{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:17:07Z","timestamp":1760548627858},"reference-count":87,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Syst Biol"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Autoantigens have been reported in a variety of tumors, providing insight into the interplay between malignancies and the immune response, and also giving rise to novel diagnostic and therapeutic concepts. Why certain tumor-associated proteins induce an immune response remains largely elusive.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>This paper analyzes the proposed link between increased abundance of a protein in cancerous tissue and the increased potential of the protein for induction of a humoral immune response, using ovarian cancer as an example. Public domain data sources on differential gene expression and on autoantigens associated with this malignancy were extracted and compared, using bioinformatics analysis, on the levels of individual genes and proteins, transcriptional coregulation, joint functional pathways, and shared protein-protein interaction networks. Finally, a selected list of ovarian cancer-associated, differentially regulated proteins was tested experimentally for reactivity with antibodies prevalent in sera of ovarian cancer patients.<\/jats:p>\n            <jats:p>Genes reported as showing differential expression in ovarian cancer exhibited only minor overlap with the public domain list of ovarian cancer autoantigens. However, experimental screening for antibodies directed against antigenic determinants from ovarian cancer-associated proteins yielded clear reactions with sera.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>A link between tumor protein abundance and the likelihood of induction of a humoral immune response in ovarian cancer appears evident.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-0509-2-2","type":"journal-article","created":{"date-parts":[[2008,3,7]],"date-time":"2008-03-07T19:13:30Z","timestamp":1204917210000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Linking the ovarian cancer transcriptome and immunome"],"prefix":"10.1186","volume":"2","author":[{"given":"Ronald","family":"Rapberger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Perco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Sax","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Pangerl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Siehs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietmar","family":"Pils","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Bernthaler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arno","family":"Lukas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Krainer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,1,3]]},"reference":[{"issue":"8","key":"159_CR1","doi-asserted-by":"publisher","first-page":"4844","DOI":"10.4049\/jimmunol.172.8.4844","volume":"172","author":"Y Ichiki","year":"2004","unstructured":"Ichiki Y, Takenoyama M, Mizukami M, So T, Sugaya M, Yasuda M, So T, Hanagiri T, Sugio K, Yasumoto K: Simultaneous cellular and humoral immune response against mutated p53 in a patient with lung cancer. J Immunol. 2004, 172 (8): 4844-4850.","journal-title":"J Immunol"},{"issue":"2","key":"159_CR2","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1084\/jem.187.2.265","volume":"187","author":"E Jager","year":"1998","unstructured":"Jager E, Chen YT, Drijfhout JW, Karbach J, Ringhoffer M, Jager D, Arand M, Wada H, Noguchi Y, Stockert E, Old LJ, Knuth A: Simultaneous humoral and cellular immune response against cancer-testis antigen NY-ESO-1: definition of human histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes. J Exp Med. 1998, 187 (2): 265-270.","journal-title":"J Exp Med"},{"issue":"11","key":"159_CR3","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1093\/jnci\/djh145","volume":"96","author":"A Sreekumar","year":"2004","unstructured":"Sreekumar A, Laxman B, Rhodes DR, Bhagavathula S, Harwood J, Giacherio D, Ghosh D, Sanda MG, Rubin MA, Chinnaiyan AM: Humoral immune response to alpha-methylacyl-CoA racemase and prostate cancer. J Natl Cancer Inst. 2004, 96 (11): 834-843.","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"159_CR4","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/nrc1782","volume":"6","author":"KE de Visser","year":"2006","unstructured":"de Visser KE, Eichten A, Coussens LM: Paradoxical roles of the immune system during cancer development. Nat Rev Cancer. 2006, 6 (1): 24-37.","journal-title":"Nat Rev Cancer"},{"issue":"5-6","key":"159_CR5","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S1359-6446(05)03720-7","volume":"11","author":"AS De Groot","year":"2006","unstructured":"De Groot AS: Immunomics: discovering new targets for vaccines and therapeutics. Drug Discov Today. 