{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T01:37:54Z","timestamp":1775525874051,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Syst Biol"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Waves propagating in \"excitable media\" is a reliable way to transmit signals in space. A fascinating example where living cells comprise such a medium is Dictyostelium D. which propagates waves of chemoattractant to attract distant cells. While neutrophils chemotax in a similar fashion as Dictyostelium D., it is unclear if chemoattractant waves exist in mammalian tissues and what mechanisms could propagate them.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We propose that chemoattractant cytokine waves may naturally develop as a result of NF-<jats:italic>\u03ba<\/jats:italic>B response. Using a heuristic mathematical model of NF-<jats:italic>\u03ba<\/jats:italic>B-like circuits coupled in space we show that the known characteristics of NF-<jats:italic>\u03ba<\/jats:italic>B response favor cytokine waves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While the propagating wave of cytokines is generally beneficial for inflammation resolution, our model predicts that there exist special conditions that can cause chronic inflammation and re-occurrence of acute inflammatory response.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1752-0509-5-115","type":"journal-article","created":{"date-parts":[[2011,7,20]],"date-time":"2011-07-20T06:25:20Z","timestamp":1311143120000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Modeling the NF-\u03baB mediated inflammatory response predicts cytokine waves in tissue"],"prefix":"10.1186","volume":"5","author":[{"given":"Pernille","family":"Yde","sequence":"first","affiliation":[]},{"given":"Benedicte","family":"Mengel","sequence":"additional","affiliation":[]},{"given":"Mogens H","family":"Jensen","sequence":"additional","affiliation":[]},{"given":"Sandeep","family":"Krishna","sequence":"additional","affiliation":[]},{"given":"Ala","family":"Trusina","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2011,7,19]]},"reference":[{"issue":"6","key":"713_CR1","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.cell.2010.03.006","volume":"140","author":"R Medzhitov","year":"2010","unstructured":"Medzhitov R: Inflammation 2010: new adventures of an old flame. Cell. 2010, 140 (6): 771-776. http:\/\/dx.doi.org\/10.1016\/j.cell.2010.03.006 10.1016\/j.cell.2010.03.006","journal-title":"Cell"},{"issue":"6","key":"713_CR2","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.cell.2010.02.029","volume":"140","author":"C Nathan","year":"2010","unstructured":"Nathan C, Ding A: Nonresolving inflammation. Cell. 2010, 140 (6): 871-882. http:\/\/dx.doi.org\/10.1016\/j.cell.2010.02.029 10.1016\/j.cell.2010.02.029","journal-title":"Cell"},{"issue":"5002","key":"713_CR3","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1126\/science.2011747","volume":"252","author":"J Lechleiter","year":"1991","unstructured":"Lechleiter J, Girard S, Peralta E, Clapham D: Spiral calcium wave propagation and annihilation in Xenopus laevis oocytes. Science. 1991, 252 (5002): 123-126. 10.1126\/science.2011747","journal-title":"Science"},{"issue":"899","key":"713_CR4","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1098\/rspb.1952.0054","volume":"140","author":"AL HODGKIN","year":"1952","unstructured":"HODGKIN AL, HUXLEY AF: Propagation of electrical signals along giant nerve fibers. Proc R Soc Lond B Biol Sci. 1952, 140 (899): 177-183. 10.1098\/rspb.1952.0054","journal-title":"Proc R Soc Lond B Biol Sci"},{"key":"713_CR5","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1002\/cm.10133","volume":"56","author":"J Geiger","year":"2003","unstructured":"Geiger J, Wessels D, Soll DR: Human polymorphonuclear leukocytes respond to waves of chemoattractant, like Dictyostelium. Cell Motil Cytoskeleton. 