{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T18:27:45Z","timestamp":1772735265063,"version":"3.50.1"},"reference-count":90,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Syst Biol"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>MicroRNA regulate mRNA levels in a tissue specific way, either by inducing degradation of the transcript or by inhibiting translation or transcription. Putative mRNA targets of microRNA identified from seed sequence matches are available in many databases. However, such matches have a high false positive rate and cannot identify tissue specificity of regulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We describe a simple method to identify direct mRNA targets of microRNA dysregulated in cancers from expression level measurements in patient matched tumor\/normal samples. The word \"direct\" is used here in a strict sense to: a) represent mRNA which have an exact seed sequence match to the microRNA in their 3'UTR, b) the seed sequence match is strictly conserved across mouse, human, rat and dog genomes, c) the mRNA and microRNA expression levels can distinguish tumor from normal with high significance and d) the microRNA\/mRNA expression levels are strongly and significantly anti-correlated in tumor and\/or normal samples. We apply and validate the method using clear cell Renal Cell Carcinoma (ccRCC) and matched normal kidney samples, limiting our analysis to mRNA targets which undergo degradation of the mRNA transcript because of a perfect seed sequence match. Dysregulated microRNA and mRNA are first identified by comparing their expression levels in tumor vs normal samples. Putative dysregulated microRNA\/mRNA pairs are identified from these using seed sequence matches, requiring that the seed sequence be conserved in human\/dog\/rat\/mouse genomes. These are further pruned by requiring a strong anti-correlation signature in tumor and\/or normal samples. The method revealed many new regulations in ccRCC. For instance, loss of miR-149, miR-200c and mir-141 causes gain of function of oncogenes (KCNMA1, LOX), VEGFA and SEMA6A respectively and increased levels of miR-142-3p, miR-185, mir-34a, miR-224, miR-21 cause loss of function of tumor suppressors LRRC2, PTPN13, SFRP1, ERBB4, and (SLC12A1, TCF21) respectively. We also found strong anti-correlation between VEGFA and the miR-200 family of microRNA: miR-200a*, 200b, 200c and miR-141. Several identified microRNA\/mRNA pairs were validated on an independent set of matched ccRCC\/normal samples. The regulation of SEMA6A by miR-141 was verified by a transfection assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We describe a simple and reliable method to identify direct gene targets of microRNA in any cancer. The constraints we impose (strong dysregulation signature for microRNA and mRNA levels between tumor\/normal samples, evolutionary conservation of seed sequence and strong anti-correlation of expression levels) remove spurious matches and identify a subset of robust, tissue specific, functional mRNA targets of dysregulated microRNA.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1752-0509-4-51","type":"journal-article","created":{"date-parts":[[2010,4,27]],"date-time":"2010-04-27T06:16:21Z","timestamp":1272348981000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":205,"title":["Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma"],"prefix":"10.1186","volume":"4","author":[{"given":"Huiqing","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela R","family":"Brannon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anupama R","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Alexe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W","family":"Seiler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Arreola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay H","family":"Oza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Juan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis S","family":"Liou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shridar","family":"Ganesan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold J","family":"Levine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WK","family":"Rathmell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyan V","family":"Bhanot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,4,27]]},"reference":[{"key":"440_CR1","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nrg1990","volume":"8","author":"K Chen","year":"2007","unstructured":"Chen K, Rajewsky N: The evolution of gene regulation by transcription factors and microRNAs. Nat Rev Genet. 2007, 8: 93-103. 10.1038\/nrg1990","journal-title":"Nat Rev Genet"},{"issue":"7","key":"440_CR2","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/nrg1379","volume":"5","author":"L He","year":"2004","unstructured":"He L, Hannon GJ: MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet. 2004, 5 (7): 522-531. 10.1038\/nrg1379","journal-title":"Nat Rev Genet"},{"key":"440_CR3","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/nrm1644","volume":"6","author":"NV Kim","year":"2005","unstructured":"Kim NV: MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol. 2005, 6: 376-385. 