2006, 11 (5-6): 203-209.","journal-title":"Drug Discov Today"},{"issue":"12","key":"159_CR6","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1056\/NEJMe058157","volume":"353","author":"OJ Finn","year":"2005","unstructured":"Finn OJ: Immune response as a biomarker for cancer detection and a lot more. N Engl J Med. 2005, 353 (12): 1288-1290.","journal-title":"N Engl J Med"},{"issue":"2 Pt 1","key":"159_CR7","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1164\/ajrccm.161.2.9905028","volume":"161","author":"Y Hirasawa","year":"2000","unstructured":"Hirasawa Y, Kohno N, Yokoyama A, Kondo K, Hiwada K, Miyake M: Natural autoantibody to MUC1 is a prognostic indicator for non-small cell lung cancer. Am J Respir Crit Care Med. 2000, 161 (2 Pt 1): 589-594.","journal-title":"Am J Respir Crit Care Med"},{"issue":"9","key":"159_CR8","first-page":"740","volume":"32","author":"A Takeda","year":"2000","unstructured":"Takeda A, Shimada H, Nakajima K, Suzuki T, Hori S, Hayashi H, Arima M, Kouzu T, Ochiai T, Isono K: Impact of circulating p53 autoantibody monitoring after endoscopic resection in mucosal gastric cancer. Endoscopy. 2000, 32 (9): 740-741.","journal-title":"Endoscopy"},{"issue":"12","key":"159_CR9","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1056\/NEJMoa051931","volume":"353","author":"X Wang","year":"2005","unstructured":"Wang X, Yu J, Sreekumar A, Varambally S, Shen R, Giacherio D, Mehra R, Montie JE, Pienta KJ, Sanda MG, Kantoff PW, Rubin MA, Wei JT, Ghosh D, Chinnaiyan AM: Autoantibody signatures in prostate cancer. N Engl J Med. 2005, 353 (12): 1224-1235.","journal-title":"N Engl J Med"},{"key":"159_CR10","first-page":"207","volume":"103","author":"YT Chen","year":"2005","unstructured":"Chen YT, Gure AO, Scanlan MJ: Serological analysis of expression cDNA libraries (SEREX): an immunoscreening technique for identifying immunogenic tumor antigens. Methods Mol Med. 2005, 103: 207-216.","journal-title":"Methods Mol Med"},{"issue":"4","key":"159_CR11","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1002\/ijc.11269","volume":"106","author":"O Minenkova","year":"2003","unstructured":"Minenkova O, Pucci A, Pavoni E, De Tomassi A, Fortugno P, Gargano N, Cianfriglia M, Barca S, De Placido S, Martignetti A, Felici F, Cortese R, Monaci P: Identification of tumor-associated antigens by screening phage-displayed human cDNA libraries with sera from tumor patients. Int J Cancer. 2003, 106 (4): 534-544.","journal-title":"Int J Cancer"},{"key":"159_CR12","first-page":"5","volume":"3","author":"A Mischo","year":"2003","unstructured":"Mischo A, Wadle A, Watzig K, Jager D, Stockert E, Santiago D, Ritter G, Regitz E, Jager E, Knuth A, Old L, Pfreundschuh M, Renner C: Recombinant antigen expression on yeast surface (RAYS) for the detection of serological immune responses in cancer patients. Cancer Immun. 2003, 3: 5-","journal-title":"Cancer Immun"},{"issue":"3","key":"159_CR13","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1002\/1521-4141(200103)31:3<716::AID-IMMU716>3.0.CO;2-9","volume":"31","author":"M Sioud","year":"2001","unstructured":"Sioud M, Hansen MH: Profiling the immune response in patients with breast cancer by phage-displayed cDNA libraries. Eur J Immunol. 2001, 31 (3): 716-725.","journal-title":"Eur J Immunol"},{"issue":"3","key":"159_CR14","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1080\/03602530500205309","volume":"37","author":"RC Zangar","year":"2005","unstructured":"Zangar RC, Varnum SM, Bollinger N: Studying cellular processes and detecting disease with protein microarrays. Drug Metab Rev. 2005, 37 (3): 473-487.","journal-title":"Drug Metab Rev"},{"issue":"5","key":"159_CR15","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/S0952-7915(97)80053-2","volume":"9","author":"U Sahin","year":"1997","unstructured":"Sahin U, Tureci O, Pfreundschuh M: Serological identification of human tumor antigens. Curr Opin Immunol. 1997, 9 (5): 709-716.","journal-title":"Curr Opin Immunol"},{"issue":"4","key":"159_CR16","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1021\/pr0500814","volume":"4","author":"KS Anderson","year":"2005","unstructured":"Anderson KS, LaBaer J: The sentinel within: exploiting the immune system for cancer biomarkers. J Proteome Res. 2005, 4 (4): 1123-1133.","journal-title":"J Proteome Res"},{"issue":"1","key":"159_CR17","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nbt774","volume":"21","author":"PJ Mintz","year":"2003","unstructured":"Mintz PJ, Kim J, Do KA, Wang X, Zinner RG, Cristofanilli M, Arap MA, Hong WK, Troncoso P, Logothetis CJ, Pasqualini R, Arap W: Fingerprinting the circulating repertoire of antibodies from cancer patients. Nat Biotechnol. 