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One hypothesis to explain this heterogeneity suggests that clustered miRNAs are functionally related by virtue of co-targeting downstream pathways.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Integrating of miRNA cluster information with protein protein interaction (PPI) network data, our research supports the hypothesis of the functional coordination of clustered miRNAs and links it to the topological features of miRNAs' targets in PPI network. Specifically, our results demonstrate that clustered miRNAs jointly regulate proteins in close proximity of the PPI network. The possibility that two proteins yield to this coordinated regulation is negatively correlated with their distance in PPI network. Guided by the knowledge of this preference, we found several network communities enriched with target genes of miRNA clusters. In addition, our results demonstrate that the variance of this propensity can also partly be explained by protein's connectivity and miRNA's conservation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>In summary, this work supports the hypothesis of intra-cluster coordination and investigates the extent of this coordination.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-0509-3-65","type":"journal-article","created":{"date-parts":[[2009,6,26]],"date-time":"2009-06-26T18:13:50Z","timestamp":1246040030000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":98,"title":["Clustered microRNAs' coordination in regulating protein-protein interaction network"],"prefix":"10.1186","volume":"3","author":[{"given":"Xiongying","family":"Yuan","sequence":"first","affiliation":[]},{"given":"Changning","family":"Liu","sequence":"additional","affiliation":[]},{"given":"Pengcheng","family":"Yang","sequence":"additional","affiliation":[]},{"given":"Shunmin","family":"He","sequence":"additional","affiliation":[]},{"given":"Qi","family":"Liao","sequence":"additional","affiliation":[]},{"given":"Shuli","family":"Kang","sequence":"additional","affiliation":[]},{"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2009,6,26]]},"reference":[{"issue":"17","key":"333_CR1","doi-asserted-by":"publisher","first-page":"4663","DOI":"10.1093\/emboj\/cdf476","volume":"21","author":"Y Lee","year":"2002","unstructured":"Lee Y, Jeon K, Lee JT, Kim S, Kim VN: MicroRNA maturation: stepwise processing and subcellular localization. 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