2003, 56: 27-44. http:\/\/dx.doi.org\/10.1002\/cm.10133 10.1002\/cm.10133","journal-title":"Cell Motil Cytoskeleton"},{"issue":"5","key":"713_CR6","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1084\/jem.181.5.1763","volume":"181","author":"JD Loike","year":"1995","unstructured":"Loike JD, el Khoury J, Cao L, Richards CP, Rascoff H, Mandeville JT, Maxfield FR, Silverstein SC: Fibrin regulates neutrophil migration in response to interleukin 8, leukotriene B4, tumor necrosis factor, and formyl-methionyl-leucyl-phenylalanine. J Exp Med. 1995, 181 (5): 1763-1772. 10.1084\/jem.181.5.1763","journal-title":"J Exp Med"},{"issue":"5","key":"713_CR7","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1155\/S0962935194000487","volume":"3","author":"O Rekdal","year":"1994","unstructured":"Rekdal O, Konopski Z, Svendsen JS, Winberg JO, Espevik T, Osterud B: The TNF Receptors p55 and p75 Mediate Chemotaxis of PMN Induced by TNFalpha and a TNFalpha 36-62 Peptide. Mediators Inflamm. 1994, 3 (5): 347-352. http:\/\/dx.doi.org\/10.1155\/S0962935194000487 10.1155\/S0962935194000487","journal-title":"Mediators Inflamm"},{"issue":"2","key":"713_CR8","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1136\/gut.2005.084665","volume":"56","author":"T Aleksic","year":"2007","unstructured":"Aleksic T, Baumann B, Wagner M, Adler G, Wirth T, Weber CK: Cellular immune reaction in the pancreas is induced by constitutively active IkappaB kinase-2. Gut. 2007, 56 (2): 227-236. http:\/\/dx.doi.org\/10.1136\/gut.2005.084665 10.1136\/gut.2005.084665","journal-title":"Gut"},{"key":"713_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0370-1573(92)90098-K","volume":"218","author":"E Meron","year":"1992","unstructured":"Meron E: Pattern formation in excitable media. Physics Reports. 1992, 218: 1-66. 10.1016\/0370-1573(92)90098-K. http:\/\/www.sciencedirect.com\/science\/article\/B6TVP-46SXPNW-7W\/2\/abaed74d9adfb66d4e4e6177ba4354d2 10.1016\/0370-1573(92)90098-K","journal-title":"Physics Reports"},{"issue":"12","key":"713_CR10","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1161\/01.RES.0000130526.20854.fa","volume":"94","author":"M Nian","year":"2004","unstructured":"Nian M, Lee P, Khaper N, Liu P: Inflammatory cytokines and postmyocardial infarction remodeling. Circ Res. 2004, 94 (12): 1543-1553. http:\/\/dx.doi.org\/10.1161\/01.RES.0000130526.20854.fa 10.1161\/01.RES.0000130526.20854.fa","journal-title":"Circ Res"},{"issue":"9","key":"713_CR11","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/S0962-8924(01)02064-5","volume":"11","author":"V Baud","year":"2001","unstructured":"Baud V, Karin M: Signal transduction by tumor necrosis factor and its relatives. Trends in Cell Biology. 2001, 11 (9): 372-377. http:\/\/www.sciencedirect.com\/science\/article\/B6TCX-43RK8XD-K\/2\/233bb0952eb0afb21c6a7db67cef4314 10.1016\/S0962-8924(01)02064-5","journal-title":"Trends in Cell Biology"},{"issue":"9","key":"713_CR12","doi-asserted-by":"publisher","first-page":"5039","DOI":"10.1073\/pnas.95.9.5039","volume":"95","author":"E Albrecht","year":"1998","unstructured":"Albrecht E, Petty HR: Cellular memory: neutrophil orientation reverses during temporally decreasing chemoattractant concentrations. Proc Natl Acad Sci USA. 1998, 95 (9): 5039-5044. 10.1073\/pnas.95.9.5039","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"713_CR13","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/jlb.67.5.651","volume":"67","author":"PR Ebrahimzadeh","year":"2000","unstructured":"Ebrahimzadeh PR, H\u00f6gfors C, Braide M: Neutrophil chemotaxis in moving gradients of fMLP. J Leukoc Biol. 2000, 67 (5): 651-661.","journal-title":"J Leukoc Biol"},{"key":"713_CR14","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/0014-4827(81)90040-9","volume":"136","author":"MG Vicker","year":"1981","unstructured":"Vicker MG: Ideal and non-ideal concentration gradient propagation in chemotaxis studies. Exp Cell Res. 1981, 136: 91-100. 