2003, 21 (1): 57-63.","journal-title":"Nat Biotechnol"},{"issue":"3","key":"159_CR18","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1158\/0008-5472.CAN-05-2452","volume":"66","author":"J Humer","year":"2006","unstructured":"Humer J, Waltenberger A, Grassauer A, Kurz M, Valencak J, Rapberger R, Hahn S, Lower R, Wolff K, Bergmann M, Muster T, Mayer B, Pehamberger H: Identification of a melanoma marker derived from melanoma-associated endogenous retroviruses. Cancer Res. 2006, 66 (3): 1658-1663.","journal-title":"Cancer Res"},{"issue":"3","key":"159_CR19","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/S0002-9440(10)61770-1","volume":"159","author":"M Lu","year":"2001","unstructured":"Lu M, Nakamura RM, Dent ED, Zhang JY, Nielsen FC, Christiansen J, Chan EK, Tan EM: Aberrant expression of fetal RNA-binding protein p62 in liver cancer and liver cirrhosis. Am J Pathol. 2001, 159 (3): 945-953.","journal-title":"Am J Pathol"},{"issue":"19","key":"159_CR20","first-page":"4362","volume":"56","author":"M Sauter","year":"1996","unstructured":"Sauter M, Roemer K, Best B, Afting M, Schommer S, Seitz G, Hartmann M, Mueller-Lantzsch N: Specificity of antibodies directed against Env protein of human endogenous retroviruses in patients with germ cell tumors. Cancer Res. 1996, 56 (19): 4362-4365.","journal-title":"Cancer Res"},{"issue":"35","key":"159_CR21","doi-asserted-by":"publisher","first-page":"5010","DOI":"10.1038\/sj.onc.1202872","volume":"18","author":"LT da Costa","year":"1999","unstructured":"da Costa LT, He TC, Yu J, Sparks AB, Morin PJ, Polyak K, Laken S, Vogelstein B, Kinzler KW: CDX2 is mutated in a colorectal cancer with normal APC\/beta-catenin signaling. Oncogene. 1999, 18 (35): 5010-5014.","journal-title":"Oncogene"},{"issue":"5","key":"159_CR22","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/sj.onc.1201971","volume":"17","author":"C Wicking","year":"1998","unstructured":"Wicking C, Simms LA, Evans T, Walsh M, Chawengsaksophak K, Beck F, Chenevix-Trench G, Young J, Jass J, Leggett B, Wainwright B: CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer. Oncogene. 1998, 17 (5): 657-659.","journal-title":"Oncogene"},{"issue":"22","key":"159_CR23","first-page":"6380","volume":"52","author":"B Schlichtholz","year":"1992","unstructured":"Schlichtholz B, Legros Y, Gillet D, Gaillard C, Marty M, Lane D, Calvo F, Soussi T: The immune response to p53 in breast cancer patients is directed against immunodominant epitopes unrelated to the mutational hot spot. Cancer Res. 1992, 52 (22): 6380-6384.","journal-title":"Cancer Res"},{"issue":"7","key":"159_CR24","first-page":"1777","volume":"60","author":"T Soussi","year":"2000","unstructured":"Soussi T: p53 Antibodies in the sera of patients with various types of cancer: a review. Cancer Res. 2000, 60 (7): 1777-1788.","journal-title":"Cancer Res"},{"issue":"7","key":"159_CR25","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1182\/blood.V93.7.2158","volume":"93","author":"N Brass","year":"1999","unstructured":"Brass N, Racz A, Bauer C, Heckel D, Sybrecht G, Meese E: Role of amplified genes in the production of autoantibodies. Blood. 1999, 93 (7): 2158-2166.","journal-title":"Blood"},{"key":"159_CR26","unstructured":"Cancer Immunome Database., http:\/\/www2.licr.org\/CancerImmunomeDB\/"},{"key":"159_CR27","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1186\/1471-2105-8-224","volume":"8","author":"A Platzer","year":"2007","unstructured":"Platzer A, Perco P, Lukas A, Mayer B: Characterization of protein-interaction networks in tumors. BMC Bioinformatics. 2007, 8: 224-","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"159_CR28","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/gcc.20265","volume":"45","author":"G Bignell","year":"2006","unstructured":"Bignell G, Smith R, Hunter C, Stephens P, Davies H, Greenman C, Teague J, Butler A, Edkins S, Stevens C, O'Meara S, Parker A, Avis T, Barthorpe S, Brackenbury L, Buck G, Clements J, Cole J, Dicks E, Edwards K, Forbes S, Gorton M, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jones D, Kosmidou V, Laman R, Lugg R, Menzies A, Perry J, Petty R, Raine K, Shepherd R, Small A, Solomon H, Stephens Y, Tofts C, Varian J, Webb A, West S, Widaa S, Yates A, Gillis AJ, Stoop HJ, van Gurp RJ, Oosterhuis JW, Looijenga LH, Futreal PA, Wooster R, Stratton MR: Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults. Genes Chromosomes Cancer. 2006, 45 (1): 42-46.","journal-title":"Genes Chromosomes Cancer"},{"issue":"17","key":"159_CR29","doi-asserted-by":"crossref","first-page":"7591","DOI":"10.1158\/0008-5472.CAN-05-1855","volume":"65","author":"H Davies","year":"2005","unstructured":"Davies H, Hunter C, Smith R, Stephens P, Greenman C, Bignell G, Teague J, Butler A, Edkins S, Stevens C, Parker A, O'Meara S, Avis T, Barthorpe S, Brackenbury L, Buck G, Clements J, Cole J, Dicks E, Edwards K, Forbes S, Gorton M, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jones D, Kosmidou V, Laman R, Lugg R, Menzies A, Perry J, Petty R, Raine K, Shepherd R, Small A, Solomon H, Stephens Y, Tofts C, Varian J, Webb A, West S, Widaa S, Yates A, Brasseur F, Cooper CS, Flanagan AM, Green A, Knowles M, Leung SY, Looijenga LH, Malkowicz B, Pierotti MA, Teh BT, Yuen ST, Lakhani SR, Easton DF, Weber BL, Goldstraw P, Nicholson AG, Wooster