{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T12:16:01Z","timestamp":1773836161740,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Syst Biol"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1186\/1752-0509-4-s1-s8","type":"journal-article","created":{"date-parts":[[2010,5,28]],"date-time":"2010-05-28T18:14:40Z","timestamp":1275070480000},"source":"Crossref","is-referenced-by-count":17,"title":["Non-compartment model to compartment model pharmacokinetics transformation meta-analysis \u2013 a multivariate nonlinear mixed model"],"prefix":"10.1186","volume":"4","author":[{"given":"Zhiping","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seongho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara K","family":"Quinney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,5,28]]},"reference":[{"issue":"2","key":"530_CR1","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0167-6296(02)00126-1","volume":"22","author":"JA DiMasi","year":"2003","unstructured":"DiMasi JA, Hansen RW, Grabowski HG: The price of innovation: new estimates of drug development costs. Journal of Health Economics. 2003, 22 (2): 151-185. 10.1016\/S0167-6296(02)00126-1","journal-title":"Journal of Health Economics"},{"issue":"8","key":"530_CR2","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1038\/nrd1470","volume":"3","author":"I Kola","year":"2004","unstructured":"Kola I, Landis J: Can the pharmaceutical industry reduce attrition rates?. Nature Reviews Drug Discovery. 2004, 3 (8): 711-715. 10.1038\/nrd1470","journal-title":"Nature Reviews Drug Discovery"},{"key":"530_CR3","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/sj.clpt.6100014","volume":"81","author":"RL Woosley","year":"2007","unstructured":"Woosley RL: Drug development and the FDA\u2019s critical path initiative. Clinical Pharmacology and Therapeutics. 2007, 129-133. 81","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"530_CR4","first-page":"276","volume":"117","author":"M Veit","year":"2007","unstructured":"Veit M: New strategies for drug development. Berl. Munch. Tierarztl. Wochenschr. 276-287. 117","journal-title":"Berl. Munch. Tierarztl. Wochenschr."},{"key":"530_CR5","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1182\/blood-2004-06-2111","volume":"105","author":"G D'Andrea","year":"2005","unstructured":"D'Andrea G e a: A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin. Blood. 2005, 645-649. 105","journal-title":"Blood"},{"key":"530_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clpt.2004.08.009","volume":"77","author":"JB Kirchheiner","year":"2005","unstructured":"Kirchheiner JB: J. Clinical consequences of cytochrome P450 2C9 polymorphisms. Clin. Pharmacol. Ther. 2005, 1-16. 77","journal-title":"Clin. Pharmacol. Ther."},{"key":"530_CR7","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1124\/jpet.106.104364","volume":"318","author":"I Badagnani","year":"2005","unstructured":"Badagnani I e a: Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants. J. Pharmacol. Exp. Ther. 521-529. 318","journal-title":"Exp. Ther."},{"key":"530_CR8","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1097\/01.fpc.0000199500.46842.4a","volume":"16","author":"SI Hung","year":"2006","unstructured":"Hung S I e a: Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. Pharmacogenet. Genom. 2006, 297-306. 10.1097\/01.fpc.0000199500.46842.4a. 16","journal-title":"Pharmacogenet. Genom"},{"issue":"4","key":"530_CR9","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1177\/106002809202600411","volume":"26","author":"JD Cleary","year":"1992","unstructured":"Cleary JD, Taylor JW, Chapman SW: Itraconazole in antifungal therapy. Ann Pharmacother. 1992, 26 (4): 502-9.","journal-title":"Ann Pharmacother"},{"issue":"12","key":"530_CR10","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1248\/yakushi1947.115.12_953","volume":"115","author":"M Yamazaki","year":"1995","unstructured":"Yamazaki M, Nishigaki R, Suzuki H, Sugiyama Y: [Kinetic analysis of hepatobiliary transport of drugs, importance of carrier-mediated transport]. Yakugaku Zasshi. 1995, 115 (12): 953-77.","journal-title":"Yakugaku Zasshi"},{"issue":"5","key":"530_CR11","first-page":"270","volume":"25","author":"H Okuda","year":"1997","unstructured":"Okuda H, Nishiyama T, Ogura K, Nagayama S, Ikeda K, Yamaguchi S, Nakamura Y, Kawaguchi Y, Watabe T: Lethal drug interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs. Drug Metab Dispos. 1997, 25 (5): 270-3.","journal-title":"Drug Metab Dispos"},{"issue":"1","key":"530_CR12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/sj.clpt.6100235","volume":"82","author":"RL Lalonde","year":"2007","unstructured":"Lalonde RL, Hutmacher MM, Ewy W, Nichols DJ, Milligan PA, Corrigan BW, Lockwood PA, Marshall SA, Benincosa LJ, Tensfeldt TG, Parivar K, Amantea M, Glue P, Koide H, Miller R: Model-based drug development. Clin Pharmacol Ther. 2007, 82 (1): 21-32. 10.1038\/sj.clpt.6100235","journal-title":"Clin Pharmacol Ther"},{"issue":"5","key":"530_CR13","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1080\/10543400701513926","volume":"17","author":"MKS Chang","year":"2007","unstructured":"Chang MKS, Bull J, Chiu YY, Wang W, Wakeford C, McCarthy K: Innovative approaches in drug development. J Biopharm Stat. 2007, 17 (5): 775-89. 10.1080\/10543400701513926","journal-title":"J Biopharm Stat"},{"issue":"4","key":"530_CR14","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1002\/bimj.200510237","volume":"48","author":"ON RT","year":"2006","unstructured":"RT ON: FDA's critical path initiative: a perspective on contributions of biostatistics. Biom J. 2006, 48 (4): 559-64. 