10.1038\/nrm1644","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"12","key":"440_CR4","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1261\/rna.2248605","volume":"11","author":"RS Pillai","year":"2005","unstructured":"Pillai RS: MicroRNA function: multiple mechanisms for a tiny RNA?. RNA. 2005, 11 (12): 1753-1761. 10.1261\/rna.2248605","journal-title":"RNA"},{"issue":"11","key":"440_CR5","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/nrc1997","volume":"6","author":"GA Calin","year":"2006","unstructured":"Calin GA, Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer. 2006, 6 (11): 857-866. 10.1038\/nrc1997","journal-title":"Nat Rev Cancer"},{"issue":"7","key":"440_CR6","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1073\/pnas.0510565103","volume":"103","author":"S Volinia","year":"2006","unstructured":"Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F, Visone R, Iorio M, Roldo C, Ferracin M, Prueitt RL, Yanaihara N, Lanza G, Scarpa A, Vecchione A, Negrini M, Harris CC, Croce CM: A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA. 2006, 103 (7): 2257-2261. 10.1073\/pnas.0510565103","journal-title":"Proc Natl Acad Sci USA"},{"key":"440_CR7","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/nrc1840","volume":"6","author":"FJ Esquela-Kerscher ASlack","year":"2006","unstructured":"Esquela-Kerscher ASlack FJ: Oncomirs - microRNAs with a role in cancer. Nat Rev Can. 2006, 6: 259-269. 10.1038\/nrc1840.","journal-title":"Nat Rev Can"},{"issue":"7148","key":"440_CR8","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1038\/nature05939","volume":"447","author":"L He","year":"2007","unstructured":"He L, He X, Lim LP, de Stanchina E, Xuan Z, Liang Y, Xue W, Zender L, Magnus J, Ridzon D, Jackson AL, Linsley PS, Chen C, Lowe SW, Cleary MA, Hannon GJ: A microRNA component of the p53 tumour suppressor network. Nature. 2007, 447 (7148): 1130-1134. 10.1038\/nature05939","journal-title":"Nature"},{"key":"440_CR9","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.4161\/cc.7.17.6597","volume":"7","author":"S Deng","year":"2008","unstructured":"Deng S, Calin GA, Croce CM, Coukos G, Zhang L: Mechanisms of microRNA deregulation in human cancer. Cell Cycle. 2008, 7: 2643-2646.","journal-title":"Cell Cycle"},{"key":"440_CR10","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/nature03702","volume":"435","author":"J Lu","year":"2005","unstructured":"Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR, Golub TR: MicroRNA expression profiles classify human cancers. Nature. 2005, 435: 834-838. 10.1038\/nature03702","journal-title":"Nature"},{"key":"440_CR11","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1101\/gr.2845604","volume":"14","author":"O Barad","year":"2004","unstructured":"Barad O, Meiri E, Avniel A, Aharonov R, Barzilai A, Bentwich I, Einav U, Gilad S, Hurban P, Karov Y, Lobenhofer EK, Sharon E, Shiboleth YM, Shtutman M, Bentwich Z, Einat P: MicroRNA expression detected by oligonucleotide microarrays: system establishment and expression profiling in human tissues. Genome Res. 2004, 14: 2486-2494. 10.1101\/gr.2845604","journal-title":"Genome Res"},{"issue":"5","key":"440_CR12","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.urolonc.2007.01.019","volume":"25","author":"F Gottardo","year":"2007","unstructured":"Gottardo F, Liu CG, Ferracin M, Calin GA, Fassan M, Bassi P, Sevignani C, Byrne D, Negrini M, Pagano F, Gomella LG, Croce CM, Baffa R: Micro-RNA profiling in kidney and bladder cancers. Urol Oncol. 2007, 25 (5): 387-392.","journal-title":"Urol Oncol"},{"issue":"10","key":"440_CR13","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1016\/j.ejso.2009.04.010","volume":"35","author":"Y Huang","year":"2009","unstructured":"Huang Y, Dai Y, Yang J, Chen T, Yin Y, Tang M, Hu C, Zhang L: Microarray analysis of microRNA expression in renal clear cell carcinoma. Eur J Surg Oncol. 2009, 35 (10): 1119-1123.","journal-title":"Eur J Surg Oncol"},{"issue":"9B","key":"440_CR14","doi-asserted-by":"publisher","first-page":"3918","DOI":"10.1111\/j.1582-4934.2009.00705.x","volume":"13","author":"M Jung","year":"2009","unstructured":"Jung M, Mollenkopf HJ, Grimm C, Wagner I, Albrecht M, Waller T, Pilarsky C, Johannsen M, Stephan C, Lehrach H, Nietfeld W, Rudel T, Jung K, Kristiansen G: MicroRNA profiling of clear cell renal cell cancer identifies a robust signature to define renal malignancy. J Cell Mol Med. 2009, 13 (9B): 3918-28. 10.1111\/j.1582-4934.2009.00705.x","journal-title":"J Cell Mol Med"},{"key":"440_CR15","unstructured":"Juan D, Alexe G, Antes T, Liu H, Madabhushi A, Delisi C, Ganesan S, Bhanot G, Liou L: MicroRNA Expression Profile in Clear-Cell Kidney Cancer. J Urology. ,"},{"issue":"1-2","key":"440_CR16","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.clinbiochem.2009.07.020","volume":"43","author":"TF Chow","year":"2009","unstructured":"Chow TF, Youssef YM, Lianidou E, Romaschin AD, Honey RJ, Stewart R, Pace KT, Yousef GM: Differential expression profiling of microRNAs and their potential involvement in renal cell carcinoma pathogenesis. Clin Biochem. 