R, Stratton MR, Futreal PA: Somatic mutations of the protein kinase gene family in human lung cancer. Cancer Res. 2005, 65 (17): 7591-7595.","journal-title":"Cancer Res"},{"issue":"3","key":"159_CR30","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1159\/000030006","volume":"19","author":"S von Mensdorff-Pouilly","year":"1998","unstructured":"von Mensdorff-Pouilly S, Gourevitch MM, Kenemans P, Verstraeten AA, van Kamp GJ, Kok A, van Uffelen K, Snijdewint FG, Paul MA, Meijer S, Hilgers J: An enzyme-linked immunosorbent assay for the measurement of circulating antibodies to polymorphic epithelial mucin (MUC1). Tumour Biol. 1998, 19 (3): 186-195.","journal-title":"Tumour Biol"},{"issue":"13","key":"159_CR31","first-page":"4782","volume":"9","author":"JH Kim","year":"2003","unstructured":"Kim JH, Herlyn D, Wong KK, Park DC, Schorge JO, Lu KH, Skates SJ, Cramer DW, Berkowitz RS, Mok SC: Identification of epithelial cell adhesion molecule autoantibody in patients with ovarian cancer. Clin Cancer Res. 2003, 9 (13): 4782-4791.","journal-title":"Clin Cancer Res"},{"issue":"6","key":"159_CR32","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s002620050536","volume":"47","author":"S Mosolits","year":"1999","unstructured":"Mosolits S, Harmenberg U, Ruden U, Ohman L, Nilsson B, Wahren B, Fagerberg J, Mellstedt H: Autoantibodies against the tumour-associated antigen GA733-2 in patients with colorectal carcinoma. Cancer Immunol Immunother. 1999, 47 (6): 315-320.","journal-title":"Cancer Immunol Immunother"},{"issue":"10","key":"159_CR33","doi-asserted-by":"publisher","first-page":"3814","DOI":"10.1158\/1078-0432.CCR-04-2304","volume":"11","author":"M Ho","year":"2005","unstructured":"Ho M, Hassan R, Zhang J, Wang QC, Onda M, Bera T, Pastan I: Humoral immune response to mesothelin in mesothelioma and ovarian cancer patients. Clin Cancer Res. 2005, 11 (10): 3814-3820.","journal-title":"Clin Cancer Res"},{"issue":"2","key":"159_CR34","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/j.1600-0897.2005.00287.x","volume":"54","author":"JL Luborsky","year":"2005","unstructured":"Luborsky JL, Barua A, Shatavi SV, Kebede T, Abramowicz J, Rotmensch J: Anti-tumor antibodies in ovarian cancer. Am J Reprod Immunol. 2005, 54 (2): 55-62.","journal-title":"Am J Reprod Immunol"},{"issue":"3","key":"159_CR35","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1074\/mcp.M100029-MCP200","volume":"1","author":"F Le Naour","year":"2002","unstructured":"Le Naour F, Brichory F, Misek DE, Brechot C, Hanash SM, Beretta L: A distinct repertoire of autoantibodies in hepatocellular carcinoma identified by proteomic analysis. Mol Cell Proteomics. 2002, 1 (3): 197-203.","journal-title":"Mol Cell Proteomics"},{"issue":"24","key":"159_CR36","first-page":"6895","volume":"60","author":"F Gautier","year":"2000","unstructured":"Gautier F, Irminger-Finger I, Gregoire M, Meflah K, Harb J: Identification of an apoptotic cleavage product of BARD1 as an autoantigen: a potential factor in the antitumoral response mediated by apoptotic bodies. Cancer Res. 2000, 60 (24): 6895-6900.","journal-title":"Cancer Res"},{"key":"159_CR37","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/j.1525-1438.2006.00310.x","volume":"16 Suppl 1","author":"H Jiang","year":"2006","unstructured":"Jiang H, Feng Y: Hypoxia-inducible factor 1alpha (HIF-1alpha) correlated with tumor growth and apoptosis in ovarian cancer. Int J Gynecol Cancer. 2006, 16 Suppl 1: 405-412.","journal-title":"Int J Gynecol Cancer"},{"issue":"26","key":"159_CR38","doi-asserted-by":"publisher","first-page":"12823","DOI":"10.1073\/pnas.91.26.12823","volume":"91","author":"DG Johnson","year":"1994","unstructured":"Johnson DG, Cress WD, Jakoi L, Nevins JR: Oncogenic capacity of the E2F1 gene. Proc Natl Acad Sci U S A. 1994, 91 (26): 12823-12827.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"159_CR39","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/ng1578","volume":"37","author":"DR Rhodes","year":"2005","unstructured":"Rhodes DR, Kalyana-Sundaram S, Mahavisno V, Barrette TR, Ghosh D, Chinnaiyan AM: Mining for regulatory programs in the cancer transcriptome. Nat Genet. 2005, 37 (6): 579-583.","journal-title":"Nat Genet"},{"issue":"12","key":"159_CR40","first-page":"1761","volume":"5","author":"A Seth","year":"1990","unstructured":"Seth A, Papas TS: The c-ets-1 proto-oncogene has oncogenic activity and is positively autoregulated. Oncogene. 1990, 5 (12): 1761-1767.","journal-title":"Oncogene"},{"issue":"Database issue","key":"159_CR41","doi-asserted-by":"publisher","first-page":"D354","DOI":"10.1093\/nar\/gkj102","volume":"34","author":"M Kanehisa","year":"2006","unstructured":"Kanehisa M, Goto S, Hattori M, Aoki-Kinoshita KF, Itoh M, Kawashima S, Katayama T, Araki M, Hirakawa M: From genomics to chemical genomics: new developments in KEGG. Nucleic Acids Res. 2006, 34 (Database issue): D354-7.","journal-title":"Nucleic Acids Res"},{"key":"159_CR42","doi-asserted-by":"crossref","unstructured":"Brown KR, Jurisica I: Online predicted human interaction database. Bioinformatics. 