{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:48:28Z","timestamp":1787068108358,"version":"build-2736575974"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,3,3]],"date-time":"2008-03-03T00:00:00Z","timestamp":1204502400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Syst Biol"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1186\/1752-0509-2-24","type":"journal-article","created":{"date-parts":[[2008,3,4]],"date-time":"2008-03-04T02:14:36Z","timestamp":1204596876000},"source":"Crossref","is-referenced-by-count":78,"title":["OptCircuit: An optimization based method for computational design of genetic circuits"],"prefix":"10.1186","volume":"2","author":[{"given":"Madhukar S","family":"Dasika","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costas D","family":"Maranas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,3,3]]},"reference":[{"key":"181_CR1","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/nature04335","volume":"438","author":"D Sprinzak","year":"2005","unstructured":"Sprinzak D, Elowitz MB: Reconstruction of genetic circuits. Nature. 2005, 438: 443-448. 10.1038\/nature04335","journal-title":"Nature"},{"key":"181_CR2","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1529\/biophysj.104.044131","volume":"87","author":"XJ Feng","year":"2004","unstructured":"Feng XJ, Hooshangi S, Chen D, Li G, Weiss R: Optimizing genetic circuits by global sensitivity analysis. Biophys J. 2004, 87: 2195-2202. 10.1529\/biophysj.104.044131","journal-title":"Biophys J"},{"key":"181_CR3","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/nature01257","volume":"420","author":"J Hasty","year":"2002","unstructured":"Hasty J, McMillen D, Collins JJ: Engineered gene circuits. Nature. 2002, 420: 224-230. 10.1038\/nature01257","journal-title":"Nature"},{"key":"181_CR4","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/nature04342","volume":"438","author":"D Endy","year":"2005","unstructured":"Endy D: Foundations for engineering biology. Nature. 2005, 438: 449-453. 10.1038\/nature04342","journal-title":"Nature"},{"key":"181_CR5","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1126\/science.1089072","volume":"301","author":"U Alon","year":"2003","unstructured":"Alon U: Biological networks: the tinkerer as an engineer. Science. 2003, 301: 1866-1867. 10.1126\/science.1089072","journal-title":"Science"},{"key":"181_CR6","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/35002131","volume":"403","author":"TS Gardner","year":"2000","unstructured":"Gardner TS, Cantor CR, Collins JJ: Construction of a genetic toggle switch in Escherichia coli. Nature. 2000, 403: 339-342. 10.1038\/35002131","journal-title":"Nature"},{"key":"181_CR7","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/35002125","volume":"403","author":"MB Elowitz","year":"2000","unstructured":"Elowitz MB, Leibler S: A synthetic oscillatory network of transcriptional regulators. Nature. 2000, 403: 335-338. 10.1038\/35002125","journal-title":"Nature"},{"key":"181_CR8","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1073\/pnas.022642299","volume":"99","author":"D McMillen","year":"2002","unstructured":"McMillen D, Kopell N, Hasty J, Collins JJ: Synchronizing genetic relaxation oscillators by intercell signaling. Proc Natl Acad Sci USA. 2002, 99: 679-684. 10.1073\/pnas.022642299","journal-title":"Proc Natl Acad Sci USA"},{"key":"181_CR9","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/nature03508","volume":"435","author":"E Fung","year":"2005","unstructured":"Fung E, Wong WW, Suen JK, Bulter T, Lee SG: A synthetic gene-metabolic oscillator. Nature. 2005, 435: 118-122. 10.1038\/nature03508","journal-title":"Nature"},{"key":"181_CR10","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/S0092-8674(03)00346-5","volume":"113","author":"MR Atkinson","year":"2003","unstructured":"Atkinson MR, Savageau MA, Myers JT, Ninfa AJ: Development of genetic circuitry exhibiting toggle switch or oscillatory behavior in Escherichia coli. Cell. 2003, 113: 597-607. 