10.1016\/0014-4827(81)90040-9","journal-title":"Exp Cell Res"},{"key":"713_CR15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1242\/jcs.84.1.263","volume":"84","author":"MG Vicker","year":"1986","unstructured":"Vicker MG, Lackie JM, Schill W: Neutrophil leucocyte chemotaxis is not induced by a spatial gradient of chemoattractant. J Cell Sci. 1986, 84: 263-280.","journal-title":"J Cell Sci"},{"issue":"47","key":"713_CR16","doi-asserted-by":"publisher","first-page":"44715","DOI":"10.1074\/jbc.M202524200","volume":"277","author":"SJ Han","year":"2002","unstructured":"Han SJ, Ko HM, Choi JH, Seo KH, Lee HS, Choi EK, Choi IW, Lee HK, Im SY: Molecular mechanisms for lipopolysaccharide-induced biphasic activation of nuclear factor-kappa B (NF-kappa B). J Biol Chem. 2002, 277 (47): 44715-44721. http:\/\/dx.doi.org\/10.1074\/jbc.M202524200 10.1074\/jbc.M202524200","journal-title":"J Biol Chem"},{"issue":"5596","key":"713_CR17","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1126\/science.1071914","volume":"298","author":"A Hoffmann","year":"2002","unstructured":"Hoffmann A, Levchenko A, Scott ML, Baltimore D: The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science. 2002, 298 (5596): 1241-1245. http:\/\/dx.doi.org\/10.1126\/science.1071914 10.1126\/science.1071914","journal-title":"Science"},{"issue":"5924","key":"713_CR18","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1126\/science.1164860","volume":"324","author":"L Ashall","year":"2009","unstructured":"Ashall L, Horton CA, Nelson DE, Paszek P, Harper CV, Sillitoe K, Ryan S, Spiller DG, Unitt JF, Broomhead DS, Kell DB, Rand DA, S\u00e9e V, White MRH: Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription. Science. 2009, 324 (5924): 242-246. http:\/\/dx.doi.org\/10.1126\/science.1164860 10.1126\/science.1164860","journal-title":"Science"},{"issue":"7303","key":"713_CR19","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/nature09145","volume":"466","author":"S Tay","year":"2010","unstructured":"Tay S, Hughey JJ, Lee TK, Lipniacki T, Quake SR, Covert MW: Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing. Nature. 2010, 466 (7303): 267-271. http:\/\/dx.doi.org\/10.1038\/nature09145 10.1038\/nature09145","journal-title":"Nature"},{"issue":"21","key":"713_CR20","doi-asserted-by":"publisher","first-page":"7451","DOI":"10.1128\/MCB.01101-07","volume":"27","author":"JE Hutti","year":"2007","unstructured":"Hutti JE, Turk BE, Asara JM, Ma A, Cantley LC, Abbott DW: IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway. Mol Cell Biol. 2007, 27 (21): 7451-7461. http:\/\/dx.doi.org\/10.1128\/MCB.01101-07 10.1128\/MCB.01101-07","journal-title":"Mol Cell Biol"},{"issue":"11","key":"713_CR21","doi-asserted-by":"publisher","first-page":"7036","DOI":"10.1074\/jbc.M708690200","volume":"283","author":"K Enesa","year":"2008","unstructured":"Enesa K, Zakkar M, Chaudhury H, Luong LA, Rawlinson L, Mason JC, Haskard DO, Dean JLE, Evans PC: NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling. J Biol Chem. 2008, 283 (11): 7036-7045. http:\/\/dx.doi.org\/10.1074\/jbc.M708690200 10.1074\/jbc.M708690200","journal-title":"J Biol Chem"},{"issue":"Pt 16","key":"713_CR22","doi-asserted-by":"publisher","first-page":"2834","DOI":"10.1242\/jcs.069641","volume":"123","author":"DA Turner","year":"2010","unstructured":"Turner DA, Paszek P, Woodcock DJ, Nelson DE, Horton CA, Wang Y, Spiller DG, Rand DA, White MRH, Harper CV: Physiological levels of TNFalpha stimulation induce stochastic dynamics of NF-kappaB responses in single living cells. J Cell Sci. 2010, 123 (Pt 16): 2834-2843. http:\/\/dx.doi.org\/10.1242\/jcs.069641","journal-title":"J Cell Sci"},{"issue":"3","key":"713_CR23","doi-asserted-by":"publisher","first-page":"036009","DOI":"10.1088\/1478-3975\/6\/3\/036009","volume":"6","author":"S Krishna","year":"2009","unstructured":"Krishna S, Semsey S, Jensen MH: Frustrated bistability as a means to engineer oscillations in biological systems. Phys Biol. 2009, 6 (3): 036009- http:\/\/dx.doi.org\/10.1088\/1478-3975\/6\/3\/036009 10.1088\/1478-3975\/6\/3\/036009","journal-title":"Phys Biol"},{"issue":"5885","key":"713_CR24","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1126\/science.1156951","volume":"321","author":"TYC Tsai","year":"2008","unstructured":"Tsai TYC, Choi YS, Ma W, Pomerening JR, Tang C, Ferrell JE: Robust, tunable biological oscillations from interlinked positive and negative feedback loops. Science. 