2005, 21 (9): 2076-2082. England","DOI":"10.1093\/bioinformatics\/bti273"},{"issue":"11","key":"159_CR43","doi-asserted-by":"publisher","first-page":"4376","DOI":"10.1091\/mbc.E03-05-0279","volume":"14","author":"ME Schaner","year":"2003","unstructured":"Schaner ME, Ross DT, Ciaravino G, Sorlie T, Troyanskaya O, Diehn M, Wang YC, Duran GE, Sikic TL, Caldeira S, Skomedal H, Tu IP, Hernandez-Boussard T, Johnson SW, O'Dwyer PJ, Fero MJ, Kristensen GB, Borresen-Dale AL, Hastie T, Tibshirani R, van de Rijn M, Teng NN, Longacre TA, Botstein D, Brown PO, Sikic BI: Gene expression patterns in ovarian carcinomas. Mol Biol Cell. 2003, 14 (11): 4376-4386.","journal-title":"Mol Biol Cell"},{"issue":"3","key":"159_CR44","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1073\/pnas.98.3.1176","volume":"98","author":"JB Welsh","year":"2001","unstructured":"Welsh JB, Zarrinkar PP, Sapinoso LM, Kern SG, Behling CA, Monk BJ, Lockhart DJ, Burger RA, Hampton GM: Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer. Proc Natl Acad Sci U S A. 2001, 98 (3): 1176-1181.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"159_CR45","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1074\/mcp.M500279-MCP200","volume":"4","author":"M Uhlen","year":"2005","unstructured":"Uhlen M, Bjorling E, Agaton C, Szigyarto CA, Amini B, Andersen E, Andersson AC, Angelidou P, Asplund A, Asplund C, Berglund L, Bergstrom K, Brumer H, Cerjan D, Ekstrom M, Elobeid A, Eriksson C, Fagerberg L, Falk R, Fall J, Forsberg M, Bjorklund MG, Gumbel K, Halimi A, Hallin I, Hamsten C, Hansson M, Hedhammar M, Hercules G, Kampf C, Larsson K, Lindskog M, Lodewyckx W, Lund J, Lundeberg J, Magnusson K, Malm E, Nilsson P, Odling J, Oksvold P, Olsson I, Oster E, Ottosson J, Paavilainen L, Persson A, Rimini R, Rockberg J, Runeson M, Sivertsson A, Skollermo A, Steen J, Stenvall M, Sterky F, Stromberg S, Sundberg M, Tegel H, Tourle S, Wahlund E, Walden A, Wan J, Wernerus H, Westberg J, Wester K, Wrethagen U, Xu LL, Hober S, Ponten F: A human protein atlas for normal and cancer tissues based on antibody proteomics. Mol Cell Proteomics. 2005, 4 (12): 1920-1932.","journal-title":"Mol Cell Proteomics"},{"issue":"14","key":"159_CR46","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1038\/sj.onc.1210010","volume":"26","author":"MT Berlingieri","year":"2007","unstructured":"Berlingieri MT, Pallante P, Guida M, Nappi C, Masciullo V, Scambia G, Ferraro A, Leone V, Sboner A, Barbareschi M, Ferro A, Troncone G, Fusco A: UbcH10 expression may be a useful tool in the prognosis of ovarian carcinomas. Oncogene. 2007, 26 (14): 2136-2140.","journal-title":"Oncogene"},{"issue":"2","key":"159_CR47","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1158\/1078-0432.CCR-05-1477","volume":"12","author":"R Hassan","year":"2006","unstructured":"Hassan R, Remaley AT, Sampson ML, Zhang J, Cox DD, Pingpank J, Alexander R, Willingham M, Pastan I, Onda M: Detection and quantitation of serum mesothelin, a tumor marker for patients with mesothelioma and ovarian cancer. Clin Cancer Res. 2006, 12 (2): 447-453.","journal-title":"Clin Cancer Res"},{"issue":"11","key":"159_CR48","doi-asserted-by":"publisher","first-page":"4961","DOI":"10.1073\/pnas.90.11.4961","volume":"90","author":"J Kupryjanczyk","year":"1993","unstructured":"Kupryjanczyk J, Thor AD, Beauchamp R, Merritt V, Edgerton SM, Bell DA, Yandell DW: p53 gene mutations and protein accumulation in human ovarian cancer. Proc Natl Acad Sci U S A. 1993, 90 (11): 4961-4965.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"159_CR49","first-page":"455","volume":"138","author":"CC van Niekerk","year":"1991","unstructured":"van Niekerk CC, Boerman OC, Ramaekers FC, Poels LG: Marker profile of different phases in the transition of normal human ovarian epithelium to ovarian carcinomas. Am J Pathol. 1991, 138 (2): 455-463.","journal-title":"Am J Pathol"},{"issue":"5","key":"159_CR50","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1002\/ijc.21428","volume":"118","author":"JY Wu","year":"2006","unstructured":"Wu JY, Vlastos AT, Pelte MF, Caligo MA, Bianco A, Krause KH, Laurent GJ, Irminger-Finger I: Aberrant expression of BARD1 in breast and ovarian cancers with poor prognosis. Int J Cancer. 2006, 118 (5): 1215-1226.","journal-title":"Int J Cancer"},{"issue":"2","key":"159_CR51","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.cancergencyto.2004.12.014","volume":"161","author":"V Wang","year":"2005","unstructured":"Wang V, Li C, Lin M, Welch W, Bell D, Wong YF, Berkowitz R, Mok SC, Bandera CA: Ovarian cancer is a heterogeneous disease. Cancer Genet Cytogenet. 2005, 161 (2): 170-173.","journal-title":"Cancer Genet Cytogenet"},{"issue":"1","key":"159_CR52","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1002\/ijc.10801","volume":"103","author":"Y Hamanaka","year":"2003","unstructured":"Hamanaka Y, Suehiro Y, Fukui M, Shikichi K, Imai K, Hinoda Y: Circulating anti-MUC1 IgG antibodies as a favorable prognostic factor for pancreatic cancer. Int J Cancer. 