{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T13:47:04Z","timestamp":1768830424413,"version":"3.49.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Syst Biol"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Every cell of the mammalian organism needs iron as trace element in numerous oxido-reductive processes as well as for transport and storage of oxygen. The very versatility of ionic iron makes it a toxic entity which can catalyze the production of radicals that damage vital membranous and macromolecular assemblies in the cell. The mammalian organism maintains therefore a complex regulatory network of iron uptake, excretion and intra-body distribution. Intracellular regulation in different cell types is intertwined with a global hormonal signalling structure. Iron deficiency as well as excess of iron are frequent and serious human disorders. They can affect every cell, but also the organism as a whole.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Here, we present a kinematic model of the dynamic system of iron pools and fluxes. It is based on ferrokinetic data and chemical measurements in C57BL6 wild-type mice maintained on iron-deficient, iron-adequate, or iron-loaded diet. The tracer iron levels in major tissues and organs (16 compartment) were followed for 28 days. The evaluation resulted in a whole-body model of fractional clearance rates. The analysis permits calculation of absolute flux rates in the steady-state, of iron distribution into different organs, of tracer-accessible pool sizes and of residence times of iron in the different compartments in response to three states of iron-repletion induced by the dietary regime.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>This mathematical model presents a comprehensive physiological picture of mice under three different diets with varying iron contents. The quantitative results reflect systemic properties of iron metabolism: dynamic closedness, hierarchy of time scales, switch-over response and dynamics of iron storage in parenchymal organs.<\/jats:p>\n            <jats:p>Therefore, we could assess which parameters will change under dietary perturbations and study in quantitative terms when those changes take place.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-0509-4-112","type":"journal-article","created":{"date-parts":[[2010,8,13]],"date-time":"2010-08-13T06:17:42Z","timestamp":1281680262000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Systems analysis of iron metabolism: the network of iron pools and fluxes"],"prefix":"10.1186","volume":"4","author":[{"given":"Tiago JS","family":"Lopes","sequence":"first","affiliation":[]},{"given":"Tatyana","family":"Luganskaja","sequence":"additional","affiliation":[]},{"given":"Maja","family":"Vuji\u0107 Spasi\u0107","sequence":"additional","affiliation":[]},{"given":"Matthias W","family":"Hentze","sequence":"additional","affiliation":[]},{"given":"Martina U","family":"Muckenthaler","sequence":"additional","affiliation":[]},{"given":"Klaus","family":"Sch\u00fcmann","sequence":"additional","affiliation":[]},{"given":"Jens G","family":"Reich","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2010,8,13]]},"reference":[{"key":"501_CR1","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/S0092-8674(04)00343-5","volume":"117","author":"MW Hentze","year":"2004","unstructured":"Hentze MW, Muckenthaler MU, Andrews NC: Balancing acts: molecular control of mammalian iron metabolism. 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