{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:31:10Z","timestamp":1767961870517,"version":"3.49.0"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,5,17]],"date-time":"2010-05-17T00:00:00Z","timestamp":1274054400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Syst Biol"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1186\/1752-0509-4-67","type":"journal-article","created":{"date-parts":[[2010,5,18]],"date-time":"2010-05-18T02:16:22Z","timestamp":1274148982000},"source":"Crossref","is-referenced-by-count":58,"title":["An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer"],"prefix":"10.1186","volume":"4","author":[{"given":"Raj","family":"Chari","sequence":"first","affiliation":[]},{"given":"Bradley P","family":"Coe","sequence":"additional","affiliation":[]},{"given":"Emily A","family":"Vucic","sequence":"additional","affiliation":[]},{"given":"William W","family":"Lockwood","sequence":"additional","affiliation":[]},{"given":"Wan L","family":"Lam","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2010,5,17]]},"reference":[{"issue":"9381","key":"456_CR1","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/S0140-6736(03)14023-8","volume":"362","author":"JC Chang","year":"2003","unstructured":"Chang JC, Wooten EC, Tsimelzon A, Hilsenbeck SG, Gutierrez MC, Elledge R, Mohsin S, Osborne CK, Chamness GC, Allred DC, et al.: Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer. Lancet. 2003, 362 (9381): 362-369. 10.1016\/S0140-6736(03)14023-8","journal-title":"Lancet"},{"issue":"3","key":"456_CR2","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1002\/jcp.21554","volume":"217","author":"BP Coe","year":"2008","unstructured":"Coe BP, Chari R, Lockwood WW, Lam WL: Evolving strategies for global gene expression analysis of cancer. J Cell Physiol. 2008, 217 (3): 590-597. 10.1002\/jcp.21554","journal-title":"J Cell Physiol"},{"issue":"6797","key":"456_CR3","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/35021093","volume":"406","author":"CM Perou","year":"2000","unstructured":"Perou CM, Sorlie T, Eisen MB, Rijn van de M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, et al.: Molecular portraits of human breast tumours. Nature. 2000, 406 (6797): 747-752. 10.1038\/35021093","journal-title":"Nature"},{"issue":"19","key":"456_CR4","doi-asserted-by":"publisher","first-page":"10869","DOI":"10.1073\/pnas.191367098","volume":"98","author":"T Sorlie","year":"2001","unstructured":"Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, Rijn van de M, Jeffrey SS, et al.: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA. 2001, 98 (19): 10869-10874. 10.1073\/pnas.191367098","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6871","key":"456_CR5","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/415530a","volume":"415","author":"LJ van 't Veer","year":"2002","unstructured":"van 't Veer LJ, Dai H, Vijver van de MJ, He YD, Hart AA, Mao M, Peterse HL, Kooy van der K, Marton MJ, Witteveen AT, et al.: Gene expression profiling predicts clinical outcome of breast cancer. Nature. 2002, 415 (6871): 530-536. 10.1038\/415530a","journal-title":"Nature"},{"key":"456_CR6","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/1471-2407-6-96","volume":"6","author":"J Fridlyand","year":"2006","unstructured":"Fridlyand J, Snijders AM, Ylstra B, Li H, Olshen A, Segraves R, Dairkee S, Tokuyasu T, Ljung BM, Jain AN, et al.: Breast tumor copy number aberration phenotypes and genomic instability. BMC Cancer. 