{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:59:09Z","timestamp":1762541949844},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,8,9]],"date-time":"2010-08-09T00:00:00Z","timestamp":1281312000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Syst Biol"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1186\/1752-0509-4-108","type":"journal-article","created":{"date-parts":[[2010,8,10]],"date-time":"2010-08-10T06:16:04Z","timestamp":1281420964000},"source":"Crossref","is-referenced-by-count":14,"title":["Bridging time scales in cellular decision making with a stochastic bistable switch"],"prefix":"10.1186","volume":"4","author":[{"given":"Steffen","family":"Waldherr","sequence":"first","affiliation":[]},{"given":"Jingbo","family":"Wu","sequence":"additional","affiliation":[]},{"given":"Frank","family":"Allg\u00f6wer","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2010,8,9]]},"reference":[{"key":"497_CR1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.cocis.2009.04.004","volume":"15","author":"ML Martins","year":"2010","unstructured":"Martins ML, Ferreira SC, Vilela MJ: Multiscale models for biological systems. Curr Opin Colloid Interface Sci. 2010, 15: 18-23. 10.1016\/j.cocis.2009.04.004.","journal-title":"Curr Opin Colloid Interface Sci"},{"key":"497_CR2","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1063\/1.1349894","volume":"11","author":"JE Ferrell","year":"2001","unstructured":"Ferrell JE, Xiong W: Bistability in cell signaling: How to make continuous processes discontinuous, and reversible processes irreversible. Chaos. 2001, 11: 227-236. 10.1063\/1.1349894","journal-title":"Chaos"},{"issue":"5365","key":"497_CR3","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1126\/science.280.5365.895","volume":"280","author":"JE Ferrell","year":"1998","unstructured":"Ferrell JE, Machleder EM: The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes. Science. 1998, 280 (5365): 895-898. 10.1126\/science.280.5365.895","journal-title":"Science"},{"issue":"35","key":"497_CR4","doi-asserted-by":"publisher","first-page":"36892","DOI":"10.1074\/jbc.M404893200","volume":"279","author":"T Eissing","year":"2004","unstructured":"Eissing T, Conzelmann H, Gilles ED, Allg\u00f6wer F, Bullinger E, Scheurich P: Bistability Analyses of a Caspase Activation Model for Receptor-induced Apoptosis. J Biol Chem. 2004, 279 (35): 36892-97. 10.1074\/jbc.M404893200","journal-title":"J Biol Chem"},{"key":"497_CR5","doi-asserted-by":"publisher","first-page":"e1000268","DOI":"10.1371\/journal.pcbi.1000268","volume":"5","author":"V Chickarmane","year":"2009","unstructured":"Chickarmane V, Enver T, Peterson C: Computational modeling of the hematopoietic erythroid-myeloid switch reveals insights into cooperativity, priming, and irreversibility. PLoS Comput Biol. 2009, 5: e1000268- 10.1371\/journal.pcbi.1000268","journal-title":"PLoS Comput Biol"},{"key":"497_CR6","doi-asserted-by":"publisher","first-page":"7304","DOI":"10.1073\/pnas.0509874103","volume":"103","author":"JT Mettetal","year":"2006","unstructured":"Mettetal JT, Muzzey D, Pedraza JM, Ozbudak EM, van Oudenaarden A: Predicting stochastic gene expression dynamics in single cells. Proc Natl Acad Sci. 2006, 103: 7304-9. 10.1073\/pnas.0509874103","journal-title":"Proc Natl Acad Sci"},{"issue":"9","key":"497_CR7","doi-asserted-by":"publisher","first-page":"e239","DOI":"10.1371\/journal.pbio.0050239","volume":"5","author":"BB Kaufmann","year":"2007","unstructured":"Kaufmann BB, Yang Q, Mettetal JT, van Oudenaarden A: Heritable Stochastic Switching Revealed by Single-Cell Genealogy. PLoS Biology. 2007, 5 (9): e239- 10.1371\/journal.pbio.0050239","journal-title":"PLoS Biology"},{"issue":"22","key":"497_CR8","doi-asserted-by":"publisher","first-page":"8372","DOI":"10.1073\/pnas.0507818103","volume":"103","author":"T Tian","year":"2006","unstructured":"Tian T, Burrage K: Stochastic models for regulatory networks of the genetic toggle switch. Proc Natl Acad Sci. 2006, 103 (22): 8372-8377. 10.1073\/pnas.0507818103","journal-title":"Proc Natl Acad Sci"},{"key":"497_CR9","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1745-6150-2-13","volume":"2","author":"S Krishnamurthy","year":"2007","unstructured":"Krishnamurthy S, Smith E, Krakauer D, Fontana W: The stochastic behavior of a molecular switching circuit with feedback. Biol Direct. 