2009, 43 (1-2): 150-158. 10.1016\/j.clinbiochem.2009.07.020","journal-title":"Clin Biochem"},{"issue":"11","key":"440_CR17","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1038\/sj.onc.1203449","volume":"19","author":"A Alimov","year":"2000","unstructured":"Alimov A, Kost-Alimova M, Liu J, Li C, Bergerheim U, Imreh S, Klein G, Zabarovsky ER: Combined LOH\/CGH analysis proves the existence of interstitial 3p deletions in renal cell carcinoma. Oncogene. 2000, 19 (11): 1392-1399. 10.1038\/sj.onc.1203449","journal-title":"Oncogene"},{"issue":"9","key":"440_CR18","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.1073\/pnas.0307323101","volume":"101","author":"GA Calin","year":"2004","unstructured":"Calin GA, Sevignani C, Dumitru CD, Hyslop T, Noch E, Yendamuri S, Shimizu M, Rattan S, Bullrich F, Negrini M, Croce CM: Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA. 2004, 101 (9): 2999-3004. 10.1073\/pnas.0307323101","journal-title":"Proc Natl Acad Sci USA"},{"issue":"15","key":"440_CR19","doi-asserted-by":"publisher","first-page":"6162","DOI":"10.1158\/0008-5472.CAN-08-0144","volume":"68","author":"S Ambs","year":"2008","unstructured":"Ambs S, Prueitt RL, Yi M, Hudson RS, Howe TM, Petrocca F, Wallace TA, Liu CG, Volinia S, Calin GA, Yfantis HG, Stephens RM, Croce CM: Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. Cancer Res. 2008, 68 (15): 6162-6170. 10.1158\/0008-5472.CAN-08-0144","journal-title":"Cancer Res"},{"key":"440_CR20","doi-asserted-by":"publisher","first-page":"6130","DOI":"10.1158\/0008-5472.CAN-07-0533","volume":"67","author":"KP Porkka","year":"2007","unstructured":"Porkka KP, Pfeiffer MJ, Waltering KK, Vessella RL, Tammela TL, Visakorpi T: MicroRNA expression profiling in prostate cancer. Cancer Res. 2007, 67: 6130-6135. 10.1158\/0008-5472.CAN-07-0533","journal-title":"Cancer Res"},{"issue":"5","key":"440_CR21","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1111\/j.1365-2141.2008.07077.x","volume":"141","author":"CH Lawrie","year":"2008","unstructured":"Lawrie CH, Gal S, Dunlop HM, Pushkaran B, Liggins AP, Pulford K, Banham AH, Pezzella F, Boultwood J, Wainscoat JS, Hatton CS, Harris AL: Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br J Haematol. 2008, 141 (5): 672-675. 10.1111\/j.1365-2141.2008.07077.x","journal-title":"Br J Haematol"},{"key":"440_CR22","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ygyno.2008.08.036","volume":"112","author":"KE Resnick","year":"2009","unstructured":"Resnick KE, Alder H, Hagan JP, Richardson DL, Croce CM, Cohn DE: The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform. Gynecol Oncol. 2009, 112: 55-59. 10.1016\/j.ygyno.2008.08.036","journal-title":"Gynecol Oncol"},{"issue":"5","key":"440_CR23","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1097\/MOU.0b013e328277f180","volume":"17","author":"B Ljungberg","year":"2007","unstructured":"Ljungberg B: Prognostic markers in renal cell carcinoma. Curr Opin Urol. 2007, 17 (5): 303-308. 10.1097\/MOU.0b013e328277f180","journal-title":"Curr Opin Urol"},{"issue":"7","key":"440_CR24","doi-asserted-by":"publisher","first-page":"2152","DOI":"10.1158\/1535-7163.MCT-08-0021","volume":"7","author":"O Kovalchuk","year":"2008","unstructured":"Kovalchuk O, Filkowski J, Meservy J, Ilnytskyy Y, Tryndyak VP, Chekhun VF, Pogribny IP: Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin. Mol Cancer Ther. 2008, 7 (7): 2152-2159. 10.1158\/1535-7163.MCT-08-0021","journal-title":"Mol Cancer Ther"},{"issue":"11","key":"440_CR25","doi-asserted-by":"publisher","first-page":"3981","DOI":"10.1158\/0008-5472.CAN-03-3900","volume":"64","author":"R Nahta","year":"2004","unstructured":"Nahta R, Takahashi T, Ueno NT, Hung MC, Esteva FJ: P27kip1 down-regulation is associated with trastuzumab resistance in breast cancer cells. Cancer Res. 2004, 64 (11): 3981-3986. 10.1158\/0008-5472.CAN-03-3900","journal-title":"Cancer Res"},{"key":"440_CR26","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1007\/s11605-008-0584-x","volume":"12","author":"M Dillhoff","year":"2008","unstructured":"Dillhoff M, Liu J, Frankel W, Croce C, Bloomston M: MicroRNA-21 is overexpressed in pancreatic cancer and a potential predictor of survival. J Gastrointest Surg. 2008, 12: 2171-2176. 10.1007\/s11605-008-0584-x","journal-title":"J Gastrointest Surg"},{"key":"440_CR27","doi-asserted-by":"publisher","first-page":"2720","DOI":"10.1056\/NEJMe0808667","volume":"359","author":"FJ Slack","year":"2008","unstructured":"Slack FJ, Weidhaas JB: MicroRNA in cancer prognosis. N Engl J Med. 2008, 359: 2720-2722. 10.1056\/NEJMe0808667","journal-title":"N Engl J Med"},{"issue":"4","key":"440_CR28","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1158\/0008-5472.CAN-08-3559","volume":"69","author":"DR Hurst","year":"2009","unstructured":"Hurst DR, Edmonds MD, Scott GK, Benz CC, Vaidya KS, Welch DR: Breast cancer metastasis suppressor 1 up-regulates miR-146, Which suppresses breast cancer metastasis. Cancer Res. 2009, 69 (4): 1279-1283. 