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Inferred connections are verified by gene enrichment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>We find that this core network has a generalized clustering coefficient that is much higher than chance. The inferred Boolean transfer functions have a mean p-bias of 0.41, and thus similar amounts of activation and repression interactions. However, the distribution of p-biases differs significantly from what is expected by chance that, along with the high mean connectivity, is found to cause the core GRN of <jats:italic>S. cerevisiae<\/jats:italic>'s to have an overall sensitivity similar to critical Boolean networks. In agreement, we find that the amount of information propagated between nodes in finite time series is much higher in the inferred core GRN of <jats:italic>S. cerevisiae<\/jats:italic> than what is expected by chance.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>We suggest that <jats:italic>S. cerevisiae<\/jats:italic> is likely to have evolved a core GRN with enhanced information propagation among its genes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-0509-4-143","type":"journal-article","created":{"date-parts":[[2010,10,26]],"date-time":"2010-10-26T18:14:50Z","timestamp":1288116890000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Information propagation within the Genetic Network of Saccharomyces cerevisiae"],"prefix":"10.1186","volume":"4","author":[{"given":"Sharif","family":"Chowdhury","sequence":"first","affiliation":[]},{"given":"Jason","family":"Lloyd-Price","sequence":"additional","affiliation":[]},{"given":"Olli-Pekka","family":"Smolander","sequence":"additional","affiliation":[]},{"given":"Wayne CV","family":"Baici","sequence":"additional","affiliation":[]},{"given":"Timothy R","family":"Hughes","sequence":"additional","affiliation":[]},{"given":"Olli","family":"Yli-Harja","sequence":"additional","affiliation":[]},{"given":"Gordon","family":"Chua","sequence":"additional","affiliation":[]},{"given":"Andre S","family":"Ribeiro","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2010,10,26]]},"reference":[{"issue":"3","key":"554_CR1","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.jtbi.2009.08.024","volume":"261","author":"X Dai","year":"2009","unstructured":"Dai X, Healy S, Yli-Harja O, Ribeiro A: Tuning cell differentiation patterns and single cell dynamics by regulating proteins' functionalities in a Toggle Switch. 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