2007, 2: 13- 10.1186\/1745-6150-2-13","journal-title":"Biol Direct"},{"issue":"3","key":"497_CR10","doi-asserted-by":"publisher","first-page":"e1000699","DOI":"10.1371\/journal.pcbi.1000699","volume":"6","author":"C Song","year":"2010","unstructured":"Song C, Phenix H, Abedi V, Scott M, Ingalls BP, Kaern M, Perkins TJ: Estimating the stochastic bifurcation structure of cellular networks. PLoS Comput Biol. 2010, 6 (3): e1000699- 10.1371\/journal.pcbi.1000699","journal-title":"PLoS Comput Biol"},{"issue":"13","key":"497_CR11","doi-asserted-by":"publisher","first-page":"7714","DOI":"10.1073\/pnas.1332628100","volume":"100","author":"FJ Isaacs","year":"2003","unstructured":"Isaacs FJ, Hasty J, Cantor CR, Collins JJ: Prediction and measurement of an autoregulatory genetic module. Proc Natl Acad Sci. 2003, 100 (13): 7714-7719. 10.1073\/pnas.1332628100","journal-title":"Proc Natl Acad Sci"},{"issue":"1-2","key":"497_CR12","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0303-7207(99)00240-3","volume":"163","author":"JE Fortune","year":"2000","unstructured":"Fortune JE, Cushman RA, Wahl CM, Kito S: The primordial to primary follicle transition. Mol Cell Endocrinol. 2000, 163 (1-2): 53-60. 10.1016\/S0303-7207(99)00240-3","journal-title":"Mol Cell Endocrinol"},{"issue":"5","key":"497_CR13","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1093\/humupd\/dmi020","volume":"11","author":"MK Skinner","year":"2005","unstructured":"Skinner MK: Regulation of primordial follicle assembly and development. Hum Reprod Update. 2005, 11 (5): 461-471. 10.1093\/humupd\/dmi020","journal-title":"Hum Reprod Update"},{"issue":"9","key":"497_CR14","doi-asserted-by":"publisher","first-page":"4262","DOI":"10.1210\/en.140.9.4262","volume":"140","author":"JA Parrott","year":"1999","unstructured":"Parrott JA, Skinner MK: Kit-ligand\/stem cell factor induces primordial follicle development and initiates folliculogenesis. Endocrinol. 1999, 140 (9): 4262-4271. 10.1210\/en.140.9.4262.","journal-title":"Endocrinol"},{"issue":"5630","key":"497_CR15","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1126\/science.1086336","volume":"301","author":"DH Castrillon","year":"2003","unstructured":"Castrillon DH, Miao L, Kollipara R, Horner JW, DePinho RA: Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science. 2003, 301 (5630): 215-218. 10.1126\/science.1086336","journal-title":"Science"},{"issue":"1-2","key":"497_CR16","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.mce.2003.12.001","volume":"214","author":"EE Nilsson","year":"2004","unstructured":"Nilsson EE, Skinner MK: Kit ligand and basic fibroblast growth factor interactions in the induction of ovarian primordial to primary follicle transition. Mol Cell Endocrinol. 2004, 214 (1-2): 19-25. 10.1016\/j.mce.2003.12.001","journal-title":"Mol Cell Endocrinol"},{"issue":"1-2","key":"497_CR17","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S0303-7207(01)00699-2","volume":"187","author":"R Braw-Tal","year":"2002","unstructured":"Braw-Tal R: The initiation of follicle growth: the oocyte or the somatic cells?. Mol Cell Endocrinol. 2002, 187 (1-2): 11-18. 10.1016\/S0303-7207(01)00699-2","journal-title":"Mol Cell Endocrinol"},{"issue":"3","key":"497_CR18","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1128\/MMBR.59.3.423-450.1995","volume":"59","author":"J Ross","year":"1995","unstructured":"Ross J: mRNA stability in mammalian cells. Microbiol Rev. 1995, 59 (3): 423-450.","journal-title":"Microbiol Rev"},{"issue":"12","key":"497_CR19","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1002\/bies.950131209","volume":"13","author":"JL Hargrove","year":"1991","unstructured":"Hargrove JL, Hulsey MG, Beale EG: The kinetics of mammalian gene expression. Bioessays. 1991, 13 (12): 667-674. 10.1002\/bies.950131209","journal-title":"Bioessays"},{"issue":"10","key":"497_CR20","doi-asserted-by":"publisher","first-page":"e309","DOI":"10.1371\/journal.pbio.0040309","volume":"4","author":"A Raj","year":"2006","unstructured":"Raj A, Peskin CS, Tranchina D, Vargas DY, Tyagi S: Stochastic mRNA Synthesis in Mammalian Cells. PLoS Biol. 2006, 4 (10): e309- 10.1371\/journal.pbio.0040309","journal-title":"PLoS Biol"},{"issue":"47","key":"497_CR21","doi-asserted-by":"publisher","first-page":"17807","DOI":"10.1073\/pnas.0608512103","volume":"103","author":"L Warren","year":"2006","unstructured":"Warren L, Bryder D, Weissman IL, Quake SR: Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR. Proc Natl Acad Sci. 2006, 103 (47): 17807-17812. 