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The human microbial pathogen <jats:italic>Helicobacter pylori<\/jats:italic> can induce chronic gastritis, peptic ulceration and more rarely, gastric adenocarcinoma. The <jats:italic>H. pylori<\/jats:italic> effector protein cytotoxin associated gene A (CagA), which is translocated via a type IV secretion system (T4SS) into epithelial cells, intracellularly modulates the c-Met receptor and promotes cellular processes leading to cell scattering, which could contribute to the invasiveness of tumour cells. Using a logical modelling framework, the presented work aims at analysing the c-Met signal transduction network and how it is interfered by <jats:italic>H. pylori<\/jats:italic> infection, which might be of importance for tumour development.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A logical model of HGF and <jats:italic>H. pylori<\/jats:italic> induced c-Met signal transduction is presented in this work. The formalism of logical interaction hypergraphs (LIH) was used to construct the network model. The molecular interactions included in the model were all assembled manually based on a careful meta-analysis of published experimental results. Our model reveals the differences and commonalities of the response of the network upon HGF and <jats:italic>H. pylori<\/jats:italic> induced c-Met signalling. As another important result, using the formalism of minimal intervention sets, phospholipase C\u03b31 (PLC\u03b31) was identified as knockout target for repressing the activation of the extracellular signal regulated kinase 1\/2 (ERK1\/2), a signalling molecule directly linked to cell scattering in <jats:italic>H. pylori<\/jats:italic> infected cells. The model predicted only an effect on ERK1\/2 for the <jats:italic>H. pylori<\/jats:italic> stimulus, but not for HGF treatment. This result could be confirmed experimentally in MDCK cells using a specific pharmacological inhibitor against PLC\u03b31. The <jats:italic>in silico<\/jats:italic> predictions for the knockout of two other network components were also verified experimentally.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This work represents one of the first approaches in the direction of host-pathogen systems biology aiming at deciphering signalling changes brought about by pathogenic bacteria. The suitability of our network model is demonstrated by an <jats:italic>in silico<\/jats:italic> prediction of a relevant target against pathogen infection.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-0509-2-4","type":"journal-article","created":{"date-parts":[[2008,1,15]],"date-time":"2008-01-15T07:15:05Z","timestamp":1200381305000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Host-pathogen systems biology: logical modelling of hepatocyte growth factor and Helicobacter pylori induced c-Met signal transduction"],"prefix":"10.1186","volume":"2","author":[{"given":"Raimo","family":"Franke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Wundrack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernst-Dieter","family":"Gilles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Klamt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thilo","family":"K\u00e4hne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Naumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,1,14]]},"reference":[{"key":"161_CR1","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1128\/iai.60.7.2657-2666.1992","volume":"60","author":"LT Hu","year":"1992","unstructured":"Hu LT, Foxall PA, Russell R, Mobley HL: Purification of recombinant Helicobacter pylori urease apoenzyme encoded by ureA and ureB. 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