{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:18:25Z","timestamp":1764688705207},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T00:00:00Z","timestamp":1227657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Syst Biol"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1186\/1752-0509-2-102","type":"journal-article","created":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T19:13:09Z","timestamp":1227726789000},"source":"Crossref","is-referenced-by-count":20,"title":["From pathway to population \u2013 a multiscale model of juxtacrine EGFR-MAPK signalling"],"prefix":"10.1186","volume":"2","author":[{"given":"DC","family":"Walker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NT","family":"Georgopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Southgate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,11,26]]},"reference":[{"issue":"6","key":"259_CR1","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.ccr.2008.04.020","volume":"13","author":"J Wei","year":"2008","unstructured":"Wei J, Wunderlich M, Fox C, Alvarez S, Cigudosa J, Wilhelm J, Zheng Y, Cancelas J, Gu Y, Jansen M, Dimartino J, Mulloy J: Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia. Cancer Cell. 2008, 13 (6): 483-95. 10.1016\/j.ccr.2008.04.020","journal-title":"Cancer Cell"},{"issue":"10","key":"259_CR2","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1007\/s00125-008-1103-z","volume":"51","author":"A Wojtusciszyn","year":"2008","unstructured":"Wojtusciszyn A, Armanet M, Morel P, Berney T, Bosco D: Insulin secretion from human beta cells is heterogeneous and dependent on cell-to-cell contacts. Diabetologia. 2008, 51 (10): 1843-1852. 10.1007\/s00125-008-1103-z","journal-title":"Diabetologia"},{"issue":"1\u20133","key":"259_CR3","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.biosystems.2004.05.025","volume":"76","author":"D Walker","year":"2004","unstructured":"Walker D, Southgate J, Hill G, Holcombe M, Hose D, Wood S, Macneil S, Smallwood R: The Epitheliome: modelling the social behaviour of cells. Biosystems. 2004, 76 (1\u20133): 89-100. 10.1016\/j.biosystems.2004.05.025","journal-title":"Biosystems"},{"issue":"3","key":"259_CR4","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1109\/TNB.2004.833680","volume":"3","author":"D Walker","year":"2004","unstructured":"Walker D, Hill G, Wood S, Smallwood R, Southgate J: Agent-based computational modeling of wounded epithelial cell monolayers. IEEE Transactions in Nanobioscience. 2004, 3 (3): 153-163. 10.1109\/TNB.2004.833680.","journal-title":"IEEE Transactions in Nanobioscience"},{"issue":"5","key":"259_CR5","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1089\/ten.2006.12.2301","volume":"12","author":"DC Walker","year":"2006","unstructured":"Walker DC, Sun T, Macneil S, Smallwood RH: Modeling the effect of exogenous calcium on keratinocyte and HaCat cell proliferation and differentiation using an agent-based computational paradigm. Tissue Engineering. 2006, 12 (5): 2301-2309. 10.1089\/ten.2006.12.2301","journal-title":"Tissue Engineering"},{"issue":"3","key":"259_CR6","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/j.jtbi.2006.04.020","volume":"242","author":"D Walker","year":"2006","unstructured":"Walker D, Wood S, Southgate J, Holcombe M, Smallwood R: An integrated agent-mathematical model of the effect of intercellular signalling via the Epidermal Growth Factor Receptor on cell proliferation. Journal of Theoretical Biology. 2006, 242 (3): 774-789. 10.1016\/j.jtbi.2006.04.020","journal-title":"Journal of Theoretical Biology"},{"issue":"1","key":"259_CR7","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.yexcr.2005.02.004","volume":"306","author":"C Varley","year":"2005","unstructured":"Varley C, Hill G, Pellegrin S, Shaw N, Selby P, Trejdosiewicz L, Southgate J: Autocrine Regulation of Human Urothelial Cell Proliferation and Migration during Regenerative Responses In Vitro. Experimental Cell Research. 2005, 306 (1): 216-229. 