2006, 6: 96- 10.1186\/1471-2407-6-96","journal-title":"BMC Cancer"},{"issue":"2","key":"456_CR7","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/75985","volume":"25","author":"DG Albertson","year":"2000","unstructured":"Albertson DG, Ylstra B, Segraves R, Collins C, Dairkee SH, Kowbel D, Kuo WL, Gray JW, Pinkel D: Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene. Nat Genet. 2000, 25 (2): 144-146. 10.1038\/75985","journal-title":"Nat Genet"},{"issue":"13","key":"456_CR8","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1038\/sj.onc.1209985","volume":"26","author":"SF Chin","year":"2007","unstructured":"Chin SF, Wang Y, Thorne NP, Teschendorff AE, Pinder SE, Vias M, Naderi A, Roberts I, Barbosa-Morais NL, Garcia MJ, et al.: Using array-comparative genomic hybridization to define molecular portraits of primary breast cancers. Oncogene. 2007, 26 (13): 1959-1970. 10.1038\/sj.onc.1209985","journal-title":"Oncogene"},{"issue":"14","key":"456_CR9","doi-asserted-by":"publisher","first-page":"7952","DOI":"10.1073\/pnas.151241198","volume":"98","author":"AN Jain","year":"2001","unstructured":"Jain AN, Chin K, Borresen-Dale AL, Erikstein BK, Eynstein Lonning P, Kaaresen R, Gray JW: Quantitative analysis of chromosomal CGH in human breast tumors associates copy number abnormalities with p53 status and patient survival. Proc Natl Acad Sci USA. 2001, 98 (14): 7952-7957. 10.1073\/pnas.151241198","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"456_CR10","doi-asserted-by":"publisher","first-page":"R1186","DOI":"10.1186\/bcr1356","volume":"7","author":"TL Naylor","year":"2005","unstructured":"Naylor TL, Greshock J, Wang Y, Colligon T, Yu QC, Clemmer V, Zaks TZ, Weber BL: High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization. Breast Cancer Res. 2005, 7 (6): R1186-1198. 10.1186\/bcr1356","journal-title":"Breast Cancer Res"},{"issue":"1","key":"456_CR11","doi-asserted-by":"publisher","first-page":"R9","DOI":"10.1186\/bcr1370","volume":"8","author":"A Shadeo","year":"2006","unstructured":"Shadeo A, Lam WL: Comprehensive copy number profiles of breast cancer cell model genomes. Breast Cancer Res. 2006, 8 (1): R9- 10.1186\/bcr1370","journal-title":"Breast Cancer Res"},{"issue":"6","key":"456_CR12","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.ccr.2006.10.009","volume":"10","author":"K Chin","year":"2006","unstructured":"Chin K, DeVries S, Fridlyand J, Spellman PT, Roydasgupta R, Kuo WL, Lapuk A, Neve RM, Qian Z, Ryder T, et al.: Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell. 2006, 10 (6): 529-541. 10.1016\/j.ccr.2006.10.009","journal-title":"Cancer Cell"},{"issue":"10","key":"456_CR13","doi-asserted-by":"publisher","first-page":"R215","DOI":"10.1186\/gb-2007-8-10-r215","volume":"8","author":"SF Chin","year":"2007","unstructured":"Chin SF, Teschendorff AE, Marioni JC, Wang Y, Barbosa-Morais NL, Thorne NP, Costa JL, Pinder SE, Wiel van de MA, Green AR, et al.: High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer. Genome Biol. 2007, 8 (10): R215- 10.1186\/gb-2007-8-10-r215","journal-title":"Genome Biol"},{"issue":"21","key":"456_CR14","first-page":"6240","volume":"62","author":"E Hyman","year":"2002","unstructured":"Hyman E, Kauraniemi P, Hautaniemi S, Wolf M, Mousses S, Rozenblum E, Ringner M, Sauter G, Monni O, Elkahloun A, et al.: Impact of DNA amplification on gene expression patterns in breast cancer. Cancer Res. 2002, 62 (21): 6240-6245.","journal-title":"Cancer Res"},{"issue":"20","key":"456_CR15","doi-asserted-by":"publisher","first-page":"12963","DOI":"10.1073\/pnas.162471999","volume":"99","author":"JR Pollack","year":"2002","unstructured":"Pollack JR, Sorlie T, Perou CM, Rees CA, Jeffrey SS, Lonning PE, Tibshirani R, Botstein D, Borresen-Dale AL, Brown PO: Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors. Proc Natl Acad Sci USA. 2002, 99 (20): 12963-12968. 