10.1158\/0008-5472.CAN-08-3559","journal-title":"Cancer Res"},{"key":"440_CR29","first-page":"305420","volume":"2009","author":"KO Ng Enders","year":"2009","unstructured":"Ng Enders KO, Chris LP Wong, SK Ma, Kwong A: MicroRNA as New Players for Diagnosis, Prognosis and Therapeutic Targets in Breast Cancer. J Oncology. 2009, 2009: 305420-","journal-title":"J Oncology"},{"key":"440_CR30","first-page":"189","volume":"12","author":"D Barh","year":"2008","unstructured":"Barh D, Parida S, Parida BP, Viswanathan G: Let-7, miR-125, miR-205, and miR-296 are prospective therapeutic agents in breast cancer molecular medicine. Gene Ther and Mol Biol. 2008, 12: 189-206.","journal-title":"Gene Ther and Mol Biol"},{"key":"440_CR31","doi-asserted-by":"publisher","first-page":"2753","DOI":"10.1016\/j.ejca.2008.09.037","volume":"44","author":"MV Iorio","year":"2008","unstructured":"Iorio MV, Casalini P, Tagliabue E, Menard S, Croce CM: MicroRNA profiling as a tool to understand prognosis, therapy response and resistance in breast cancer. Eur J Cancer. 2008, 44: 2753-2759. 10.1016\/j.ejca.2008.09.037","journal-title":"Eur J Cancer"},{"key":"440_CR32","first-page":"1161","volume":"23","author":"DC Corney","year":"2008","unstructured":"Corney DC, Nikitin AY: MicroRNA and ovarian cancer. Histol Histopathol. 2008, 23: 1161-1169.","journal-title":"Histol Histopathol"},{"key":"440_CR33","doi-asserted-by":"publisher","first-page":"e2436","DOI":"10.1371\/journal.pone.0002436","volume":"3","author":"N Dahiya","year":"2008","unstructured":"Dahiya N, Sherman-Baust CA, Wang TL, Davidson B, Shih Ie M, Zhang Y, Wood W, Becker KG, Morin PJ: MicroRNA expression and identification of putative miRNA targets in ovarian cancer. PLoS ONE. 2008, 3: e2436- 10.1371\/journal.pone.0002436","journal-title":"PLoS ONE"},{"issue":"42","key":"440_CR34","doi-asserted-by":"publisher","first-page":"5643","DOI":"10.1038\/onc.2008.171","volume":"27","author":"D Bhaumik","year":"2008","unstructured":"Bhaumik D, Scott GK, Schokrpur S, Patil CK, Campisi J, Benz CC: Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells. Oncogene. 2008, 27 (42): 5643-5647. 10.1038\/onc.2008.171","journal-title":"Oncogene"},{"key":"440_CR35","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1002\/path.2359","volume":"215","author":"ET Verghese","year":"2008","unstructured":"Verghese ET, AM Hanby, V Spiers, TA Hughes: Small is beautiful: microRNA and breast cancer - where are we now?. J Pathol. 2008, 215: 214-221. 10.1002\/path.2359","journal-title":"J Pathol"},{"issue":"16","key":"440_CR36","doi-asserted-by":"publisher","first-page":"7065","DOI":"10.1158\/0008-5472.CAN-05-1783","volume":"65","author":"MV Iorio","year":"2005","unstructured":"Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, Magri E, Pedriali M, Fabbri M, Campiglio M, M\u00e9nard S, Palazzo JP, Rosenberg A, Musiani P, Volinia S, Nenci I, Calin GA, Querzoli P, Negrini M, Croce CM: MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 2005, 65 (16): 7065-7070. 10.1158\/0008-5472.CAN-05-1783","journal-title":"Cancer Res"},{"issue":"18","key":"440_CR37","doi-asserted-by":"publisher","first-page":"8699","DOI":"10.1158\/0008-5472.CAN-07-1936","volume":"67","author":"MicroRNA signatures in human ovarian cancer","year":"2007","unstructured":", : MicroRNA signatures in human ovarian cancer. Cancer Res. 2007, 67 (18): 8699-8707. 10.1158\/0008-5472.CAN-07-1936","journal-title":"Cancer Res"},{"issue":"3","key":"440_CR38","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.ccr.2006.01.025","volume":"9","author":"N Yanaihara","year":"2006","unstructured":"Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M, Stephens RM, Okamoto A, Yokota J, Tanaka T, Calin GA, Liu CG, Croce CM, Harris CC: Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell. 2006, 9 (3): 189-198. 10.1016\/j.ccr.2006.01.025","journal-title":"Cancer Cell"},{"issue":"14","key":"440_CR39","doi-asserted-by":"publisher","first-page":"6029","DOI":"10.1158\/0008-5472.CAN-05-0137","volume":"65","author":"JA Chan","year":"2005","unstructured":"Chan JA, Krichevsky AM, Kosik KS: MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res. 2005, 65 (14): 6029-6033. 10.1158\/0008-5472.CAN-05-0137","journal-title":"Cancer Res"},{"issue":"13","key":"440_CR40","doi-asserted-by":"publisher","first-page":"6031","DOI":"10.1158\/0008-5472.CAN-06-0561","volume":"67","author":"WO Lui","year":"2007","unstructured":"Lui WO, Pourmand N, Patterson BK, Fire A: Patterns of known and novel small RNAs in human cervical cancer. Cancer Res. 2007, 67 (13): 6031-6043. 10.1158\/0008-5472.CAN-06-0561","journal-title":"Cancer Res"},{"issue":"4","key":"440_CR41","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/nbt1392","volume":"26","author":"N Rosenfeld","year":"2008","unstructured":"Rosenfeld N, Aharonov R, Meiri E, Rosenwald S, Spector Y, Zepeniuk M, Benjamin H, Shabes N, Tabak S, Levy A, Lebanony D, Goren Y, Silberschein E, Targan N, Ben-Ari A, Gilad S: MicroRNAs accurately identify cancer tissue origin. Nature Biotech. 2008, 26 (4): 462-469. 10.1038\/nbt1392.","journal-title":"Nature Biotech"},{"issue":"32","key":"440_CR42","doi-asserted-by":"publisher","first-page":"23716","DOI":"10.1074\/jbc.M701805200","volume":"282","author":"S Galardi","year":"2007","unstructured":"Galardi S, Mercatelli N, Giorda E, Massalini S, Frajese GV, Ciafr\u00e8 SA, Farace MG: miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27kip1. J Biol Chem. 2007, 282 (32): 23716-23724. 