2003, 103 (1): 97-100.","journal-title":"Int J Cancer"},{"key":"159_CR53","doi-asserted-by":"publisher","first-page":"S31","DOI":"10.1038\/ng1570","volume":"37 Suppl","author":"DR Rhodes","year":"2005","unstructured":"Rhodes DR, Chinnaiyan AM: Integrative analysis of the cancer transcriptome. Nat Genet. 2005, 37 Suppl: S31-7.","journal-title":"Nat Genet"},{"issue":"22","key":"159_CR54","first-page":"6448","volume":"60","author":"MS Mitchell","year":"2000","unstructured":"Mitchell MS, Kan-Mitchell J, Minev B, Edman C, Deans RJ: A novel melanoma gene (MG50) encoding the interleukin 1 receptor antagonist and six epitopes recognized by human cytolytic T lymphocytes. Cancer Res. 2000, 60 (22): 6448-6456.","journal-title":"Cancer Res"},{"issue":"1","key":"159_CR55","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.cancergencyto.2005.12.011","volume":"168","author":"Y Takahashi","year":"2006","unstructured":"Takahashi Y, Ishii Y, Nishida Y, Ikarashi M, Nagata T, Nakamura T, Yamamori S, Asai S: Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH. Cancer Genet Cytogenet. 2006, 168 (1): 30-35.","journal-title":"Cancer Genet Cytogenet"},{"key":"159_CR56","unstructured":"PubMed., http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=PubMed"},{"issue":"Web Server issu","key":"159_CR57","doi-asserted-by":"publisher","first-page":"W475","DOI":"10.1093\/nar\/gkh353","volume":"32","author":"S Karanam","year":"2004","unstructured":"Karanam S, Moreno CS: CONFAC: automated application of comparative genomic promoter analysis to DNA microarray datasets. Nucleic Acids Res. 2004, 32 (Web Server issue): W475-84.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"159_CR58","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1093\/nar\/28.1.316","volume":"28","author":"E Wingender","year":"2000","unstructured":"Wingender E, Chen X, Hehl R, Karas H, Liebich I, Matys V, Meinhardt T, Pruss M, Reuter I, Schacherer F: TRANSFAC: an integrated system for gene expression regulation. Nucleic Acids Res. 2000, 28 (1): 316-319.","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"159_CR59","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.biosystems.2005.08.001","volume":"82","author":"P Perco","year":"2005","unstructured":"Perco P, Kainz A, Mayer G, Lukas A, Oberbauer R, Mayer B: Detection of coregulation in differential gene expression profiles. Biosystems. 2005, 82 (3): 235-247.","journal-title":"Biosystems"},{"issue":"1","key":"159_CR60","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1093\/nar\/gkg056","volume":"31","author":"GD Bader","year":"2003","unstructured":"Bader GD, Betel D, Hogue CWV: BIND: the Biomolecular Interaction Network Database. Nucleic Acids Res. 2003, 31 (1): 248-250. England","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"159_CR61","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0014-5793(01)03293-8","volume":"513","author":"A Zanzoni","year":"2002","unstructured":"Zanzoni A, Montecchi-Palazzi L, Quondam M, Ausiello G, Helmer-Citterich M, Cesareni G: MINT: a Molecular INTeraction database. FEBS Lett. 2002, 513 (1): 135-140.","journal-title":"FEBS Lett"},{"issue":"Database issue","key":"159_CR62","doi-asserted-by":"publisher","first-page":"D169","DOI":"10.1093\/nar\/gkj148","volume":"34","author":"HW Mewes","year":"2006","unstructured":"Mewes HW, Frishman D, Mayer KF, Munsterkotter M, Noubibou O, Pagel P, Rattei T, Oesterheld M, Ruepp A, Stumpflen V: MIPS: analysis and annotation of proteins from whole genomes in 2005. Nucleic Acids Res. 2006, 34 (Database issue): D169-72.","journal-title":"Nucleic Acids Res"},{"key":"159_CR63","first-page":"D497","volume-title":"Nucleic Acids Res","author":"S Peri","year":"2004","unstructured":"Peri S, Navarro JD, Kristiansen TZ, Amanchy R, Surendranath V, Muthusamy B, Gandhi TKB, Chandrika KN, Deshpande N, Suresh S, Rashmi BP, Shanker K, Padma N, Niranjan V, Harsha HC, Talreja N, Vrushabendra BM, Ramya MA, Yatish AJ, Joy M, Shivashankar HN, Kavitha MP, Menezes M, Choudhury DR, Ghosh N, Saravana R, Chandran S, Mohan S, Jonnalagadda CK, Prasad CK, Kumar-Sinha C, Deshpande KS, Pandey A: Human protein reference database as a discovery resource for proteomics. Nucleic Acids Res. 2004, 32 Database issue: D497-501. England"},{"issue":"6B","key":"159_CR64","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1101\/gr.956303","volume":"13","author":"H Suzuki","year":"2003","unstructured":"Suzuki H, Saito R, Kanamori M, Kai C, Schonbach C, Nagashima T, Hosaka J, Hayashizaki Y: The mammalian protein-protein interaction database and its viewing system that is linked to the main FANTOM2 viewer. Genome Res. 2003, 13 (6B): 1534-1541.","journal-title":"Genome Res"},{"key":"159_CR65","first-page":"367","volume-title":"Pac Symp Biocomput","author":"JY Chen","year":"2006","unstructured":"Chen JY, Shen C, Sivachenko AY: Mining alzheimer disease relevant proteins from integrated protein interactome data. Pac Symp Biocomput. 