2008, 321 (5885): 126-129. http:\/\/dx.doi.org\/10.1126\/science.1156951 10.1126\/science.1156951","journal-title":"Science"},{"issue":"2","key":"713_CR25","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/j.1432-1033.1988.tb14384.x","volume":"177","author":"JV Castell","year":"1988","unstructured":"Castell JV, Geiger T, Gross V, Andus T, Walter E, Hirano T, Kishimoto T, Heinrich PC: Plasma clearance, organ distribution and target cells of interleukin-6\/hepatocyte-stimulating factor in the rat. Eur J Biochem. 1988, 177 (2): 357-361. 10.1111\/j.1432-1033.1988.tb14384.x","journal-title":"Eur J Biochem"},{"issue":"6","key":"713_CR26","doi-asserted-by":"crossref","first-page":"3972","DOI":"10.4049\/jimmunol.135.6.3972","volume":"135","author":"BA Beutler","year":"1985","unstructured":"Beutler BA, Milsark IW, Cerami A: Cachectin\/tumor necrosis factor: production, distribution, and metabolic fate in vivo. J Immunol. 1985, 135 (6): 3972-3977.","journal-title":"J Immunol"},{"issue":"5","key":"713_CR27","doi-asserted-by":"publisher","first-page":"2945","DOI":"10.1074\/jbc.M510085200","volume":"281","author":"R Cheong","year":"2006","unstructured":"Cheong R, Bergmann A, Werner SL, Regal J, Hoffmann A, Levchenko A: Transient IkappaB kinase activity mediates temporal NF-kappaB dynamics in response to a wide range of tumor necrosis factor-alpha doses. J Biol Chem. 2006, 281 (5): 2945-2950. http:\/\/dx.doi.org\/10.1074\/jbc.M510085200","journal-title":"J Biol Chem"},{"issue":"7","key":"713_CR28","doi-asserted-by":"publisher","first-page":"e1000422","DOI":"10.1371\/journal.pcbi.1000422","volume":"5","author":"D Geberth","year":"2009","unstructured":"Geberth D, H\u00fctt MT: Predicting the distribution of spiral waves from cell properties in a developmental-path model of Dictyostelium pattern formation. PLoS Comput Biol. 2009, 5 (7): e1000422- http:\/\/dx.doi.org\/10.1371\/journal.pcbi.1000422 10.1371\/journal.pcbi.1000422","journal-title":"PLoS Comput Biol"},{"issue":"5981","key":"713_CR29","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1126\/science.1183415","volume":"328","author":"T Gregor","year":"2010","unstructured":"Gregor T, Fujimoto K, Masaki N, Sawai S: The onset of collective behavior in social amoebae. Science. 2010, 328 (5981): 1021-1025. http:\/\/dx.doi.org\/10.1126\/science.1183415 10.1126\/science.1183415","journal-title":"Science"},{"issue":"11","key":"713_CR30","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1161\/01.CIR.99.11.1492","volume":"99","author":"MW Irwin","year":"1999","unstructured":"Irwin MW, Mak S, Mann DL, Qu R, Penninger JM, Yan A, Dawood F, Wen WH, Shou Z, Liu P: Tissue Expression and Immunolocalization of Tumor Necrosis Factor-alpha in Postinfarction Dysfunctional Myocardium. Circulation. 1999, 99 (11): 1492-1498. http:\/\/circ.ahajournals.org\/cgi\/content\/abstract\/99\/11\/1492","journal-title":"Circulation"},{"issue":"2","key":"713_CR31","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1161\/01.CIR.98.2.149","volume":"98","author":"K Ono","year":"1998","unstructured":"Ono K, Matsumori A, Shioi T, Furukawa Y, Sasayama S: Cytokine Gene Expression After Myocardial Infarction in Rat Hearts: Possible Implication in Left Ventricular Remodeling. Circulation. 1998, 98 (2): 149-156. http:\/\/circ.ahajournals.org\/cgi\/content\/abstract\/98\/2\/149","journal-title":"Circulation"},{"key":"713_CR32","first-page":"227","volume":"135","author":"MI Cybulsky","year":"1989","unstructured":"Cybulsky MI, McComb DJ, Movat HZ: Protein synthesis dependent and independent mechanisms of neutrophil emigration. Different mechanisms of inflammation in rabbits induced by interleukin-1, tumor necrosis factor alpha or endotoxin versus leukocyte chemoattractants. Am J Pathol. 1989, 135: 227-237.","journal-title":"Am J Pathol"},{"issue":"2","key":"713_CR33","first-page":"75","volume":"24","author":"HZ Movat","year":"1986","unstructured":"Movat HZ, Cybulsky MI, Colditz IG: Emigration and accumulation of PMN-leukocytes induced by endotoxin, interleukin 1 and other chemotactic substances. Folia Histochem Cytobiol. 