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This process is further complicated by occurrences of missing or conflicting information and the absence of common annotation standards between different data sources.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>In this article, we report a semi-automated methodology aimed at streamlining the process of metabolic network reconstruction by enabling the integration of different genome-wide databases of metabolic reactions. We present results obtained by applying this methodology to the metabolic network of the plant <jats:italic>Arabidopsis thaliana<\/jats:italic>. A systematic comparison of compounds and reactions between two genome-wide databases allowed us to obtain a high-quality core consensus reconstruction, which was validated for stoichiometric consistency. A lower level of consensus led to a larger reconstruction, which has a lower quality standard but provides a baseline for further manual curation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This semi-automated methodology may be applied to other organisms and help to streamline the process of genome-scale network reconstruction in order to accelerate the transfer of such models to applications.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-0509-4-114","type":"journal-article","created":{"date-parts":[[2010,8,17]],"date-time":"2010-08-17T06:14:24Z","timestamp":1282025664000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Integration of metabolic databases for the reconstruction of genome-scale metabolic networks"],"prefix":"10.1186","volume":"4","author":[{"given":"Karin","family":"Radrich","sequence":"first","affiliation":[]},{"given":"Yoshimasa","family":"Tsuruoka","sequence":"additional","affiliation":[]},{"given":"Paul","family":"Dobson","sequence":"additional","affiliation":[]},{"given":"Albert","family":"Gevorgyan","sequence":"additional","affiliation":[]},{"given":"Neil","family":"Swainston","sequence":"additional","affiliation":[]},{"given":"Gino","family":"Baart","sequence":"additional","affiliation":[]},{"given":"Jean-Marc","family":"Schwartz","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2010,8,16]]},"reference":[{"key":"503_CR1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1042\/BJ20071115","volume":"409","author":"LJ Sweetlove","year":"2008","unstructured":"Sweetlove LJ, Fell DA, Fernie AR: Getting to grips with the plant metabolic network. 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