10.1074\/jbc.M701805200","journal-title":"J Biol Chem"},{"issue":"3","key":"440_CR43","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1677\/ERC-07-0129","volume":"14","author":"R Visone","year":"2007","unstructured":"Visone R, Russo L, Pallante P, De Martino I, Ferraro A, Leone V, Borbone E, Petrocca F, Alder H, Croce CM, Fusco A: MicroRNAs miR-221 and miR-222, both overexpressed in human thyroid papillary carcinomas, regulate p27Kip1 protein levels and cell cycle. Endocr Relat Cancer. 2007, 14 (3): 791-798. 10.1677\/ERC-07-0129","journal-title":"Endocr Relat Cancer"},{"issue":"6","key":"440_CR44","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1158\/0008-5472.CAN-08-2920","volume":"69","author":"MV Iorio","year":"2009","unstructured":"Iorio MV, Casalini P, Piovan C, Di Leva G, Merlo A, Triulzi T, M\u00e9nard S, Croce CM, Tagliabue E: microRNA-205 regulates HER3 in human breast cancer. Cancer Res. 2009, 69 (6): 2195-2200. 10.1158\/0008-5472.CAN-08-2920","journal-title":"Cancer Res"},{"issue":"6","key":"440_CR45","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.cell.2007.10.054","volume":"131","author":"F Yu","year":"2007","unstructured":"Yu F, Yao H, Zhu P, Zhang X, Pan Q, Gong C, Huang Y, Hu X, Su F, Lieberman J, Song E: let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell. 2007, 131 (6): 1109-1123. 10.1016\/j.cell.2007.10.054","journal-title":"Cell"},{"issue":"5","key":"440_CR46","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.molcel.2007.05.010","volume":"26","author":"TC Chang","year":"2007","unstructured":"Chang TC, Wentzel EA, Kent OA, Ramachandran K, Mullendore M, Lee KH, Feldmann G, Yamakuchi M, Ferlito M, Lowenstein CJ, Arking DE, Beer MA, Maitra A, Mendell JT: Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell. 2007, 26 (5): 745-752. 10.1016\/j.molcel.2007.05.010","journal-title":"Mol Cell"},{"key":"440_CR47","doi-asserted-by":"publisher","first-page":"5394","DOI":"10.1093\/nar\/gki863","volume":"33","author":"J Jiang","year":"2005","unstructured":"Jiang J, Lee EJ, Gusev Y, Schmittgen TD: Real-time expression profiling of microRNA precursors in human cancer cell lines. Nucleic Acids Res. 2005, 33: 5394-5403. 10.1093\/nar\/gki863","journal-title":"Nucleic Acids Res"},{"key":"440_CR48","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/1471-2105-5-139","volume":"5","author":"NR Smalheiser","year":"2004","unstructured":"Smalheiser NR, Torvik VI: A population-based statistical approach identifies parameters characteristic of human microRNA-mRNA interactions. BMC Bioinformatics. 2004, 5: 139- 10.1186\/1471-2105-5-139","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"440_CR49","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1186\/gb-2003-5-1-r1","volume":"5","author":"AJ Enright","year":"2003","unstructured":"Enright AJ, John B, Gaul U, Tuschl T, Sander C, Marks DS: MicroRNA targets in Drosophila. Genome Biol. 2003, 5 (1): R1- 10.1186\/gb-2003-5-1-r1","journal-title":"Genome Biol"},{"issue":"5","key":"440_CR50","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/ng1536","volume":"37","author":"A Krek","year":"2005","unstructured":"Krek A, Gr\u00fcn D, Poy MN, Wolf R, Rosenberg L, Epstein EJ, MacMenamin P, da Piedade I, Gunsalus KC, Stoffel M, Rajewsky N: Combinatorial microRNA target predictions. Nat Genet. 2005, 37 (5): 495-500. 10.1038\/ng1536","journal-title":"Nat Genet"},{"issue":"1","key":"440_CR51","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.molcel.2007.06.017","volume":"27","author":"A Grimson","year":"2007","unstructured":"Grimson A, Farh KK, Johnston WK, Garrett-Engele P, Lim LP, Bartel DP: MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell. 2007, 27 (1): 91-105. 10.1016\/j.molcel.2007.06.017","journal-title":"Mol Cell"},{"key":"440_CR52","doi-asserted-by":"publisher","first-page":"S8","DOI":"10.1038\/ng1798","volume":"38","author":"N Rajewsky","year":"2006","unstructured":"Rajewsky N: microRNA target predictions in animals. Nat Genet. 2006, 38: S8-13. 10.1038\/ng1798","journal-title":"Nat Genet"},{"issue":"11","key":"440_CR53","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1038\/nmeth954","volume":"3","author":"P Sethupathy","year":"2006","unstructured":"Sethupathy P, Megraw M, Hatzigeorgiou AG: A guide through present computational approaches for the identification of mammalian microRNA targets. Nat Methods. 2006, 3 (11): 881-886. 10.1038\/nmeth954","journal-title":"Nat Methods"},{"key":"440_CR54","doi-asserted-by":"publisher","first-page":"D149","DOI":"10.1093\/nar\/gkl904","volume":"35","author":"M Megraw","year":"2007","unstructured":"Megraw M, Sethupathy P, Corda B, Hatzigeorgiou AG: miRGen: a database for the study of animal microRNA genomic organization and function. Nucleic Acids Res. 2007, 35: D149-155. 10.1093\/nar\/gkl904","journal-title":"Nucleic Acids Res"},{"key":"440_CR55","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1261\/rna.2239606","volume":"12","author":"P Sethupathy","year":"2006","unstructured":"Sethupathy P, Corda B, Hatzigeorgiou AG: TarBase: A comprehensive database of experimentally supported animal microRNA targets. RNA. 2006, 12: 192-197. 