2006, 367-378."},{"issue":"13","key":"159_CR66","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.1002\/elps.200600064","volume":"27","author":"P Perco","year":"2006","unstructured":"Perco P, Rapberger R, Siehs C, Lukas A, Oberbauer R, Mayer G, Mayer B: Transforming omics data into context: bioinformatics on genomics and proteomics raw data. Electrophoresis. 2006, 27 (13): 2659-2675.","journal-title":"Electrophoresis"},{"key":"159_CR67","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/S0065-3233(00)54009-1","volume":"54","author":"K Nakai","year":"2000","unstructured":"Nakai K: Protein sorting signals and prediction of subcellular localization. Adv Protein Chem. 2000, 54: 277-344.","journal-title":"Adv Protein Chem"},{"issue":"4","key":"159_CR68","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/S0888-7543(05)80111-9","volume":"14","author":"K Nakai","year":"1992","unstructured":"Nakai K, Kanehisa M: A knowledge base for predicting protein localization sites in eukaryotic cells. Genomics. 1992, 14 (4): 897-911.","journal-title":"Genomics"},{"issue":"1","key":"159_CR69","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/j.1048-891X.2005.15007.x","volume":"15","author":"X Zhang","year":"2005","unstructured":"Zhang X, Feng J, Cheng Y, Yao Y, Ye X, Fu T, Cheng H: Characterization of differentially expressed genes in ovarian cancer by cDNA microarrays. Int J Gynecol Cancer. 2005, 15 (1): 50-57.","journal-title":"Int J Gynecol Cancer"},{"issue":"49","key":"159_CR70","doi-asserted-by":"publisher","first-page":"8171","DOI":"10.1038\/sj.onc.1207979","volume":"23","author":"L De Cecco","year":"2004","unstructured":"De Cecco L, Marchionni L, Gariboldi M, Reid JF, Lagonigro MS, Caramuta S, Ferrario C, Bussani E, Mezzanzanica D, Turatti F, Delia D, Daidone MG, Oggionni M, Bertuletti N, Ditto A, Raspagliesi F, Pilotti S, Pierotti MA, Canevari S, Schneider C: Gene expression profiling of advanced ovarian cancer: characterization of a molecular signature involving fibroblast growth factor 2. Oncogene. 2004, 23 (49): 8171-8183.","journal-title":"Oncogene"},{"issue":"49","key":"159_CR71","doi-asserted-by":"publisher","first-page":"8065","DOI":"10.1038\/sj.onc.1207959","volume":"23","author":"H Donninger","year":"2004","unstructured":"Donninger H, Bonome T, Radonovich M, Pise-Masison CA, Brady J, Shih JH, Barrett JC, Birrer MJ: Whole genome expression profiling of advance stage papillary serous ovarian cancer reveals activated pathways. Oncogene. 2004, 23 (49): 8065-8077.","journal-title":"Oncogene"},{"issue":"1","key":"159_CR72","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.jsgi.2003.07.004","volume":"11","author":"JM Lancaster","year":"2004","unstructured":"Lancaster JM, Dressman HK, Whitaker RS, Havrilesky L, Gray J, Marks JR, Nevins JR, Berchuck A: Gene expression patterns that characterize advanced stage serous ovarian cancers. J Soc Gynecol Investig. 2004, 11 (1): 51-59.","journal-title":"J Soc Gynecol Investig"},{"issue":"4","key":"159_CR73","first-page":"847","volume":"24","author":"BC Lee","year":"2004","unstructured":"Lee BC, Cha K, Avraham S, Avraham HK: Microarray analysis of differentially expressed genes associated with human ovarian cancer. Int J Oncol. 2004, 24 (4): 847-851.","journal-title":"Int J Oncol"},{"issue":"1","key":"159_CR74","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1002\/ijc.20408","volume":"112","author":"AD Santin","year":"2004","unstructured":"Santin AD, Zhan F, Bellone S, Palmieri M, Cane S, Bignotti E, Anfossi S, Gokden M, Dunn D, Roman JJ, O'Brien TJ, Tian E, Cannon MJ, Shaughnessy J, Pecorelli S: Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: identification of candidate molecular markers for ovarian cancer diagnosis and therapy. Int J Cancer. 2004, 112 (1): 14-25.","journal-title":"Int J Cancer"},{"issue":"1","key":"159_CR75","first-page":"43","volume":"14","author":"Y Collins","year":"2004","unstructured":"Collins Y, Tan DF, Pejovic T, Mor G, Qian F, Rutherford T, Varma R, McQuaid D, Driscoll D, Jiang M, Deeb G, Lele S, Nowak N, Odunsi K: Identification of differentially expressed genes in clinically distinct groups of serous ovarian carcinomas using cDNA microarray. Int J Mol Med. 2004, 14 (1): 43-53.","journal-title":"Int J Mol Med"},{"issue":"2","key":"159_CR76","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0002-9440(10)63306-8","volume":"165","author":"K Hibbs","year":"2004","unstructured":"Hibbs K, Skubitz KM, Pambuccian SE, Casey RC, Burleson KM, Oegema TR, Thiele JJ, Grindle SM, Bliss RL, Skubitz AP: Differential gene expression in ovarian carcinoma: identification of potential biomarkers. Am J Pathol. 