10.1016\/j.yexcr.2005.02.004","journal-title":"Experimental Cell Research"},{"issue":"1","key":"259_CR8","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1158\/1541-7786.MCR-07-0134","volume":"6","author":"N MacLaine","year":"2008","unstructured":"MacLaine N, Wood M, Holder J, Rees R, Southgate J: Sensitivity of normal, paramalignant, and malignant human urothelial cells to inhibitors of the epidermal growth factor receptor signaling pathway. Molecular Cancer Research. 2008, 6 (1): 53-63. 10.1158\/1541-7786.MCR-07-0134","journal-title":"Molecular Cancer Research"},{"key":"259_CR9","doi-asserted-by":"crossref","first-page":"4499","DOI":"10.1242\/jcs.113.24.4499","volume":"113 Pt 24","author":"A Asthagiri","year":"2000","unstructured":"Asthagiri A, Reinhart C, Horwitz A, Lauffenburger D: The role of transient ERK2 signals in fibronectin- and insulin-mediated DNA synthesis. J Cell Sci. 2000, 113 Pt 24: 4499-4510.","journal-title":"J Cell Sci"},{"key":"259_CR10","volume-title":"Molecular Systems Biology","author":"A Wolf-Yadlin","year":"2006","unstructured":"Wolf-Yadlin A, Kumar N, Zhang Y, Hautaniemi S, Zaman M, Kim H, Grantcharova V, Lauffenburger D, White F: Effects of HER2 overexpression on cell signaling networks governing proliferation and migration. Molecular Systems Biology. 2006"},{"issue":"10","key":"259_CR11","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1016\/j.cellsig.2005.03.026","volume":"17","author":"A Singh","year":"2005","unstructured":"Singh A, Harris R: Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Cellular Signalling. 2005, 17 (10): 1183-1193. 10.1016\/j.cellsig.2005.03.026","journal-title":"Cellular Signalling"},{"key":"259_CR12","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1002\/1521-1878(200009)22:9<818::AID-BIES7>3.0.CO;2-6","volume":"22","author":"K Roovers","year":"2000","unstructured":"Roovers K, Assoian RK: Integrating the MAP kinase signal into the G1 phase cell cycle machinery. BioEssays. 2000, 22: 818-826. 10.1002\/1521-1878(200009)22:9<818::AID-BIES7>3.0.CO;2-6","journal-title":"BioEssays"},{"issue":"12","key":"259_CR13","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.cub.2006.04.044","volume":"16","author":"T Yamamoto","year":"2006","unstructured":"Yamamoto T, Ebisuya M, Ashida F, Okamoto K, Yonehara S, Nishida E: Continuous ERK activation downregulates antiproliferative genes throughout G1 phase to allow cell-cycle progression. Current Biology. 2006, 16 (12): 1171-1182. 10.1016\/j.cub.2006.04.044","journal-title":"Current Biology"},{"issue":"3","key":"259_CR14","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S0014-5793(00)02037-8","volume":"482","author":"F Brightman","year":"2000","unstructured":"Brightman F, Fell D: Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells. FEBS Letters. 2000, 482 (3): 169-174. 10.1016\/S0014-5793(00)02037-8","journal-title":"FEBS Letters"},{"key":"259_CR15","doi-asserted-by":"publisher","first-page":"30169","DOI":"10.1074\/jbc.274.42.30169","volume":"274","author":"B Kholodenko","year":"1999","unstructured":"Kholodenko B, Demin O, Moehren G, Hoek J: Quantification of short term signaling by the epidermal growth factor receptor. Journal of Biological Chemistry. 1999, 274: 30169-30181. 10.1074\/jbc.274.42.30169","journal-title":"Journal of Biological Chemistry"},{"key":"259_CR16","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1038\/nbt0402-370","volume":"20","author":"B Schoeberl","year":"2002","unstructured":"Schoeberl B, Eichler-Jonsson C, Gilles ED, M\u00fcller G: Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors. Nature Biotechnology. 2002, 20: 370-375. 10.1038\/nbt0402-370","journal-title":"Nature Biotechnology"},{"issue":"2","key":"259_CR17","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1042\/bj20021824","volume":"373","author":"M Hatakeyama","year":"2003","unstructured":"Hatakeyama M, Kimura S, Naka T, Kawasak iT, Yumoto N, Ichikawa M, Kim J, Saito K, Saeki M, Shirouzu M, Yokoyama S, Konagaya A: A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling. Biochemical Journal. 