1986, 24 (2): 75-88.","journal-title":"Folia Histochem Cytobiol"},{"issue":"29","key":"713_CR34","doi-asserted-by":"publisher","first-page":"10840","DOI":"10.1073\/pnas.0604085103","volume":"103","author":"S Krishna","year":"2006","unstructured":"Krishna S, Jensen MH, Sneppen K: Minimal model of spiky oscillations in NF-kappaB signaling. Proc Natl Acad Sci USA. 2006, 103 (29): 10840-10845. http:\/\/dx.doi.org\/10.1073\/pnas.0604085103 10.1073\/pnas.0604085103","journal-title":"Proc Natl Acad Sci USA"},{"key":"713_CR35","volume-title":"arxive[physics.bio-ph]","author":"B Mengel","year":"2009","unstructured":"Mengel B, Krishna S, Jensen MH, Trusina A: Theoretical analyses predict A20 regulates period of NF-kB oscillation. arxive[physics.bio-ph]. 2009, 0911.0529:"},{"issue":"25","key":"713_CR36","doi-asserted-by":"publisher","first-page":"11644","DOI":"10.1073\/pnas.0913798107","volume":"107","author":"P Paszek","year":"2010","unstructured":"Paszek P, Ryan S, Ashall L, Sillitoe K, Harper CV, Spiller DG, Rand DA, White MRH: Population robustness arising from cellular heterogeneity. Proc Natl Acad Sci USA. 2010, 107 (25): 11644-11649. http:\/\/dx.doi.org\/10.1073\/pnas.0913798107 10.1073\/pnas.0913798107","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5742","key":"713_CR37","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1126\/science.1113319","volume":"309","author":"SL Werner","year":"2005","unstructured":"Werner SL, Barken D, Hoffmann A: Stimulus specificity of gene expression programs determined by temporal control of IKK activity. Science. 2005, 309 (5742): 1857-1861. http:\/\/dx.doi.org\/10.1126\/science.1113319 10.1126\/science.1113319","journal-title":"Science"},{"issue":"5963","key":"713_CR38","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1126\/science.1183021","volume":"327","author":"A Iwasaki","year":"2010","unstructured":"Iwasaki A, Medzhitov R: Regulation of adaptive immunity by the innate immune system. Science. 2010, 327 (5963): 291-295. http:\/\/dx.doi.org\/10.1126\/science.1183021 10.1126\/science.1183021","journal-title":"Science"},{"key":"713_CR39","first-page":"1","volume":"124","author":"MI Cybulsky","year":"1986","unstructured":"Cybulsky MI, Cybulsky IJ, Movat HZ: Neutropenic responses to intradermal injections of Escherichia coli. Effects on the kinetics of polymorphonuclear leukocyte emigration. Am J Pathol. 1986, 124: 1-9.","journal-title":"Am J Pathol"},{"issue":"4","key":"713_CR40","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.4049\/jimmunol.133.4.2169","volume":"133","author":"IG Colditz","year":"1984","unstructured":"Colditz IG, Movat HZ: Kinetics of neutrophil accumulation in acute inflammatory lesions induced by chemotaxins and chemotaxinigens. J Immunol. 1984, 133 (4): 2169-2173.","journal-title":"J Immunol"},{"issue":"3","key":"713_CR41","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/BF00920077","volume":"12","author":"IG Colditz","year":"1988","unstructured":"Colditz IG: Two patterns of early neutrophil accumulation in acute inflammatory lesions. Inflammation. 1988, 12 (3): 251-263. 10.1007\/BF00920077","journal-title":"Inflammation"},{"issue":"23","key":"713_CR42","doi-asserted-by":"publisher","first-page":"12258","DOI":"10.1073\/pnas.94.23.12258","volume":"94","author":"K Francis","year":"1997","unstructured":"Francis K, Palsson BO: Effective intercellular communication distances are determined by the relative time constants for cyto\/chemokine secretion and diffusion. Proc Natl Acad Sci USA. 1997, 94 (23): 12258-12262. 10.1073\/pnas.94.23.12258","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["BMC Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1752-0509-5-115.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T06:23:32Z","timestamp":1686205412000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsystbiol.biomedcentral.com\/articles\/10.1186\/1752-0509-5-115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,19]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["713"],"URL":"https:\/\/doi.org\/10.1186\/1752-0509-5-115","relation":{},"ISSN":["1752-0509"],"issn-type":[{"value":"1752-0509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,19]]},"assertion":[{"value":"24 February 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2011","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2011","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"115"}}