10.1073\/pnas.162471999","journal-title":"Proc Natl Acad Sci USA"},{"key":"456_CR16","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1186\/1471-2164-7-324","volume":"7","author":"R Chari","year":"2006","unstructured":"Chari R, Lockwood WW, Coe BP, Chu A, Macey D, Thomson A, Davies JJ, MacAulay C, Lam WL: SIGMA: a system for integrative genomic microarray analysis of cancer genomes. BMC Genomics. 2006, 7: 324- 10.1186\/1471-2164-7-324","journal-title":"BMC Genomics"},{"issue":"3","key":"456_CR17","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/ng1307","volume":"36","author":"AS Ishkanian","year":"2004","unstructured":"Ishkanian AS, Malloff CA, Watson SK, DeLeeuw RJ, Chi B, Coe BP, Snijders A, Albertson DG, Pinkel D, Marra MA, et al.: A tiling resolution DNA microarray with complete coverage of the human genome. Nat Genet. 2004, 36 (3): 299-303. 10.1038\/ng1307","journal-title":"Nat Genet"},{"issue":"2","key":"456_CR18","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1002\/ijc.22335","volume":"120","author":"WW Lockwood","year":"2007","unstructured":"Lockwood WW, Coe BP, Williams AC, MacAulay C, Lam WL: Whole genome tiling path array CGH analysis of segmental copy number alterations in cervical cancer cell lines. Int J Cancer. 2007, 120 (2): 436-443. 10.1002\/ijc.22335","journal-title":"Int J Cancer"},{"key":"456_CR19","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1186\/1471-2105-6-274","volume":"6","author":"M Khojasteh","year":"2005","unstructured":"Khojasteh M, Lam WL, Ward RK, MacAulay C: A stepwise framework for the normalization of array CGH data. BMC Bioinformatics. 2005, 6: 274- 10.1186\/1471-2105-6-274","journal-title":"BMC Bioinformatics"},{"issue":"18","key":"456_CR20","doi-asserted-by":"publisher","first-page":"3636","DOI":"10.1093\/bioinformatics\/bth355","volume":"20","author":"K Jong","year":"2004","unstructured":"Jong K, Marchiori E, Meijer G, Vaart AV, Ylstra B: Breakpoint identification and smoothing of array comparative genomic hybridization data. Bioinformatics. 2004, 20 (18): 3636-3637. 10.1093\/bioinformatics\/bth355","journal-title":"Bioinformatics"},{"issue":"12","key":"456_CR21","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1038\/sj.bjc.6603167","volume":"94","author":"BP Coe","year":"2006","unstructured":"Coe BP, Lockwood WW, Girard L, Chari R, Macaulay C, Lam S, Gazdar AF, Minna JD, Lam WL: Differential disruption of cell cycle pathways in small cell and non-small cell lung cancer. Br J Cancer. 2006, 94 (12): 1927-1935. 10.1038\/sj.bjc.6603167","journal-title":"Br J Cancer"},{"issue":"2","key":"456_CR22","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1093\/biostatistics\/kxl042","volume":"8","author":"B Carvalho","year":"2007","unstructured":"Carvalho B, Bengtsson H, Speed TP, Irizarry RA: Exploration, normalization, and genotype calls of high-density oligonucleotide SNP array data. Biostatistics. 2007, 8 (2): 485-499. 10.1093\/biostatistics\/kxl042","journal-title":"Biostatistics"},{"issue":"8","key":"456_CR23","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1093\/bioinformatics\/bth069","volume":"20","author":"M Lin","year":"2004","unstructured":"Lin M, Wei LJ, Sellers WR, Lieberfarb M, Wong WH, Li C: dChipSNP: significance curve and clustering of SNP-array-based loss-of-heterozygosity data. Bioinformatics. 2004, 20 (8): 1233-1240. 