2004, 165 (2): 397-414.","journal-title":"Am J Pathol"},{"issue":"3","key":"159_CR77","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/sj.bjc.6601603","volume":"90","author":"TR Adib","year":"2004","unstructured":"Adib TR, Henderson S, Perrett C, Hewitt D, Bourmpoulia D, Ledermann J, Boshoff C: Predicting biomarkers for ovarian cancer using gene-expression microarrays. Br J Cancer. 2004, 90 (3): 686-692.","journal-title":"Br J Cancer"},{"issue":"13","key":"159_CR78","first-page":"4811","volume":"9","author":"KK Zorn","year":"2003","unstructured":"Zorn KK, Jazaeri AA, Awtrey CS, Gardner GJ, Mok SC, Boyd J, Birrer MJ: Choice of normal ovarian control influences determination of differentially expressed genes in ovarian cancer expression profiling studies. Clin Cancer Res. 2003, 9 (13): 4811-4818.","journal-title":"Clin Cancer Res"},{"issue":"41","key":"159_CR79","doi-asserted-by":"publisher","first-page":"6289","DOI":"10.1038\/sj.onc.1205785","volume":"21","author":"D Matei","year":"2002","unstructured":"Matei D, Graeber TG, Baldwin RL, Karlan BY, Rao J, Chang DD: Gene expression in epithelial ovarian carcinoma. Oncogene. 2002, 21 (41): 6289-6298.","journal-title":"Oncogene"},{"issue":"10","key":"159_CR80","first-page":"2923","volume":"62","author":"GP Sawiris","year":"2002","unstructured":"Sawiris GP, Sherman-Baust CA, Becker KG, Cheadle C, Teichberg D, Morin PJ: Development of a highly specialized cDNA array for the study and diagnosis of epithelial ovarian cancer. Cancer Res. 2002, 62 (10): 2923-2928.","journal-title":"Cancer Res"},{"issue":"15","key":"159_CR81","first-page":"5895","volume":"61","author":"V Shridhar","year":"2001","unstructured":"Shridhar V, Lee J, Pandita A, Iturria S, Avula R, Staub J, Morrissey M, Calhoun E, Sen A, Kalli K, Keeney G, Roche P, Cliby W, Lu K, Schmandt R, Mills GB, Bast RC, James CD, Couch FJ, Hartmann LC, Lillie J, Smith DI: Genetic analysis of early- versus late-stage ovarian tumors. Cancer Res. 2001, 61 (15): 5895-5904.","journal-title":"Cancer Res"},{"issue":"10","key":"159_CR82","first-page":"3869","volume":"61","author":"CD Hough","year":"2001","unstructured":"Hough CD, Cho KR, Zonderman AB, Schwartz DR, Morin PJ: Coordinately up-regulated genes in ovarian cancer. Cancer Res. 2001, 61 (10): 3869-3876.","journal-title":"Cancer Res"},{"issue":"19","key":"159_CR83","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1093\/jnci\/93.19.1458","volume":"93","author":"SC Mok","year":"2001","unstructured":"Mok SC, Chao J, Skates S, Wong K, Yiu GK, Muto MG, Berkowitz RS, Cramer DW: Prostasin, a potential serum marker for ovarian cancer: identification through microarray technology. J Natl Cancer Inst. 2001, 93 (19): 1458-1464.","journal-title":"J Natl Cancer Inst"},{"issue":"22","key":"159_CR84","first-page":"6281","volume":"60","author":"CD Hough","year":"2000","unstructured":"Hough CD, Sherman-Baust CA, Pizer ES, Montz FJ, Im DD, Rosenshein NB, Cho KR, Riggins GJ, Morin PJ: Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer. Cancer Res. 2000, 60 (22): 6281-6287.","journal-title":"Cancer Res"},{"issue":"23","key":"159_CR85","first-page":"6744","volume":"60","author":"RS Ismail","year":"2000","unstructured":"Ismail RS, Baldwin RL, Fang J, Browning D, Karlan BY, Gasson JC, Chang DD: Differential gene expression between normal and tumor-derived ovarian epithelial cells. Cancer Res. 2000, 60 (23): 6744-6749.","journal-title":"Cancer Res"},{"issue":"18","key":"159_CR86","first-page":"5007","volume":"60","author":"K Ono","year":"2000","unstructured":"Ono K, Tanaka T, Tsunoda T, Kitahara O, Kihara C, Okamoto A, Ochiai K, Takagi T, Nakamura Y: Identification by cDNA microarray of genes involved in ovarian carcinogenesis. Cancer Res. 2000, 60 (18): 5007-5011.","journal-title":"Cancer Res"},{"issue":"2","key":"159_CR87","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/S0378-1119(99)00342-X","volume":"238","author":"M Schummer","year":"1999","unstructured":"Schummer M, Ng WV, Bumgarner RE, Nelson PS, Schummer B, Bednarski DW, Hassell L, Baldwin RL, Karlan BY, Hood L: Comparative hybridization of an array of 21, 500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas. Gene. 1999, 238 (2): 375-385.","journal-title":"Gene"}],"container-title":["BMC Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-0509-2-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T02:14:00Z","timestamp":1630462440000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsystbiol.biomedcentral.com\/articles\/10.1186\/1752-0509-2-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,3]]},"references-count":87,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["159"],"URL":"https:\/\/doi.org\/10.1186\/1752-0509-2-2","relation":{},"ISSN":["1752-0509"],"issn-type":[{"value":"1752-0509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,3]]},"assertion":[{"value":"5 April 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2008","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2008","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"2"}}