{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:52:55Z","timestamp":1773535975151,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,6,17]],"date-time":"2009-06-17T00:00:00Z","timestamp":1245196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Syst Biol"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1186\/1752-0509-3-64","type":"journal-article","created":{"date-parts":[[2009,6,17]],"date-time":"2009-06-17T14:15:07Z","timestamp":1245248107000},"source":"Crossref","is-referenced-by-count":18,"title":["Stochastic simulation and analysis of biomolecular reaction networks"],"prefix":"10.1186","volume":"3","author":[{"given":"John M","family":"Frazier","sequence":"first","affiliation":[]},{"given":"Yaroslav","family":"Chushak","sequence":"additional","affiliation":[]},{"given":"Brent","family":"Foy","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2009,6,17]]},"reference":[{"key":"332_CR1","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1126\/science.1070919","volume":"297","author":"MB Elowitz","year":"2002","unstructured":"Elowitz MB, Levine AJ, Siggia ED, Swain PS: Stochastic gene expression in a single cell. Science. 2002, 297: 1183-1186. 10.1126\/science.1070919","journal-title":"Science"},{"key":"332_CR2","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/nrg1615","volume":"6","author":"M Kaern","year":"2005","unstructured":"Kaern M, Elston TC, Blake WJ, Collins JJ: Stochasticity in gene expressions: From theories to phenotypes. Nat Rev Genetics. 2005, 6: 451-464. 10.1038\/nrg1615.","journal-title":"Nat Rev Genetics"},{"key":"332_CR3","volume-title":"Computational Analysis of Biochemical Systems","author":"EO Voit","year":"2000","unstructured":"Voit EO: Computational Analysis of Biochemical Systems. 2000, Cambridge, UK: Cambridge University Press"},{"key":"332_CR4","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1021\/j100540a008","volume":"81","author":"D Gillespie","year":"1977","unstructured":"Gillespie D: Exact stochastic simulation of coupled chemical reactions. J Phys Chem. 1977, 81: 2340-2361. 10.1021\/j100540a008.","journal-title":"J Phys Chem"},{"key":"332_CR5","doi-asserted-by":"publisher","DOI":"10.7551\/mitpress\/9780262195485.001.0001","volume-title":"Systems Modeling in Cell Biology, From Concepts to Nuts and Bolts","author":"Z Szallasi","year":"2006","unstructured":"Szallasi Z, Stelling J, Periwal V: Systems Modeling in Cell Biology, From Concepts to Nuts and Bolts. 2006, Cambridge, MA: MIT Press"},{"key":"332_CR6","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.febslet.2004.09.046","volume":"576","author":"K Ishikawa","year":"2004","unstructured":"Ishikawa K, Sato K, Shima Y, Urabe I, Yomo T: Expression of a cascading genetic network within liposomes. FEBS Letters. 2004, 576: 387-390. 10.1016\/j.febslet.2004.09.046","journal-title":"FEBS Letters"},{"key":"332_CR7","doi-asserted-by":"publisher","first-page":"17669","DOI":"10.1073\/pnas.0408236101","volume":"101","author":"V Noireaux","year":"2004","unstructured":"Noireaux V, Libchaber A: A vesicle bioreactor as a step toward an artificial cell assembly. Proc National Acad Sci USA. 2004, 101: 17669-17674. 10.1073\/pnas.0408236101.","journal-title":"Proc National Acad Sci USA"},{"key":"332_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1088\/1478-3975\/2\/3\/P01","volume":"2","author":"V Noireaux","year":"2005","unstructured":"Noireaux V, Bar-Ziv R, Godefroy J, Salman H, Libchaber A: Toward an artificial cell based on gene expression in vesicles. Phys Bio. 2005, 2: 1-8. 10.1088\/1478-3975\/2\/3\/P01.","journal-title":"Phys Bio"},{"key":"332_CR9","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/1074-5521(95)90031-4","volume":"2","author":"T Oberholzer","year":"1995","unstructured":"Oberholzer T, Albrizio M, Luisi PL: Polymerase chain reaction in liposomes. Chem Bio. 1995, 2: 677-682. 10.1016\/1074-5521(95)90031-4.","journal-title":"Chem Bio"},{"key":"332_CR10","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0167-7799(02)01909-1","volume":"20","author":"A Pohorille","year":"2002","unstructured":"Pohorille A, Deamer D: Artificial cells: prospects for biotechnology. TRENDS in Biotech. 2002, 20: 123-128. 10.1016\/S0167-7799(02)01909-1.","journal-title":"TRENDS in Biotech"},{"key":"332_CR11","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/S1389-1723(01)80322-4","volume":"92","author":"W Yu","year":"2001","unstructured":"Yu W, Sato K, Wakabayashi M, Nakaishi T, Ko-Mitamura EP, Shima Y, Urabe I, Yomo T: Synthesis of functional protein in liposome. J Biosci Bioeng. 2001, 92: 590-593. 