10.1093\/bioinformatics\/bth069","journal-title":"Bioinformatics"},{"issue":"7118","key":"456_CR24","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/nature05329","volume":"444","author":"R Redon","year":"2006","unstructured":"Redon R, Ishikawa S, Fitch KR, Feuk L, Perry GH, Andrews TD, Fiegler H, Shapero MH, Carson AR, Chen W, et al.: Global variation in copy number in the human genome. Nature. 2006, 444 (7118): 444-454. 10.1038\/nature05329","journal-title":"Nature"},{"issue":"3","key":"456_CR25","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1093\/bioinformatics\/btg405","volume":"20","author":"L Gautier","year":"2004","unstructured":"Gautier L, Cope L, Bolstad BM, Irizarry RA: affy--analysis of Affymetrix GeneChip data at the probe level. Bioinformatics. 2004, 20 (3): 307-315. 10.1093\/bioinformatics\/btg405","journal-title":"Bioinformatics"},{"issue":"10","key":"456_CR26","doi-asserted-by":"publisher","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","volume":"5","author":"RC Gentleman","year":"2004","unstructured":"Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, et al.: Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 2004, 5 (10): R80- 10.1186\/gb-2004-5-10-r80","journal-title":"Genome Biol"},{"key":"456_CR27","doi-asserted-by":"crossref","unstructured":"Karolchik D, Kuhn RM, Baertsch R, Barber GP, Clawson H, Diekhans M, Giardine B, Harte RA, Hinrichs AS, Hsu F: The UCSC Genome Browser Database: 2008 update. Nucleic Acids Res. 2008, D773-779. 36 Database,","DOI":"10.1093\/nar\/gkm966"},{"issue":"3","key":"456_CR28","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1101\/gr.4410706","volume":"16","author":"M Bibikova","year":"2006","unstructured":"Bibikova M, Lin Z, Zhou L, Chudin E, Garcia EW, Wu B, Doucet D, Thomas NJ, Wang Y, Vollmer E, et al.: High-throughput DNA methylation profiling using universal bead arrays. Genome Res. 2006, 16 (3): 383-393. 10.1101\/gr.4410706","journal-title":"Genome Res"},{"key":"456_CR29","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1186\/1471-2105-9-422","volume":"9","author":"R Chari","year":"2008","unstructured":"Chari R, Coe BP, Wedseltoft C, Benetti M, Wilson IM, Vucic EA, MacAulay C, Ng RT, Lam WL: SIGMA2: a system for the integrative genomic multi-dimensional analysis of cancer genomes, epigenomes, and transcriptomes. BMC Bioinformatics. 2008, 9: 422- 10.1186\/1471-2105-9-422","journal-title":"BMC Bioinformatics"},{"issue":"10","key":"456_CR30","doi-asserted-by":"publisher","first-page":"e7464","DOI":"10.1371\/journal.pone.0007464","volume":"4","author":"J Soh","year":"2009","unstructured":"Soh J, Okumura N, Lockwood WW, Yamamoto H, Shigematsu H, Zhang W, Chari R, Shames DS, Tang X, MacAulay C, et al.: Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells. PLoS One. 2009, 4 (10): e7464- 10.1371\/journal.pone.0007464","journal-title":"PLoS One"},{"issue":"3","key":"456_CR31","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.molmed.2009.01.005","volume":"15","author":"M Tuna","year":"2009","unstructured":"Tuna M, Knuutila S, Mills GB: Uniparental disomy in cancer. Trends Mol Med. 2009, 15 (3): 120-128. 10.1016\/j.molmed.2009.01.005","journal-title":"Trends Mol Med"},{"issue":"5584","key":"456_CR32","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1126\/science.1072545","volume":"297","author":"H Yan","year":"2002","unstructured":"Yan H, Yuan W, Velculescu VE, Vogelstein B, Kinzler KW: Allelic variation in human gene expression. Science. 2002, 297 (5584): 1143- 10.1126\/science.1072545","journal-title":"Science"},{"issue":"25","key":"456_CR33","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1056\/NEJMoa021967","volume":"347","author":"MJ van de Vijver","year":"2002","unstructured":"Vijver van de MJ, He YD, van't Veer LJ, Dai H, Hart AA, Voskuil DW, Schreiber GJ, Peterse JL, Roberts C, Marton MJ, et al.: A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med. 2002, 347 (25): 1999-2009. 