2003, 373 (2): 451-463. 10.1042\/BJ20021824","journal-title":"Biochemical Journal"},{"issue":"4","key":"259_CR18","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1083\/jcb.142.4.1105","volume":"142","author":"CL Adams","year":"1998","unstructured":"Adams CL, Chen YT, Smith SJ, Nelson WJ: Mechansims of Epithelial Cell-Cell Adhesion and Cell Compaction Revealed by High-resolution Tracking of E-Cadherin-Green Flourescent Protein. Journal of Cell Biology. 1998, 142 (4): 1105-1119. 10.1083\/jcb.142.4.1105","journal-title":"Journal of Cell Biology"},{"issue":"5","key":"259_CR19","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1016\/S0006-3495(93)81253-0","volume":"65","author":"A Kusumi","year":"1993","unstructured":"Kusumi A, Sako Y, Yamamoto M: Confined lateral diffusion of membrane receptors as studied by single particle tracking (nanovid microscopy). Effects of calcium-induced differentiation in cultured epithelial cells. Biophysical Journal. 1993, 65 (5): 2021-2040. 10.1016\/S0006-3495(93)81253-0","journal-title":"Biophysical Journal"},{"issue":"4","key":"259_CR20","first-page":"583","volume":"71","author":"J Southgate","year":"1994","unstructured":"Southgate J, Hutton KR, Thomas DFM, Trejdosiewicz LK: Normal human urothelial cells in vitro: proliferation and induction of stratification. Laboratory Investigation. 1994, 71 (4): 583-594.","journal-title":"Laboratory Investigation"},{"issue":"8","key":"259_CR21","doi-asserted-by":"publisher","first-page":"4005","DOI":"10.1073\/pnas.070052697","volume":"97","author":"W Baumgartner","year":"2000","unstructured":"Baumgartner W, Hinterdorfer P, Ness W, Raab A, Vestweber D, Schindler H, Drenckhahn D: Cadherin interaction probed by atomic force microscopy. Proc Nat Acad Sci USA. 2000, 97 (8): 4005-4010. 10.1073\/pnas.070052697","journal-title":"Proc Nat Acad Sci USA"},{"issue":"6","key":"259_CR22","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1083\/jcb.200403043","volume":"167","author":"Y-S Chu","year":"2004","unstructured":"Chu Y-S, Thomas WA, Eder O, Pincet F, Perez E, Thiery JP, Dufour S: Force measurements in E-cadherin-mediated cell doublets reveal rapid adhesion strengthened by actin cytoskeleton remodeling through Rac and Cdc42. Journal of Cell Biology. 2004, 167 (6): 1183-1194. 10.1083\/jcb.200403043","journal-title":"Journal of Cell Biology"},{"key":"259_CR23","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1083\/jcb.127.6.1957","volume":"127","author":"J Lee","year":"1994","unstructured":"Lee J, Leonard M, Oliver T, Ishihara A, Jacobson K: Traction forces generated by locomoting keratocytes. Journal of Cell Biology. 1994, 127: 1957-1964. 10.1083\/jcb.127.6.1957","journal-title":"Journal of Cell Biology"},{"issue":"1","key":"259_CR24","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.ydbio.2004.11.012","volume":"278","author":"RA Foty","year":"2005","unstructured":"Foty RA, Steinberg MS: The differential adhesion hypothesis: a direct evaluation. Developmental Biology. 2005, 278 (1): 255-263. 10.1016\/j.ydbio.2004.11.012","journal-title":"Developmental Biology"},{"issue":"14","key":"259_CR25","doi-asserted-by":"publisher","first-page":"3563","DOI":"10.1021\/bi00466a020","volume":"29","author":"C Waters","year":"1990","unstructured":"Waters C, Oberg K, Carpenter G, Overholser K: Rate constants for binding, dissociation, and internalization of EGF: effect of receptor occupancy and ligand concentration. Biochemistry. 1990, 29 (14): 3563-3569. 10.1021\/bi00466a020","journal-title":"Biochemistry"},{"key":"259_CR26","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/S0014-5793(02)02370-0","volume":"514","author":"CM Nelson","year":"2002","unstructured":"Nelson CM, Chen CS: Cell-cell signalling by direct contact increases cell proliferation via a P13K-dependent signal. FEBS Letters. 2002, 514: 238-242. 