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The majority of current systems biology modelling research, including that of auxin transport, uses numerical simulations to study the behaviour of large systems of deterministic ordinary differential equations, with little consideration of alternative modelling frameworks.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>In this case study, we solve an auxin-transport model using analytical methods, deterministic numerical simulations and stochastic numerical simulations. Although the three approaches in general predict the same behaviour, the approaches provide different information that we use to gain distinct insights into the modelled biological system. We show in particular that the analytical approach readily provides straightforward mathematical expressions for the concentrations and transport speeds, while the stochastic simulations naturally provide information on the variability of the system.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our study provides a constructive comparison which highlights the advantages and disadvantages of each of the considered modelling approaches. This will prove helpful to researchers when weighing up which modelling approach to select. In addition, the paper goes some way to bridging the gap between these approaches, which in the future we hope will lead to integrative hybrid models.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-0509-4-34","type":"journal-article","created":{"date-parts":[[2010,3,26]],"date-time":"2010-03-26T19:14:12Z","timestamp":1269630852000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Stochastic and deterministic multiscale models for systems biology: an auxin-transport case study"],"prefix":"10.1186","volume":"4","author":[{"given":"Jamie","family":"Twycross","sequence":"first","affiliation":[]},{"given":"Leah R","family":"Band","sequence":"additional","affiliation":[]},{"given":"Malcolm J","family":"Bennett","sequence":"additional","affiliation":[]},{"given":"John R","family":"King","sequence":"additional","affiliation":[]},{"given":"Natalio","family":"Krasnogor","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2010,3,26]]},"reference":[{"key":"423_CR1","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1146\/annurev.arplant.58.032806.103805","volume":"59","author":"R Benjamins","year":"2008","unstructured":"Benjamins R, Scheres B: Auxin: the looping star in plant development. 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