10.1056\/NEJMoa021967","journal-title":"N Engl J Med"},{"issue":"6","key":"456_CR34","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1093\/bioinformatics\/17.6.520","volume":"17","author":"O Troyanskaya","year":"2001","unstructured":"Troyanskaya O, Cantor M, Sherlock G, Brown P, Hastie T, Tibshirani R, Botstein D, Altman RB: Missing value estimation methods for DNA microarrays. Bioinformatics. 2001, 17 (6): 520-525. 10.1093\/bioinformatics\/17.6.520","journal-title":"Bioinformatics"},{"issue":"2","key":"456_CR35","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1593\/neo.07112","volume":"9","author":"DR Rhodes","year":"2007","unstructured":"Rhodes DR, Kalyana-Sundaram S, Mahavisno V, Varambally R, Yu J, Briggs BB, Barrette TR, Anstet MJ, Kincead-Beal C, Kulkarni P, et al.: Oncomine 3.0: genes, pathways, and networks in a collection of 18, 000 cancer gene expression profiles. Neoplasia. 2007, 9 (2): 166-180. 10.1593\/neo.07112","journal-title":"Neoplasia"},{"issue":"1","key":"456_CR36","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s10549-007-9758-6","volume":"111","author":"N Johnson","year":"2008","unstructured":"Johnson N, Speirs V, Curtin NJ, Hall AG: A comparative study of genome-wide SNP, CGH microarray and protein expression analysis to explore genotypic and phenotypic mechanisms of acquired antiestrogen resistance in breast cancer. Breast Cancer Res Treat. 2008, 111 (1): 55-63. 10.1007\/s10549-007-9758-6","journal-title":"Breast Cancer Res Treat"},{"issue":"5","key":"456_CR37","first-page":"1265","volume":"26","author":"CD Jee","year":"2005","unstructured":"Jee CD, Lee HS, Bae SI, Yang HK, Lee YM, Rho MS, Kim WH: Loss of caspase-1 gene expression in human gastric carcinomas and cell lines. Int J Oncol. 2005, 26 (5): 1265-1271.","journal-title":"Int J Oncol"},{"issue":"5","key":"456_CR38","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1002\/1097-0215(200002)9999:9999<::AID-IJC1113>3.0.CO;2-U","volume":"91","author":"T Ueki","year":"2001","unstructured":"Ueki T, Takeuchi T, Nishimatsu H, Kajiwara T, Moriyama N, Narita Y, Kawabe K, Ueki K, Kitamura T: Silencing of the caspase-1 gene occurs in murine and human renal cancer cells and causes solid tumor growth in vivo. Int J Cancer. 2001, 91 (5): 673-679. 10.1002\/1097-0215(200002)9999:9999<::AID-IJC1113>3.0.CO;2-U","journal-title":"Int J Cancer"},{"key":"456_CR39","doi-asserted-by":"crossref","unstructured":"Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 2008, 455 (7216): 1061-1068.","DOI":"10.1038\/nature07385"},{"issue":"5897","key":"456_CR40","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1126\/science.1164382","volume":"321","author":"DW Parsons","year":"2008","unstructured":"Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Siu IM, Gallia GL, et al.: An integrated genomic analysis of human glioblastoma multiforme. Science. 2008, 321 (5897): 1807-1812. 10.1126\/science.1164382","journal-title":"Science"},{"issue":"23","key":"456_CR41","doi-asserted-by":"publisher","first-page":"2926","DOI":"10.1093\/bioinformatics\/btl483","volume":"22","author":"JT Chang","year":"2006","unstructured":"Chang JT, Nevins JR: GATHER: a systems approach to interpreting genomic signatures. Bioinformatics. 2006, 22 (23): 2926-2933. 