10.1261\/rna.2239606","journal-title":"RNA"},{"issue":"9","key":"440_CR56","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1038\/nsmb1138","volume":"13","author":"D Didiano","year":"2006","unstructured":"Didiano D, Hobert O: Perfect seed pairing is not a generally reliable predictor for miRNA-target interactions. Nat Struct Mol Biol. 2006, 13 (9): 849-851. 10.1038\/nsmb1138","journal-title":"Nat Struct Mol Biol"},{"key":"440_CR57","first-page":"115","volume":"342","author":"NR Smalheiser","year":"2006","unstructured":"Smalheiser NR, Torvik VI: Complications in mammalian microRNA target prediction. Methods Mol Biol. 2006, 342: 115-127.","journal-title":"Methods Mol Biol"},{"key":"440_CR58","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1146\/annurev.med.59.053006.104707","volume":"60","author":"R Garzon","year":"2009","unstructured":"Garzon R, Calin GA, Croce CM: MicroRNAs in Cancer. Annu Rev Med. 2009, 60: 167-179. 10.1146\/annurev.med.59.053006.104707","journal-title":"Annu Rev Med"},{"issue":"1","key":"440_CR59","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1586\/14737140.8.1.63","volume":"8","author":"WK Rathmell","year":"2008","unstructured":"Rathmell WK, Chen S: VHL inactivation in renal cell carcinoma: implications for diagnosis, prognosis and treatment. Expert Rev Anticancer Ther. 2008, 8 (1): 63-73. 10.1586\/14737140.8.1.63","journal-title":"Expert Rev Anticancer Ther"},{"issue":"5","key":"440_CR60","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1007\/s12094-007-0055-y","volume":"9","author":"MJ Calzada","year":"2007","unstructured":"Calzada MJ, del Peso L: Hypoxia-inducible factors and cancer. Clin Transl Oncol. 2007, 9 (5): 278-289. 10.1007\/s12094-007-0055-y","journal-title":"Clin Transl Oncol"},{"key":"440_CR61","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.molmed.2007.04.001","volume":"13","author":"DG Duda","year":"2007","unstructured":"Duda DG, Batchelor TT, Willett CG, Jain RK: VEGF-targeted cancer therapy strategies: current progress, hurdles and future prospects. Trends Mol Med. 2007, 13: 223-230. 10.1016\/j.molmed.2007.04.001","journal-title":"Trends Mol Med"},{"key":"440_CR62","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1002\/cncr.20749","volume":"103","author":"V Ficarra","year":"2005","unstructured":"Ficarra V, Martignoni G, Maffei N, Brunelli M, Novara G, Zanolla L, Pea M, Artibani W: Original and reviewed nuclear grading according to the Fuhrman system: a multivariate analysis of 388 patients with conventional renal cell carcinoma. Cancer. 2005, 103: 68-75. 10.1002\/cncr.20749","journal-title":"Cancer"},{"issue":"11","key":"440_CR63","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1101\/gr.184501","volume":"11","author":"JM Boer","year":"2001","unstructured":"Boer JM, Huber WK, S\u00fcltmann H, Wilmer F, von Heydebreck A, Haas S, Korn B, Gunawan B, Vente A, F\u00fczesi L, Vingron M, Poustka A: Identification and classification of differentially expressed genes in renal cell carcinoma by expression profiling on a global human 31, 500-element cDNA array. Genome Res. 2001, 11 (11): 1861-1870.","journal-title":"Genome Res"},{"key":"440_CR64","unstructured":"Brannon AR, Reddy A, Seiler M, Arreola A, Moore DT, Pruthi RS, Wallen EM, Nielsen ME, Liu H, Ljungberg B, Zhao H, Brooks JD, Nathanson KL, Ganesan S, Bhanot G, Rathmell WK: Molecular Stratification of Clear Cell Renal Cell Carcinoma by Consensus Clustering Reveals Distinct Subtypes and Survival Patterns. Genes and Cancer. ,"},{"key":"440_CR65","volume-title":"Proceedings of the 12th International Conference on Research in Computational Molecular Biology (RECOMB08): Singapore","author":"H Liu","year":"2008","unstructured":"Liu H, Alexe G, Juan D, Antes T, Liou L, Ganesan S, Bhanot G: A Procedure to identify MicroRNA gene targets in human kidney cancer. Proceedings of the 12th International Conference on Research in Computational Molecular Biology (RECOMB08): Singapore. 2008,"},{"key":"440_CR66","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3892\/ijo_00000318","volume":"35","author":"D Petillo","year":"2009","unstructured":"Petillo D, Kort EJ, Anema J, Furge KA, Yang XJ, Teh BT: MicroRNA profiling of human kidney cancer subtypes. Int J Oncol. 2009, 35: 109-114. 10.3892\/ijo_00000318","journal-title":"Int J Oncol"},{"issue":"21","key":"440_CR67","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1093\/jnci\/91.21.1820","volume":"91","author":"M Tamura","year":"1999","unstructured":"Tamura M, Gu J, Tran H, Yamada KM: PTEN gene and integrin signaling in cancer. J Natl Cancer Inst. 1999, 91 (21): 1820-1828. 10.1093\/jnci\/91.21.1820","journal-title":"J Natl Cancer Inst"},{"issue":"6","key":"440_CR68","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1093\/annonc\/mdi182","volume":"16","author":"S Hara","year":"2005","unstructured":"Hara S, Oya M, Mizuno R, Horiguchi A, Marumo K, Murai M: Akt activation in renal cell carcinoma: contribution of a decreased PTEN expression and the induction of apoptosis by an Akt inhibitor. Ann Oncol. 