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Computationally, the basic goal of this network comparison or 'querying' is to uncover identical or similar subnetworks by mapping the queried network (e.g. a pathway or functional module) to another network or network database. Such comparative analysis may reveal biologically or clinically important pathways or regulatory networks. In particular, we argue that user-friendly tools for network querying will greatly enhance our ability to study the fundamental properties of biomolecular networks at a system-wide level.<\/jats:p>","DOI":"10.1186\/1752-0509-2-5","type":"journal-article","created":{"date-parts":[[2008,1,18]],"date-time":"2008-01-18T19:12:53Z","timestamp":1200683573000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Biomolecular network querying: a promising approach in systems biology"],"prefix":"10.1186","volume":"2","author":[{"given":"Shihua","family":"Zhang","sequence":"first","affiliation":[]},{"given":"Xiang-Sun","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Luonan","family":"Chen","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2008,1,18]]},"reference":[{"key":"162_CR1","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1101\/gr.207401","volume":"11","author":"D Greenbaum","year":"2001","unstructured":"Greenbaum D, Luscombe NM, Jansen R, Qian J, Gerstein M: Interrelating different types of genomic data, from proteome to secretome: 'oming in on function. 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