10.1093\/bioinformatics\/btl483","journal-title":"Bioinformatics"},{"issue":"8","key":"456_CR42","doi-asserted-by":"publisher","first-page":"772","DOI":"10.4161\/cbt.3.8.994","volume":"3","author":"KE Bachman","year":"2004","unstructured":"Bachman KE, Argani P, Samuels Y, Silliman N, Ptak J, Szabo S, Konishi H, Karakas B, Blair BG, Lin C, et al.: The PIK3CA gene is mutated with high frequency in human breast cancers. Cancer Biol Ther. 2004, 3 (8): 772-775. 10.4161\/cbt.3.8.994","journal-title":"Cancer Biol Ther"},{"issue":"4905","key":"456_CR43","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1126\/science.2470152","volume":"244","author":"DJ Slamon","year":"1989","unstructured":"Slamon DJ, Godolphin W, Jones LA, Holt JA, Wong SG, Keith DE, Levin WJ, Stuart SG, Udove J, Ullrich A, et al.: Studies of the HER-2\/neu proto-oncogene in human breast and ovarian cancer. Science. 1989, 244 (4905): 707-712. 10.1126\/science.2470152","journal-title":"Science"},{"issue":"6","key":"456_CR44","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1002\/j.1460-2075.1994.tb06386.x","volume":"13","author":"D Stein","year":"1994","unstructured":"Stein D, Wu J, Fuqua SA, Roonprapunt C, Yajnik V, D'Eustachio P, Moskow JJ, Buchberg AM, Osborne CK, Margolis B: The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer. Embo J. 1994, 13 (6): 1331-1340.","journal-title":"Embo J"},{"issue":"33","key":"456_CR45","doi-asserted-by":"publisher","first-page":"4615","DOI":"10.1038\/onc.2008.98","volume":"27","author":"WW Lockwood","year":"2008","unstructured":"Lockwood WW, Chari R, Coe BP, Girard L, Macaulay C, Lam S, Gazdar AF, Minna JD, Lam WL: DNA amplification is a ubiquitous mechanism of oncogene activation in lung and other cancers. Oncogene. 2008, 27 (33): 4615-4624. 10.1038\/onc.2008.98","journal-title":"Oncogene"},{"issue":"15","key":"456_CR46","doi-asserted-by":"publisher","first-page":"6084","DOI":"10.1158\/0008-5472.CAN-07-6854","volume":"68","author":"K Stemke-Hale","year":"2008","unstructured":"Stemke-Hale K, Gonzalez-Angulo AM, Lluch A, Neve RM, Kuo WL, Davies M, Carey M, Hu Z, Guan Y, Sahin A, et al.: An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res. 2008, 68 (15): 6084-6091. 10.1158\/0008-5472.CAN-07-6854","journal-title":"Cancer Res"},{"issue":"14","key":"456_CR47","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1007\/s00018-007-7054-6","volume":"64","author":"E Wang","year":"2007","unstructured":"Wang E, Lenferink A, O'Connor-McCourt M: Cancer systems biology: exploring cancer-associated genes on cellular networks. Cell Mol Life Sci. 2007, 64 (14): 1752-1762. 10.1007\/s00018-007-7054-6","journal-title":"Cell Mol Life Sci"},{"issue":"17","key":"456_CR48","first-page":"3869","volume":"53","author":"GS Bova","year":"1993","unstructured":"Bova GS, Carter BS, Bussemakers MJ, Emi M, Fujiwara Y, Kyprianou N, Jacobs SC, Robinson JC, Epstein JI, Walsh PC, et al.: Homozygous deletion and frequent allelic loss of chromosome 8p22 loci in human prostate cancer. Cancer Res. 1993, 53 (17): 3869-3873.","journal-title":"Cancer Res"},{"issue":"2-3","key":"456_CR49","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1159\/000134480","volume":"75","author":"K Chinen","year":"1996","unstructured":"Chinen K, Isomura M, Izawa K, Fujiwara Y, Ohata H, Iwamasa T, Nakamura Y: Isolation of 45 exon-like fragments from 8p22-->p21.3, a region that is commonly deleted in hepatocellular, colorectal, and non-small cell lung carcinomas. Cytogenet Cell Genet. 1996, 75 (2-3): 190-196. 10.1159\/000134480","journal-title":"Cytogenet Cell Genet"},{"issue":"1","key":"456_CR50","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1186\/1471-2407-8-288","volume":"8","author":"SL Cooke","year":"2008","unstructured":"Cooke SL, Pole JC, Chin SF, Ellis IO, Caldas C, Edwards PA: High-resolution array CGH clarifies events occurring on 8p in carcinogenesis. BMC Cancer. 