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We propose an experimentally-grounded model of gene regulatory networks (GRNs) that are coupled by protein diffusion and comprise a meta-GRN implemented on cellularised domains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Steady states of the meta-GRN model correspond to gene expression profiles typical of hair and non-hair epidermal cells. The simulations also render spatial patterns that match the cellular arrangements observed in root and leaf epidermis. As in actual plants, such patterns are robust in the face of diverse perturbations. We validated the model by checking that it also reproduced the patterns of reported mutants. The meta-GRN model shows that interlinked sub-networks contribute redundantly to the formation of robust hair patterns and permits to advance novel and testable predictions regarding the effect of cell shape, signalling pathways and additional gene interactions affecting spatial cell-patterning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The spatial meta-GRN model integrates available experimental data and contributes to further understanding of the<jats:italic>Arabidopsis<\/jats:italic>epidermal system. It also provides a systems biology framework to explore the interplay among sub-networks of a GRN, cell-to-cell communication, cell shape and domain traits, which could help understanding of general aspects of patterning processes. For instance, our model suggests that the information needed for cell fate determination emerges from dynamic processes that depend upon molecular components inside and outside differentiating cells, suggesting that the classical distinction of lineage<jats:italic>versus<\/jats:italic>positional cell differentiation may be instrumental but rather artificial. It also suggests that interlinkage of nonlinear and redundant sub-networks in larger networks is important for pattern robustness. Pursuing dynamic analyses of larger (genomic) coupled networks is still not possible. A repertoire of well-characterised regulatory modules, like the one presented here, will, however, help to uncover general principles of the patterning-associated networks, as well as the peculiarities that originate diversity.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1752-0509-2-98","type":"journal-article","created":{"date-parts":[[2008,11,18]],"date-time":"2008-11-18T07:49:06Z","timestamp":1226994546000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Interlinked nonlinear subnetworks underlie the formation of robust cellular patterns in Arabidopsis epidermis: a dynamic spatial model"],"prefix":"10.1186","volume":"2","author":[{"given":"Mariana","family":"Ben\u00edtez","sequence":"first","affiliation":[]},{"given":"Carlos","family":"Espinosa-Soto","sequence":"additional","affiliation":[]},{"given":"Pablo","family":"Padilla-Longoria","sequence":"additional","affiliation":[]},{"given":"Elena R","family":"Alvarez-Buylla","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2008,11,17]]},"reference":[{"key":"255_CR1","volume-title":"Dear Mr. Darwin: Letters on the Evolution of Life and Human Nature","author":"G Dover","year":"2006","unstructured":"Dover G: Dear Mr. Darwin: Letters on the Evolution of Life and Human Nature. 2006, University of California Press"},{"key":"255_CR2","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1104\/pp.125.1.112","volume":"125","author":"B Scheres","year":"2001","unstructured":"Scheres B: Plant cell identity. 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