10.1002\/bimj.200510237","journal-title":"Biom J"},{"issue":"3","key":"530_CR15","doi-asserted-by":"publisher","first-page":"E544","DOI":"10.1208\/aapsj070355","volume":"7","author":"JY Chien","year":"2005","unstructured":"Chien JY, Heathman MA, de Alwis DP, Sinha V: Pharmacokinetics\/Pharmacodynamics and the stages of drug development: role of modeling and simulation. The AAPS Journal. 2005, 7 (3): E544-E559. 10.1208\/aapsj070355","journal-title":"The AAPS Journal"},{"key":"530_CR16","volume-title":"Clinical Pharmacokinetics Concept and Applications.","author":"M Rowland","year":"1995","unstructured":"Rowland M, Tozer TN: Clinical Pharmacokinetics Concept and Applications. 1995, Lippincott Williams & Wilkins, Third","edition":"Third"},{"key":"530_CR17","volume-title":"Nonlinear models for repeated measurment data.","author":"M Davidian","year":"1995","unstructured":"Davidian M, Giltinan DM: Nonlinear models for repeated measurment data. 1995, Chapman and Hall"},{"issue":"1","key":"530_CR18","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/j.0006-341X.2000.00263.x","volume":"56","author":"JC Wakefield","year":"2000","unstructured":"Wakefield JC, Rahman N: The combination of population pharmacokinetic studies. Biometrics. 2000, 56 (1): 263-70. 10.1111\/j.0006-341X.2000.00263.x","journal-title":"Biometrics"},{"issue":"1","key":"530_CR19","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1111\/1541-0420.00008","volume":"59","author":"HF Lopes","year":"2003","unstructured":"Lopes HF, Muller P, Rosner GL: Bayesian meta-analysis for longitudinal data models using multivariate mixture priors. Biometrics. 2003, 59 (1): 66-75. 10.1111\/1541-0420.00008","journal-title":"Biometrics"},{"issue":"20","key":"530_CR20","doi-asserted-by":"publisher","first-page":"3700","DOI":"10.1002\/sim.2837","volume":"26","author":"L Li","year":"2007","unstructured":"Li L, Yu M, Chin R, Lucksiri A, Flockhart D, Hall S: Drug-Drug Interaction Prediction: A Bayesian Meta-Analysis Approach. Statistis in Medicine. 2007, 26 (20): 3700-3721. 10.1002\/sim.2837.","journal-title":"Statistis in Medicine"},{"issue":"6","key":"530_CR21","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1080\/10543400802369004","volume":"18","author":"M Yu","year":"2008","unstructured":"Yu M, et al.: A Bayesian meta-analysis on published sample mean and variance pharmacokinetic data with application to drug-drug interaction prediction. J Biopharm Stat. 2008, 18 (6): 1063-83. 10.1080\/10543400802369004","journal-title":"J Biopharm Stat"},{"key":"530_CR22","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/S0167-9473(97)00012-1","volume":"25","author":"RD Wolfinger","year":"1997","unstructured":"Wolfinger RD: Two Taylor-series approximations methods for nonlinear mixed models. Journal of Computational Statistics and Data Analysis. 1997, 25: 465-490. 10.1016\/S0167-9473(97)00012-1.","journal-title":"Journal of Computational Statistics and Data Analysis"},{"key":"530_CR23","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1080\/00949659308811554","volume":"48","author":"R Wolfinger","year":"1993","unstructured":"Wolfinger R, O'Connell M: Generalized linear mixed models: a pseudo-likelihood approach. Journal of statistical Computation and Simulation. 1993, 48: 233-243. 10.1080\/00949659308811554.","journal-title":"Journal of statistical Computation and Simulation"},{"issue":"3","key":"530_CR24","doi-asserted-by":"publisher","first-page":"673","DOI":"10.2307\/2532087","volume":"46","author":"ML Lindstrom","year":"1990","unstructured":"Lindstrom ML, Bates DM: Nonlinear mixed effects models for repeated measures data. Biometrics. 1990, 46 (3): 673-87. 10.2307\/2532087","journal-title":"Biometrics"},{"key":"530_CR25","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1093\/biomet\/80.4.791","volume":"80","author":"RD Wolfinger","year":"1993","unstructured":"Wolfinger RD: Laplace's Approximation for Nonlinear Mixed Models. Biometrika. 1993, 80: 791-795. 10.1093\/biomet\/80.4.791.","journal-title":"Biometrika"},{"key":"530_CR26","volume-title":"Multiple comparisons and Multiple Tests.","author":"P Westfall","year":"1999","unstructured":"Westfall P, Hochberg Y, Wolfinger RD, Rorn D, Tobias RD: Multiple comparisons and Multiple Tests. 1999"},{"key":"530_CR27","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1093\/biomet\/83.2.447","volume":"83","author":"EF Vonesh","year":"1996","unstructured":"Vonesh EF: A Note on Laplace's Approximation in Nonlinear Mixed Effects Models. Biometrika. 1996, 83: 447-452. 10.1093\/biomet\/83.2.447.","journal-title":"Biometrika"}],"container-title":["BMC Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-0509-4-S1-S8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1752-0509-4-S1-S8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-0509-4-S1-S8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T02:16:52Z","timestamp":1548209812000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsystbiol.biomedcentral.com\/articles\/10.1186\/1752-0509-4-S1-S8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":27,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["530"],"URL":"https:\/\/doi.org\/10.1186\/1752-0509-4-s1-s8","relation":{},"ISSN":["1752-0509"],"issn-type":[{"value":"1752-0509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5]]},"article-number":"S8"}}