10.1073\/pnas.0608512103","journal-title":"Proc Natl Acad Sci"},{"key":"497_CR22","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.biosystems.2007.01.003","volume":"90","author":"T Eissing","year":"2007","unstructured":"Eissing T, Waldherr S, Allg\u00f6wer F, Scheurich P, Bullinger E: Steady state and (bi-)stability evaluation of simple protease signalling networks. BioSystems. 2007, 90: 591-601. 10.1016\/j.biosystems.2007.01.003","journal-title":"BioSystems"},{"issue":"2","key":"497_CR23","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1006\/jtbi.2000.1068","volume":"203","author":"JL Cherry","year":"2000","unstructured":"Cherry JL, Adler FR: How to make a Biological Switch. J Theor Biol. 2000, 203 (2): 117-133. 10.1006\/jtbi.2000.1068","journal-title":"J Theor Biol"},{"key":"497_CR24","volume-title":"Stochastic processes in physics and chemistry","author":"NG van Kampen","year":"1981","unstructured":"van Kampen NG: Stochastic processes in physics and chemistry. 1981, North-Holland Amsterdam"},{"issue":"1-3","key":"497_CR25","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/0378-4371(92)90283-V","volume":"188","author":"DT Gillespie","year":"1992","unstructured":"Gillespie DT: A rigorous derivation of the chemical master equation. Physica A: Statist Theor Phys. 1992, 188 (1-3): 404-425. 10.1016\/0378-4371(92)90283-V.","journal-title":"Physica A: Statist Theor Phys"},{"key":"497_CR26","doi-asserted-by":"publisher","first-page":"4999","DOI":"10.1063\/1.1545446","volume":"118","author":"CV Rao","year":"2003","unstructured":"Rao CV, Arkin AP: Stochastic chemical kinetics and the quasi-steady-state assumption: Application to the Gillespie algorithm. J Chem Phys. 2003, 118: 4999-5010. 10.1063\/1.1545446.","journal-title":"J Chem Phys"},{"issue":"5","key":"497_CR27","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1007\/BF02458272","volume":"56","author":"J Nu\u00f1o","year":"1994","unstructured":"Nu\u00f1o J, Tarazona P: Lifetimes of small catalytic networks. Bull Math Biol. 1994, 56 (5): 875-898.","journal-title":"Bull Math Biol"},{"issue":"4","key":"497_CR28","doi-asserted-by":"publisher","first-page":"044104","DOI":"10.1063\/1.2145882","volume":"124","author":"B Munsky","year":"2006","unstructured":"Munsky B, Khammash M: The finite state projection algorithm for the solution of the chemical master equation. J Chem Phys. 2006, 124 (4): 044104- 10.1063\/1.2145882","journal-title":"J Chem Phys"},{"issue":"4","key":"497_CR29","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.jtbi.2007.06.016","volume":"248","author":"M Kaufman","year":"2007","unstructured":"Kaufman M, Soule C, Thomas R: A new necessary condition on interaction graphs for multistationarity. J Theor Biol. 2007, 248 (4): 675-685. 10.1016\/j.jtbi.2007.06.016","journal-title":"J Theor Biol"},{"issue":"5","key":"497_CR30","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1210\/en.139.5.2240","volume":"139","author":"JA Parrott","year":"1998","unstructured":"Parrott JA, Skinner MK: Thecal cell-granulosa cell interactions involve a positive feedback loop among keratinocyte growth factor, hepatocyte growth factor, and Kit ligand during ovarian follicular development. Endocrinol. 1998, 139 (5): 2240-2245. 10.1210\/en.139.5.2240.","journal-title":"Endocrinol"},{"key":"497_CR31","first-page":"153","volume-title":"Reproductive Endocrinology","author":"J Yeh","year":"1999","unstructured":"Yeh J, Adashi EY: The ovarian life cycle. Reproductive Endocrinology. Edited by: Yen SSC, Jaffe RB. 1999, 153-190. Saunders Philadelphia"},{"issue":"7","key":"497_CR32","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1093\/oxfordjournals.humrep.a019422","volume":"11","author":"MJ Faddy","year":"1996","unstructured":"Faddy MJ, Gosden RG: A model conforming the decline in follicle numbers to the age of menopause in women. Hum Reprod. 1996, 11 (7): 1484-1486.","journal-title":"Hum Reprod"},{"issue":"3","key":"497_CR33","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1095\/biolreprod50.3.653","volume":"50","author":"A Gougeon","year":"1994","unstructured":"Gougeon A, Ecochard R, Thalabard JC: Age-related changes of the population of human ovarian follicles: increase in the disappearance rate of non-growing and early-growing follicles in aging women. Biol Reprod. 