10.1016\/S0092-8674(03)00346-5","journal-title":"Cell"},{"key":"181_CR11","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1038\/nature03461","volume":"434","author":"S Basu","year":"2005","unstructured":"Basu S, Gerchman Y, Collins CH, Arnold FH, Weiss R: A synthetic multicellular system for programmed pattern formation. Nature. 2005, 434: 1130-1134. 10.1038\/nature03461","journal-title":"Nature"},{"key":"181_CR12","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1073\/pnas.040411297","volume":"97","author":"J Hasty","year":"2000","unstructured":"Hasty J, Pradines J, Dolnik M, Collins JJ: Noise-based switches and amplifiers for gene expression. Proc Natl Acad Sci USA. 2000, 97: 2075-2080. 10.1073\/pnas.040411297","journal-title":"Proc Natl Acad Sci USA"},{"key":"181_CR13","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1002\/(SICI)1521-1878(200006)22:6<507::AID-BIES3>3.0.CO;2-0","volume":"22","author":"EM Judd","year":"2000","unstructured":"Judd EM, Laub MT, McAdams HH: Toggles and oscillators: new genetic circuit designs. Bioessays. 2000, 22: 507-509. 10.1002\/(SICI)1521-1878(200006)22:6<507::AID-BIES3>3.0.CO;2-0","journal-title":"Bioessays"},{"key":"181_CR14","doi-asserted-by":"publisher","first-page":"8414","DOI":"10.1073\/pnas.0402940101","volume":"101","author":"H Kobayashi","year":"2004","unstructured":"Kobayashi H, Kaern M, Araki M, Chung K, Gardner TS: Programmable cells: interfacing natural and engineered gene networks. Proc Natl Acad Sci USA. 2004, 101: 8414-8419. 10.1073\/pnas.0402940101","journal-title":"Proc Natl Acad Sci USA"},{"key":"181_CR15","doi-asserted-by":"publisher","first-page":"3581","DOI":"10.1073\/pnas.0408507102","volume":"102","author":"S Hooshangi","year":"2005","unstructured":"Hooshangi S, Thiberge S, Weiss R: Ultrasensitivity and noise propagation in a synthetic transcriptional cascade. Proc Natl Acad Sci USA. 2005, 102: 3581-3586. 10.1073\/pnas.0408507102","journal-title":"Proc Natl Acad Sci USA"},{"key":"181_CR16","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jmb.2003.09.049","volume":"334","author":"S Mangan","year":"2003","unstructured":"Mangan S, Zaslaver A, Alon U: The coherent feedforward loop serves as a sign-sensitive delay element in transcription networks. J Mol Biol. 2003, 334: 197-204. 10.1016\/j.jmb.2003.09.049","journal-title":"J Mol Biol"},{"key":"181_CR17","doi-asserted-by":"publisher","first-page":"11980","DOI":"10.1073\/pnas.2133841100","volume":"100","author":"S Mangan","year":"2003","unstructured":"Mangan S, Alon U: Structure and function of the feed-forward loop network motif. Proc Natl Acad Sci USA. 2003, 100: 11980-11985. 10.1073\/pnas.2133841100","journal-title":"Proc Natl Acad Sci USA"},{"key":"181_CR18","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/35014651","volume":"405","author":"A Becskei","year":"2000","unstructured":"Becskei A, Serrano L: Engineering stability in gene networks by autoregulation. Nature. 2000, 405: 590-593. 10.1038\/35014651","journal-title":"Nature"},{"key":"181_CR19","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1038\/nbt833","volume":"21","author":"VJ Martin","year":"2003","unstructured":"Martin VJ, Pitera DJ, Withers ST, Newman JD, Keasling JD: Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nat Biotechnol. 2003, 21: 796-802. 10.1038\/nbt833","journal-title":"Nat Biotechnol"},{"key":"181_CR20","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.jmb.2005.10.076","volume":"355","author":"JC Anderson","year":"2006","unstructured":"Anderson JC, Clarke EJ, Arkin AP, Voigt CA: Environmentally controlled invasion of cancer cells by engineered bacteria. J Mol Biol. 2006, 355: 619-627. 10.1016\/j.jmb.2005.10.076","journal-title":"J Mol Biol"},{"key":"181_CR21","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/nature04405","volume":"438","author":"A Levskaya","year":"2005","unstructured":"Levskaya A, Chevalier AA, Tabor JJ, Simpson ZB, Lavery LA: Synthetic biology: engineering Escherichia coli to see light. Nature. 2005, 438: 441-442. 