2008, 8 (1): 288- 10.1186\/1471-2407-8-288","journal-title":"BMC Cancer"},{"issue":"3","key":"456_CR51","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1002\/gcc.2870130308","volume":"13","author":"ML Yaremko","year":"1995","unstructured":"Yaremko ML, Recant WM, Westbrook CA: Loss of heterozygosity from the short arm of chromosome 8 is an early event in breast cancers. Genes Chromosomes Cancer. 1995, 13 (3): 186-191. 10.1002\/gcc.2870130308","journal-title":"Genes Chromosomes Cancer"},{"issue":"13","key":"456_CR52","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1101\/gad.8.13.1502","volume":"8","author":"A Giovane","year":"1994","unstructured":"Giovane A, Pintzas A, Maira SM, Sobieszczuk P, Wasylyk B: Net, a new ets transcription factor that is activated by Ras. Genes Dev. 1994, 8 (13): 1502-1513. 10.1101\/gad.8.13.1502","journal-title":"Genes Dev"},{"issue":"1","key":"456_CR53","doi-asserted-by":"publisher","first-page":"76","DOI":"10.4161\/cbt.6.1.3551","volume":"6","author":"J He","year":"2007","unstructured":"He J, Pan Y, Hu J, Albarracin C, Wu Y, Dai JL: Profile of Ets gene expression in human breast carcinoma. Cancer Biol Ther. 2007, 6 (1): 76-82.","journal-title":"Cancer Biol Ther"},{"issue":"12","key":"456_CR54","doi-asserted-by":"publisher","first-page":"e486","DOI":"10.1371\/journal.pmed.0030486","volume":"3","author":"DS Shames","year":"2006","unstructured":"Shames DS, Girard L, Gao B, Sato M, Lewis CM, Shivapurkar N, Jiang A, Perou CM, Kim YH, Pollack JR, et al.: A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies. PLoS Med. 2006, 3 (12): e486- 10.1371\/journal.pmed.0030486","journal-title":"PLoS Med"},{"issue":"11","key":"456_CR55","doi-asserted-by":"publisher","first-page":"2417","DOI":"10.1002\/cncr.21538","volume":"104","author":"D Pils","year":"2005","unstructured":"Pils D, Horak P, Gleiss A, Sax C, Fabjani G, Moebus VJ, Zielinski C, Reinthaller A, Zeillinger R, Krainer M: Five genes from chromosomal band 8p22 are significantly down-regulated in ovarian carcinoma: N33 and EFA6R have a potential impact on overall survival. Cancer. 2005, 104 (11): 2417-2429. 10.1002\/cncr.21538","journal-title":"Cancer"},{"issue":"5","key":"456_CR56","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1158\/1078-0432.CCR-07-1658","volume":"14","author":"MC Cheang","year":"2008","unstructured":"Cheang MC, Voduc D, Bajdik C, Leung S, McKinney S, Chia SK, Perou CM, Nielsen TO: Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype. Clin Cancer Res. 2008, 14 (5): 1368-1376. 10.1158\/1078-0432.CCR-07-1658","journal-title":"Clin Cancer Res"},{"issue":"12","key":"456_CR57","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1093\/annonc\/mdp492","volume":"20","author":"O Gluz","year":"2009","unstructured":"Gluz O, Liedtke C, Gottschalk N, Pusztai L, Nitz U, Harbeck N: Triple-negative breast cancer--current status and future directions. Ann Oncol. 2009, 20 (12): 1913-1927. 10.1093\/annonc\/mdp492","journal-title":"Ann Oncol"},{"issue":"1","key":"456_CR58","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1002\/cncr.22381","volume":"109","author":"EA Rakha","year":"2007","unstructured":"Rakha EA, El-Sayed ME, Green AR, Lee AH, Robertson JF, Ellis IO: Prognostic markers in triple-negative breast cancer. Cancer. 2007, 109 (1): 25-32. 