2005, 16 (6): 928-933. 10.1093\/annonc\/mdi182","journal-title":"Ann Oncol"},{"issue":"4","key":"440_CR69","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1101\/gad.14.4.391","volume":"14","author":"W Zundel","year":"2000","unstructured":"Zundel W, Schindler C, Haas-Kogan D, Koong A, Kaper F, Chen E, Gottschalk AR, Ryan HE, Johnson RS, Jefferson AB, Stokoe D, Giaccia AJ: Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev. 2000, 14 (4): 391-396.","journal-title":"Genes Dev"},{"issue":"11","key":"440_CR70","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1002\/cncr.22677","volume":"109","author":"AJ Pantuck","year":"2007","unstructured":"Pantuck AJ, Seligson DB, Klatte T, Yu H, Leppert JT, Moore L, O'Toole T, Gibbons J, Belldegrun AS, Figlin RA: Prognostic relevance of the mTOR pathway in renal cell carcinoma: implications for molecular patient selection for targeted therapy. Cancer. 2007, 109 (11): 2257-2267. 10.1002\/cncr.22677","journal-title":"Cancer"},{"issue":"14","key":"440_CR71","doi-asserted-by":"publisher","first-page":"6806","DOI":"10.1158\/0008-5472.CAN-07-0513","volume":"67","author":"M Dromard","year":"2007","unstructured":"Dromard M, Bompard G, Glondu-Lassis M, Puech C, Chalbos D, Freiss G: The putative tumor suppressor gene PTPN13\/PTPL1 induces apoptosis through insulin receptor substrate-1 dephosphorylation. Cancer Res. 2007, 67 (14): 6806-6813. 10.1158\/0008-5472.CAN-07-0513","journal-title":"Cancer Res"},{"issue":"4","key":"440_CR72","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.cdp.2006.06.002","volume":"30","author":"A Felipe","year":"2006","unstructured":"Felipe A, Vicente R, Villalonga N, Roura-Ferrer M, Mart\u00ednez-M\u00e1rmol R, Sol\u00e9 L, Ferreres JC, Condom E: Potassium channels: new targets in cancer therapy. Cancer Detect Prev. 2006, 30 (4): 375-385. 10.1016\/j.cdp.2006.06.002","journal-title":"Cancer Detect Prev"},{"issue":"6","key":"440_CR73","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/sj.onc.1206153","volume":"22","author":"K Yamazaki","year":"2003","unstructured":"Yamazaki K, Sakamoto M, Ohta T, Kanai Y, Ohki M, Hirohashi S: Overexpression of KIT in chromophobe renal cell carcinoma. Oncogene. 2003, 22 (6): 847-52. 10.1038\/sj.onc.1206153","journal-title":"Oncogene"},{"issue":"12","key":"440_CR74","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1111\/j.1349-7006.2007.00619.x","volume":"98","author":"KK Dutta","year":"2007","unstructured":"Dutta KK, Zhong Y, Liu YT, Yamada T, Akatsuka S, Hu Q, Yoshihara M, Ohara H, Takehashi M, Shinohara T, Masutani H, Onuki J, Toyokuni S: Association of microRNA-34a overexpression with proliferation is cell type-dependent. Cancer Sci. 2007, 98 (12): 1845-1852. 10.1111\/j.1349-7006.2007.00619.x","journal-title":"Cancer Sci"},{"issue":"16","key":"440_CR75","doi-asserted-by":"publisher","first-page":"4740","DOI":"10.1158\/1078-0432.CCR-07-0143","volume":"13","author":"ML Gumz","year":"2007","unstructured":"Gumz ML, Zou H, Kreinest PA, Childs AC, Belmonte LS, LeGrand SN, Wu KJ, Luxon BA, Sinha M, Parker AS, Sun LZ, Ahlquist DA, Wood CG, Copland JA: Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma. Clin Cancer Res. 2007, 13 (16): 4740-4749. 10.1158\/1078-0432.CCR-07-0143","journal-title":"Clin Cancer Res"},{"issue":"3","key":"440_CR76","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1158\/1078-0432.1119.11.3","volume":"11","author":"V Barbashina","year":"2005","unstructured":"Barbashina V, Salazar P, Holland EC, Rosenblum MK, Ladanyi M: Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene. Clin Cancer Res. 2005, 11 (3): 1119-1128.","journal-title":"Clin Cancer Res"},{"issue":"1","key":"440_CR77","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1158\/1078-0432.CCR-05-1431","volume":"12","author":"KO Henrich","year":"2006","unstructured":"Henrich KO, Fischer M, Mertens D, Benner A, Wiedemeyer R, Brors B, Oberthuer A, Berthold F, Wei JS, Khan J, Schwab M, Westermann F: Reduced expression of CAMTA1 correlates with adverse outcome in neuroblastoma patients. Clin Cancer Res. 2006, 12 (1): 131-138. 10.1158\/1078-0432.CCR-05-1431","journal-title":"Clin Cancer Res"},{"issue":"5","key":"440_CR78","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1080\/02841860410028574","volume":"43","author":"M Thomasson","year":"2004","unstructured":"Thomasson M, Hedman H, Junttila TT, Elenius K, Ljungberg B, Henriksson R: ErbB4 is downregulated in renal cell carcinoma--a quantitative RT-PCR and immunohistochemical analysis of the epidermal growth factor receptor family. Acta Oncol. 2004, 43 (5): 453-459. 10.1080\/02841860410028574","journal-title":"Acta Oncol"},{"issue":"5","key":"440_CR79","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1158\/1078-0432.CCR-07-1755","volume":"14","author":"C Camps","year":"2008","unstructured":"Camps C, Buffa FM, Colella S, Moore J, Sotiriou C, Sheldon H, Harris AL, Gleadle JM, Ragoussis J: hsa-miR-210 Is induced by hypoxia and is an independent prognostic factor in breast cancer. Clin Cancer Res. 2008, 14 (5): 1340-1348. 