10.1038\/nature04405","journal-title":"Nature"},{"key":"181_CR22","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1038\/nature03151","volume":"432","author":"J Tian","year":"2004","unstructured":"Tian J, Gong H, Sheng N, Zhou X, Gulari E: Accurate multiplex gene synthesis from programmable DNA microchips. Nature. 2004, 432: 1050-1054. 10.1038\/nature03151","journal-title":"Nature"},{"key":"181_CR23","unstructured":"Website title., http:\/\/parts.mit.edu"},{"key":"181_CR24","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S0955-0674(03)00017-6","volume":"15","author":"JJ Tyson","year":"2003","unstructured":"Tyson JJ, Chen KC, Novak B: Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell. Curr Opin Cell Biol. 2003, 15: 221-231. 10.1016\/S0955-0674(03)00017-6","journal-title":"Curr Opin Cell Biol"},{"key":"181_CR25","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1063\/1.1345702","volume":"11","author":"J Hasty","year":"2001","unstructured":"Hasty J, Isaacs F, Dolnik M, McMillen D, Collins JJ: Designer gene networks: Towards fundamental cellular control. Chaos. 2001, 11: 207-220. 10.1063\/1.1345702","journal-title":"Chaos"},{"key":"181_CR26","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1146\/annurev.genom.3.030502.111004","volume":"3","author":"A Gilman","year":"2002","unstructured":"Gilman A, Arkin AP: Genetic \"code\": representations and dynamical models of genetic components and networks. Annu Rev Genomics Hum Genet. 2002, 3: 341-369. 10.1146\/annurev.genom.3.030502.111004","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"181_CR27","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1007\/s10955-005-7009-y","volume":"121","author":"L Glass","year":"2005","unstructured":"Glass L, Perkins TJ, Mason J, Siegelmann HT, Edwards R: Chaotic Dynamics in an Electronic Model of a Genetic Network. Journal of Statistical Physics. 2005, 121: 969-994. 10.1007\/s10955-005-7009-y.","journal-title":"Journal of Statistical Physics"},{"key":"181_CR28","first-page":"54","volume-title":"The Device physics of Cellular Logic Gates","author":"S Basu","year":"2002","unstructured":"Basu S, Weiss R: The Device physics of Cellular Logic Gates. 2002, 54-61."},{"key":"181_CR29","volume-title":"Toward in vivo Digital Circuits","author":"R Weiss","year":"1999","unstructured":"Weiss R, Homay GE, Knight TF: Toward in vivo Digital Circuits. 1999"},{"key":"181_CR30","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1063\/1.1786683","volume":"14","author":"J Mason","year":"2004","unstructured":"Mason J, Linsay PS, Collins JJ, Glass L: Evolving complex dynamics in electronic models of genetic networks. Chaos. 2004, 14: 707-715. 10.1063\/1.1786683","journal-title":"Chaos"},{"key":"181_CR31","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1126\/science.1067407","volume":"296","author":"CC Guet","year":"2002","unstructured":"Guet CC, Elowitz MB, Hsing W, Leibler S: Combinatorial synthesis of genetic networks. Science. 2002, 296: 1466-1470. 10.1126\/science.1067407","journal-title":"Science"},{"key":"181_CR32","doi-asserted-by":"publisher","first-page":"3873","DOI":"10.1529\/biophysj.105.064204","volume":"89","author":"LM Tuttle","year":"2005","unstructured":"Tuttle LM, Salis H, Tomshine J, Kaznessis YN: Model-driven designs of an oscillating gene network. Biophys J. 2005, 89: 3873-3883. 10.1529\/biophysj.105.064204","journal-title":"Biophys J"},{"key":"181_CR33","doi-asserted-by":"publisher","first-page":"16587","DOI":"10.1073\/pnas.252535999","volume":"99","author":"Y Yokobayashi","year":"2002","unstructured":"Yokobayashi Y, Weiss R, Arnold FH: Directed evolution of a genetic circuit. Proc Natl Acad Sci USA. 2002, 99: 16587-16591. 10.1073\/pnas.252535999","journal-title":"Proc Natl Acad Sci USA"},{"key":"181_CR34","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1073\/pnas.0304532101","volume":"101","author":"P Francois","year":"2004","unstructured":"Francois P, Hakim V: Design of genetic networks with specified functions by evolution in silico. Proc Natl Acad Sci USA. 2004, 101: 580-585. 