1994, 50 (3): 653-663. 10.1095\/biolreprod50.3.653","journal-title":"Biol Reprod"},{"issue":"9","key":"497_CR34","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1093\/humrep\/16.9.2014","volume":"16","author":"JP de Bruin","year":"2001","unstructured":"de Bruin JP, Bovenhuis H, van Noord PA, Pearson PL, van Arendonk JA, te Velde ER, Kuurman WW, Dorland M: The role of genetic factors in age at natural menopause. Hum Reprod. 2001, 16 (9): 2014-2018. 10.1093\/humrep\/16.9.2014","journal-title":"Hum Reprod"},{"issue":"2","key":"497_CR35","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1530\/REP-07-0119","volume":"134","author":"E Nilsson","year":"2007","unstructured":"Nilsson E, Rogers N, Skinner MK: Actions of anti-Mullerian hormone on the ovarian transcriptome to inhibit primordial to primary follicle transition. Reproduction. 2007, 134 (2): 209-221. 10.1530\/REP-07-0119","journal-title":"Reproduction"},{"issue":"1-2","key":"497_CR36","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.mce.2004.09.008","volume":"234","author":"JA Visser","year":"2005","unstructured":"Visser JA, Themmen APN: Anti-M\u00fcllerian hormone and folliculogenesis. Mol Cell Endocrinol. 2005, 234 (1-2): 81-86. 10.1016\/j.mce.2004.09.008","journal-title":"Mol Cell Endocrinol"},{"issue":"4","key":"497_CR37","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1093\/oxfordjournals.humrep.a136036","volume":"10","author":"MJ Faddy","year":"1995","unstructured":"Faddy MJ, Gosden RG: A mathematical model of follicle dynamics in the human ovary. Hum Reprod. 1995, 10 (4): 770-775.","journal-title":"Hum Reprod"},{"key":"497_CR38","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1073\/pnas.0810012106","volume":"106","author":"PD Silva-Buttkus","year":"2009","unstructured":"Silva-Buttkus PD, Marcelli G, Franks S, Stark J, Hardy K: Inferring biological mechanisms from spatial analysis: Prediction of a local inhibitor in the ovary. Proc Natl Acad Sci. 2009, 106: 456-461. 10.1073\/pnas.0810012106","journal-title":"Proc Natl Acad Sci"},{"key":"497_CR39","volume-title":"The Theory of Matrices","author":"P Lancaster","year":"1985","unstructured":"Lancaster P, Tismenetsky M: The Theory of Matrices. 1985, San Diego: Academic Press"},{"key":"497_CR40","volume-title":"Monotone Dynamical Systems. An Introduction to the Theory of Competitive and Cooperative Systems, Volume 41 of","author":"HL Smith","year":"1995","unstructured":"Smith HL: Monotone Dynamical Systems. An Introduction to the Theory of Competitive and Cooperative Systems, Volume 41 of. 1995, Mathematical Surveys and Monographs. Providence, Rhode Island: American Mathematical Society"},{"issue":"25","key":"497_CR41","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1021\/j100540a008","volume":"81","author":"DT Gillespie","year":"1977","unstructured":"Gillespie DT: Exact stochastic simulation of coupled chemical reactions. J Phys Chem. 1977, 81 (25): 2340-2361. 10.1021\/j100540a008.","journal-title":"J Phys Chem"},{"issue":"2","key":"497_CR42","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1142\/S0219720005001132","volume":"3","author":"S Ramsey","year":"2005","unstructured":"Ramsey S, Orrell D, Bolouri H: Dizzy: Stochastic Simulation of Large-Scale Genetic Regulatory Networks. J Bioinform Comput Biol. 2005, 3 (2): 415-436. 10.1142\/S0219720005001132","journal-title":"J Bioinform Comput Biol"}],"container-title":["BMC Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-0509-4-108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1752-0509-4-108\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-0509-4-108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T05:33:07Z","timestamp":1591767187000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsystbiol.biomedcentral.com\/articles\/10.1186\/1752-0509-4-108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,9]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["497"],"URL":"https:\/\/doi.org\/10.1186\/1752-0509-4-108","relation":{},"ISSN":["1752-0509"],"issn-type":[{"value":"1752-0509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,9]]},"article-number":"108"}}