10.1263\/jbb.92.590","journal-title":"J Biosci Bioeng"},{"key":"332_CR12","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1063\/1.1378322","volume":"115","author":"D Gillespie","year":"2001","unstructured":"Gillespie D: Approximate accelerated stochastic simulations of chemically reacting systems. J Chem Phys. 2001, 115: 1716-10.1063\/1.1378322.","journal-title":"J Chem Phys"},{"key":"332_CR13","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/S0968-0004(97)01103-1","volume":"22","author":"P Mendez","year":"1997","unstructured":"Mendez P: Biochemistry by numbers: Simulation of biochemical pathways with Gepasi 3. Trends Biochem Sci. 1997, 22: 361-363. 10.1016\/S0968-0004(97)01103-1","journal-title":"Trends Biochem Sci"},{"key":"332_CR14","volume-title":"Animating the Cellular Map: Proceedings of the 9th International Meeting on BioThermoKinetics","author":"HM Sauro","year":"2000","unstructured":"Sauro HM: Jarnac: A system for interactive metabolic analysis. Animating the Cellular Map: Proceedings of the 9th International Meeting on BioThermoKinetics. 2000, Stellenbosch University Press, Stellenbosch, ZA"},{"key":"332_CR15","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1093\/bioinformatics\/btf851","volume":"19","author":"H de Jong","year":"2003","unstructured":"de Jong H, Geiselmann J, Hernandez C, Page M: Genetic network analyzer: Quantitative simulation of genetic regulatory networks. Bioinfor. 2003, 19: 336-344. 10.1093\/bioinformatics\/btf851.","journal-title":"Bioinfor"},{"key":"332_CR16","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/1471-2105-5-24","volume":"5","author":"D Adalsteinsson","year":"2004","unstructured":"Adalsteinsson D, McMillen D, Elston TC: Biochemical Network Stochastic Simulator (BioNetS): software for stochastic modeling of biochemical networks. BMC Bioinform. 2004, 5: 24-10.1186\/1471-2105-5-24.","journal-title":"BMC Bioinform"},{"key":"332_CR17","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1093\/bioinformatics\/bth067","volume":"20","author":"P Dhar","year":"2004","unstructured":"Dhar P, Meng TC, Somani S, Ye L, Sairam S, et al.: Cellware \u2013 a multi-algorithmic software for computational systems biology. Bioinform. 2004, 20: 1319-1321. 10.1093\/bioinformatics\/bth067.","journal-title":"Bioinform"},{"key":"332_CR18","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1142\/S0219720005001132","volume":"3","author":"S Ramsey","year":"2005","unstructured":"Ramsey S, Orrell D, Bolouri H: Dizzy: Stochastic simulation of large-scale genetic regulatory networks. J Bioinform Comput Biol. 2005, 3: 415-436. 10.1142\/S0219720005001132","journal-title":"J Bioinform Comput Biol"},{"key":"332_CR19","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1093\/bioinformatics\/btg442","volume":"20","author":"K Takahashi","year":"2004","unstructured":"Takahashi K, Kaizu K, Hu B, Tomita M: A multi-algorithm, multi-scale method for cell simulation. Bioinform. 2004, 20: 538-546. 10.1093\/bioinformatics\/btg442.","journal-title":"Bioinform"},{"key":"332_CR20","first-page":"345","volume":"1","author":"Y Chushak","year":"2007","unstructured":"Chushak Y, Foy B, Frazier J: Biomolecular Network Simulator: Software for Stochastic Simulation of Cellular Biological Processes. Proceeding of the Spring Simulation Multiconference. 2007, 1: 345-349.","journal-title":"Proceeding of the Spring Simulation Multiconference"},{"key":"332_CR21","volume-title":"Markov Processes: An Introduction for Physical Scientist","author":"D Gillespie","year":"1991","unstructured":"Gillespie D: Markov Processes: An Introduction for Physical Scientist. 1991, Academic Press, London, New York, San Diego"},{"key":"332_CR22","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1093\/bioinformatics\/btg015","volume":"19","author":"M Hucka","year":"2003","unstructured":"Hucka M, Finney A, Sauro HM, Bolouri H, et al.: The systems biology markup language (SBML): A medium for representation and exchange of biochemical network models. Bioinfor. 2003, 19: 524-531. 10.1093\/bioinformatics\/btg015.","journal-title":"Bioinfor"}],"container-title":["BMC Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-0509-3-64.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1752-0509-3-64\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-0509-3-64.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T21:05:57Z","timestamp":1548191157000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsystbiol.biomedcentral.com\/articles\/10.1186\/1752-0509-3-64"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,17]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["332"],"URL":"https:\/\/doi.org\/10.1186\/1752-0509-3-64","relation":{},"ISSN":["1752-0509"],"issn-type":[{"value":"1752-0509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,17]]},"article-number":"64"}}