10.1073\/pnas.0304532101","journal-title":"Proc Natl Acad Sci USA"},{"key":"181_CR35","doi-asserted-by":"publisher","first-page":"16904","DOI":"10.1073\/pnas.262658899","volume":"99","author":"D Battogtokh","year":"2002","unstructured":"Battogtokh D, Asch DK, Case ME, Arnold J, Schuttler HB: An ensemble method for idenitfying regulatory circuits with special reference to the qa gene cluster of Neurospora crassa. Proc Natl Acad Sci USA. 2002, 99: 16904-16909. 10.1073\/pnas.262658899","journal-title":"Proc Natl Acad Sci USA"},{"key":"181_CR36","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1023\/B:NACO.0000006774.27778.f0","volume":"2","author":"S Basu","year":"2003","unstructured":"Basu S, Karig D, Weiss R: Engineering signal processing in cells: Towards molecular concentration band detection. Natural Computing. 2003, 2: 463-478. 10.1023\/B:NACO.0000006774.27778.f0.","journal-title":"Natural Computing"},{"key":"181_CR37","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1126\/science.271.5251.990","volume":"271","author":"KC Keiler","year":"1996","unstructured":"Keiler KC, Waller PR, Sauer RT: Role of a peptide tagging system in degradation of proteins synthesized from damaged messenger RNA. Science. 1996, 271: 990-993. 10.1126\/science.271.5251.990","journal-title":"Science"},{"key":"181_CR38","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1093\/nar\/25.6.1203","volume":"25","author":"R Lutz","year":"1997","unstructured":"Lutz R, Bujard H: Independent and tight regulation of transcriptional units in Escherichia coli via the LacR\/O, the TetR\/O and AraC\/I1\u2013I2 regulatory elements 10.1093\/nar\/25.6.1203. Nucl Acids Res. 1997, 25: 1203-1210.","journal-title":"Nucl Acids Res"},{"key":"181_CR39","doi-asserted-by":"publisher","first-page":"26108","DOI":"10.1063\/1.2208927","volume":"16","author":"S Hooshangi","year":"2006","unstructured":"Hooshangi S, Weiss R: The effect of negative feedback on noise propagation in transcriptional gene networks. Chaos. 2006, 16: 26108-26108. 10.1063\/1.2208927.","journal-title":"Chaos"},{"key":"181_CR40","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1088\/1478-3975\/3\/4\/007","volume":"3","author":"H Salis","year":"2006","unstructured":"Salis H, Kaznessis YN: Computer-aided design of modular protein devices: Boolean AND gene activation. Phys Biol. 2006, 3: 295-310. 10.1088\/1478-3975\/3\/4\/007","journal-title":"Phys Biol"},{"key":"181_CR41","doi-asserted-by":"publisher","first-page":"3196","DOI":"10.1529\/biophysj.106.083485","volume":"91","author":"J Tomshine","year":"2006","unstructured":"Tomshine J, Kaznessis YN: Optimization of a stochastically simulated gene network model via simulated annealing. Biophys J. 2006, 91: 3196-3205. 10.1529\/biophysj.106.083485","journal-title":"Biophys J"},{"key":"181_CR42","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1752-0509-1-7","volume":"1","author":"V Sotiropoulos","year":"2007","unstructured":"Sotiropoulos V, Kaznessis YN: Synthetic tetracycline-inducible regulatory networks: computer-aided design of dynamic phenotypes. BMC Syst Biol. 2007, 1: 7- 10.1186\/1752-0509-1-7","journal-title":"BMC Syst Biol"},{"key":"181_CR43","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.1101\/gr.1198103","volume":"13","author":"DE Zak","year":"2003","unstructured":"Zak DE, Gonye GE, Schwaber JS, Doyle FJ: Importance of input perturbations and stochastic gene expression in the reverse engineering of genetic regulatory networks: insights from an identifiability analysis of an in silico network. Genome Res. 2003, 13: 2396-2405. 10.1101\/gr.1198103","journal-title":"Genome Res"},{"key":"181_CR44","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1002\/bit.10731","volume":"83","author":"BP Kramer","year":"2003","unstructured":"Kramer BP, Weber W, Fussenegger M: Artificial regulatory networks and cascades for discrete multilevel transgene control in mammalian cells. Biotechnol Bioeng. 2003, 83: 810-820. 