Embo J. 1991, 10 (13): 4145-4152.","journal-title":"Embo J"},{"issue":"2","key":"7_CR24","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/genetics\/128.2.225","volume":"128","author":"A Wissmann","year":"1991","unstructured":"Wissmann A, Wray LV, Somaggio U, Baumeister R, Geissendorfer M, Hillen W: Selection for Tn10 tet repressor binding to tet operator in Escherichia coli: isolation of temperature-sensitive mutants and combinatorial mutagenesis in the DNA binding motif. Genetics. 1991, 128 (2): 225-232.","journal-title":"Genetics"},{"issue":"35","key":"7_CR25","doi-asserted-by":"publisher","first-page":"10914","DOI":"10.1021\/bi001018p","volume":"39","author":"O Scholz","year":"2000","unstructured":"Scholz O, Schubert P, Kintrup M, Hillen W: Tet repressor induction without Mg2+. Biochemistry. 2000, 39 (35): 10914-10920. 10.1021\/bi001018p","journal-title":"Biochemistry"},{"issue":"2","key":"7_CR26","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1006\/jmbi.1997.1540","volume":"276","author":"V Helbl","year":"1998","unstructured":"Helbl V, Hillen W: Stepwise selection of TetR variants recognizing tet operator 4C with high affinity and specificity. J Mol Biol. 1998, 276 (2): 313-318. 10.1006\/jmbi.1997.1540","journal-title":"J Mol Biol"},{"issue":"2","key":"7_CR27","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1006\/jmbi.1997.1539","volume":"276","author":"V Helbl","year":"1998","unstructured":"Helbl V, Tiebel B, Hillen W: Stepwise selection of TetR variants recognizing tet operator 6C with high affinity and specificity. J Mol Biol. 1998, 276 (2): 319-324. 10.1006\/jmbi.1997.1539","journal-title":"J Mol Biol"},{"issue":"10","key":"7_CR28","doi-asserted-by":"publisher","first-page":"2875","DOI":"10.1093\/nar\/18.10.2875","volume":"18","author":"C Sizemore","year":"1990","unstructured":"Sizemore C, Wissmann A, Gulland U, Hillen W: Quantitative analysis of Tn10 Tet repressor binding to a complete set of tet operator mutants. Nucleic Acids Res. 1990, 18 (10): 2875-2880. 10.1093\/nar\/18.10.2875","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"7_CR29","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/0022-2836(88)90273-2","volume":"202","author":"A Wissmann","year":"1988","unstructured":"Wissmann A, Meier I, Hillen W: Saturation mutagenesis of the Tn10-encoded tet operator O1. Identification of base-pairs involved in Tet repressor recognition. J Mol Biol. 1988, 202 (3): 397-406. 10.1016\/0022-2836(88)90273-2","journal-title":"J Mol Biol"},{"key":"7_CR30","doi-asserted-by":"crossref","unstructured":"Gibson MA, Bruck J: Efficient exact stochastic simulation of chemical systems with many species and many channels. Journal of Physical Chemistry A. 2000, 104 (9): 1876-10.1021\/jp993732q. ACS, Washington, DC, USA","DOI":"10.1021\/jp993732q"},{"issue":"2","key":"7_CR31","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1046\/j.1432-1327.2000.01026.x","volume":"267","author":"A Sigler","year":"2000","unstructured":"Sigler A, Schubert P, Hillen W, Niederweis M: Permeation of tetracyclines through membranes of liposomes and Escherichia coli. Eur J Biochem. 2000, 267 (2): 527-534. 10.1046\/j.1432-1327.2000.01026.x","journal-title":"Eur J Biochem"},{"issue":"5","key":"7_CR32","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1006\/jmbi.1996.0431","volume":"260","author":"MM Levandoski","year":"1996","unstructured":"Levandoski MM, Tsodikov OV, Frank DE, Melcher SE, Saecker RM, Record MT: Cooperative and anticooperative effects in binding of the first and second plasmid Osym operators to a LacI tetramer: evidence for contributions of non-operator DNA binding by wrapping and looping. J Mol Biol. 1996, 260 (5): 697-717. 10.1006\/jmbi.1996.0431","journal-title":"J Mol Biol"},{"issue":"2","key":"7_CR33","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1093\/nar\/gkh200","volume":"32","author":"A Kamionka","year":"2004","unstructured":"Kamionka A, Bogdanska-Urbaniak J, Scholz O, Hillen W: Two mutations in the tetracycline repressor change the inducer anhydrotetracycline to a corepressor. Nucleic Acids Res. 2004, 32 (2): 842-847. 