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To maximise the benefits of this growing body of models, the field needs centralised model repositories that will encourage, facilitate and promote model dissemination and reuse. Ideally, the models stored in these repositories should be extensively tested and encoded in community-supported and standardised formats. In addition, the models and their components should be cross-referenced with other resources in order to allow their unambiguous identification.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Description<\/jats:title>\n            <jats:p>BioModels Database <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.ebi.ac.uk\/biomodels\/\" ext-link-type=\"uri\">http:\/\/www.ebi.ac.uk\/biomodels\/<\/jats:ext-link> is aimed at addressing exactly these needs. It is a freely-accessible online resource for storing, viewing, retrieving, and analysing published, peer-reviewed quantitative models of biochemical and cellular systems. The structure and behaviour of each simulation model distributed by BioModels Database are thoroughly checked; in addition, model elements are annotated with terms from controlled vocabularies as well as linked to relevant data resources. Models can be examined online or downloaded in various formats. Reaction network diagrams generated from the models are also available in several formats. BioModels Database also provides features such as online simulation and the extraction of components from large scale models into smaller submodels. Finally, the system provides a range of web services that external software systems can use to access up-to-date data from the database.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>BioModels Database has become a recognised reference resource for systems biology. It is being used by the community in a variety of ways; for example, it is used to benchmark different simulation systems, and to study the clustering of models based upon their annotations. Model deposition to the database today is advised by several publishers of scientific journals. The models in BioModels Database are freely distributed and reusable; the underlying software infrastructure is also available from SourceForge <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/sourceforge.net\/projects\/biomodels\/\" ext-link-type=\"uri\">https:\/\/sourceforge.net\/projects\/biomodels\/<\/jats:ext-link> under the GNU General Public License.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1752-0509-4-92","type":"journal-article","created":{"date-parts":[[2010,7,27]],"date-time":"2010-07-27T06:15:13Z","timestamp":1280211313000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":435,"title":["BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models"],"prefix":"10.1186","volume":"4","author":[{"given":"Chen","family":"Li","sequence":"first","affiliation":[]},{"given":"Marco","family":"Donizelli","sequence":"additional","affiliation":[]},{"given":"Nicolas","family":"Rodriguez","sequence":"additional","affiliation":[]},{"given":"Harish","family":"Dharuri","sequence":"additional","affiliation":[]},{"given":"Lukas","family":"Endler","sequence":"additional","affiliation":[]},{"given":"Vijayalakshmi","family":"Chelliah","sequence":"additional","affiliation":[]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[]},{"given":"Enuo","family":"He","sequence":"additional","affiliation":[]},{"given":"Arnaud","family":"Henry","sequence":"additional","affiliation":[]},{"given":"Melanie I","family":"Stefan","sequence":"additional","affiliation":[]},{"given":"Jacky L","family":"Snoep","sequence":"additional","affiliation":[]},{"given":"Michael","family":"Hucka","sequence":"additional","affiliation":[]},{"given":"Nicolas","family":"Le Nov\u00e8re","sequence":"additional","affiliation":[]},{"given":"Camille","family":"Laibe","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2010,6,29]]},"reference":[{"key":"481_CR1","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.pbiomolbio.2004.01.004","volume":"85","author":"CM Lloyd","year":"2004","unstructured":"Lloyd CM, Halstead MDB, Nielsen PF: CellML: its future, present and past. 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