10.1158\/1078-0432.CCR-07-1755","journal-title":"Clin Cancer Res"},{"issue":"4","key":"440_CR80","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/sj.cdd.4402310","volume":"15","author":"R Kulshreshtha","year":"2008","unstructured":"Kulshreshtha R, Davuluri RV, Calin GA, Ivan M: A microRNA component of the hypoxic response. Cell Death Differ. 2008, 15 (4): 667-671. 10.1038\/sj.cdd.4402310","journal-title":"Cell Death Differ"},{"key":"440_CR81","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1186\/1471-2407-7-226","volume":"7","author":"M Baudis","year":"2007","unstructured":"Baudis M: Genomic imbalances in 5918 malignant epithelial tumors: an explorative meta-analysis of chromosomal CGH data. BMC Cancer. 2007, 7: 226- 10.1186\/1471-2407-7-226","journal-title":"BMC Cancer"},{"issue":"6","key":"440_CR82","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1083\/jcb.147.6.1195","volume":"147","author":"A Yamaguchi","year":"1999","unstructured":"Yamaguchi A, Hori O, Stern DM, Hartmann E, Ogawa S, Tohyama M: Stress-associated endoplasmic reticulum protein 1 (SERP1)\/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation. J Cell Biol. 1999, 147 (6): 1195-1204. 10.1083\/jcb.147.6.1195","journal-title":"J Cell Biol"},{"issue":"4","key":"440_CR83","first-page":"957","volume":"62","author":"M Wilhelm","year":"2002","unstructured":"Wilhelm M, Veltman JA, Olshen AB, Jain AN, Moore DH, Presti JC, Kovacs G, Waldman FM: Array-based comparative genomic hybridization for the differential diagnosis of renal cell cancer. Cancer Res. 2002, 62 (4): 957-960.","journal-title":"Cancer Res"},{"issue":"22","key":"440_CR84","doi-asserted-by":"publisher","first-page":"14910","DOI":"10.1074\/jbc.C800074200","volume":"283","author":"M Korpal","year":"2008","unstructured":"Korpal M, Lee ES, Hu G, Kang Y: The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem. 2008, 283 (22): 14910-14914. 10.1074\/jbc.C800074200","journal-title":"J Biol Chem"},{"issue":"7","key":"440_CR85","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1101\/gad.1640608","volume":"22","author":"SM Park","year":"2008","unstructured":"Park SM, Gaur AB, Lengyel E, Peter ME: The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev. 2008, 22 (7): 894-907. 10.1101\/gad.1640608","journal-title":"Genes Dev"},{"issue":"6","key":"440_CR86","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1038\/embor.2008.74","volume":"9","author":"U Burk","year":"2008","unstructured":"Burk U, Schubert J, Wellner U, Schmalhofer O, Vincan E, Spaderna S, Brabletz T: A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep. 2008, 9 (6): 582-589. 10.1038\/embor.2008.74","journal-title":"EMBO Rep"},{"issue":"4","key":"440_CR87","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1002\/path.2437","volume":"216","author":"C Nakada","year":"2008","unstructured":"Nakada C, Matsuura K, Tsukamoto Y, Tanigawa M, Yoshimoto T, Narimatsu T, Nguyen LT, Hijiya N, Uchida T, Sato F, Mimata H, Seto M, Moriyama M: Genome-wide microRNA expression profiling in renal cell carcinoma: significant down-regulation of miR-141 and miR-200c. J Pathol. 2008, 216 (4): 418-427. 10.1002\/path.2437","journal-title":"J Pathol"},{"issue":"6","key":"440_CR88","doi-asserted-by":"publisher","first-page":"659","DOI":"10.4161\/cbt.4.6.1733","volume":"4","author":"M Dhanabal","year":"2005","unstructured":"Dhanabal M, Wu F, Alvarez E, McQueeney KD, Jeffers M, MacDougall J, Boldog FL, Hackett C, Shenoy S, Khramtsov N, Weiner J, Lichenstein HS, LaRochelle WJ: Recombinant semaphorin 6A-1 ectodomain inhibits in vivo growth factor and tumor cell line-induced angiogenesis. Cancer Biol Ther. 2005, 4 (6): 659-668.","journal-title":"Cancer Biol Ther"},{"key":"440_CR89","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1126\/science.286.5439.531","volume":"286","author":"TR Golub","year":"1999","unstructured":"Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP, Coller H, Loh ML, Downing JR, Caligiuri MA, Bloomfield CD, Lander ES: Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science. 1999, 286: 531-537. 10.1126\/science.286.5439.531","journal-title":"Science"},{"issue":"16","key":"440_CR90","doi-asserted-by":"publisher","first-page":"9440","DOI":"10.1073\/pnas.1530509100","volume":"100","author":"JD Storey","year":"2003","unstructured":"Storey JD, Tibshirani R: Statistical significance for genomewide studies. Proc Natl Acad Sci USA. 2003, 100 (16): 9440-9445. 10.1073\/pnas.1530509100","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["BMC Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-0509-4-51.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T22:32:09Z","timestamp":1685572329000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsystbiol.biomedcentral.com\/articles\/10.1186\/1752-0509-4-51"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,27]]},"references-count":90,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["440"],"URL":"https:\/\/doi.org\/10.1186\/1752-0509-4-51","relation":{},"ISSN":["1752-0509"],"issn-type":[{"value":"1752-0509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,27]]},"assertion":[{"value":"12 November 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"51"}}