10.1016\/S0014-5793(02)02370-0","journal-title":"FEBS Letters"},{"issue":"3","key":"259_CR27","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1083\/jcb.200510087","volume":"173","author":"W Liu","year":"2006","unstructured":"Liu W, Nelson C, Pirone M, Chen C: E-cadherin engagement stimulates proliferation via Rac1. Journal of Cell Biology. 2006, 173 (3): 431-441. 10.1083\/jcb.200510087","journal-title":"Journal of Cell Biology"},{"issue":"1","key":"259_CR28","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.jtbi.2007.01.019","volume":"247","author":"I van Leeuwen","year":"2007","unstructured":"van Leeuwen I, Byrne H, Jensen O, King J: Elucidating the interactions between the adhesive and transcriptional functions of beta-catenin in normal and cancerous cells. Journal of Theoretical Biology. 2007, 247 (1): 77-102. 10.1016\/j.jtbi.2007.01.019","journal-title":"Journal of Theoretical Biology"},{"issue":"1","key":"259_CR29","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1049\/sb:20045011","volume":"1","author":"H Conzelmann","year":"2001","unstructured":"Conzelmann H, Saez-Rodriguez J, Sauter T, Bullinger E, Allgower F, Gilles E: Reduction of mathematical models of signal transduction networks: simulation-based approach applied to EGF receptor signalling. Systems Biology. 2001, 1 (1): 159-169. 10.1049\/sb:20045011.","journal-title":"Systems Biology"},{"issue":"27","key":"259_CR30","doi-asserted-by":"publisher","first-page":"19347","DOI":"10.1074\/jbc.274.27.19347","volume":"274","author":"S Pece","year":"1999","unstructured":"Pece S, Chiariello M, Murga C, Gutkind JS: Activation of the protein kinase Akt\/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex. Journal of Biological Chemistry. 1999, 274 (27): 19347-19351. 10.1074\/jbc.274.27.19347","journal-title":"Journal of Biological Chemistry"},{"issue":"12","key":"259_CR31","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1242\/jcs.114.12.2301","volume":"114","author":"A DeWitt","year":"2001","unstructured":"DeWitt A, Dong J, Wiley H, Lauffenburger D: Quantitative analysis of the EGF receptor autocrine system reveals cryptic regulation of cell response by ligand capture. Journal of Cell Science. 2001, 114 (12): 2301-2313.","journal-title":"Journal of Cell Science"},{"key":"259_CR32","doi-asserted-by":"publisher","first-page":"15368","DOI":"10.1073\/pnas.95.26.15368","volume":"95","author":"L Lauffenburger","year":"1998","unstructured":"Lauffenburger L, Oehrtman GT, Walker L, Wiley HS: Real-time quantitative measurement of autocrine ligand binding indicates that autocrine loops are spatially localized. Proc Nat Acad Sci USA. 1998, 95: 15368-15373. 10.1073\/pnas.95.26.15368","journal-title":"Proc Nat Acad Sci USA"},{"issue":"5","key":"259_CR33","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1002\/(SICI)1097-0290(19980305)57:5<571::AID-BIT9>3.0.CO;2-D","volume":"57","author":"G Oehrtman","year":"1998","unstructured":"Oehrtman G, Wiley H, Lauffenburger D: Escape of autocrine ligands into extracellular medium: experimental test of theoretical model predictions. Biotechnology and Bioengineering. 1998, 57 (5): 571-582. 10.1002\/(SICI)1097-0290(19980305)57:5<571::AID-BIT9>3.0.CO;2-D.","journal-title":"Biotechnology and Bioengineering"}],"container-title":["BMC Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-0509-2-102.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1752-0509-2-102\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-0509-2-102.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T08:46:35Z","timestamp":1632386795000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsystbiol.biomedcentral.com\/articles\/10.1186\/1752-0509-2-102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,26]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["259"],"URL":"https:\/\/doi.org\/10.1186\/1752-0509-2-102","relation":{},"ISSN":["1752-0509"],"issn-type":[{"value":"1752-0509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,26]]},"article-number":"102"}}