10.1002\/cncr.22381","journal-title":"Cancer"},{"issue":"14","key":"456_CR59","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1038\/onc.2009.489","volume":"29","author":"N Turner","year":"2010","unstructured":"Turner N, Lambros MB, Horlings HM, Pearson A, Sharpe R, Natrajan R, Geyer FC, van Kouwenhove M, Kreike B, Mackay A, et al.: Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets. Oncogene. 2010, 29 (14): 2013-2023. 10.1038\/onc.2009.489","journal-title":"Oncogene"},{"issue":"2","key":"456_CR60","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1158\/1078-0432.CCR-08-1791","volume":"15","author":"F Andre","year":"2009","unstructured":"Andre F, Job B, Dessen P, Tordai A, Michiels S, Liedtke C, Richon C, Yan K, Wang B, Vassal G, et al.: Molecular characterization of breast cancer with high-resolution oligonucleotide comparative genomic hybridization array. Clin Cancer Res. 2009, 15 (2): 441-451. 10.1158\/1078-0432.CCR-08-1791","journal-title":"Clin Cancer Res"},{"issue":"1","key":"456_CR61","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1002\/ijc.23518","volume":"123","author":"F Bertucci","year":"2008","unstructured":"Bertucci F, Finetti P, Cervera N, Esterni B, Hermitte F, Viens P, Birnbaum D: How basal are triple-negative breast cancers?. Int J Cancer. 2008, 123 (1): 236-240. 10.1002\/ijc.23518","journal-title":"Int J Cancer"},{"issue":"6","key":"456_CR62","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1002\/gcc.20550","volume":"47","author":"W Han","year":"2008","unstructured":"Han W, Jung EM, Cho J, Lee JW, Hwang KT, Yang SJ, Kang JJ, Bae JY, Jeon YK, Park IA, et al.: DNA copy number alterations and expression of relevant genes in triple-negative breast cancer. Genes Chromosomes Cancer. 2008, 47 (6): 490-499. 10.1002\/gcc.20550","journal-title":"Genes Chromosomes Cancer"},{"issue":"5","key":"456_CR63","doi-asserted-by":"publisher","first-page":"R65","DOI":"10.1186\/bcr1771","volume":"9","author":"B Kreike","year":"2007","unstructured":"Kreike B, van Kouwenhove M, Horlings H, Weigelt B, Peterse H, Bartelink H, van MJ: Gene expression profiling and histopathological characterization of triple-negative\/basal-like breast carcinomas. Breast Cancer Res. 2007, 9 (5): R65- 10.1186\/bcr1771","journal-title":"Breast Cancer Res"},{"issue":"1","key":"456_CR64","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/ng1060","volume":"33","author":"S Ramaswamy","year":"2003","unstructured":"Ramaswamy S, Ross KN, Lander ES, Golub TR: A molecular signature of metastasis in primary solid tumors. Nat Genet. 2003, 33 (1): 49-54. 10.1038\/ng1060","journal-title":"Nat Genet"},{"issue":"9460","key":"456_CR65","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/S0140-6736(05)70933-8","volume":"365","author":"Y Wang","year":"2005","unstructured":"Wang Y, Klijn JG, Zhang Y, Sieuwerts AM, Look MP, Yang F, Talantov D, Timmermans M, Meijer-van Gelder ME, Yu J, et al.: Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet. 2005, 365 (9460): 671-679.","journal-title":"Lancet"}],"container-title":["BMC Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-0509-4-67.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1752-0509-4-67\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-0509-4-67.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T03:54:38Z","timestamp":1559102078000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsystbiol.biomedcentral.com\/articles\/10.1186\/1752-0509-4-67"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,17]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["456"],"URL":"https:\/\/doi.org\/10.1186\/1752-0509-4-67","relation":{},"ISSN":["1752-0509"],"issn-type":[{"value":"1752-0509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,17]]},"article-number":"67"}}