10.1093\/nar\/gkh200","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"7_CR34","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1023\/A:1020611919599","volume":"18","author":"S Kedracka-Krok","year":"1999","unstructured":"Kedracka-Krok S, Wasylewski Z: Kinetics and equilibrium studies of Tet repressor-operator interaction. J Protein Chem. 1999, 18 (1): 117-125. 10.1023\/A:1020611919599","journal-title":"J Protein Chem"},{"issue":"3","key":"7_CR35","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/S0022-2836(83)80166-1","volume":"169","author":"W Hillen","year":"1983","unstructured":"Hillen W, Gatz C, Altschmied L, Schollmeier K, Meier I: Control of expression of the Tn10-encoded tetracycline resistance genes. Equilibrium and kinetic investigation of the regulatory reactions. J Mol Biol. 1983, 169 (3): 707-721. 10.1016\/S0022-2836(83)80166-1","journal-title":"J Mol Biol"},{"issue":"6","key":"7_CR36","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1128\/AEM.64.6.2240-2246.1998","volume":"64","author":"JB Andersen","year":"1998","unstructured":"Andersen JB, Sternberg C, Poulsen LK, Bjorn SP, Givskov M, Molin S: New unstable variants of green fluorescent protein for studies of transient gene expression in bacteria. Appl Environ Microbiol. 1998, 64 (6): 2240-2246.","journal-title":"Appl Environ Microbiol"},{"key":"7_CR37","first-page":"70","volume-title":"Antibiotics Annual","author":"AR English","year":"1954","unstructured":"English AR, P'an SY, McBride TJ, Gardocki JF, Van Halsema G, Wright AW: Tetracycline-Microbiologic, Pharmacologic, and Clinical Evaluation. Antibiotics Annual. 1954, 70-80."},{"issue":"3","key":"7_CR38","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1093\/nar\/12.3.1697","volume":"12","author":"E Bertrand-Burggraf","year":"1984","unstructured":"Bertrand-Burggraf E, Lefevre JF, Daune M: A new experimental approach for studying the association between RNA polymerase and the tet promoter of pBR322. Nucleic Acids Res. 1984, 12 (3): 1697-1706. 10.1093\/nar\/12.3.1697","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"7_CR39","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1021\/bi00404a003","volume":"27","author":"C Kleinschmidt","year":"1988","unstructured":"Kleinschmidt C, Tovar K, Hillen W, Porschke D: Dynamics of repressor-operator recognition: the Tn10-encoded tetracycline resistance control. Biochemistry. 1988, 27 (4): 1094-1104. 10.1021\/bi00404a003","journal-title":"Biochemistry"},{"issue":"10","key":"7_CR40","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1128\/jb.176.10.2807-2813.1994","volume":"176","author":"U Vogel","year":"1994","unstructured":"Vogel U, Jensen KF: The RNA chain elongation rate in Escherichia coli depends on the growth rate. J Bacteriol. 1994, 176 (10): 2807-2813.","journal-title":"J Bacteriol"},{"issue":"2","key":"7_CR41","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/0022-2836(91)90211-N","volume":"222","author":"MA Sorensen","year":"1991","unstructured":"Sorensen MA, Pedersen S: Absolute in vivo translation rates of individual codons in Escherichia coli. The two glutamic acid codons GAA and GAG are translated with a threefold difference in rate. J Mol Biol. 1991, 222 (2): 265-280. 10.1016\/0022-2836(91)90211-N","journal-title":"J Mol Biol"},{"key":"7_CR42","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1093\/genetics\/149.4.1633","volume":"149","author":"A Arkin","year":"1998","unstructured":"Arkin A, Ross J, McAdams HH: Stochastic kinetic analysis ofdevelopmental pathway bifurcation in phage lambda-infected Escherichiacoli cells. Genetics. 1998, 149: 1633-1648.","journal-title":"Genetics"},{"issue":"25","key":"7_CR43","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1021\/j100540a008","volume":"81","author":"DT Gillespie","year":"1977","unstructured":"Gillespie DT: Exact stochastic simulation of coupled chemical reactions. J Phys Chem. 1977, 81 (25): 2340 -22361. 