10.1002\/bit.10731","journal-title":"Biotechnol Bioeng"},{"key":"181_CR45","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/nrg1471","volume":"5","author":"H Kitano","year":"2004","unstructured":"Kitano H: Biological robustness. Nature Reviews Genetics. 2004, 5: 826-837. 10.1038\/nrg1471","journal-title":"Nature Reviews Genetics"},{"key":"181_CR46","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1006\/jtbi.2000.1068","volume":"203","author":"JL Cherry","year":"2000","unstructured":"Cherry JL, Adler FR: How to make a biological switch. J Theor Biol. 2000, 203: 117-133. 10.1006\/jtbi.2000.1068","journal-title":"J Theor Biol"},{"key":"181_CR47","volume-title":"Cincinnati","author":"NH El-Farra","year":"2005","unstructured":"El-Farra NH: An Optimization-Based Method for the Design of Robust Synthetic Switches in Biological Networks. Cincinnati. 2005"},{"key":"181_CR48","doi-asserted-by":"publisher","first-page":"S457","DOI":"10.1016\/S0098-1354(97)00091-4","volume":"21","author":"MJ Mohideen","year":"1997","unstructured":"Mohideen MJ, Perkins JD, Pistikopoulos EN: Towards an Efficient Numerical Procedure for Mixed Integer Optimal Control. Computers and Chemical Engineering. 1997, 21: S457-S462.","journal-title":"Computers and Chemical Engineering"},{"key":"181_CR49","first-page":"2461","volume":"47","author":"AR Sirdeshpande","year":"2001","unstructured":"Sirdeshpande AR, Ierapetritou MG, Androulakis IP: Design of Flexible Reduced Kinetic Mechanisms. Process Systems Engineering. 2001, 47: 2461-2473.","journal-title":"Process Systems Engineering"},{"key":"181_CR50","volume-title":"A Robust and Efficient Mixed-Integer Non-Linear Dynamic Optimization Approach for Simultaneous Design and Control","author":"AF Tlacuahuac","year":"2004","unstructured":"Tlacuahuac AF, Beigler LT: A Robust and Efficient Mixed-Integer Non-Linear Dynamic Optimization Approach for Simultaneous Design and Control. 2004"},{"key":"181_CR51","first-page":"760","volume":"41","author":"V Bansal","year":"2002","unstructured":"Bansal V, Perkins JD, Pistikopoulos EN: A Case Study in Simultaneous Design and Control Using Rigorous Mixed-Integer Dynamic Optimization Models. IndEngChemRes. 2002, 41: 760-778.","journal-title":"IndEngChemRes"},{"key":"181_CR52","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/S0098-1354(02)00261-2","volume":"27","author":"V Bansal","year":"2003","unstructured":"Bansal V, Sakizlis V, Ross R, Perkins JD, Pistikopoulos EN: New algorithms for mixed-integer dynamic optimization. Computers and Chemical Engineering. 2003, 27: 647-688. 10.1016\/S0098-1354(02)00261-2.","journal-title":"Computers and Chemical Engineering"},{"key":"181_CR53","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1002\/aic.10494","volume":"51","author":"B Chachuat","year":"2005","unstructured":"Chachuat B, Singer AB, Barton PI: Global Mixed-Integer Dynamic optimization. AIChe Journal. 2005, 51: 2235-2253. 10.1002\/aic.10494.","journal-title":"AIChe Journal"},{"key":"181_CR54","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195100563.001.0001","volume-title":"Nonlinear and Mixed-Integer Optimization","author":"CA Floudas","year":"1995","unstructured":"Floudas CA: Nonlinear and Mixed-Integer Optimization. 1995, Fundamentals and Applications: Oxford University Press"}],"container-title":["BMC Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-0509-2-24.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1752-0509-2-24\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-0509-2-24.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,5]],"date-time":"2021-09-05T01:49:26Z","timestamp":1630806566000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsystbiol.biomedcentral.com\/articles\/10.1186\/1752-0509-2-24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,3]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["181"],"URL":"https:\/\/doi.org\/10.1186\/1752-0509-2-24","relation":{},"ISSN":["1752-0509"],"issn-type":[{"value":"1752-0509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,3]]},"article-number":"24"}}