10.1021\/j100540a008.","journal-title":"J Phys Chem"},{"issue":"4","key":"7_CR44","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/0021-9991(76)90041-3","volume":"22","author":"DT Gillespie","year":"1976","unstructured":"Gillespie DT: A general method for numerically simulating the stochastic time evolution of coupled chemical reactions. Journal of Computational Physics. 1976, 22 (4): 403 -4434. 10.1016\/0021-9991(76)90041-3.","journal-title":"Journal of Computational Physics"},{"issue":"4","key":"7_CR45","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1063\/1.1378322","volume":"115","author":"DT Gillespie","year":"2001","unstructured":"Gillespie DT: Journal of Chemical Physics. 2001, 115 (4): 1716-10.1063\/1.1378322.Approximate accelerated stochastic simulation of chemically reacting systems ,J. Chem. Phys. (USA) 10.1063\/1.1378322","journal-title":"Journal of Chemical Physics"},{"issue":"16","key":"7_CR46","doi-asserted-by":"publisher","first-page":"8229","DOI":"10.1063\/1.1613254","volume":"119","author":"DT Gillespie","year":"2003","unstructured":"Gillespie DT, Petzold LR: Journal of Chemical Physics. 2003, 119 (16): 8229-10.1063\/1.1613254.Improved leap-size selection for accelerated stochastic simulation J. Chem. Phys. (USA)","journal-title":"Journal of Chemical Physics"},{"key":"7_CR47","volume-title":"J. Chem. Phys. (USA)","author":"EL Haseltine","year":"2002","unstructured":"Haseltine EL, Rawlings JB: Journal of Chemical Physics. 2002, 117 (15): 6959-10.1063\/1.1505860.Approximate simulation of coupled fast and slow reactions for stochastic chemical kinetics, AIP,J. Chem. Phys. (USA)","edition":"117"},{"issue":"3","key":"7_CR48","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1016\/S0006-3495(04)74207-1","volume":"86","author":"J Puchalka","year":"2004","unstructured":"Puchalka J, Kierzek AM: Bridging the gap between stochastic and deterministic regimes in the kinetic simulations of the biochemical reaction networks. Biophys J. 2004, 86 (3): 1357-1372.","journal-title":"Biophys J"},{"issue":"1","key":"7_CR49","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1093\/bioinformatics\/btg376","volume":"20","author":"K Vasudeva","year":"2004","unstructured":"Vasudeva K, Bhalla US: Adaptive stochastic-deterministic chemical kinetic simulations. Bioinformatics. 2004, 20 (1): 78-84. 10.1093\/bioinformatics\/btg376","journal-title":"Bioinformatics"},{"issue":"5","key":"7_CR50","doi-asserted-by":"publisher","first-page":"54103","DOI":"10.1063\/1.1835951","volume":"122","author":"H Salis","year":"2005","unstructured":"Salis H, Kaznessis Y: Accurate hybrid stochastic simulation of a system of coupled chemical or biochemical reactions. J Chem Phys. 2005, 122 (5): 54103- 10.1063\/1.1835951","journal-title":"J Chem Phys"},{"key":"7_CR51","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/1471-2105-7-93","volume":"7","author":"H Salis","year":"2006","unstructured":"Salis H, Sotiropoulos V, Kaznessis Y: Multiscale Hy3S: Hybrid Stochastic Simulations for Supercomputers. BMC Bioinformatics. 2006, 7: 93- 10.1186\/1471-2105-7-93","journal-title":"BMC Bioinformatics"},{"key":"7_CR52","unstructured":"Hy3S -- Hybrid Stochastic Simulation for Supercomputers. http:\/\/hysss.sourceforge.net\/examples.shtml"}],"container-title":["BMC Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-0509-1-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1752-0509-1-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-0509-1-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,8]],"date-time":"2021-08-08T04:05:30Z","timestamp":1628395530000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsystbiol.biomedcentral.com\/articles\/10.1186\/1752-0509-1-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,9]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["7"],"URL":"https:\/\/doi.org\/10.1186\/1752-0509-1-7","relation":{},"ISSN":["1752-0509"],"issn-type":[{"value":"1752-0509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,9]]},"article-number":"7"}}